{"id":"https://openalex.org/W4389542996","doi":"https://doi.org/10.1109/embc40787.2023.10340468","title":"Learning Spectral Fractional Anisotropy and Mean Diffusivity Features as Neuroimaging Biomarkers for Tracking White Matter Integrity Changes in Myotonic Dystrophy Type 1 Patients using Deep Convolutional Neural Networks","display_name":"Learning Spectral Fractional Anisotropy and Mean Diffusivity Features as Neuroimaging Biomarkers for Tracking White Matter Integrity Changes in Myotonic Dystrophy Type 1 Patients using Deep Convolutional Neural Networks","publication_year":2023,"publication_date":"2023-07-24","ids":{"openalex":"https://openalex.org/W4389542996","doi":"https://doi.org/10.1109/embc40787.2023.10340468","pmid":"https://pubmed.ncbi.nlm.nih.gov/38083393"},"language":"en","primary_location":{"id":"doi:10.1109/embc40787.2023.10340468","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/embc40787.2023.10340468","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050275034","display_name":"Tahereh Kamali","orcid":"https://orcid.org/0000-0002-7455-9013"},"institutions":[{"id":"https://openalex.org/I4210157890","display_name":"Neurological Surgery","ror":"https://ror.org/04r0gp612","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210157890"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tahereh Kamali","raw_affiliation_strings":["Stanford University School of Medicine,Department of Neurology and Neurological Sciences,California,USA","Department of Neurology and Neurological Sciences, Stanford University School of Medicine, California, USA"],"affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine,Department of Neurology and Neurological Sciences,California,USA","institution_ids":["https://openalex.org/I97018004","https://openalex.org/I4210157890"]},{"raw_affiliation_string":"Department of Neurology and Neurological Sciences, Stanford University School of Medicine, California, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042201706","display_name":"John Day","orcid":"https://orcid.org/0000-0002-0086-9529"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4210157890","display_name":"Neurological Surgery","ror":"https://ror.org/04r0gp612","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210157890"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John W. Day","raw_affiliation_strings":["Stanford University School of Medicine,Department of Neurology and Neurological Sciences,California,USA","Department of Neurology and Neurological Sciences, Stanford University School of Medicine, California, USA"],"affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine,Department of Neurology and Neurological Sciences,California,USA","institution_ids":["https://openalex.org/I97018004","https://openalex.org/I4210157890"]},{"raw_affiliation_string":"Department of Neurology and Neurological Sciences, Stanford University School of Medicine, California, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063127106","display_name":"Gayle K. Deutsch","orcid":"https://orcid.org/0000-0001-6886-4356"},"institutions":[{"id":"https://openalex.org/I4210157890","display_name":"Neurological Surgery","ror":"https://ror.org/04r0gp612","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210157890"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gayle K. Deutsch","raw_affiliation_strings":["Stanford University School of Medicine,Department of Neurology and Neurological Sciences,California,USA","Department of Neurology and Neurological Sciences, Stanford University School of Medicine, California, USA"],"affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine,Department of Neurology and Neurological Sciences,California,USA","institution_ids":["https://openalex.org/I97018004","https://openalex.org/I4210157890"]},{"raw_affiliation_string":"Department of Neurology and Neurological Sciences, Stanford University School of Medicine, California, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024738169","display_name":"Jacinda B. Sampson","orcid":"https://orcid.org/0000-0002-4991-6496"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4210157890","display_name":"Neurological Surgery","ror":"https://ror.org/04r0gp612","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210157890"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacinda B. Sampson","raw_affiliation_strings":["Stanford University School of Medicine,Department of Neurology and Neurological Sciences,California,USA","Department of Neurology and Neurological Sciences, Stanford University School of Medicine, California, USA"],"affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine,Department of Neurology and Neurological Sciences,California,USA","institution_ids":["https://openalex.org/I97018004","https://openalex.org/I4210157890"]},{"raw_affiliation_string":"Department of Neurology and Neurological Sciences, Stanford University School of Medicine, California, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035087788","display_name":"Alejandro