{"id":"https://openalex.org/W2979450910","doi":"https://doi.org/10.1109/embc.2019.8857109","title":"High oxygen fraction during airway opening is key to effective airway rescue in obese subjects","display_name":"High oxygen fraction during airway opening is key to effective airway rescue in obese subjects","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2979450910","doi":"https://doi.org/10.1109/embc.2019.8857109","mag":"2979450910","pmid":"https://pubmed.ncbi.nlm.nih.gov/31946373"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2019.8857109","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2019.8857109","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://nottingham-repository.worktribe.com/output/2648394","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074605466","display_name":"Marianna Laviola","orcid":"https://orcid.org/0000-0001-6279-6137"},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marianna Laviola","raw_affiliation_strings":["Division of Clinical Neuroscience, School of Medicine, University of Nottingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Neuroscience, School of Medicine, University of Nottingham, UK","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076375776","display_name":"Christian Niklas","orcid":"https://orcid.org/0000-0002-8887-0996"},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christian Niklas","raw_affiliation_strings":["Division of Clinical Neuroscience, School of Medicine, University of Nottingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Neuroscience, School of Medicine, University of Nottingham, UK","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006914611","display_name":"Husam Alahmadi","orcid":"https://orcid.org/0009-0002-2613-0973"},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Husam Alahmadi","raw_affiliation_strings":["Division of Clinical Neuroscience, School of Medicine, University of Nottingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Neuroscience, School of Medicine, University of Nottingham, UK","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046143595","display_name":"Anup Das","orcid":"https://orcid.org/0000-0002-2918-4208"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anup Das","raw_affiliation_strings":["School of Engineering, University of Warwick, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Engineering, University of Warwick, UK","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077819322","display_name":"Declan G. Bates","orcid":"https://orcid.org/0000-0003-1395-9846"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Declan G Bates","raw_affiliation_strings":["School of Engineering, University of Warwick, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Engineering, University of Warwick, UK","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035273460","display_name":"Jonathan G. Hardman","orcid":"https://orcid.org/0000-0002-8959-8058"},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jonathan G Hardman","raw_affiliation_strings":["Division of Clinical Neuroscience, School of Medicine, University of Nottingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Neuroscience, School of Medicine, University of Nottingham, UK","institution_ids":["https://openalex.org/I142263535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18316769,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"104","issue":null,"first_page":"2357","last_page":"2360"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10830","display_name":"Airway Management and Intubation Techniques","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10830","display_name":"Airway Management and Intubation Techniques","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11260","display_name":"Tracheal and airway disorders","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/airway","display_name":"Airway","score":0.8138959407806396},{"id":"https://openalex.org/keywords/fraction","display_name":"Fraction (chemistry)","score":0.4971771538257599},{"id":"https://openalex.org/keywords/key","display_name":"Key (lock)","score":0.4968123733997345},{"id":"https://openalex.org/keywords/rescue-therapy","display_name":"Rescue therapy","score":0.4306895434856415},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4277246594429016},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.313173770904541},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.2352464497089386},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.16947031021118164},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.1497420370578766},{"id":"https://openalex.org/keywords/computer-security","display_name":"Computer security","score":0.12010926008224487},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.05054327845573425}],"concepts":[{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.8138959407806396},{"id":"https://openalex.org/C149629883","wikidata":"https://www.wikidata.org/wiki/Q660926","display_name":"Fraction (chemistry)","level":2,"score":0.4971771538257599},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.4968123733997345},{"id":"https://openalex.org/C2776485726","wikidata":"https://www.wikidata.org/wiki/Q17141389","display_name":"Rescue