{"id":"https://openalex.org/W2979772822","doi":"https://doi.org/10.1109/embc.2019.8857619","title":"Microdevice for Evaluating Ion Channel Expression by Axon-Targeted Recording to Cultured Neurons","display_name":"Microdevice for Evaluating Ion Channel Expression by Axon-Targeted Recording to Cultured Neurons","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2979772822","doi":"https://doi.org/10.1109/embc.2019.8857619","mag":"2979772822","pmid":"https://pubmed.ncbi.nlm.nih.gov/31946072"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2019.8857619","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2019.8857619","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090447356","display_name":"Kenta Shimba","orcid":"https://orcid.org/0000-0003-1156-260X"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kenta Shimba","raw_affiliation_strings":["School of Engineering, the University of Tokyo, Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"School of Engineering, the University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023773587","display_name":"Koji Sakai","orcid":"https://orcid.org/0000-0002-5585-7074"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Sakai","raw_affiliation_strings":["School of Engineering, the University of Tokyo, Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"School of Engineering, the University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108832608","display_name":"Kiyoshi Kotani","orcid":null},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoshi Kotani","raw_affiliation_strings":["Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032635092","display_name":"Yasuhiko Jimbo","orcid":"https://orcid.org/0009-0004-6005-5043"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiko Jimbo","raw_affiliation_strings":["School of Engineering, the University of Tokyo, Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"School of Engineering, the University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5090447356"],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":null,"apc_paid":null,"fwci":0.1079,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.43215285,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"2019","issue":null,"first_page":"1044","last_page":"1047"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/axon","display_name":"Axon","score":0.8071786165237427},{"id":"https://openalex.org/keywords/spike-sorting","display_name":"Spike sorting","score":0.6504967212677002},{"id":"https://openalex.org/keywords/ion-channel","display_name":"Ion channel","score":0.6345444321632385},{"id":"https://openalex.org/keywords/nerve-conduction-velocity","display_name":"Nerve conduction velocity","score":0.5639674067497253},{"id":"https://openalex.org/keywords/thermal-conduction","display_name":"Thermal conduction","score":0.5037519335746765},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.495230108499527},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.49079617857933044},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.47349056601524353},{"id":"https://openalex.org/keywords/sodium-channel","display_name":"Sodium channel","score":0.4659807085990906},{"id":"https://openalex.org/keywords/channel-blocker","display_name":"Channel blocker","score":0.459931880235672},{"id":"https://openalex.org/keywords/cortical-neurons","display_name":"Cortical neurons","score":0.4547944664955139},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4351786971092224},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3028560280799866},{"id":"https://openalex.org/keywords/sorting","display_name":"Sorting","score":0.2879541516304016},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.2604355812072754},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22455176711082458},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.17632198333740234},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.07895773649215698},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.07119330763816833},{"id":"https://openalex.org/keywords/sodium","display_name":"Sodium","score":0.06341621279716492}],"concepts":[{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.8071786165237427},{"id":"https://openalex.org/C2777613131","wikidata":"https://www.wikidata.org/wiki/Q2003571","display_name":"Spike sorting","level":3,"score":0.6504967212677002},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.6345444321632385},{"id":"https://openalex.org/C179253579","wikidata":"https://www.wikidata.org/wiki/Q6276958","display_name":"Nerve conduction velocity","level":2,"score":0.5639674067497253},{"id":"https://openalex.org/C172100665","wikidata":"https://www.wikidata.org/wiki/Q7465774","display_name":"Thermal