{"id":"https://openalex.org/W4389543074","doi":"https://doi.org/10.1109/embc40787.2023.10340183","title":"A Cuff Lead for Delivering Ionic Direct Current (iDC) to Block Neural Activities of Sciatic Nerve*","display_name":"A Cuff Lead for Delivering Ionic Direct Current (iDC) to Block Neural Activities of Sciatic Nerve*","publication_year":2023,"publication_date":"2023-07-24","ids":{"openalex":"https://openalex.org/W4389543074","doi":"https://doi.org/10.1109/embc40787.2023.10340183","pmid":"https://pubmed.ncbi.nlm.nih.gov/38083560"},"language":"en","primary_location":{"id":"doi:10.1109/embc40787.2023.10340183","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/embc40787.2023.10340183","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12302378/pdf/nihms-2099029.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080279060","display_name":"Chaojun Cheng","orcid":"https://orcid.org/0000-0002-9200-6500"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"C. Cheng","raw_affiliation_strings":["Johns Hopkins University,Department of Otolaryngology Head and Neck Surgery,Baltimore,MD,USA,21208"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins University,Department of Otolaryngology Head and Neck Surgery,Baltimore,MD,USA,21208","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011392125","display_name":"Grace E. Foxworthy","orcid":"https://orcid.org/0000-0001-5105-2175"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. E. Foxworthy","raw_affiliation_strings":["Johns Hopkins University,Department of Biomedical Engineering,Baltimore,USA,MD21208"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins University,Department of Biomedical Engineering,Baltimore,USA,MD21208","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087974714","display_name":"Gene Y. Fridman","orcid":"https://orcid.org/0000-0002-2208-8993"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Y. Fridman","raw_affiliation_strings":["Johns Hopkins University,Department of Otolaryngology Head and Neck Surgery and the Department of Biomedical Engineering,Baltimore,USA,MD21208"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins University,Department of Otolaryngology Head and Neck Surgery and the Department of Biomedical Engineering,Baltimore,USA,MD21208","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5080279060"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21784708,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2023","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10784","display_name":"Muscle activation and electromyography studies","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sciatic-nerve","display_name":"Sciatic nerve","score":0.8324123620986938},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.6696564555168152},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.5489396452903748},{"id":"https://openalex.org/keywords/compound-muscle-action-potential","display_name":"Compound muscle action potential","score":0.48981377482414246},{"id":"https://openalex.org/keywords/electrode","display_name":"Electrode","score":0.47385480999946594},{"id":"https://openalex.org/keywords/cuff","display_name":"Cuff","score":0.4558916687965393},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.217433899641037},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.18814852833747864},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.17080697417259216},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.16719049215316772},{"id":"https://openalex.org/keywords/surgery","display_name":"Surgery","score":0.10278463363647461}],"concepts":[{"id":"https://openalex.org/C2781149210","wikidata":"https://www.wikidata.org/wiki/Q307869","display_name":"Sciatic nerve","level":2,"score":0.8324123620986938},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6696564555168152},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5489396452903748},{"id":"https://openalex.org/C151626666","wikidata":"https://www.wikidata.org/wiki/Q5156844","display_name":"Compound muscle action potential","level":3,"score":0.48981377482414246},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.47385480999946594},{"id":"https://openalex.org/C2780017030","wikidata":"https://www.wikidata.org/wiki/Q368366","display_name":"Cuff","level":2,"score":0.4558916687965393},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.217433899641037},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18814852833747864},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17080697417259216},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.16719049215316772},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.10278463363647461},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009417","descriptor_name":"Nerve Tissue","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009417","descriptor_name":"Nerve Tissue","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009417","descriptor_name":"Nerve Tissue","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009417","descriptor_name":"Nerve