{"id":"https://openalex.org/W4389576993","doi":"https://doi.org/10.1109/embc40787.2023.10340273","title":"Physiologically-Based Pharmacokinetic Modeling of Blood Clearance of Liver Fluorescent Markers for the Assessment of the Degree of Hepatic Ischemia-Reperfusion Injury <sup>*</sup>","display_name":"Physiologically-Based Pharmacokinetic Modeling of Blood Clearance of Liver Fluorescent Markers for the Assessment of the Degree of Hepatic Ischemia-Reperfusion Injury <sup>*</sup>","publication_year":2023,"publication_date":"2023-07-24","ids":{"openalex":"https://openalex.org/W4389576993","doi":"https://doi.org/10.1109/embc40787.2023.10340273","pmid":"https://pubmed.ncbi.nlm.nih.gov/38082711"},"language":"en","primary_location":{"id":"doi:10.1109/embc40787.2023.10340273","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/embc40787.2023.10340273","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009031326","display_name":"Christopher Monti","orcid":null},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher Monti","raw_affiliation_strings":["Medical College of Wisconsin"],"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001255219","display_name":"Said H. Audi","orcid":"https://orcid.org/0000-0002-4887-604X"},"institutions":[{"id":"https://openalex.org/I102461120","display_name":"Marquette University","ror":"https://ror.org/04gr4te78","country_code":"US","type":"education","lineage":["https://openalex.org/I102461120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Said H. Audi","raw_affiliation_strings":["Marquette University"],"affiliations":[{"raw_affiliation_string":"Marquette University","institution_ids":["https://openalex.org/I102461120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027038317","display_name":"Justin Womack","orcid":"https://orcid.org/0000-0001-9957-9822"},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin Womack","raw_affiliation_strings":["Medical College of Wisconsin"],"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007647579","display_name":"Seung\u2010Keun Hong","orcid":"https://orcid.org/0000-0001-5686-7541"},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seung-Keun Hong","raw_affiliation_strings":["Medical College of Wisconsin"],"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100541690","display_name":"Yongqiang Yang","orcid":"https://orcid.org/0000-0002-7109-6164"},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yongqiang Yang","raw_affiliation_strings":["Medical College of Wisconsin"],"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100615685","display_name":"Joohyun Kim","orcid":"https://orcid.org/0000-0001-5371-2317"},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joohyun Kim","raw_affiliation_strings":["Medical College of Wisconsin"],"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061756444","display_name":"Ranjan K. Dash","orcid":"https://orcid.org/0000-0001-6751-0679"},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ranjan K. Dash","raw_affiliation_strings":["Medical College of Wisconsin"],"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5009031326"],"corresponding_institution_ids":["https://openalex.org/I204308271"],"apc_list":null,"apc_paid":null,"fwci":0.238,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.70756641,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"2023","issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"Pharmacokinetics","score":0.7064735293388367},{"id":"https://openalex.org/keywords/multidrug-resistance-associated-protein-2","display_name":"Multidrug resistance-associated protein 2","score":0.687880277633667},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"Liver transplantation","score":0.6445144414901733},{"id":"https://openalex.org/keywords/physiologically-based-pharmacokinetic-modelling","display_name":"Physiologically based pharmacokinetic modelling","score":0.6350745558738708},{"id":"https://openalex.org/keywords/liver-injury","display_name":"Liver injury","score":0.5355622172355652},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.4870169758796692},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4855741858482361},{"id":"https://openalex.org/keywords/bile-salt-export-pump","display_name":"Bile Salt Export Pump","score":0.4779489040374756},{"id":"https://openalex.org/keywords/distribution","display_name":"Distribution (mathematics)","score":0.45165714621543884},{"id":"https://openalex.org/keywords/transplantation","display_name":"Transplantation","score":0.44073039293289185},{"id":"https://openalex.org/keywords/bilirubin","display_name":"Bilirubin","score":0.4312129616737366},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3810247778892517},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3679742217063904},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1886114478111267},{"id":"https://openalex.org/keywords/transporter","display_name":"Transporter","score":0.1444849669933319},{"id":"https://openalex.org/keywords/atp-binding-cassette-transporter","display_name":"ATP-binding cassette transporter","score":0.09731501340866089}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7064735293388367},{"id":"https://openalex.org/C36201501","wikidata":"https://www.wikidata.org/wiki/Q17907816","display_name":"Multidrug resistance-associated protein 2","level":5,"score":0.687880277633667},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.6445144414901733},{"id":"https://openalex.org/C185867374","wikidata":"https://www.wikidata.org/wiki/Q2562769","display_name":"Physiologically