{"id":"https://openalex.org/W4389542462","doi":"https://doi.org/10.1109/embc40787.2023.10339967","title":"Dynamic Magnetic Resonance Vascular Fingerprinting During Hypercapnia for Quantitative and Multiparametric Cerebrovascular Reactivity Measures","display_name":"Dynamic Magnetic Resonance Vascular Fingerprinting During Hypercapnia for Quantitative and Multiparametric Cerebrovascular Reactivity Measures","publication_year":2023,"publication_date":"2023-07-24","ids":{"openalex":"https://openalex.org/W4389542462","doi":"https://doi.org/10.1109/embc40787.2023.10339967","pmid":"https://pubmed.ncbi.nlm.nih.gov/38083275"},"language":"en","primary_location":{"id":"doi:10.1109/embc40787.2023.10339967","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc40787.2023.10339967","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111100173","display_name":"Gregory J. Wheeler","orcid":null},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gregory J. Wheeler","raw_affiliation_strings":["University of California,Davis Department of Biomedical Engineering,Davis,CA,USA,95616"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California,Davis Department of Biomedical Engineering,Davis,CA,USA,95616","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092591279","display_name":"Quimby N. Lee","orcid":"https://orcid.org/0000-0002-3999-0174"},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Quimby N. Lee","raw_affiliation_strings":["University of California,Davis Department of Neurology,Sacramento,CA,USA,85817"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California,Davis Department of Neurology,Sacramento,CA,USA,85817","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042398270","display_name":"Audrey P. Fan","orcid":"https://orcid.org/0000-0001-5850-6117"},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Audrey P. Fan","raw_affiliation_strings":["University of California,Davis Department of Biomedical Engineering,Davis,CA,USA,95616","Davis Department of Neurology, University of California, Sacramento, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California,Davis Department of Biomedical Engineering,Davis,CA,USA,95616","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Davis Department of Neurology, University of California, Sacramento, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111100173"],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.37238981,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2023","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypercapnia","display_name":"Hypercapnia","score":0.643639087677002},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.5983944535255432},{"id":"https://openalex.org/keywords/nuclear-magnetic-resonance","display_name":"Nuclear magnetic resonance","score":0.42395055294036865},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3599305748939514},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.18973252177238464},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.15669414401054382},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.13956567645072937}],"concepts":[{"id":"https://openalex.org/C2777037550","wikidata":"https://www.wikidata.org/wiki/Q615759","display_name":"Hypercapnia","level":3,"score":0.643639087677002},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5983944535255432},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.42395055294036865},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3599305748939514},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18973252177238464},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.15669414401054382},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13956567645072937},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D002561","descriptor_name":"Cerebrovascular Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002561","descriptor_name":"Cerebrovascular Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002561","descriptor_name":"Cerebrovascular Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002561","descriptor_name":"Cerebrovascular Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002561","descriptor_name":"Cerebrovascular Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002561","descriptor_name":"Cerebrovascular Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006935","descriptor_name":"Hypercapnia","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006935","descriptor_name":"Hypercapnia","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006935","descriptor_name":"Hypercapnia","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