Murad","orcid":null},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I2802966293","display_name":"Urban College of Boston","ror":"https://ror.org/02yec8h85","country_code":"US","type":"education","lineage":["https://openalex.org/I2802966293"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alejandro Murad","raw_affiliation_strings":["US Discovery Biology,UCB Biopharma,Boston,USA","UCB Biopharma, US Discovery Biology, Boston, USA"],"affiliations":[{"raw_affiliation_string":"US Discovery Biology,UCB Biopharma,Boston,USA","institution_ids":["https://openalex.org/I2802966293"]},{"raw_affiliation_string":"UCB Biopharma, US Discovery Biology, Boston, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027082642","display_name":"Jeremy Chaufty","orcid":null},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I2802966293","display_name":"Urban College of Boston","ror":"https://ror.org/02yec8h85","country_code":"US","type":"education","lineage":["https://openalex.org/I2802966293"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy Chaufty","raw_affiliation_strings":["US Discovery Biology,UCB Biopharma,Boston,USA","UCB Biopharma, US Discovery Biology, Boston, USA"],"affiliations":[{"raw_affiliation_string":"US Discovery Biology,UCB Biopharma,Boston,USA","institution_ids":["https://openalex.org/I2802966293"]},{"raw_affiliation_string":"UCB Biopharma, US Discovery Biology, Boston, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060040870","display_name":"Dana Parker","orcid":"https://orcid.org/0000-0002-9822-412X"},"institutions":[{"id":"https://openalex.org/I4210157890","display_name":"Neurological Surgery","ror":"https://ror.org/04r0gp612","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210157890"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dana Parker","raw_affiliation_strings":["Stanford University School of Medicine,Department of Neurology and Neurological Sciences,California,USA","Department of Neurology and Neurological Sciences, Stanford University School of Medicine, California, USA"],"affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine,Department of Neurology and Neurological Sciences,California,USA","institution_ids":["https://openalex.org/I97018004","https://openalex.org/I4210157890"]},{"raw_affiliation_string":"Department of Neurology and Neurological Sciences, Stanford University School of Medicine, California, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081661210","display_name":"Jeffrey R. Wozniak","orcid":"https://orcid.org/0000-0002-7132-8519"},"institutions":[{"id":"https://openalex.org/I4210131307","display_name":"Institute of Behavioral Sciences","ror":"https://ror.org/03c6bf397","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210131307"]},{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210097178","display_name":"Behavioral Pharma (United States)","ror":"https://ror.org/011bspp78","country_code":"US","type":"company","lineage":["https://openalex.org/I4210097178"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Jeffrey R. Wozniak","raw_affiliation_strings":["University of Minnesota,Department of Psychiatry and Behavioral Sciences,USA","Department of Psychiatry and Behavioral Sciences, University of Minnesota, USA"],"affiliations":[{"raw_affiliation_string":"University of Minnesota,Department of Psychiatry and Behavioral Sciences,USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210131307","https://openalex.org/I4210097178"]},{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, University of Minnesota, USA","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5050275034"],"corresponding_institution_ids":["https://openalex.org/I4210157890","https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":0.2356,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.61859294,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"2023","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9905999898910522,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9882000088691711,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fractional-anisotropy","display_name":"Fractional anisotropy","score":0.8879640102386475},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.7092956900596619},{"id":"https://openalex.org/keywords/myotonic-dystrophy","display_name":"Myotonic dystrophy","score":0.6922321319580078},{"id":"https://openalex.org/keywords/white-matter","display_name":"White matter","score":0.6866990327835083},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.6421393156051636},{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"Diffusion MRI","score":0.5797315239906311},{"id":"https://openalex.org/keywords/anisotropy","display_name":"Anisotropy","score":0.5118809938430786},{"id":"https://openalex.org/keywords/thermal-diffusivity","display_name":"Thermal