based pharmacokinetic modelling","level":3,"score":0.6350745558738708},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.5355622172355652},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4870169758796692},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4855741858482361},{"id":"https://openalex.org/C2910800957","wikidata":"https://www.wikidata.org/wiki/Q15315873","display_name":"Bile Salt Export Pump","level":4,"score":0.4779489040374756},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.45165714621543884},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.44073039293289185},{"id":"https://openalex.org/C2777513400","wikidata":"https://www.wikidata.org/wiki/Q104219","display_name":"Bilirubin","level":2,"score":0.4312129616737366},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3810247778892517},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3679742217063904},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1886114478111267},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.1444849669933319},{"id":"https://openalex.org/C44312359","wikidata":"https://www.wikidata.org/wiki/Q286958","display_name":"ATP-binding cassette transporter","level":4,"score":0.09731501340866089},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016031","descriptor_name":"Liver Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016031","descriptor_name":"Liver Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016031","descriptor_name":"Liver Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016031","descriptor_name":"Liver Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016031","descriptor_name":"Liver Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc40787.2023.10340273","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/embc40787.2023.10340273","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:38082711","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38082711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.800000011920929,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1973935956","https://openalex.org/W2017674624","https://openalex.org/W2034203400","https://openalex.org/W2069098752","https://openalex.org/W2077480196","https://openalex.org/W2083588657","https://openalex.org/W2148182245","https://openalex.org/W2263335503","https://openalex.org/W2523266737","https://openalex.org/W3014770989","https://openalex.org/W3048804547","https://openalex.org/W4282942287","https://openalex.org/W4292651726","https://openalex.org/W6692729327"],"related_works":["https://openalex.org/W2384256670","https://openalex.org/W2437132565","https://openalex.org/W2966516879","https://openalex.org/W2030031769","https://openalex.org/W2061283151","https://openalex.org/W2074274895","https://openalex.org/W4387692376","https://openalex.org/W2395736687","https://openalex.org/W2010588449","https://openalex.org/W2887171645"],"abstract_inverted_index":{"During":[0],"liver":[1,143,212],"transplantation,":[2],"ischemia-reperfusion":[3],"injury":[4],"(IRI)":[5],"is":[6,20,83,157],"inevitable":[7],"and":[8,51,119,145],"decreases":[9],"the":[10,14,27,33,43,52,63,66,74,81,105,148,163,177,185,190,198,207],"overall":[11],"success":[12],"of":[13,29,46,54,65,76,141,165,187,192,209],"surgery.":[15],"While":[16],"guidelines":[17],"exist,":[18],"there":[19],"no":[21],"reliable":[22],"way":[23],"to":[24,59,98,121,160,183,201],"quantitatively":[25],"assess":[26],"degree":[28,53,208],"IRI":[30,188,210],"present":[31],"in":[32,62,162],"liver.":[34],"Our":[35],"recent":[36],"study":[37,196],"has":[38],"shown":[39],"a":[40,135,203],"correlation":[41],"between":[42],"bile-to-plasma":[44],"ratio":[45],"FDA-approved":[47],"sodium":[48],"fluorescein":[49],"(SF)":[50],"hepatic":[55,67,166],"IRI,":[56],"presumably":[57],"due":[58],"IRI-induced":[60],"decrease":[61],"activity":[64,164,191],"multidrug":[68],"resistance-associated":[69],"protein":[70],"2":[71],"(MRP2);":[72],"however,":[73],"contribution":[75],"SF":[77,101,111,130,142,154,172],"blood":[78,102],"clearance":[79,103,146,174],"via":[80,104,147],"bile":[82,120,155,173],"still":[84],"convoluted":[85],"with":[86,176],"other":[87],"factors,":[88],"such":[89],"as":[90],"renal":[91],"clearance.":[92],"In":[93],"this":[94],"work,":[95],"we":[96,108,133],"sought":[97],"computationally":[99],"model":[100,140,179,204],"bile.":[106,149],"First,":[107],"converted":[109],"extant":[110],"fluorescence":[112],"data":[113],"from":[114],"rat":[115],"whole":[116],"blood,":[117],"plasma,":[118],"concentrations":[122],"using":[123],"calibration":[124],"curves.":[125],"Next,":[126],"based":[127],"on":[128,189],"these":[129],"concentration":[131,156],"data,":[132],"generated":[134],"\"liver-centric\",":[136],"physiologically-based":[137],"pharmacokinetic":[138],"(PBPK)":[139],"uptake":[144],"Model":[150],"simulations":[151,169],"show":[152],"that":[153,171],"highly":[158],"sensitive":[159],"change":[161],"MPR2.":[167],"These":[168],"suggest":[170],"along":[175],"PBPK":[178],"can":[180],"be":[181],"used":[182],"quantify":[184],"effect":[186],"MRP2.Clinical":[193],"Relevance-":[194],"This":[195],"establishes":[197],"theory":[199],"necessary":[200],"generate":[202],"for":[205],"predicting":[206],"during":[211],"transplantation.":[213]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2025-12-21T01:58:51.020947","created_date":"2025-10-10T00:00:00"}
