{"id":"https://openalex.org/W4389543153","doi":"https://doi.org/10.1109/embc40787.2023.10340437","title":"DEPAS: De-novo Pathology Semantic Masks using a Generative Model","display_name":"DEPAS: De-novo Pathology Semantic Masks using a Generative Model","publication_year":2023,"publication_date":"2023-07-24","ids":{"openalex":"https://openalex.org/W4389543153","doi":"https://doi.org/10.1109/embc40787.2023.10340437","pmid":"https://pubmed.ncbi.nlm.nih.gov/38082796"},"language":"en","primary_location":{"id":"doi:10.1109/embc40787.2023.10340437","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc40787.2023.10340437","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039494777","display_name":"Ariel Larey","orcid":"https://orcid.org/0000-0002-5006-9300"},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Ariel Larey","raw_affiliation_strings":["Faculty of Medicine, Technion - IIT,Biophysics and Systems Biology,Department of Physiology,Haifa,Israel","Department of Physiology, Biophysics and Systems Biology, Faculty of Medicine, Technion - IIT, Haifa, Israel","Faculty of Computer Science, Technion - IIT, Haifa, Israel"],"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Technion - IIT,Biophysics and Systems Biology,Department of Physiology,Haifa,Israel","institution_ids":["https://openalex.org/I174306211"]},{"raw_affiliation_string":"Department of Physiology, Biophysics and Systems Biology, Faculty of Medicine, Technion - IIT, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]},{"raw_affiliation_string":"Faculty of Computer Science, Technion - IIT, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077139721","display_name":"Nati Daniel","orcid":"https://orcid.org/0000-0002-0939-3379"},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Nati Daniel","raw_affiliation_strings":["Faculty of Medicine, Technion - IIT,Biophysics and Systems Biology,Department of Physiology,Haifa,Israel","Department of Physiology, Biophysics and Systems Biology, Faculty of Medicine, Technion - IIT, Haifa, Israel"],"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Technion - IIT,Biophysics and Systems Biology,Department of Physiology,Haifa,Israel","institution_ids":["https://openalex.org/I174306211"]},{"raw_affiliation_string":"Department of Physiology, Biophysics and Systems Biology, Faculty of Medicine, Technion - IIT, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023083640","display_name":"Eliel Aknin","orcid":"https://orcid.org/0000-0003-4591-7018"},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Eliel Aknin","raw_affiliation_strings":["Faculty of Medicine, Technion - IIT,Biophysics and Systems Biology,Department of Physiology,Haifa,Israel","Faculty of Industrial Engineering, Technion - IIT, Haifa, Israel","Department of Physiology, Biophysics and Systems Biology, Faculty of Medicine, Technion - IIT, Haifa, Israel"],"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Technion - IIT,Biophysics and Systems Biology,Department of Physiology,Haifa,Israel","institution_ids":["https://openalex.org/I174306211"]},{"raw_affiliation_string":"Faculty of Industrial Engineering, Technion - IIT, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]},{"raw_affiliation_string":"Department of Physiology, Biophysics and Systems Biology, Faculty of Medicine, Technion - IIT, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041993817","display_name":"Yael Fisher","orcid":"https://orcid.org/0000-0002-9798-7061"},"institutions":[{"id":"https://openalex.org/I2801301638","display_name":"Rambam Health Care Campus","ror":"https://ror.org/01fm87m50","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801301638"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yael Fisher","raw_affiliation_strings":["Rambam Health Care Campus,Division of Pathology,Haifa,Israel","Division of Pathology, Rambam Health Care Campus, Haifa, Israel"],"affiliations":[{"raw_affiliation_string":"Rambam Health Care Campus,Division of Pathology,Haifa,Israel","institution_ids":["https://openalex.org/I2801301638"]},{"raw_affiliation_string":"Division of Pathology, Rambam Health Care Campus, Haifa, Israel","institution_ids":["https://openalex.org/I2801301638"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017505256","display_name":"Yonatan Savir","orcid":"https://orcid.org/0000-0002-5345-8491"},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yonatan Savir","raw_affiliation_strings":["Faculty of Medicine, Technion - IIT,Biophysics and Systems Biology,Department of Physiology,Haifa,Israel","Department