diffusivity","score":0.44980350136756897},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.44697463512420654},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.44289931654930115},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.4342940151691437},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.43112149834632874},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3776184320449829},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.31605812907218933},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.28914469480514526},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.28120163083076477},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2205740213394165},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2019011378288269},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.1891147792339325},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.16035807132720947},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.15015292167663574},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.14990702271461487}],"concepts":[{"id":"https://openalex.org/C89916169","wikidata":"https://www.wikidata.org/wiki/Q17014600","display_name":"Fractional anisotropy","level":4,"score":0.8879640102386475},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.7092956900596619},{"id":"https://openalex.org/C2778063965","wikidata":"https://www.wikidata.org/wiki/Q1860507","display_name":"Myotonic dystrophy","level":2,"score":0.6922321319580078},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.6866990327835083},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.6421393156051636},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.5797315239906311},{"id":"https://openalex.org/C85725439","wikidata":"https://www.wikidata.org/wiki/Q466686","display_name":"Anisotropy","level":2,"score":0.5118809938430786},{"id":"https://openalex.org/C37668627","wikidata":"https://www.wikidata.org/wiki/Q3381809","display_name":"Thermal diffusivity","level":2,"score":0.44980350136756897},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.44697463512420654},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.44289931654930115},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.4342940151691437},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.43112149834632874},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3776184320449829},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.31605812907218933},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28914469480514526},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.28120163083076477},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2205740213394165},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2019011378288269},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.1891147792339325},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.16035807132720947},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.15015292167663574},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.14990702271461487},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009223","descriptor_name":"Myotonic Dystrophy","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009223","descriptor_name":"Myotonic Dystrophy","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009223","descriptor_name":"Myotonic Dystrophy","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009223","descriptor_name":"Myotonic Dystrophy","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009223","descriptor_name":"Myotonic Dystrophy","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009223","descriptor_name":"Myotonic Dystrophy","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009223","descriptor_name":"Myotonic Dystrophy","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009223","descriptor_name":"Myotonic Dystrophy","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009223","descriptor_name":"Myotonic Dystrophy","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009223","descriptor_name":"Myotonic Dystrophy","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009223","descriptor_name":"Myotonic Dystrophy","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009223","descriptor_name":"Myotonic Dystrophy","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009223","descriptor_name":"Myotonic Dystrophy","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009223","descriptor_name":"Myotonic Dystrophy","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009223","descriptor_name":"Myotonic Dystrophy","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D009223","descriptor_name":"Myotonic Dystrophy","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D009223","descriptor_name":"Myotonic Dystrophy","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D009223","descriptor_name":"Myotonic Dystrophy","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D009223","descriptor_name":"Myotonic Dystrophy","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D009223","descriptor_name":"Myotonic Dystrophy","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D009223","descriptor_name":"Myotonic