{"id":"https://openalex.org/W2980257165","doi":"https://doi.org/10.1109/embc.2019.8857457","title":"Pre-diabetic patients with severe obstructive sleep apnea: novel parameters of hypoxia during sleep correlate with insulin resistance","display_name":"Pre-diabetic patients with severe obstructive sleep apnea: novel parameters of hypoxia during sleep correlate with insulin resistance","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2980257165","doi":"https://doi.org/10.1109/embc.2019.8857457","mag":"2980257165","pmid":"https://pubmed.ncbi.nlm.nih.gov/31946983"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2019.8857457","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2019.8857457","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057299776","display_name":"Eleni Perantoni","orcid":null},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"E. Perantoni","raw_affiliation_strings":["laboratory of computing, medical informatics and biomedical imaging technologies, Aristotle University of Thessaloniki, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"laboratory of computing, medical informatics and biomedical imaging technologies, Aristotle University of Thessaloniki, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073664202","display_name":"Dimitris Filos","orcid":"https://orcid.org/0000-0001-5613-652X"},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"D. Filos","raw_affiliation_strings":["laboratory of computing, medical informatics and biomedical imaging technologies, Aristotle University of Thessaloniki, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"laboratory of computing, medical informatics and biomedical imaging technologies, Aristotle University of Thessaloniki, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076310368","display_name":"Konstantinos Archontogeorgis","orcid":null},"institutions":[{"id":"https://openalex.org/I147962203","display_name":"Democritus University of Thrace","ror":"https://ror.org/03bfqnx40","country_code":"GR","type":"education","lineage":["https://openalex.org/I147962203"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"K. Archontogeorgis","raw_affiliation_strings":["MSc Program in Sleep Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MSc Program in Sleep Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Greece","institution_ids":["https://openalex.org/I147962203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113837879","display_name":"P Steiropoulos","orcid":null},"institutions":[{"id":"https://openalex.org/I147962203","display_name":"Democritus University of Thrace","ror":"https://ror.org/03bfqnx40","country_code":"GR","type":"education","lineage":["https://openalex.org/I147962203"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"P. Steiropoulos","raw_affiliation_strings":["MSc Program in Sleep Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MSc Program in Sleep Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Greece","institution_ids":["https://openalex.org/I147962203"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078023454","display_name":"Ioanna Chouvarda","orcid":"https://orcid.org/0000-0001-8915-6658"},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"I.C. Chouvarda","raw_affiliation_strings":["laboratory of computing, medical informatics and biomedical imaging technologies, Aristotle University of Thessaloniki, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"laboratory of computing, medical informatics and biomedical imaging technologies, Aristotle University of Thessaloniki, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0931,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.868791,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"4","issue":null,"first_page":"5002","last_page":"5005"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.9884999990463257,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obstructive-sleep-apnea","display_name":"Obstructive sleep apnea","score":0.7937652468681335},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"Insulin resistance","score":0.7133481502532959},{"id":"https://openalex.org/keywords/hypoxia","display_name":"Hypoxia (environmental)","score":0.696902871131897},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6905606985092163},{"id":"https://openalex.org/keywords/sleep-apnea","display_name":"Sleep apnea","score":0.6164581179618835},{"id":"https://openalex.org/keywords/sleep","display_name":"Sleep (system call)","score":0.6059306859970093},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"Diabetes mellitus","score":0.5132579803466797},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.4964609742164612},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.4583932161331177},{"id":"https://openalex.org/keywords/insulin","display_name":"Insulin","score":0.34837859869003296},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.3286575675010681},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.11487141251564026},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.07125911116600037},{"id":"https://openalex.org/keywords/oxygen","display_name":"Oxygen","score":0.04717284440994263}],"concepts":[{"id":"https://openalex.org/C2776006263","wikidata":"https://www.wikidata.org/wiki/Q16606552","display_name":"Obstructive sleep apnea","level":2,"score":0.7937652468681335},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7133481502532959},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.696902871131897},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6905606985092163},{"id":"https://openalex.org/C2777935920","wikidata":"https://www.wikidata.org/wiki/Q213600","display_name":"Sleep