{"id":"https://openalex.org/W2979751663","doi":"https://doi.org/10.1109/embc.2019.8857897","title":"Preictal Time Assessment using Heart Rate Variability Features in Drug-resistant Epilepsy Patients","display_name":"Preictal Time Assessment using Heart Rate Variability Features in Drug-resistant Epilepsy Patients","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2979751663","doi":"https://doi.org/10.1109/embc.2019.8857897","mag":"2979751663","pmid":"https://pubmed.ncbi.nlm.nih.gov/31947396"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2019.8857897","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2019.8857897","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064320561","display_name":"Adriana Leal","orcid":"https://orcid.org/0000-0001-5421-9284"},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Adriana Leal","raw_affiliation_strings":["CISUC, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CISUC, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057342960","display_name":"Mauro F. Pinto","orcid":"https://orcid.org/0000-0002-9359-4324"},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Mauro Pinto","raw_affiliation_strings":["CISUC, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CISUC, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083997342","display_name":"J. Henriques","orcid":"https://orcid.org/0000-0003-4622-474X"},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jorge Henriques","raw_affiliation_strings":["CISUC, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CISUC, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065574884","display_name":"M.G. Ruano","orcid":"https://orcid.org/0000-0002-0014-9257"},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Maria da Graca Ruano","raw_affiliation_strings":["CISUC, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CISUC, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083637401","display_name":"P. Carvalho","orcid":"https://orcid.org/0000-0002-9847-0590"},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Paulo de Carvalho","raw_affiliation_strings":["CISUC, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CISUC, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010197657","display_name":"C\u00e9sar Teixeira","orcid":"https://orcid.org/0000-0001-9396-1211"},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Cesar Teixeira","raw_affiliation_strings":["CISUC, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CISUC, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I76903346"],"apc_list":null,"apc_paid":null,"fwci":0.3096,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.5120308,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"2019","issue":null,"first_page":"6776","last_page":"6779"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11021","display_name":"ECG Monitoring and Analysis","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ictal","display_name":"Ictal","score":0.8682950735092163},{"id":"https://openalex.org/keywords/epilepsy","display_name":"Epilepsy","score":0.7788967490196228},{"id":"https://openalex.org/keywords/electroencephalography","display_name":"Electroencephalography","score":0.6398112177848816},{"id":"https://openalex.org/keywords/linear-discriminant-analysis","display_name":"Linear discriminant analysis","score":0.5860257148742676},{"id":"https://openalex.org/keywords/epileptic-seizure","display_name":"Epileptic seizure","score":0.49735620617866516},{"id":"https://openalex.org/keywords/heart-rate-variability","display_name":"Heart rate variability","score":0.49309489130973816},{"id":"https://openalex.org/keywords/convulsion","display_name":"Convulsion","score":0.4432106614112854},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.41757088899612427},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.3405766487121582},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.32603567838668823},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.31936347484588623},{"id":"https://openalex.org/keywords/heart-rate","display_name":"Heart rate","score":0.3138398230075836},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.29559043049812317},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2861745357513428},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.23461824655532837}],"concepts":[{"id":"https://openalex.org/C17755696","wikidata":"https://www.wikidata.org/wiki/Q16564780","display_name":"Ictal","level":3,"score":0.8682950735092163},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.7788967490196228},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.6398112177848816},{"id":"https://openalex.org/C69738355","wikidata":"https://www.wikidata.org/wiki/Q1228929","display_name":"Linear discriminant analysis","level":2,"score":0.5860257148742676},{"id":"https://openalex.org/C2779334592","wikidata":"https://www.wikidata.org/wiki/Q6279182","display_name":"Epileptic seizure","level":3,"score":0.49735620617866516},{"id":"https://openalex.org/C71635504","wikidata":"https://www.wikidata.org/wiki/Q933954","display_name":"Heart