{"id":"https://openalex.org/W2980055151","doi":"https://doi.org/10.1109/embc.2019.8857285","title":"Neuroprotection of Glibenclamide against Brain Injury after Cardiac Arrest via Modulation of NLRP3 Inflammasome","display_name":"Neuroprotection of Glibenclamide against Brain Injury after Cardiac Arrest via Modulation of NLRP3 Inflammasome","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2980055151","doi":"https://doi.org/10.1109/embc.2019.8857285","mag":"2980055151","pmid":"https://pubmed.ncbi.nlm.nih.gov/31946797"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2019.8857285","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2019.8857285","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6986273","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059811588","display_name":"Xiuli Yang","orcid":"https://orcid.org/0000-0001-8277-4285"},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiuli Yang","raw_affiliation_strings":["Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA"],"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100741929","display_name":"Zhuoran Wang","orcid":"https://orcid.org/0000-0001-5175-8645"},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhuoran Wang","raw_affiliation_strings":["Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA"],"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100612505","display_name":"Xiaofeng Jia","orcid":"https://orcid.org/0000-0003-1445-8525"},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaofeng Jia","raw_affiliation_strings":["Department of Neurosurgery, Anatomy Neurobiology, Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA"],"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Anatomy Neurobiology, Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I126744593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5059811588"],"corresponding_institution_ids":["https://openalex.org/I126744593"],"apc_list":null,"apc_paid":null,"fwci":1.5591,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.82944779,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"2019","issue":null,"first_page":"4209","last_page":"4212"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroprotection","display_name":"Neuroprotection","score":0.8771789073944092},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6702386736869812},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.6268938183784485},{"id":"https://openalex.org/keywords/hippocampal-formation","display_name":"Hippocampal formation","score":0.6018310189247131},{"id":"https://openalex.org/keywords/glibenclamide","display_name":"Glibenclamide","score":0.5767838358879089},{"id":"https://openalex.org/keywords/brain-damage","display_name":"Brain damage","score":0.4920212924480438},{"id":"https://openalex.org/keywords/asphyxia","display_name":"Asphyxia","score":0.4883851408958435},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.45771849155426025},{"id":"https://openalex.org/keywords/inflammasome","display_name":"Inflammasome","score":0.44212716817855835},{"id":"https://openalex.org/keywords/return-of-spontaneous-circulation","display_name":"Return of spontaneous circulation","score":0.4360520839691162},{"id":"https://openalex.org/keywords/inflammation","display_name":"Inflammation","score":0.303187757730484},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.29963448643684387},{"id":"https://openalex.org/keywords/resuscitation","display_name":"Resuscitation","score":0.21703201532363892},{"id":"https://openalex.org/keywords/cardiopulmonary-resuscitation","display_name":"Cardiopulmonary resuscitation","score":0.2054523229598999},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.19163170456886292}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8771789073944092},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6702386736869812},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6268938183784485},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6018310189247131},{"id":"https://openalex.org/C2779768347","wikidata":"https://www.wikidata.org/wiki/Q420626","display_name":"Glibenclamide","level":3,"score":0.5767838358879089},{"id":"https://openalex.org/C2781458332","wikidata":"https://www.wikidata.org/wiki/Q720026","display_name":"Brain damage","level":2,"score":0.4920212924480438},{"id":"https://openalex.org/C2779914510","wikidata":"https://www.wikidata.org/wiki/Q193840","display_name":"Asphyxia","level":2,"score":0.4883851408958435},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45771849155426025},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.44212716817855835},{"id":"https://openalex.org/C2778619729","wikidata":"https://www.wikidata.org/wiki/Q7317197","display_name":"Return of spontaneous circulation","level":4,"score":0.4360520839691162},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.303187757730484},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29963448643684387},{"id":"https://openalex.org/C2778165595","wikidata":"https://www.wikidata.org/wiki/Q5491454","display_name":"Resuscitation","level":2,"score":0.21703201532363892},{"id":"https://openalex.org/C2777055891","wikidata":"https://www.wikidata.org/wiki/Q185325","display_name":"Cardiopulmonary resuscitation","level":3,"score":0.2054523229598999},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19163170456886292},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000066829","descriptor_name":"Neuroprotection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000066829","descriptor_name":"Neuroprotection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000066829","descriptor_name":"Neuroprotection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005905","descriptor_name":"Glyburide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005905","descriptor_name":"Glyburide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005905","descriptor_name":"Glyburide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006323","descriptor_name":"Heart