{"id":"https://openalex.org/W4389538392","doi":"https://doi.org/10.1109/embc40787.2023.10340076","title":"Simulating the Evolution of Signaling Signatures During CART-Cell and Tumor Cell Interactions","display_name":"Simulating the Evolution of Signaling Signatures During CART-Cell and Tumor Cell Interactions","publication_year":2023,"publication_date":"2023-07-24","ids":{"openalex":"https://openalex.org/W4389538392","doi":"https://doi.org/10.1109/embc40787.2023.10340076","pmid":"https://pubmed.ncbi.nlm.nih.gov/38083755"},"language":"en","primary_location":{"id":"doi:10.1109/embc40787.2023.10340076","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/embc40787.2023.10340076","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052390797","display_name":"Viren Shah","orcid":"https://orcid.org/0000-0002-2570-6486"},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Viren Shah","raw_affiliation_strings":["Medical College of Wisconsin"],"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027038317","display_name":"Justin Womack","orcid":"https://orcid.org/0000-0001-9957-9822"},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin Womack","raw_affiliation_strings":["Medical College of Wisconsin"],"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010903477","display_name":"Anthony E. Zamora","orcid":"https://orcid.org/0000-0001-5712-5339"},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony E. Zamora","raw_affiliation_strings":["Medical College of Wisconsin"],"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034361556","display_name":"Scott S. Terhune","orcid":"https://orcid.org/0000-0003-3689-7094"},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott S. Terhune","raw_affiliation_strings":["Medical College of Wisconsin"],"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061756444","display_name":"Ranjan K. Dash","orcid":"https://orcid.org/0000-0001-6751-0679"},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ranjan K. Dash","raw_affiliation_strings":["Medical College of Wisconsin"],"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5052390797"],"corresponding_institution_ids":["https://openalex.org/I204308271"],"apc_list":null,"apc_paid":null,"fwci":0.4761,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.75172849,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":"2023","issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10558","display_name":"Advancements in Semiconductor Devices and Circuit Design","score":0.9786999821662903,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cart","display_name":"Cart","score":0.9488592147827148},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor","display_name":"Chimeric antigen receptor","score":0.6442819237709045},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.6115344762802124},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"Cell therapy","score":0.5107369422912598},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.49679163098335266},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.4888879358768463},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.40740594267845154},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.38868826627731323},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.38137954473495483},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.35476964712142944},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3463174104690552},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"Immunotherapy","score":0.32811155915260315},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2983364462852478},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.14305981993675232}],"concepts":[{"id":"https://openalex.org/C2777275308","wikidata":"https://www.wikidata.org/wiki/Q234668","display_name":"Cart","level":2,"score":0.9488592147827148},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.6442819237709045},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6115344762802124},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.5107369422912598},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.49679163098335266},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4888879358768463},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40740594267845154},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.38868826627731323},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38137954473495483},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35476964712142944},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3463174104690552},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.32811155915260315},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2983364462852478},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14305981993675232},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc40787.2023.10340076","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/embc40787.2023.10340076","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:38083755","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38083755","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7300000190734863,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1971692004","https://openalex.org/W1977949161","https://openalex.org/W1989488426","https://openalex.org/W1997241837","https://openalex.org/W2009644403","https://openalex.org/W2024176268","https://openalex.org/W2029208213","https://openalex.org/W2063116057","https://openalex.org/W2092755129","https://openalex.org/W2107919289","https://openalex.org/W2157947216","https://openalex.org/W2165284694","https://openalex.org/W2336076245","https://openalex.org/W2792784285","https://openalex.org/W2912983001","https://openalex.org/W2941894376","https://openalex.org/W2951023546","https://openalex.org/W2965048805","https://openalex.org/W2992738455","https://openalex.org/W3028149335","https://openalex.org/W3041575100","https://openalex.org/W3090947236","https://openalex.org/W3134662031","https://openalex.org/W4233201187","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W3032483461","https://openalex.org/W3029001555","https://openalex.org/W4292999382","https://openalex.org/W4226401931","https://openalex.org/W3046383713","https://openalex.org/W2906766942","https://openalex.org/W4307274397","https://openalex.org/W4205148539","https://openalex.org/W4323037099","https://openalex.org/W2898362785"],"abstract_inverted_index":{"Immunotherapies":[0],"have":[1,5],"been":[2],"proven":[3],"to":[4,60,74,123],"significant":[6],"therapeutic":[7],"efficacy":[8],"in":[9,115],"the":[10,50,99,105],"treatment":[11],"of":[12,55,101,119,127],"cancer.":[13],"The":[14],"last":[15],"decade":[16],"has":[17],"seen":[18],"adoptive":[19],"cell":[20],"therapies,":[21],"such":[22],"as":[23],"chimeric":[24],"antigen":[25],"receptor":[26,135],"T-cell":[27],"(CART-cell)":[28],"therapy,":[29,57],"gain":[30],"FDA":[31],"approval":[32],"against":[33],"specific":[34],"cancers.":[35,68],"Additionally,":[36],"there":[37],"are":[38],"numerous":[39],"clinical":[40,85],"trials":[41],"ongoing":[42],"investigating":[43],"additional":[44],"designs":[45],"and":[46,52,67,84,109,112,137],"targets.":[47],"Nevertheless,":[48],"despite":[49],"excitement":[51],"promising":[53],"potential":[54],"CART-cell":[56,82,120,128],"response":[58],"rates":[59],"therapy":[61,139,144],"vary":[62],"greatly":[63],"between":[64,107],"studies,":[65],"patients,":[66],"There":[69],"remains":[70],"an":[71],"unmet":[72],"need":[73],"develop":[75],"computational":[76],"frameworks":[77],"that":[78,97],"more":[79],"accurately":[80],"predict":[81],"function":[83],"efficacy.":[86],"Here":[87],"we":[88],"present":[89],"a":[90],"coarse-grained":[91],"model":[92],"simulated":[93],"with":[94],"logical":[95],"rules":[96],"demonstrates":[98],"evolution":[100],"signaling":[102,129],"signatures":[103,130],"following":[104],"interaction":[106],"CART-cells":[108],"tumor":[110],"cells":[111],"allows":[113],"for":[114],"silico":[116],"based":[117],"prediction":[118],"functionality":[121],"prior":[122],"experimentation.Clinical":[124],"Relevance-":[125],"Analysis":[126],"can":[131],"inform":[132],"future":[133],"CAR":[134],"design":[136],"combination":[138],"approaches":[140],"aimed":[141],"at":[142],"improving":[143],"response.":[145]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2025-12-19T19:40:27.379048","created_date":"2025-10-10T00:00:00"}