006935","descriptor_name":"Hypercapnia","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006935","descriptor_name":"Hypercapnia","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006935","descriptor_name":"Hypercapnia","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc40787.2023.10339967","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc40787.2023.10339967","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:38083275","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38083275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.44999998807907104}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1817846039","https://openalex.org/W1963605401","https://openalex.org/W1977221251","https://openalex.org/W2144288697","https://openalex.org/W2149159573","https://openalex.org/W2167234030","https://openalex.org/W2288459369","https://openalex.org/W2554660039","https://openalex.org/W2793407983","https://openalex.org/W2944502856","https://openalex.org/W2987891986","https://openalex.org/W4206042750","https://openalex.org/W4385542016","https://openalex.org/W4401573665","https://openalex.org/W6870974131"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725","https://openalex.org/W2148612803"],"abstract_inverted_index":{"Magnetic":[0],"resonance":[1,242],"fingerprinting":[2,36,244],"(MRF)":[3],"represents":[4],"a":[5,96,102,107,133,164,171],"potential":[6,247],"paradigm":[7,143],"shift":[8],"in":[9,20,93,105,161,187,230],"MR":[10,34],"image":[11,23],"acquisition,":[12],"reconstruction,":[13],"and":[14,38,55,110,117,122,154,166,201,212,219,222,233,252,265],"analysis":[15,202],"using":[16],"computational":[17],"biophysical":[18],"modelling":[19],"parallel":[21],"to":[22,45,91,95,147,163,170,182,225,248],"acquisition.":[24],"Its":[25],"flexibility":[26],"allows":[27,74],"for":[28,75,115,206],"examination":[29],"of":[30,65,77,89,120,214,239,257],"cerebrovascular":[31,82,234,258],"metrics":[32,221],"through":[33],"vascular":[35,228,243,261],"(MRvF),":[37],"this":[39,131],"has":[40,245],"been":[41],"extended":[42],"even":[43],"further":[44,207],"produce":[46],"quantitative":[47,151],"cerebral":[48,188],"blood":[49,123,189],"volume":[50],"(CBV),":[51],"microvascular":[52],"vessel":[53],"radius,":[54,153],"tissue":[56],"oxygen":[57,124],"saturation":[58],"(SO":[59],"<inf":[60,138,156],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[61,139,157],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">2</inf>":[62,140,158],")":[63,141],"maps":[64],"the":[66,87,210,246],"whole":[67],"brain":[68],"simultaneously":[69],"every":[70],"few":[71],"seconds.":[72],"This":[73],"observation":[76],"rapid":[78],"physiological":[79],"changes":[80],"like":[81,260],"reactivity":[83],"(CVR),":[84],"which":[85,106],"is":[86],"ability":[88],"vessels":[90],"dilate":[92],"response":[94,162],"vasoactive":[97],"stimulus.":[98],"Here":[99],"we":[100,144],"demonstrated":[101],"novel":[103],"protocol":[104],"rapid,":[108,250],"spin-":[109],"gradient-echo":[111],"pulse":[112],"sequence":[113],"allowed":[114],"dynamic,":[116],"simultaneous":[118],"acquisition":[119],"MRvF":[121],"level":[125],"dependent":[126],"(BOLD)":[127],"measures.":[128],"By":[129],"combining":[130],"with":[132],"tailored":[134],"hypercapnic":[135],"(5%":[136],"CO":[137],"breathing":[142],"were":[145],"able":[146],"show":[148],"how":[149],"these":[150,180],"CBV,":[152],"SO":[155],"parameters":[159],"changed":[160],"stimulus":[165],"directly":[167],"compare":[168],"those":[169],"colocalized,":[172],"traditionally":[173,184],"used":[174],"BOLD":[175,218],"CVR.":[176],"We":[177],"also":[178],"compared":[179],"measures":[181],"another":[183],"utilized":[185],"technique":[186],"flow":[190],"CVR":[191,215],"from":[192],"an":[193],"arterial":[194],"spin":[195],"labelling":[196],"sequence.":[197],"These":[198],"imaging,":[199],"processing,":[200],"techniques":[203],"will":[204],"allow":[205],"investigation":[208],"into":[209],"magnitude":[211],"rate":[213],"based":[216],"on":[217],"MRvF-based":[220],"enable":[223,249],"investigations":[224],"better":[226],"understand":[227],"function":[229],"healthy":[231],"aging":[232],"diseases.Clinical":[235],"Relevance\u2014":[236],"The":[237],"development":[238],"dynamic":[240],"magnetic":[241],"quantitative,":[251],"multiparametric":[253],"functional":[254],"imaging":[255],"biomarkers":[256],"diseases":[259],"cognitive":[262],"impairment,":[263],"dementia,":[264],"Alzheimer\u2019s":[266],"disease.":[267]},"counts_by_year":[],"updated_date":"2026-05-16T08:24:45.110214","created_date":"2025-10-10T00:00:00"}