of Physiology, Biophysics and Systems Biology, Faculty of Medicine, Technion - IIT, Haifa, Israel"],"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Technion - IIT,Biophysics and Systems Biology,Department of Physiology,Haifa,Israel","institution_ids":["https://openalex.org/I174306211"]},{"raw_affiliation_string":"Department of Physiology, Biophysics and Systems Biology, Faculty of Medicine, Technion - IIT, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5039494777"],"corresponding_institution_ids":["https://openalex.org/I174306211"],"apc_list":null,"apc_paid":null,"fwci":0.3185,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.65159763,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"2023","issue":null,"first_page":"1","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9908999800682068,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9908999800682068,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10028","display_name":"Topic Modeling","score":0.9768999814987183,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.963699996471405,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6496400237083435},{"id":"https://openalex.org/keywords/generative-grammar","display_name":"Generative grammar","score":0.5756271481513977},{"id":"https://openalex.org/keywords/generative-model","display_name":"Generative model","score":0.5295915007591248},{"id":"https://openalex.org/keywords/natural-language-processing","display_name":"Natural language processing","score":0.44087332487106323},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.40289148688316345}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6496400237083435},{"id":"https://openalex.org/C39890363","wikidata":"https://www.wikidata.org/wiki/Q36108","display_name":"Generative grammar","level":2,"score":0.5756271481513977},{"id":"https://openalex.org/C167966045","wikidata":"https://www.wikidata.org/wiki/Q5532625","display_name":"Generative model","level":3,"score":0.5295915007591248},{"id":"https://openalex.org/C204321447","wikidata":"https://www.wikidata.org/wiki/Q30642","display_name":"Natural language processing","level":1,"score":0.44087332487106323},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.40289148688316345}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006652","descriptor_name":"Histological Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006652","descriptor_name":"Histological Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006652","descriptor_name":"Histological Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006652","descriptor_name":"Histological Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006652","descriptor_name":"Histological Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006652","descriptor_name":"Histological Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008397","descriptor_name":"Masks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008397","descriptor_name":"Masks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008397","descriptor_name":"Masks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010336","descriptor_name":"Pathology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010336","descriptor_name":"Pathology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010336","descriptor_name":"Pathology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012660","descriptor_name":"Semantics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012660","descriptor_name":"Semantics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012660","descriptor_name":"Semantics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012660","descriptor_name":"Semantics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012660","descriptor_name":"Semantics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012660","descriptor_name":"Semantics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc40787.2023.10340437","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc40787.2023.10340437","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:38082796","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38082796","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322108","display_name":"Ministry of Science and