rate variability","level":4,"score":0.49309489130973816},{"id":"https://openalex.org/C2777010014","wikidata":"https://www.wikidata.org/wiki/Q852376","display_name":"Convulsion","level":3,"score":0.4432106614112854},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41757088899612427},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3405766487121582},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.32603567838668823},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.31936347484588623},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.3138398230075836},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.29559043049812317},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2861745357513428},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23461824655532837},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2019.8857897","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2019.8857897","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:31947396","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31947396","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Reduced inequalities","score":0.6700000166893005,"id":"https://metadata.un.org/sdg/10"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1862394037","https://openalex.org/W1883664232","https://openalex.org/W1980829547","https://openalex.org/W1988047201","https://openalex.org/W1995342618","https://openalex.org/W1999369240","https://openalex.org/W2027927824","https://openalex.org/W2030331016","https://openalex.org/W2073803275","https://openalex.org/W2081681829","https://openalex.org/W2110661716","https://openalex.org/W2119705365","https://openalex.org/W2126030941","https://openalex.org/W2128011414","https://openalex.org/W2133082272","https://openalex.org/W2133589238","https://openalex.org/W2156480002","https://openalex.org/W2162273778","https://openalex.org/W2285072859","https://openalex.org/W2586456943"],"related_works":["https://openalex.org/W2388483581","https://openalex.org/W2362039059","https://openalex.org/W2357910987","https://openalex.org/W2028661854","https://openalex.org/W2414354334","https://openalex.org/W4312637698","https://openalex.org/W2351530129","https://openalex.org/W2370181683","https://openalex.org/W2353962268","https://openalex.org/W2041401787"],"abstract_inverted_index":{"Epileptic":[0],"seizures":[1,103,166],"are":[2],"by":[3,201],"default":[4],"associated":[5],"with":[6],"the":[7,24,28,31,40,62,69,76,106,113,123,169,181,209,220],"occurrence":[8],"of":[9,15,30,71,125,164,176,197,212],"EEG":[10],"changes":[11],"as":[12,58,109],"a":[13,72,115,126,177,187],"consequence":[14],"alterations":[16],"in":[17,39,94,105,119,153,159,168],"brain":[18,80],"activity":[19],"seconds":[20],"to":[21,121],"hours":[22],"before":[23,180],"seizure":[25,182,217],"onset.":[26],"Additionally,":[27],"influence":[29],"autonomic":[32],"nervous":[33],"system":[34],"may":[35],"also":[36],"be":[37],"reflected":[38],"electrocardiogram":[41],"(ECG)":[42],"trace.":[43],"In":[44,88],"both":[45],"biosignals":[46],"(EEG":[47],"and":[48,61,97,101,140,145,205],"ECG),":[49],"differences":[50,93],"have":[51],"been":[52,85],"reported":[53],"between":[54,78],"normal":[55],"epochs,":[56],"known":[57],"interictal":[59,213],"periods":[60],"interval":[63,128],"preceding":[64],"seizures,":[65],"preictal":[66,73,95,127,222],"period.":[67],"However,":[68],"existence":[70,124,175],"state":[74],"indicating":[75],"transition":[77,178],"epileptic":[79],"states":[81],"has":[82],"not":[83],"yet":[84],"clinically":[86],"defined.":[87],"fact,":[89],"some":[90],"studies":[91],"report":[92],"location":[96],"duration":[98],"among":[99,102],"patients":[100],"occurring":[104,167],"same":[107],"patient":[108],"well.":[110],"Based":[111],"on":[112],"above,":[114],"study":[116],"was":[117,184,199],"designed":[118],"order":[120],"investigate":[122],"specific":[129],"for":[130],"each":[131],"seizure,":[132],"using":[133,186],"heart":[134],"rate":[135],"variability":[136],"(HRV)":[137],"features.":[138],"Time":[139],"frequency":[141],"domain":[142],"features":[143],"(linear":[144],"non-linear)":[146],"were":[147,172],"extracted":[148],"from":[149,216,219],"ECG":[150],"data":[151],"acquired":[152],"37":[154],"drug-resistant":[155],"epilepsy":[156],"patients,":[157],"comprised":[158],"EPILEPSIAE":[160],"database.":[161],"A":[162],"total":[163],"209":[165],"temporal":[170],"lobe":[171],"analysed.":[173],"The":[174,192],"period":[179],"onset":[183,218],"inspected":[185],"linear":[188],"discriminant":[189],"analysis":[190],"classifier.":[191],"overall":[193],"best":[194],"performance":[195],"(88.04%\u00b112.30%":[196],"accuracy)":[198],"obtained":[200],"combining":[202],"RRMean,":[203],"NN50":[204],"SD2features":[206],"when":[207],"discriminating":[208],"50":[210,223],"min":[211],"located":[214],"farthest":[215],"nearest":[221],"min.":[224]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}