{"id":"https://openalex.org/W4389543109","doi":"https://doi.org/10.1109/embc40787.2023.10340139","title":"Modeling of Calcium-dependent Low Intensity Low Frequency Ultrasound Modulation of a Hodgkin\u2013Huxley Neuron","display_name":"Modeling of Calcium-dependent Low Intensity Low Frequency Ultrasound Modulation of a Hodgkin\u2013Huxley Neuron","publication_year":2023,"publication_date":"2023-07-24","ids":{"openalex":"https://openalex.org/W4389543109","doi":"https://doi.org/10.1109/embc40787.2023.10340139","pmid":"https://pubmed.ncbi.nlm.nih.gov/38083028"},"language":"en","primary_location":{"id":"doi:10.1109/embc40787.2023.10340139","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/embc40787.2023.10340139","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091931918","display_name":"Heba Badawe","orcid":"https://orcid.org/0000-0002-0119-0809"},"institutions":[{"id":"https://openalex.org/I98635879","display_name":"American University of Beirut","ror":"https://ror.org/04pznsd21","country_code":"LB","type":"education","lineage":["https://openalex.org/I98635879"]}],"countries":["LB"],"is_corresponding":true,"raw_author_name":"Heba M. Badawe","raw_affiliation_strings":["American University of Beirut,Neural Engineering and Nanobiosensors Group, Biomedical Engineering Program, Maroun Semaan Faculty of Engineering and Architecture,Beirut,Lebanon","Neural Engineering and Nanobiosensors Group, Biomedical Engineering Program, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"American University of Beirut,Neural Engineering and Nanobiosensors Group, Biomedical Engineering Program, Maroun Semaan Faculty of Engineering and Architecture,Beirut,Lebanon","institution_ids":["https://openalex.org/I98635879"]},{"raw_affiliation_string":"Neural Engineering and Nanobiosensors Group, Biomedical Engineering Program, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon","institution_ids":["https://openalex.org/I98635879"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072427810","display_name":"Massoud L. Khraiche","orcid":"https://orcid.org/0000-0002-4497-3168"},"institutions":[{"id":"https://openalex.org/I98635879","display_name":"American University of Beirut","ror":"https://ror.org/04pznsd21","country_code":"LB","type":"education","lineage":["https://openalex.org/I98635879"]}],"countries":["LB"],"is_corresponding":false,"raw_author_name":"Massoud L. Khraiche","raw_affiliation_strings":["American University of Beirut,Neural Engineering and Nanobiosensors Group, Biomedical Engineering Program, Maroun Semaan Faculty of Engineering and Architecture,Beirut,Lebanon","Neural Engineering and Nanobiosensors Group, Biomedical Engineering Program, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"American University of Beirut,Neural Engineering and Nanobiosensors Group, Biomedical Engineering Program, Maroun Semaan Faculty of Engineering and Architecture,Beirut,Lebanon","institution_ids":["https://openalex.org/I98635879"]},{"raw_affiliation_string":"Neural Engineering and Nanobiosensors Group, Biomedical Engineering Program, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon","institution_ids":["https://openalex.org/I98635879"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5091931918"],"corresponding_institution_ids":["https://openalex.org/I98635879"],"apc_list":null,"apc_paid":null,"fwci":0.6304,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.64979274,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"2023","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10727","display_name":"Ultrasound Imaging and Elastography","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuromodulation","display_name":"Neuromodulation","score":0.6506597995758057},{"id":"https://openalex.org/keywords/neuron","display_name":"Neuron","score":0.5934206247329712},{"id":"https://openalex.org/keywords/ultrasound","display_name":"Ultrasound","score":0.5837920308113098},{"id":"https://openalex.org/keywords/calcium","display_name":"Calcium","score":0.5828989744186401},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"Membrane