conduction","level":2,"score":0.5037519335746765},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.495230108499527},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.49079617857933044},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.47349056601524353},{"id":"https://openalex.org/C50952357","wikidata":"https://www.wikidata.org/wiki/Q424960","display_name":"Sodium channel","level":3,"score":0.4659807085990906},{"id":"https://openalex.org/C153461711","wikidata":"https://www.wikidata.org/wiki/Q5072487","display_name":"Channel blocker","level":3,"score":0.459931880235672},{"id":"https://openalex.org/C2983650178","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cortical neurons","level":2,"score":0.4547944664955139},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4351786971092224},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3028560280799866},{"id":"https://openalex.org/C111696304","wikidata":"https://www.wikidata.org/wiki/Q2303697","display_name":"Sorting","level":2,"score":0.2879541516304016},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2604355812072754},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22455176711082458},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.17632198333740234},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07895773649215698},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.07119330763816833},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.06341621279716492},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009431","descriptor_name":"Neural Conduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009431","descriptor_name":"Neural Conduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009431","descriptor_name":"Neural Conduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2019.8857619","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2019.8857619","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:31946072","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31946072","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1849803462","https://openalex.org/W1964928684","https://openalex.org/W1993305789","https://openalex.org/W2000256732","https://openalex.org/W2022659970","https://openalex.org/W2085420625","https://openalex.org/W2094137543","https://openalex.org/W2131301953","https://openalex.org/W2135575611","https://openalex.org/W2157485677","https://openalex.org/W2168375170","https://openalex.org/W2170803914","https://openalex.org/W2335515517","https://openalex.org/W2399161531","https://openalex.org/W2528382567","https://openalex.org/W2909667183"],"related_works":["https://openalex.org/W2889678141","https://openalex.org/W3210190780","https://openalex.org/W3166235535","https://openalex.org/W2775502545","https://openalex.org/W2258758453","https://openalex.org/W2068711549","https://openalex.org/W1968361507","https://openalex.org/W2124872530","https://openalex.org/W4293863178","https://openalex.org/W2562971632"],"abstract_inverted_index":{"Recording":[0],"axonal":[1,29],"conduction":[2,30,93,101,128,134,153],"will":[3],"be":[4,116,162],"a":[5,39,104,163],"strong":[6],"tool":[7,165],"to":[8,37,41],"continuously":[9],"evaluate":[10,42],"Na":[11,87,168],"channel":[12,26,88,169],"expression":[13,27],"of":[14,76],"cultured":[15],"neurons.":[16],"However,":[17],"little":[18],"is":[19,149],"known":[20],"about":[21],"the":[22,43,109,119,127,133,138,152],"relationship":[23],"between":[24],"ion":[25],"and":[28,51,57,84,90,98,112,130],"velocity.":[31],"In":[32],"this":[33],"study,":[34],"we":[35],"aim":[36],"develop":[38],"method":[40],"relationship.":[44],"A":[45],"microdevice":[46],"was":[47,62],"developed":[48],"with":[49,82,103,118],"photo-":[50],"soft-lithography.":[52],"Cortical":[53],"neurons":[54],"were":[55,72,80,95],"cultured,":[56],"activity":[58],"propagating":[59],"along":[60,154],"axons":[61,71],"recorded.":[63],"After":[64],"spike":[65],"sorting,":[66],"mixed":[67],"signal":[68],"from":[69],"multiple":[70],"sorted":[73],"into":[74],"clusters":[75],"individual":[77],"axons.":[78,157],"Axons":[79],"treated":[81],"non-selective":[83],"subtype":[85],"specific":[86],"blockers,":[89],"changes":[91],"in":[92],"delay":[94,102,129],"evaluated.":[96],"TTX":[97],"lidocaine":[99],"increased":[100,126],"different":[105,110],"manner,":[106],"suggesting":[107],"that":[108,146],"affinity":[111],"binding":[113],"kinetics":[114],"can":[115],"detected":[117],"device.":[120],"Moreover,":[121],"although":[122],"Nav":[123,147],"1.2":[124,148],"blocker":[125],"eventually":[131],"clocked":[132],"at":[135],"around":[136],"IC50,":[137],"other":[139],"blockers":[140],"did":[141],"not.":[142],"This":[143],"result":[144],"suggests":[145],"dominant":[150],"for":[151,166],"unmyelinated":[155],"cortical":[156],"Overall,":[158],"our":[159],"device":[160],"should":[161],"feasible":[164],"elucidating":[167],"properties":[170],"by":[171],"axon-targeted":[172],"recording.":[173]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}