Arrest","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006323","descriptor_name":"Heart Arrest","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006323","descriptor_name":"Heart Arrest","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016887","descriptor_name":"Cardiopulmonary Resuscitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016887","descriptor_name":"Cardiopulmonary Resuscitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016887","descriptor_name":"Cardiopulmonary Resuscitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058847","descriptor_name":"Inflammasomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058847","descriptor_name":"Inflammasomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058847","descriptor_name":"Inflammasomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc.2019.8857285","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2019.8857285","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:31946797","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31946797","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:6986273","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6986273","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Conf Proc IEEE Eng Med Biol Soc","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6986273","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6986273","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Conf Proc IEEE Eng Med Biol Soc","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8600000143051147,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W846252984","https://openalex.org/W1534620902","https://openalex.org/W1870318731","https://openalex.org/W1966634013","https://openalex.org/W1994413017","https://openalex.org/W2003922776","https://openalex.org/W2007198984","https://openalex.org/W2024861481","https://openalex.org/W2030345966","https://openalex.org/W2058056440","https://openalex.org/W2083581277","https://openalex.org/W2105676040","https://openalex.org/W2120561852","https://openalex.org/W2122828189","https://openalex.org/W2134007048","https://openalex.org/W2134735862","https://openalex.org/W2167037697","https://openalex.org/W2170397555","https://openalex.org/W2292993393","https://openalex.org/W2338397778","https://openalex.org/W2566624704","https://openalex.org/W2606409681","https://openalex.org/W2780162346","https://openalex.org/W2789732111","https://openalex.org/W2889351028","https://openalex.org/W2917462181","https://openalex.org/W6656701518","https://openalex.org/W6697274274","https://openalex.org/W6747726230"],"related_works":["https://openalex.org/W2362310617","https://openalex.org/W2355027690","https://openalex.org/W2025386567","https://openalex.org/W2105276252","https://openalex.org/W2381179763","https://openalex.org/W2381910173","https://openalex.org/W2355469984","https://openalex.org/W2393455553","https://openalex.org/W2363125982","https://openalex.org/W2152669755"],"abstract_inverted_index":{"Glibenclamide":[0],"(GBC)":[1],"improves":[2],"cerebral":[3],"outcome":[4],"after":[5,39,87,178,198,224],"cardiac":[6],"arrest":[7],"(CA)":[8],"in":[9,46,132,191,200],"rats.":[10],"We":[11],"aim":[12],"to":[13,23,58,64,118,146],"investigate":[14],"the":[15,25,33,40,65,101,122,139,147,150,182,185,192,220,233],"effect":[16],"of":[17,27,30,36,42,50,80,95,107,130,219,235,240],"GBC":[18,31,66,73,136,154,207,211],"on":[19,32,181],"electrophysiological":[20,215],"recovery":[21,161],"and":[22,89,111,120,216],"explore":[24],"mechanism":[26],"neuroprotective":[28,227],"effects":[29,228],"acute":[34,221],"stage":[35],"brain":[37,222],"injury":[38,223],"return":[41],"spontaneous":[43],"circulation":[44],"(ROSC)":[45],"a":[47,77,92,127],"rodent":[48],"model":[49],"CA.":[51,225],"16":[52],"anesthetized":[53],"male":[54],"Wistar":[55],"rats":[56,133,151],"subjected":[57],"8-min":[59],"asphyxia-CA":[60],"were":[61,116],"randomly":[62],"assigned":[63],"or":[67],"control":[68,140,148,201],"group":[69,141],"(N=8":[70],"each":[71],"group).":[72],"was":[74,126,168,188,204],"administered":[75],"with":[76,91,135,138,153,171,206,232],"loading":[78],"dose":[79,94],"10ug/kg":[81],"i.":[82],"p.":[83],"injection":[84],"10":[85],"min":[86],"ROSC":[88],"followed":[90],"maintaining":[93],"1.6ug/kg":[96],"per":[97],"8":[98],"hours":[99],"throughout":[100],"first":[102],"24":[103],"hours.":[104],"Quantitative":[105],"measures":[106],"EEG-information":[108],"quantity":[109],"(qEEG-IQ)":[110],"neurological":[112],"deficit":[113],"score":[114],"(NDS)":[115],"used":[117],"predict":[119],"evaluate":[121],"functional":[123],"outcome.":[124],"There":[125],"significant":[128],"improvement":[129],"NDS":[131,173],"treated":[134,152],"compared":[137],"(p":[142,162],"<;":[143,163],"0.01).":[144],"Compared":[145],"group,":[149],"showed":[155],"qEEG-IQ":[156],"scores":[157],"that":[158],"indicated":[159],"better":[160],"0.001).":[164],"Meanwhile,":[165],"early":[166,175],"QEEG-IQ":[167],"significantly":[169],"correlated":[170],"72-hr":[172],"as":[174,176],"45min":[177],"ROSC.":[179],"Furthermore,":[180],"molecular":[183],"basis,":[184],"NLRP3":[186,241],"inflammasome":[187,242],"strongly":[189],"activated":[190],"hippocampal":[193],"CA1":[194],"area":[195],"3":[196],"days":[197],"CA":[199],"rats,":[202],"which":[203],"suppressed":[205],"treatment.":[208],"Taken":[209],"together,":[210],"treatment":[212],"markedly":[213],"improved":[214],"neurologic":[217],"outcomes":[218],"These":[226],"may":[229],"be":[230],"associated":[231],"attenuation":[234],"inflammatory":[236],"response":[237],"via":[238],"down-regulation":[239],"signal.":[243]},"counts_by_year":[{"year":2024,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}