{"id":"https://openalex.org/W2979483023","doi":"https://doi.org/10.1109/embc.2019.8856959","title":"A Biosensor for the Detection of Acetylcholine and Diazinon","display_name":"A Biosensor for the Detection of Acetylcholine and Diazinon","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2979483023","doi":"https://doi.org/10.1109/embc.2019.8856959","mag":"2979483023","pmid":"https://pubmed.ncbi.nlm.nih.gov/31946099"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2019.8856959","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2019.8856959","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047537687","display_name":"Elisa Herrera","orcid":"https://orcid.org/0000-0003-3511-7586"},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E. G. Herrera","raw_affiliation_strings":["Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028196481","display_name":"Andrea Bonini","orcid":"https://orcid.org/0000-0001-9511-0699"},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Bonini","raw_affiliation_strings":["Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068251514","display_name":"Federico Maria Vivaldi","orcid":"https://orcid.org/0000-0003-1304-9893"},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Vivaldi","raw_affiliation_strings":["Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062561322","display_name":"Bernardo Melai","orcid":"https://orcid.org/0000-0003-3617-4937"},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"B. Melai","raw_affiliation_strings":["Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008216987","display_name":"Pietro Salvo","orcid":"https://orcid.org/0000-0003-3866-2993"},"institutions":[{"id":"https://openalex.org/I4210106076","display_name":"Istituto di Fisiologia Clinica","ror":"https://ror.org/01kdj2848","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210106076","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P. Salvo","raw_affiliation_strings":["Institute of Clinical Physiology, National Council of Research, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Physiology, National Council of Research, Pisa, Italy","institution_ids":["https://openalex.org/I4210155236","https://openalex.org/I4210106076"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024639641","display_name":"Noemi Poma","orcid":null},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"N. Poma","raw_affiliation_strings":["Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040635530","display_name":"Delio Santalucia","orcid":"https://orcid.org/0000-0002-6626-3554"},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"D. Santalucia","raw_affiliation_strings":["Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042034556","display_name":"Arno Kirchhain","orcid":"https://orcid.org/0000-0002-8095-831X"},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Kirchhain","raw_affiliation_strings":["Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060712239","display_name":"Fabio Di Francesco","orcid":"https://orcid.org/0000-0002-9285-1595"},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Di Francesco","raw_affiliation_strings":["Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4531,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.82811176,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"2019","issue":null,"first_page":"1159","last_page":"1162"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11472","display_name":"Analytical Chemistry and Sensors","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1502","display_name":"Bioengineering"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11434","display_name":"Electrochemical Analysis and Applications","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1603","display_name":"Electrochemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diazinon","display_name":"Diazinon","score":0.9773832559585571},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"Acetylcholine","score":0.9446966052055359},{"id":"https://openalex.org/keywords/biosensor","display_name":"Biosensor","score":0.8395752906799316},{"id":"https://openalex.org/keywords/acetylcholinesterase","display_name":"Acetylcholinesterase","score":0.6774800419807434},{"id":"https://openalex.org/keywords/choline","display_name":"Choline","score":0.6324992179870605},{"id":"https://openalex.org/keywords/neurotransmitter","display_name":"Neurotransmitter","score":0.5813376903533936},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5594766736030579},{"id":"https://openalex.org/keywords/detection-limit","display_name":"Detection