{"id":"https://openalex.org/W2979317633","doi":"https://doi.org/10.1109/embc.2019.8857867","title":"Non-invasive assessments of the advanced glycation end products in human skin using reflectance NIR spectroscopy","display_name":"Non-invasive assessments of the advanced glycation end products in human skin using reflectance NIR spectroscopy","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2979317633","doi":"https://doi.org/10.1109/embc.2019.8857867","mag":"2979317633","pmid":"https://pubmed.ncbi.nlm.nih.gov/31947101"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2019.8857867","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2019.8857867","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048791527","display_name":"Eui Seok Shin","orcid":null},"institutions":[{"id":"https://openalex.org/I2250650973","display_name":"Samsung (South Korea)","ror":"https://ror.org/04w3jy968","country_code":"KR","type":"company","lineage":["https://openalex.org/I2250650973"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eui Seok Shin","raw_affiliation_strings":["Samsung Advanced Institute of Technology, Samsung Electronics Co. Ltd., Suwon-si, Gyeonggi-do, KOREA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samsung Advanced Institute of Technology, Samsung Electronics Co. Ltd., Suwon-si, Gyeonggi-do, KOREA","institution_ids":["https://openalex.org/I2250650973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101899369","display_name":"Yun Sang Park","orcid":"https://orcid.org/0000-0002-8536-5118"},"institutions":[{"id":"https://openalex.org/I2250650973","display_name":"Samsung (South Korea)","ror":"https://ror.org/04w3jy968","country_code":"KR","type":"company","lineage":["https://openalex.org/I2250650973"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yun Sang Park","raw_affiliation_strings":["Samsung Advanced Institute of Technology, Samsung Electronics Co. Ltd., Suwon-si, Gyeonggi-do, KOREA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samsung Advanced Institute of Technology, Samsung Electronics Co. Ltd., Suwon-si, Gyeonggi-do, KOREA","institution_ids":["https://openalex.org/I2250650973"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102011337","display_name":"Sung Hyun Nam","orcid":"https://orcid.org/0000-0002-9773-5649"},"institutions":[{"id":"https://openalex.org/I2250650973","display_name":"Samsung (South Korea)","ror":"https://ror.org/04w3jy968","country_code":"KR","type":"company","lineage":["https://openalex.org/I2250650973"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung Hyun Nam","raw_affiliation_strings":["Samsung Advanced Institute of Technology, Samsung Electronics Co. Ltd., Suwon-si, Gyeonggi-do, KOREA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samsung Advanced Institute of Technology, Samsung Electronics Co. Ltd., Suwon-si, Gyeonggi-do, KOREA","institution_ids":["https://openalex.org/I2250650973"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.155,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.53790553,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"2019","issue":null,"first_page":"5506","last_page":"5509"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10640","display_name":"Spectroscopy and Chemometric Analyses","score":0.9861999750137329,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.9811999797821045,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycation","display_name":"Glycation","score":0.8836714029312134},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.6103023886680603},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5630166530609131},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.5608928203582764},{"id":"https://openalex.org/keywords/fluorescence-spectroscopy","display_name":"Fluorescence spectroscopy","score":0.5177797079086304},{"id":"https://openalex.org/keywords/near-infrared-spectroscopy","display_name":"Near-infrared spectroscopy","score":0.5041505098342896},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.4703117907047272},{"id":"https://openalex.org/keywords/human-skin","display_name":"Human skin","score":0.46918511390686035},{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"Principal component analysis","score":0.4690684974193573},{"id":"https://openalex.org/keywords/bayesian-multivariate-linear-regression","display_name":"Bayesian multivariate linear regression","score":0.4449879825115204},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3834002614021301},{"id":"https://openalex.org/keywords/analytical-chemistry","display_name":"Analytical Chemistry (journal)","score":0.36923736333847046},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3494887351989746},{"id":"https://openalex.org/keywords/linear-regression","display_name":"Linear regression","score":0.3191896080970764},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.24986135959625244},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.21290600299835205},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.0880122184753418},{"id":"https://openalex.org/keywords/biotechnology","display_name":"Biotechnology","score":0.08651408553123474},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.07406356930732727}],"concepts":[{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.8836714029312134},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6103023886680603},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5630166530609131},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.5608928203582764},{"id":"https://openalex.org/C158711907","wikidata":"https://www.wikidata.org/wiki/Q1768467","display_name":"Fluorescence spectroscopy","level":3,"score":0.5177797079086304},{"id":"https://openalex.org/C43571822","wikidata":"https://www.wikidata.org/wiki/Q599037","display_name":"Near-infrared