{"id":"https://openalex.org/W2979804242","doi":"https://doi.org/10.1109/embc.2019.8856600","title":"Characterization of EEG Resting-state Activity in Alzheimer\u2019s Disease by Means of Recurrence Plot Analyses","display_name":"Characterization of EEG Resting-state Activity in Alzheimer\u2019s Disease by Means of Recurrence Plot Analyses","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2979804242","doi":"https://doi.org/10.1109/embc.2019.8856600","mag":"2979804242","pmid":"https://pubmed.ncbi.nlm.nih.gov/31947167"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2019.8856600","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2019.8856600","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056964718","display_name":"Pablo N\u00f9\u00f1ez","orcid":"https://orcid.org/0000-0002-5898-6664"},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pablo Nunez","raw_affiliation_strings":["Biomedical Engineering Group, University of Valladolid, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Group, University of Valladolid, Valladolid, Spain","institution_ids":["https://openalex.org/I108103353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019033958","display_name":"Jes\u00fas Poza","orcid":"https://orcid.org/0000-0001-8577-9559"},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jesus Poza","raw_affiliation_strings":["Biomedical Engineering Group, University of Valladolid, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Group, University of Valladolid, Valladolid, Spain","institution_ids":["https://openalex.org/I108103353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066583841","display_name":"Carlos G\u00f3mez","orcid":"https://orcid.org/0000-0002-9488-0605"},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carlos Gomez","raw_affiliation_strings":["Biomedical Engineering Group, University of Valladolid, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Group, University of Valladolid, Valladolid, Spain","institution_ids":["https://openalex.org/I108103353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066312205","display_name":"Ver\u00f3nica Barroso-Garc\u00eda","orcid":"https://orcid.org/0000-0001-5648-206X"},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Veronica Barroso-Garcia","raw_affiliation_strings":["Biomedical Engineering Group, University of Valladolid, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Group, University of Valladolid, Valladolid, Spain","institution_ids":["https://openalex.org/I108103353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103212506","display_name":"Sa\u00fal J. Ruiz-G\u00f3mez","orcid":"https://orcid.org/0000-0003-1483-2265"},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Saul J. Ruiz-Gomez","raw_affiliation_strings":["Biomedical Engineering Group, University of Valladolid, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Group, University of Valladolid, Valladolid, Spain","institution_ids":["https://openalex.org/I108103353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049867577","display_name":"Aar\u00f3n Maturana-Candelas","orcid":"https://orcid.org/0000-0001-7445-6498"},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Aaron Maturana-Candelas","raw_affiliation_strings":["Biomedical Engineering Group, University of Valladolid, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Group, University of Valladolid, Valladolid, Spain","institution_ids":["https://openalex.org/I108103353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057970618","display_name":"Miguel \u00c1ngel Tola-Arribas","orcid":"https://orcid.org/0000-0003-4105-0998"},"institutions":[{"id":"https://openalex.org/I4210158107","display_name":"Hospital Universitario R\u00edo Hortega","ror":"https://ror.org/05jk45963","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158107"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Miguel A. Tola-Arribas","raw_affiliation_strings":["Department of Neurologyy, \u2018R\u00edo Hortega\u2019 University Hospital, Valladolid, Spain","Department of Neurologyy, 'R\u00edo Hortega' University Hospital, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurologyy, \u2018R\u00edo Hortega\u2019 University Hospital, Valladolid, Spain","institution_ids":["https://openalex.org/I4210158107"]},{"raw_affiliation_string":"Department of Neurologyy, 'R\u00edo Hortega' University Hospital, Valladolid, Spain","institution_ids":["https://openalex.org/I4210158107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034506800","display_name":"M\u00f3nica Cano","orcid":"https://orcid.org/0000-0003-3146-5057"},"institutions":[{"id":"https://openalex.org/I4210158107","display_name":"Hospital Universitario R\u00edo Hortega","ror":"https://ror.org/05jk45963","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158107"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Monica Cano","raw_affiliation_strings":["Department of Neurophysiology, \u2018R\u00edo Hortega\u2019 University Hospital, Valladolid, Spain","Department of Neurophysiology, 'R\u00edo Hortega' University Hospital, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurophysiology, \u2018R\u00edo Hortega\u2019 University Hospital, Valladolid, Spain","institution_ids":["https://openalex.org/I4210158107"]},{"raw_affiliation_string":"Department of Neurophysiology, 'R\u00edo Hortega' University Hospital, Valladolid, Spain","institution_ids":["https://openalex.org/I4210158107"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043513390","display_name":"Roberto Hornero","orcid":"https://orcid.org/0000-0001-9915-2570"},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Roberto Hornero","raw_affiliation_strings":["Biomedical Engineering Group, University of Valladolid, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Group, University of Valladolid, Valladolid, Spain","institution_ids":["https://openalex.org/I108103353"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2493,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.56029595,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"14","issue":null,"first_page":"5786","last_page":"5789"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/electroencephalography","display_name":"Electroencephalography","score":0.7845698595046997},{"id":"https://openalex.org/keywords/resting-state-fmri","display_name":"Resting state fMRI","score":0.6161031723022461},{"id":"https://openalex.org/keywords/beta","display_name":"BETA (programming language)","score":0.5725426077842712},{"id":"https://openalex.org/keywords/alpha","display_name":"Alpha (finance)","score":0.5207943320274353},{"id":"https://openalex.org/keywords/audiology","display_name":"Audiology","score":0.4577310383319855},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.4526897370815277},{"id":"https://openalex.org/keywords/mann\u2013whitney-u-test","display_name":"Mann\u2013Whitney U test","score":0.4481493830680847},{"id":"https://openalex.org/keywords/spurious-relationship","display_name":"Spurious relationship","score":0.4468110203742981},{"id":"https://openalex.org/keywords/frequency-analysis","display_name":"Frequency analysis","score":0.4380357265472412},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3320775032043457},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.30796459317207336},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.2949395179748535},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.29289644956588745},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2837945818901062},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.20919394493103027},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.144026517868042},{"id":"https://openalex.org/keywords/psychometrics","display_name":"Psychometrics","score":0.10228237509727478}],"concepts":[{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.7845698595046997},{"id":"https://openalex.org/C66324658","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Resting state fMRI","level":2,"score":0.6161031723022461},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.5725426077842712},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.5207943320274353},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.4577310383319855},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4526897370815277},{"id":"https://openalex.org/C12868164","wikidata":"https://www.wikidata.org/wiki/Q1424533","display_name":"Mann\u2013Whitney U test","level":2,"score":0.4481493830680847},{"id":"https://openalex.org/C97256817","wikidata":"https://www.wikidata.org/wiki/Q1462316","display_name":"Spurious relationship","level":2,"score":0.4468110203742981},{"id":"https://openalex.org/C97118885","wikidata":"https://www.wikidata.org/wiki/Q565636","display_name":"Frequency analysis","level":2,"score":0.4380357265472412},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3320775032043457},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.30796459317207336},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2949395179748535},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.29289644956588745},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2837945818901062},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.20919394493103027},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.144026517868042},{"id":"https://openalex.org/C171606756","wikidata":"https://www.wikidata.org/wiki/Q506132","display_name":"Psychometrics","level":2,"score":0.10228237509727478},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2019.8856600","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2019.8856600","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:31947167","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31947167","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1540071439","https://openalex.org/W1971546637","https://openalex.org/W1997207893","https://openalex.org/W2081681829","https://openalex.org/W2115387754","https://openalex.org/W2146348136","https://openalex.org/W2592217639","https://openalex.org/W2605432640","https://openalex.org/W2610365930","https://openalex.org/W2795372511","https://openalex.org/W2896375600","https://openalex.org/W3156519519","https://openalex.org/W6794344554"],"related_works":["https://openalex.org/W3113091479","https://openalex.org/W2162899405","https://openalex.org/W941090075","https://openalex.org/W2044987316","https://openalex.org/W3134374554","https://openalex.org/W2237480245","https://openalex.org/W2075065631","https://openalex.org/W2519167559","https://openalex.org/W4311248832","https://openalex.org/W4386113923"],"abstract_inverted_index":{"The":[0,76,131],"main":[1],"objective":[2],"of":[3,24,39,47,172,178],"this":[4],"study":[5],"was":[6,34,61],"to":[7,100,114],"characterize":[8],"EEG":[9,41,66],"resting-state":[10,159,179],"activity":[11],"in":[12,63,135,137,174],"55":[13],"Alzheimer's":[14],"disease":[15],"(AD)":[16],"patients":[17],"and":[18,56,74,80,91,145],"29":[19],"healthy":[20],"controls":[21],"by":[22],"means":[23],"TREND,":[25],"a":[26,169],"measure":[27,60],"based":[28],"on":[29],"recurrence":[30],"quantification":[31],"analysis.":[32],"TREND":[33,136,154],"computed":[35,62],"from":[36],"60-second":[37],"recordings":[38],"consecutive":[40],"activity,":[42],"divided":[43],"into":[44],"non-overlapping":[45],"windows":[46],"length":[48,112],"1,":[49],"2,":[50],"3,":[51],"5,":[52],"10,":[53],"15,":[54],"20":[55],"60":[57],"seconds.":[58],"This":[59],"the":[64,110,138,175],"conventional":[65],"frequency":[67,92,149],"bands":[68],"(delta,":[69],"theta,":[70],"alpha,":[71],"beta-1,":[72],"beta-2":[73,146],"gamma).":[75],"parameters":[77,98],"delay":[78],"(\u03c4)":[79],"embedding":[81,97],"dimension":[82],"(m)":[83],"were":[84,107,124],"first":[85],"optimized":[86],"for":[87],"every":[88],"window":[89],"size":[90],"band":[93],"under":[94],"study.":[95],"These":[96],"proved":[99],"be":[101],"frequency-dependent.":[102],"Furthermore,":[103,162],"10":[104],"s":[105],"epochs":[106],"set":[108],"as":[109],"minimum":[111],"required":[113],"avoid":[115],"spurious":[116],"results.":[117],"Statistically":[118],"significant":[119],"differences":[120,134],"between":[121],"both":[122],"groups":[123,132],"found":[125],"(p":[126],"<;":[127],"0.05,":[128],"Mann-Whitney":[129],"U-test).":[130],"showed":[133],"theta":[139],"(4-8":[140],"Hz),":[141],"beta1":[142],"(13-19":[143],"Hz)":[144,148],"(19-30":[147],"bands.":[150],"Our":[151],"results":[152],"using":[153],"suggest":[155],"that":[156,166],"AD":[157,167],"disrupts":[158],"neural":[160,180],"dynamics.":[161],"these":[163],"findings":[164],"indicate":[165],"induces":[168],"frequency-dependent":[170],"pattern":[171],"alterations":[173],"non-stationarity":[176],"levels":[177],"activity.":[181]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}