therapy","level":2,"score":0.4306895434856415},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4277246594429016},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.313173770904541},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2352464497089386},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16947031021118164},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1497420370578766},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.12010926008224487},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.05054327845573425}],"mesh":[{"descriptor_ui":"D001049","descriptor_name":"Apnea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001049","descriptor_name":"Apnea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001049","descriptor_name":"Apnea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013990","descriptor_name":"Tidal Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013990","descriptor_name":"Tidal Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013990","descriptor_name":"Tidal Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc.2019.8857109","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2019.8857109","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:31946373","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31946373","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:nottingham-repository.worktribe.com:2648394","is_oa":true,"landing_page_url":"https://nottingham-repository.worktribe.com/output/2648394","pdf_url":null,"source":{"id":"https://openalex.org/S4306402483","display_name":"Repository@Nottingham (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"acceptedVersion"}],"best_oa_location":{"id":"pmh:oai:nottingham-repository.worktribe.com:2648394","is_oa":true,"landing_page_url":"https://nottingham-repository.worktribe.com/output/2648394","pdf_url":null,"source":{"id":"https://openalex.org/S4306402483","display_name":"Repository@Nottingham (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"acceptedVersion"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/14","display_name":"Life below water","score":0.5099999904632568}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1796278849","https://openalex.org/W1968264977","https://openalex.org/W1979185241","https://openalex.org/W1995628556","https://openalex.org/W2012559533","https://openalex.org/W2068077018","https://openalex.org/W2068413506","https://openalex.org/W2070555627","https://openalex.org/W2074292200","https://openalex.org/W2103916020","https://openalex.org/W2115751527","https://openalex.org/W2116567625","https://openalex.org/W2123293370","https://openalex.org/W2143390431","https://openalex.org/W2169057912","https://openalex.org/W2181541446","https://openalex.org/W2754304655","https://openalex.org/W2904411485","https://openalex.org/W3037560079"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725","https://openalex.org/W2148612803"],"abstract_inverted_index":{"Apnea":[0],"is":[1,25,190],"common":[2],"after":[3,160],"induction":[4],"of":[5,18,32,49,56,114,120,123,193],"anesthesia":[6],"and":[7,27,29,38,59,90],"may":[8,185],"produce":[9],"dangerous":[10],"hypoxemia,":[11],"particularly":[12],"in":[13,21,46,139,147],"obese":[14],"subjects.":[15],"Optimal":[16],"management":[17],"airway":[19,96,109,116,161,178],"emergencies":[20],"obese,":[22],"apneic":[23],"subjects":[24,68,148,153],"complex":[26],"controversial,":[28],"clinical":[30],"studies":[31],"rescue":[33,44,110],"strategies":[34,45],"are":[35,180],"inherently":[36],"difficult":[37],"ethically-challenging":[39],"to":[40,172],"perform.":[41],"We":[42],"investigated":[43],"various":[47,121],"degrees":[48],"obesity,":[50],"using":[51,130],"a":[52,194],"highly-integrated,":[53],"computational":[54],"model":[55],"the":[57,115,118,191],"pulmonary":[58],"cardiovascular":[60],"systems,":[61],"configured":[62],"against":[63],"data":[64],"from":[65],"8":[66],"virtual":[67],"(body":[69],"mass":[70],"index":[71],"[BMI]":[72],"24-57":[73],"kg":[74],"m":[75],"<sup":[76],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[77,102],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">-2</sup>":[78],").":[79],"Each":[80],"subject":[81],"received":[82],"pre-oxygenation":[83],"with":[84,93,117,126,133,143,149,154],"100%":[85,127,134],"oxygen":[86,135,196],"for":[87],"3":[88],"min,":[89],"then":[91],"apnea":[92],"an":[94],"obstructed":[95],"was":[97,111],"simulated":[98],"until":[99],"SaO":[100],"<sub":[101],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">2</sub>":[103],"reached":[104],"40%.":[105],"At":[106],"that":[107,170,198],"time,":[108],"simulated,":[112],"opening":[113],"provision":[119],"patterns":[122],"tidal":[124,131,145,175],"ventilation":[125,132],"oxygen.":[128],"Rescue":[129],"provided":[136],"rapid":[137],"re-oxygenation":[138],"all":[140],"subjects,":[141],"even":[142],"small":[144],"volumes":[146,176],"large":[150],"BMI.":[151],"Overall,":[152],"larger":[155],"BMI":[156],"pre-oxygenated":[157],"faster":[158],"and,":[159],"obstruction,":[162],"developed":[163],"hypoxemia":[164],"more":[165],"quickly.":[166],"Our":[167],"results":[168],"indicate":[169],"attempts":[171],"achieve":[173],"substantial":[174],"during":[177],"rescues":[179],"probably":[181],"not":[182],"worthwhile":[183],"(and":[184],"be":[186],"counter-productive);":[187],"rather,":[188],"it":[189],"assurance":[192],"high-inspired":[195],"fraction":[197],"will":[199],"prevent":[200],"critical":[201],"hypoxemia.":[202]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