potential","score":0.47340449690818787},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.41002869606018066},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3677220642566681},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.34294986724853516},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.20177894830703735},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18584555387496948},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.11320766806602478},{"id":"https://openalex.org/keywords/acoustics","display_name":"Acoustics","score":0.10491952300071716}],"concepts":[{"id":"https://openalex.org/C2780375056","wikidata":"https://www.wikidata.org/wiki/Q905905","display_name":"Neuromodulation","level":3,"score":0.6506597995758057},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.5934206247329712},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.5837920308113098},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5828989744186401},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.47340449690818787},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.41002869606018066},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3677220642566681},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34294986724853516},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.20177894830703735},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18584555387496948},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.11320766806602478},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.10491952300071716},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc40787.2023.10340139","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/embc40787.2023.10340139","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:38083028","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38083028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.47999998927116394}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1586495425","https://openalex.org/W1968335099","https://openalex.org/W1985940938","https://openalex.org/W2025706898","https://openalex.org/W2050079318","https://openalex.org/W2089845241","https://openalex.org/W2160094115","https://openalex.org/W2162473564","https://openalex.org/W2284593242","https://openalex.org/W2293979368","https://openalex.org/W2532052240","https://openalex.org/W2909363860","https://openalex.org/W2946280472","https://openalex.org/W3045584887","https://openalex.org/W3064736735","https://openalex.org/W3087732546","https://openalex.org/W3089152033","https://openalex.org/W3098173373","https://openalex.org/W3099826137","https://openalex.org/W4210378358","https://openalex.org/W4297145938"],"related_works":["https://openalex.org/W3110657840","https://openalex.org/W4200466513","https://openalex.org/W2897335300","https://openalex.org/W2947088850","https://openalex.org/W4301179390","https://openalex.org/W4241353914","https://openalex.org/W4238433626","https://openalex.org/W2050519779","https://openalex.org/W4376453272","https://openalex.org/W2017163155"],"abstract_inverted_index":{"Non-invasive":[0],"low":[1,3],"intensity,":[2],"frequency":[4],"ultrasound":[5,31,69,95],"is":[6,58],"a":[7,45,97],"progressive":[8],"neuromodulation":[9],"approach":[10],"that":[11,41],"can":[12,79],"reach":[13],"deep":[14],"brain":[15],"areas":[16],"with":[17,138],"peak":[18],"spatial":[19],"and":[20,26,123,142],"temporal":[21],"resolution":[22],"for":[23],"highly-targeted":[24],"diagnostic":[25],"therapeutic":[27],"purposes.":[28],"Coupling":[29],"the":[30,35,55,66,71,75,82,91,104,111,115,127,134,139,144,147,152],"mechanical":[32,135],"effects":[33,93],"to":[34,65,96],"neural":[36,72,112,140,153],"membrane":[37,113,141],"comprises":[38],"different":[39],"mechanisms":[40],"are,":[42],"to-date,":[43],"still":[44],"topic":[46],"of":[47,51,59,68,94,106,126,146],"debate.":[48],"The":[49],"availability":[50],"calcium":[52,77,107,148],"ions":[53],"in":[54],"extracellular":[56],"medium":[57],"high":[60],"significance":[61],"when":[62],"it":[63],"comes":[64],"effect":[67,105],"on":[70,114],"tissue.":[73],"Whereby":[74],"generated":[76],"influx":[78],"directly":[80],"affect":[81],"voltage-gated":[83],"ion":[84],"channels,":[85,149],"amplifying":[86],"their":[87],"action.":[88],"We":[89],"modeled":[90],"flexoelectric-induced":[92],"single":[98],"firing":[99,117],"neuron,":[100],"taking":[101],"into":[102,110],"consideration":[103],"channel":[108],"embedding":[109],"neuron's":[116],"rate,":[118],"latency":[119],"response,":[120],"peak-to-peak":[121],"voltage,":[122],"general":[124],"shape":[125],"action":[128],"potential.Clinical":[129],"Relevance-":[130],"Upon":[131],"Ultrasound":[132],"sonication,":[133],"waves":[136],"interact":[137],"alter":[143],"kinetics":[145],"thus":[150],"changing":[151],"response.":[154]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-05-17T08:19:37.847499","created_date":"2025-10-10T00:00:00"}