Tissue","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009417","descriptor_name":"Nerve Tissue","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009417","descriptor_name":"Nerve Tissue","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009417","descriptor_name":"Nerve Tissue","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009417","descriptor_name":"Nerve Tissue","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012828","descriptor_name":"Silicones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012828","descriptor_name":"Silicones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012828","descriptor_name":"Silicones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012828","descriptor_name":"Silicones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012828","descriptor_name":"Silicones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012828","descriptor_name":"Silicones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012828","descriptor_name":"Silicones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012828","descriptor_name":"Silicones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc40787.2023.10340183","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/embc40787.2023.10340183","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:38083560","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38083560","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:12302378","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12302378","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12302378/pdf/nihms-2099029.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Annu Int Conf IEEE Eng Med Biol Soc","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:12302378","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12302378","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12302378/pdf/nihms-2099029.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Annu Int Conf IEEE Eng Med Biol Soc","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G253044098","display_name":null,"funder_award_id":"R01NS110893","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4999182679","display_name":null,"funder_award_id":"11089","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389543074.pdf","grobid_xml":"https://content.openalex.org/works/W4389543074.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W2015294534","https://openalex.org/W2042847772","https://openalex.org/W2052564270","https://openalex.org/W2137237108","https://openalex.org/W2344291398","https://openalex.org/W2475283744","https://openalex.org/W2739865633","https://openalex.org/W2798214928","https://openalex.org/W2804585019","https://openalex.org/W2917203101","https://openalex.org/W2938434911","https://openalex.org/W3186398049","https://openalex.org/W4200229247"],"related_works":["https://openalex.org/W1987725374","https://openalex.org/W2332571278","https://openalex.org/W1983403560","https://openalex.org/W1904305890","https://openalex.org/W2986124841","https://openalex.org/W2998726294","https://openalex.org/W2123118594","https://openalex.org/W2540255529","https://openalex.org/W2033393000","https://openalex.org/W2885678559"],"abstract_inverted_index":{"Direct":[0],"current":[1],"(DC)":[2],"applied":[3],"extracellularly":[4],"can":[5,67],"block":[6,92],"action":[7,146],"potential":[8,147],"(AP)":[9],"propagation":[10],"in":[11,35,95],"a":[12,21,60,82,103],"neuron.":[13],"This":[14,100],"suppression":[15],"paradigm":[16],"has":[17,102],"been":[18],"proposed":[19],"as":[20],"possible":[22],"treatment":[23],"for":[24,112],"blocking":[25],"nociceptive":[26],"pain.":[27],"However,":[28],"the":[29,39,45,51,56,72,76,93,96,120,123,134,138,143],"application":[30,57],"of":[31,47,58,151],"DC":[32,132],"is":[33],"limited":[34],"duration":[36],"due":[37],"to":[38,70,91,107,149],"charge":[40],"injection":[41],"constraint":[42],"imposed":[43],"by":[44],"evolution":[46],"electrochemical":[48],"reactions":[49],"at":[50],"metal":[52,73],"electrode.":[53],"To":[54],"prolong":[55],"DC,":[59],"microfluidic":[61],"lead":[62,86,101,136],"filled":[63],"with":[64,88],"conductive":[65],"electrolyte":[66],"be":[68],"used":[69],"separate":[71],"electrode":[74],"from":[75],"target":[77],"nerve.":[78,99],"Here,":[79],"we":[80],"describe":[81],"tripolar":[83],"nerve":[84,111,121,139],"cuff":[85,135],"fabricated":[87],"biocompatible":[89],"silicone":[90,105],"APs":[94],"rat":[97],"sciatic":[98,110],"self-curling":[104],"membrane":[106],"wrap":[108],"around":[109],"secured":[113],"mechanical":[114],"attachment":[115],"and":[116,122,141],"electrical":[117],"isolation":[118],"between":[119],"surrounding":[124],"muscle.":[125],"In-vivo":[126],"testing":[127],"showed":[128],"that":[129],"delivering":[130],"1.4mA":[131],"via":[133],"blocked":[137],"activity":[140],"reduced":[142],"evoked":[144],"compound":[145],"(eCAP)":[148],"30%":[150],"its":[152],"unblocked":[153],"response.":[154]},"counts_by_year":[],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