Technology","ror":"https://ror.org/032e49973"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1522301498","https://openalex.org/W1583776211","https://openalex.org/W2125389028","https://openalex.org/W2138682569","https://openalex.org/W2183341477","https://openalex.org/W2194775991","https://openalex.org/W2329659234","https://openalex.org/W2509486054","https://openalex.org/W2807888536","https://openalex.org/W2895877180","https://openalex.org/W2963073614","https://openalex.org/W2963735467","https://openalex.org/W2963800363","https://openalex.org/W3096831136","https://openalex.org/W3105747145","https://openalex.org/W3126176247","https://openalex.org/W3152579480","https://openalex.org/W3164024337","https://openalex.org/W3175929533","https://openalex.org/W3184378023","https://openalex.org/W4229449315","https://openalex.org/W4295312788","https://openalex.org/W4295443626","https://openalex.org/W4296322368","https://openalex.org/W4297249536","https://openalex.org/W4300439197","https://openalex.org/W4301206121","https://openalex.org/W4306964569","https://openalex.org/W4313125465","https://openalex.org/W6631190155","https://openalex.org/W6634851332","https://openalex.org/W6678815747","https://openalex.org/W6725939724","https://openalex.org/W6743716298","https://openalex.org/W6749278580","https://openalex.org/W6755553192","https://openalex.org/W6765779288","https://openalex.org/W6766978945"],"related_works":["https://openalex.org/W4365211920","https://openalex.org/W3014948380","https://openalex.org/W3204019825","https://openalex.org/W4380551139","https://openalex.org/W4317695495","https://openalex.org/W4287117424","https://openalex.org/W4387506531","https://openalex.org/W4238433571","https://openalex.org/W2967848559","https://openalex.org/W4299831724"],"abstract_inverted_index":{"The":[0],"integration":[1],"of":[2,29,46,52,102,117,124,181,188,193,219,222,228,268],"artificial":[3],"intelligence":[4],"(AI)":[5],"into":[6],"digital":[7],"pathology":[8],"has":[9],"the":[10,26,33,44,53,74,78,103,114,118,134,146,179,265],"potential":[11],"to":[12,39,76,87,133,183,214,235,249],"automate":[13],"and":[14,22,105,169,197,246],"improve":[15],"various":[16],"tasks,":[17],"such":[18],"as":[19,131,159],"image":[20,36,93,112,135,211],"analysis":[21],"diagnostic":[23],"decision-making.":[24],"Yet,":[25],"inherent":[27],"variability":[28],"tissues,":[30],"together":[31],"with":[32,174,224,253],"need":[34],"for":[35,56,190,264],"labeling,":[37],"lead":[38],"biased":[40],"datasets":[41,65],"that":[42,91,98,128,165,202,240],"limit":[43],"generalizability":[45],"algorithms":[47],"trained":[48],"on":[49],"them.":[50,82],"One":[51],"emerging":[54],"solutions":[55],"this":[57,150],"challenge":[58],"is":[59,86],"synthetic":[60,270],"histological":[61,107,251,271],"images.":[62],"Debiasing":[63],"real":[64,143],"require":[66],"not":[67],"only":[68],"generating":[69,269],"photorealistic":[70,216],"images":[71,144,218,252,272],"but":[72],"also":[73],"ability":[75,180],"control":[77],"cellular":[79,255],"features":[80],"within":[81],"A":[83],"common":[84],"approach":[85],"use":[88,247],"generative":[89,156,210],"methods":[90],"perform":[92],"translation":[94,136,212],"between":[95],"semantic":[96,126,139,172,186,238,276],"masks":[97,127,140,173,204,239],"reflect":[99],"prior":[100],"knowledge":[101],"tissue":[104,119,167,189],"a":[106,121,154,209,261,279],"image.":[108],"However,":[109],"unlike":[110],"other":[111],"domains,":[113],"complex":[115],"structure":[116,168],"prevents":[120],"simple":[122],"creation":[123],"histology":[125,217],"are":[129],"required":[130],"input":[132],"model,":[137,157],"while":[138,273],"extracted":[141],"from":[142],"reduce":[145],"process's":[147],"scalability.":[148],"In":[149],"work,":[151],"we":[152,200,232],"introduce":[153],"scalable":[155,280],"coined":[158],"DEPAS":[160,182,234],"(De-novo":[161],"Pathology":[162],"Semantic":[163],"Masks),":[164],"captures":[166],"generates":[170],"high-resolution":[171],"state-of-the-art":[175,262],"quality.":[176],"We":[177],"demonstrate":[178],"generate":[184,236],"realistic":[185],"maps":[187],"three":[191],"types":[192,221,227,244],"organs:":[194],"skin,":[195],"prostate,":[196],"lung.":[198],"Moreover,":[199],"show":[201],"these":[203],"can":[205],"be":[206],"processed":[207],"using":[208],"model":[213],"produce":[215,250],"two":[220,225],"cancer":[223],"different":[226,242],"staining":[229],"techniques.":[230],"Finally,":[231],"harness":[233],"multi-label":[237],"capture":[241],"cell":[243],"distributions":[245],"them":[248],"on-demand":[254],"features.":[256],"Overall,":[257],"our":[258],"work":[259],"provides":[260],"solution":[263],"challenging":[266],"task":[267],"controlling":[274],"their":[275],"information":[277],"in":[278],"way.":[281]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