limit","score":0.43631216883659363},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.35370132327079773},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.28372812271118164},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.24598780274391174},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.1941867172718048},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18201905488967896},{"id":"https://openalex.org/keywords/pesticide","display_name":"Pesticide","score":0.11818626523017883}],"concepts":[{"id":"https://openalex.org/C2779842916","wikidata":"https://www.wikidata.org/wiki/Q411202","display_name":"Diazinon","level":3,"score":0.9773832559585571},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.9446966052055359},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.8395752906799316},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.6774800419807434},{"id":"https://openalex.org/C2781123555","wikidata":"https://www.wikidata.org/wiki/Q193166","display_name":"Choline","level":2,"score":0.6324992179870605},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.5813376903533936},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5594766736030579},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.43631216883659363},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.35370132327079773},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28372812271118164},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.24598780274391174},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1941867172718048},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18201905488967896},{"id":"https://openalex.org/C161176658","wikidata":"https://www.wikidata.org/wiki/Q131656","display_name":"Pesticide","level":2,"score":0.11818626523017883},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D003976","descriptor_name":"Diazinon","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D003976","descriptor_name":"Diazinon","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D003976","descriptor_name":"Diazinon","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004800","descriptor_name":"Enzymes, Immobilized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004800","descriptor_name":"Enzymes, Immobilized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004800","descriptor_name":"Enzymes, Immobilized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1109/embc.2019.8856959","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2019.8856959","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:31946099","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31946099","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:arpi.unipi.it:11568/1025841","is_oa":false,"landing_page_url":"http://hdl.handle.net/11568/1025841","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:oai:flore.unifi.it:2158/1438465","is_oa":false,"landing_page_url":"https://hdl.handle.net/2158/1438465","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/6","score":0.5,"display_name":"Clean water and sanitation"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W112888018","https://openalex.org/W137731066","https://openalex.org/W575995186","https://openalex.org/W947546801","https://openalex.org/W1120931337","https://openalex.org/W1510572169","https://openalex.org/W1916719536","https://openalex.org/W1965222222","https://openalex.org/W1970121962","https://openalex.org/W1995060577","https://openalex.org/W2003756890","https://openalex.org/W2025045267","https://openalex.org/W2025629781","https://openalex.org/W2041570449","https://openalex.org/W2052754932","https://openalex.org/W2057104805","https://openalex.org/W2061444911","https://openalex.org/W2076018034","https://openalex.org/W2083105984","https://openalex.org/W2091836352","https://openalex.org/W2118003508","https://openalex.org/W2164029323","https://openalex.org/W2170557325","https://openalex.org/W2184397363","https://openalex.org/W2321910562","https://openalex.org/W2326753855","https://openalex.org/W2482427934","https://openalex.org/W2530503596","https://openalex.org/W2538206796","https://openalex.org/W2582197875","https://openalex.org/W2583551110","https://openalex.org/W2604490076","https://openalex.org/W2762366500","https://openalex.org/W2886750598","https://openalex.org/W4229638727","https://openalex.org/W4243184105","https://openalex.org/W4293105400","https://openalex.org/W6605546708"],"related_works":["https://openalex.org/W2012856769","https://openalex.org/W2979483023","https://openalex.org/W1980113878","https://openalex.org/W2147598425","https://openalex.org/W2032165394","https://openalex.org/W2031992050","https://openalex.org/W2066802022","https://openalex.org/W2744469733","https://openalex.org/W2060503598","https://openalex.org/W3088716885"],"abstract_inverted_index":{"Acetylcholine":[0],"is":[1,17,36],"a":[2,5,18,34,58],"neurotransmitter":[3],"and":[4,12,48,69,79,88,96,108,113],"neuromodulator":[6],"found":[7],"in":[8],"the":[9,27,39,82,93,98,106],"autonomic,":[10],"peripheral":[11],"central":[13],"nervous":[14],"systems.":[15],"Diazinon":[16],"pesticide":[19],"with":[20,66],"toxic":[21],"effects":[22],"on":[23,75],"humans,":[24],"such":[25],"as":[26],"inhibition":[28],"of":[29,41,61,84,103],"acetylcholine.":[30],"In":[31],"this":[32],"paper,":[33],"biosensor":[35,56],"proposed":[37],"for":[38,105],"detection":[40,104],"acetylcholine":[42,85,107],"(range":[43,50],"70":[44,111],"-":[45,52],"1000":[46],"\u03bcM)":[47],"diazinon":[49,109],"0.3":[51,114],"20000":[53],"ppb).":[54],"This":[55,71],"combines":[57],"pH-sensitive":[59],"layer":[60],"reduced":[62,76],"graphene":[63,77],"oxide":[64,78],"functionalized":[65],"4-aminobenzoic":[67],"acid":[68],"acetylcholinesterase.":[70],"enzyme":[72],"was":[73],"immobilized":[74],"it":[80],"catalyzed":[81],"conversion":[83],"into":[86],"choline":[87],"acetic":[89],"acid,":[90],"locally":[91],"decreasing":[92],"pH":[94],"value":[95],"triggering":[97],"sensor":[99],"response.":[100],"The":[101],"limit":[102],"were":[110],"\u03bcM":[112],"ppb,":[115],"respectively.":[116]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":8}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}