spectroscopy","level":2,"score":0.5041505098342896},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.4703117907047272},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.46918511390686035},{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.4690684974193573},{"id":"https://openalex.org/C64946054","wikidata":"https://www.wikidata.org/wiki/Q4874476","display_name":"Bayesian multivariate linear regression","level":3,"score":0.4449879825115204},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3834002614021301},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.36923736333847046},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3494887351989746},{"id":"https://openalex.org/C48921125","wikidata":"https://www.wikidata.org/wiki/Q10861030","display_name":"Linear regression","level":2,"score":0.3191896080970764},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.24986135959625244},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21290600299835205},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0880122184753418},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.08651408553123474},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.07406356930732727},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017127","descriptor_name":"Glycation End Products, Advanced","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D017127","descriptor_name":"Glycation End Products, Advanced","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D017127","descriptor_name":"Glycation End Products, Advanced","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D019265","descriptor_name":"Spectroscopy, Near-Infrared","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019265","descriptor_name":"Spectroscopy, Near-Infrared","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019265","descriptor_name":"Spectroscopy, Near-Infrared","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2019.8857867","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2019.8857867","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:31947101","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31947101","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7599999904632568}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1970375881","https://openalex.org/W2043294107","https://openalex.org/W2061380296","https://openalex.org/W2068900191","https://openalex.org/W2077871076","https://openalex.org/W2087833865","https://openalex.org/W2583594951","https://openalex.org/W2802540109","https://openalex.org/W2883415922","https://openalex.org/W2885046370","https://openalex.org/W2891028736","https://openalex.org/W2892213316","https://openalex.org/W6753875283"],"related_works":["https://openalex.org/W1534848952","https://openalex.org/W1989130740","https://openalex.org/W2093881420","https://openalex.org/W2410627602","https://openalex.org/W103511855","https://openalex.org/W2095619299","https://openalex.org/W4393539111","https://openalex.org/W3018498129","https://openalex.org/W4398177300","https://openalex.org/W2085876692"],"abstract_inverted_index":{"Advanced":[0],"glycation":[1,93,145],"end":[2],"products":[3],"(AGE)":[4],"are":[5],"produced":[6],"by":[7,51],"non-enzymatic":[8],"reaction":[9],"between":[10],"glucose":[11],"and":[12,25,29,42,74,105,121,140,149,160,201],"biomolecules":[13],"including":[14],"proteins.":[15],"AGE":[16,46,76,233],"accumulation":[17,47,77,234],"is":[18],"known":[19],"to":[20,30,69,92,231],"cause":[21],"alternations":[22],"of":[23,37,114],"structure":[24],"function":[26],"in":[27,78,79,94,99,115,134,135,168,172,217,235,236],"proteins":[28],"be":[31,163,224],"related":[32],"with":[33],"an":[34,66,227],"increased":[35],"risk":[36],"diabetic":[38],"complications,":[39],"cardiovascular":[40],"diseases,":[41],"aging":[43],"processes.":[44],"Conventionally,":[45],"has":[48],"been":[49],"estimated":[50,122,182],"measuring":[52],"auto":[53,71,124,169,178],"fluorescence":[54,72,125,170,179],"level":[55,73,126,171,180],"using":[56,83,127,187],"ultraviolet":[57],"(UV)":[58],"light":[59],"excitation.":[60],"In":[61],"this":[62,218],"study,":[63],"we":[64,96,109,153],"investigated":[65],"alternative":[67,228],"approach":[68],"estimate":[70,232],"thus":[75],"vivo":[80,116,237],"human":[81,119,173,238],"skin":[82,117,174,239,245],"NIR":[84,101,112,175,185,221],"(Near-Infrared)":[85],"spectroscopy.":[86],"To":[87],"examine":[88],"spectral":[89],"features":[90],"attributed":[91],"proteins,":[95],"first":[97],"analyzed":[98],"vitro":[100,136],"spectra":[102,113,137,186],"from":[103,118,138,183],"native":[104,139],"glycated":[106,141],"protein.":[107],"Then,":[108],"further":[110],"examined":[111],"subjects,":[120],"their":[123],"several":[128,188],"multivariate":[129,189],"regression":[130,190,194,199,204],"approaches.":[131],"Our":[132],"analysis":[133],"albumin":[142],"revealed":[143],"that":[144,155,220],"may":[146,162],"affect":[147],"-CH":[148,159],"-NH":[150,161],"stretching.":[151],"Furthermore,":[152],"elucidated":[154],"those":[156,184],"bands":[157],"for":[158,165],"responsible":[164],"the":[166,207,212],"variation":[167],"spectra.":[176],"Finally,":[177],"was":[181],"methods:":[191],"principal":[192],"component":[193],"(PCR),":[195],"partial":[196],"least":[197],"square":[198],"(PLS-R)":[200],"support":[202],"vector":[203],"(SVR).":[205],"Among":[206],"three":[208],"methods,":[209],"SVR":[210],"showed":[211],"best":[213],"performance.":[214],"We":[215],"demonstrated":[216],"study":[219],"spectroscopy":[222],"can":[223],"used":[225],"as":[226],"non-invasive":[229],"method":[230],"tissue":[240],"without":[241],"UV":[242],"radiation":[243],"on":[244],"tissue.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