apnea","level":2,"score":0.6164581179618835},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.6059306859970093},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5132579803466797},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4964609742164612},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4583932161331177},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.34837859869003296},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3286575675010681},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.11487141251564026},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.07125911116600037},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.04717284440994263},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011236","descriptor_name":"Prediabetic State","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011236","descriptor_name":"Prediabetic State","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011236","descriptor_name":"Prediabetic State","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020181","descriptor_name":"Sleep Apnea, Obstructive","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D020181","descriptor_name":"Sleep Apnea, Obstructive","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D020181","descriptor_name":"Sleep Apnea, Obstructive","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2019.8857457","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2019.8857457","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:31946983","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31946983","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7900000214576721,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W82112906","https://openalex.org/W1993546698","https://openalex.org/W2037464054","https://openalex.org/W2067956022","https://openalex.org/W2079520227","https://openalex.org/W2105727933","https://openalex.org/W2263042932","https://openalex.org/W2789703545","https://openalex.org/W2891577104","https://openalex.org/W2898689678","https://openalex.org/W2905540755"],"related_works":["https://openalex.org/W2072718982","https://openalex.org/W1984411039","https://openalex.org/W2319255337","https://openalex.org/W2591779223","https://openalex.org/W198090884","https://openalex.org/W1562849051","https://openalex.org/W2368690120","https://openalex.org/W2034082193","https://openalex.org/W4384009303","https://openalex.org/W3103314555"],"abstract_inverted_index":{"Obstructive":[0],"sleep":[1,8,17,155],"apnea":[2,18,156],"(OSA)":[3],"is":[4],"an":[5,33],"increasingly":[6],"prevalent":[7],"disorder":[9],"with":[10,32,86,118,143,145,157,169,200,212,263],"estimated":[11],"prevalence":[12],"of":[13,36,48,59,89,104,126,138,148,160,164,177,195,215,217,223,244,272,277],"moderate":[14],"to":[15],"severe":[16],"ranging":[19],"between":[20,241],"6-13%":[21],"in":[22,51,83,107,124,274],"the":[23,57,60,67,84,100,105,122,175,275],"adult":[24],"population.":[25],"Nocturnal":[26],"intermittent":[27],"hypoxia":[28,254,273],"has":[29],"been":[30],"associated":[31],"increased":[34],"risk":[35],"developing":[37],"type":[38],"2":[39],"diabetes":[40],"and":[41,97,99,150,174,221,246,265],"insulin":[42,170],"resistance":[43],"(IR).":[44],"The":[45,91,113,162],"existing":[46],"indices":[47],"hypoxia,":[49],"used":[50],"polysomnography":[52],"(PSG),":[53],"cannot":[54],"express":[55],"accurately":[56],"influence":[58],"mild":[61],"desaturations":[62,114,165,196,245],"precisely":[63],"during":[64],"sleep.":[65],"In":[66,191],"present":[68],"study,":[69],"73":[70],"subjects":[71,140,152],"without":[72],"other":[73],"comorbidities":[74],"were":[75,81,93,111,115,131,141,182,226],"examined":[76],"by":[77,204],"PSG.":[78],"Hypoxia":[79],"parameters":[80,255],"analyzed,":[82],"intervals":[85],"low":[87],"values":[88],"SpO2signal.":[90],"thresholds":[92],"set":[94],"at":[95],"94%":[96],"92%":[98],"average":[101],"value":[102],"(M)":[103],"SpO2signal,":[106],"areas":[108],"below":[109],"thresholds,":[110],"calculated.":[112],"analyzed":[116],"together":[117],"their":[119],"duration":[120,194,214,243],"within":[121],"recording":[123],"terms":[125],"SpO2signal":[127,258],"parameters.":[128],"Blood":[129],"samples":[130],"taken":[132],"for":[133],"biochemical":[134],"analysis.":[135],"A":[136,235],"total":[137,213,242],"50":[139],"diagnosed":[142],"OSAS":[144],"mean":[146,158,193],"AHI":[147,159],"56.11\u00b127.70/h":[149],"23":[151],"had":[153],"no":[154],"3.47\u00b10.6/h.":[161],"amount":[163],"was":[166,197,238],"significantly":[167,198],"correlated":[168,199,262],"levels":[171],"(r=0.301,":[172,189],"p=0.034)":[173],"percentage":[176,222],"desaturation":[178,216],"events":[179],"(Dev)":[180],"that":[181,225,253],"longer":[183],"than":[184,228],"6":[185,229],"points":[186,230],"(2":[187,231],"sec)":[188,232],"p=0.034).":[190],"addition,":[192],"IR":[201,264],"as":[202,209,211],"expressed":[203],"HOMA":[205],"index":[206],"(r=0.289,":[207],"p=0.047),":[208],"well":[210],"SpO2(r=0.322,":[218],"p":[219],"=0.025)":[220],"Dev":[224],"long":[227],"(r=0.292,":[233],"p=0.044).":[234],"strong":[236],"correlation":[237],"also":[239],"revealed":[240],"fasting":[247,266],"glucose":[248,267],"(r=0.887,":[249],"p=0.000).":[250],"Results":[251],"suggest":[252],"derived":[256],"from":[257],"analysis,":[259],"are":[260],"strongly":[261],"levels,":[268],"implying":[269],"a":[270],"role":[271],"pathogenesis":[276],"diabetes.":[278]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}