Dystrophy","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016880","descriptor_name":"Anisotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016880","descriptor_name":"Anisotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016880","descriptor_name":"Anisotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016880","descriptor_name":"Anisotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016880","descriptor_name":"Anisotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016880","descriptor_name":"Anisotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016880","descriptor_name":"Anisotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc40787.2023.10340468","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/embc40787.2023.10340468","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:38083393","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38083393","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320312574","display_name":"UCB","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W2062566447","https://openalex.org/W2117340355","https://openalex.org/W2127309075","https://openalex.org/W2157649211","https://openalex.org/W2170480020","https://openalex.org/W2227630131","https://openalex.org/W2508982726","https://openalex.org/W2912691032","https://openalex.org/W2946781176","https://openalex.org/W2954977780","https://openalex.org/W2962681100","https://openalex.org/W3081685005","https://openalex.org/W3140714476","https://openalex.org/W3168997536","https://openalex.org/W4200499857","https://openalex.org/W4242828830","https://openalex.org/W4294975402","https://openalex.org/W4297095263","https://openalex.org/W6775960533","https://openalex.org/W6843457463"],"related_works":["https://openalex.org/W3031573373","https://openalex.org/W2000010321","https://openalex.org/W2125096937","https://openalex.org/W3102902644","https://openalex.org/W4401571379","https://openalex.org/W2391066511","https://openalex.org/W2389794309","https://openalex.org/W2765793352","https://openalex.org/W2358906680","https://openalex.org/W2116365403"],"abstract_inverted_index":{"Myotonic":[0],"dystrophy":[1],"type":[2],"1":[3],"(DM1)":[4],"is":[5,73,100,156,205],"a":[6,15,49,67,88,130,144,208,222,230],"genetic":[7],"neuromuscular":[8],"progressive":[9],"multisystem":[10,162],"disease":[11,166],"that":[12,183,226],"results":[13],"in":[14,52,81,141,241],"broad":[16],"spectrum":[17],"of":[18,86,95,117,129,132,154,188,191,202,211,214],"clinical":[19,243],"central":[20],"nervous":[21],"system":[22],"(CNS)":[23],"involvement,":[24],"including":[25],"problems":[26],"with":[27,59,83,169,235],"memory,":[28],"attention,":[29],"executive":[30],"functioning,":[31],"and":[32,37,105,121,164,174,181,219],"social":[33],"cognition.":[34],"Fractional":[35],"anisotropy":[36],"mean":[38,106],"diffusivity":[39],"along-tract":[40,108],"data":[41,109,127],"calculated":[42,110],"using":[43],"diffusion":[44],"tensor":[45],"imaging":[46],"techniques":[47],"play":[48],"vital":[50],"role":[51],"assessing":[53],"white":[54,77,114],"matter":[55,78,115],"microstructural":[56],"changes":[57],"associated":[58],"neurodegeneration":[60],"caused":[61],"by":[62],"DM1.":[63,96],"In":[64],"this":[65,203],"work,":[66],"novel":[68],"spectrogram-based":[69],"deep":[70,89,223],"learning":[71,90,224],"method":[72,99],"proposed":[74,98],"to":[75,148,160,198,206,220,238],"characterize":[76],"network":[79],"alterations":[80],"DM1":[82,119,155,161,170,192,215],"the":[84,165,212,217,233,236],"goal":[85,201],"building":[87],"model":[91,137,225],"as":[92,178,229,245],"neuroimaging":[93],"biomarkers":[94],"The":[97,125,136,200],"evaluated":[101],"on":[102,216],"fractional":[103],"anisotropies":[104],"diffusivities":[107],"for":[111,232],"25":[112],"major":[113],"tracts":[116],"46":[118],"patients":[120],"96":[122],"unaffected":[123],"controls.":[124],"evaluation":[126],"consists":[128],"total":[131],"7100":[133],"spectrogram":[134],"images.":[135],"achieved":[138],"91%":[139],"accuracy":[140],"identifying":[142],"DM1,":[143],"significant":[145],"improvement":[146],"compared":[147],"previous":[149],"methods.Clinical":[150],"relevance-":[151],"Clinical":[152],"care":[153],"particularly":[157],"challenging":[158],"due":[159],"involvement":[163],"variability.":[167],"Patients":[168],"often":[171],"experience":[172],"neurological":[173],"psychological":[175],"symptoms,":[176],"such":[177],"excessive":[179],"sleepiness":[180],"apathy,":[182],"greatly":[184],"impact":[185,213],"their":[186],"quality":[187],"life.":[189],"Some":[190],"CNS":[193,218],"symptoms":[194],"may":[195],"be":[196,239],"responsive":[197],"treatment.":[199],"research":[204],"gain":[207],"deeper":[209],"understanding":[210],"develop":[221],"can":[227],"serve":[228],"biomarker":[231],"disease,":[234],"potential":[237],"used":[240],"future":[242],"trials":[244],"an":[246],"outcome":[247],"measure.":[248]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-03-02T08:37:19.008085","created_date":"2025-10-10T00:00:00"}