{"id":"https://openalex.org/W2979470587","doi":"https://doi.org/10.1109/embc.2019.8856576","title":"Multi-omic Pathway and Network Analysis to Identify Biomarkers for Hepatocellular Carcinoma","display_name":"Multi-omic Pathway and Network Analysis to Identify Biomarkers for Hepatocellular Carcinoma","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2979470587","doi":"https://doi.org/10.1109/embc.2019.8856576","mag":"2979470587","pmid":"https://pubmed.ncbi.nlm.nih.gov/31946143"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2019.8856576","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2019.8856576","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6986237","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113158949","display_name":"Megan E. Barefoot","orcid":null},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan E. Barefoot","raw_affiliation_strings":["Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027269811","display_name":"Rency S. Varghese","orcid":"https://orcid.org/0000-0002-4236-7316"},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rency S. Varghese","raw_affiliation_strings":["Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071256143","display_name":"Yuan Zhou","orcid":"https://orcid.org/0000-0002-1393-5476"},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuan Zhou","raw_affiliation_strings":["Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076306764","display_name":"Cristina Di Poto","orcid":null},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristina Di Poto","raw_affiliation_strings":["Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004962196","display_name":"Alessia Ferrarini","orcid":"https://orcid.org/0000-0002-4587-6095"},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alessia Ferrarini","raw_affiliation_strings":["Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I184565670"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025125310","display_name":"Habtom W. Ressom","orcid":"https://orcid.org/0000-0001-9296-2132"},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Habtom W. Ressom","raw_affiliation_strings":["Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I184565670"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5984,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.67452797,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"2019","issue":null,"first_page":"1350","last_page":"1354"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"Hepatocellular carcinoma","score":0.8599101305007935},{"id":"https://openalex.org/keywords/metabolomics","display_name":"Metabolomics","score":0.6334587335586548},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.613980233669281},{"id":"https://openalex.org/keywords/cirrhosis","display_name":"Cirrhosis","score":0.5974681973457336},{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"Biomarker discovery","score":0.5477475523948669},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4813193082809448},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.47614192962646484},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.4689086675643921},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.42504018545150757},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.41297999024391174},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3793952465057373},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.3525824248790741},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3021501302719116},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.14508908987045288},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.12374773621559143},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11199167370796204}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8599101305007935},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.6334587335586548},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.613980233669281},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.5974681973457336},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.5477475523948669},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4813193082809448},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.47614192962646484},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.4689086675643921},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.42504018545150757},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41297999024391174},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3793952465057373},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3525824248790741},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3021501302719116},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14508908987045288},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12374773621559143},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11199167370796204}],"mesh":[{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc.2019.8856576","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2019.8856576","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:31946143","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31946143","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:6986237","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6986237","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Conf Proc IEEE Eng Med Biol Soc","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6986237","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6986237","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Conf Proc IEEE Eng Med Biol Soc","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6800000071525574}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W173263818","https://openalex.org/W1889915419","https://openalex.org/W1962046992","https://openalex.org/W1964010911","https://openalex.org/W2020413892","https://openalex.org/W2021998283","https://openalex.org/W2032078306","https://openalex.org/W2063302086","https://openalex.org/W2075132628","https://openalex.org/W2082313666","https://openalex.org/W2096801725","https://openalex.org/W2154675099","https://openalex.org/W2162230740","https://openalex.org/W2196469775","https://openalex.org/W2318933482","https://openalex.org/W2346205130","https://openalex.org/W2400239373","https://openalex.org/W2409636417","https://openalex.org/W2471394863","https://openalex.org/W2508404459","https://openalex.org/W2557421914","https://openalex.org/W2591349253","https://openalex.org/W2592126054","https://openalex.org/W2686427836","https://openalex.org/W2774659630","https://openalex.org/W2791188516","https://openalex.org/W2804448077","https://openalex.org/W2856089702","https://openalex.org/W2884815522","https://openalex.org/W2888303476","https://openalex.org/W2889646458","https://openalex.org/W3105797230","https://openalex.org/W6606991606"],"related_works":["https://openalex.org/W2788856035","https://openalex.org/W2030335929","https://openalex.org/W1969082909","https://openalex.org/W1539981706","https://openalex.org/W1485011350","https://openalex.org/W2431325196","https://openalex.org/W3203422688","https://openalex.org/W3204852798","https://openalex.org/W2106419962","https://openalex.org/W3089769884"],"abstract_inverted_index":{"The":[0,22],"threat":[1],"of":[2,27,90,147,159,174],"Hepatocellular":[3],"Carcinoma":[4],"(HCC)":[5],"is":[6],"a":[7,39,82,101],"growing":[8],"problem,":[9],"with":[10,58],"incidence":[11],"rates":[12],"anticipated":[13],"to":[14,62,80,86,106,162],"near":[15],"double":[16],"over":[17],"the":[18,65,108,156],"next":[19],"two":[20],"decades.":[21],"increasing":[23],"burden":[24],"makes":[25],"discovery":[26],"novel":[28],"diagnostic,":[29],"prognostic,":[30],"and":[31,48,55,70,74,93,128,131,136,165,179],"therapeutic":[32],"biomarkers":[33],"distinguishing":[34],"HCC":[35,53,69,178],"from":[36,51,142],"underlying":[37],"cirrhosis":[38,60],"significant":[40],"focus.":[41],"In":[42],"this":[43,143],"study,":[44],"we":[45,77,103],"analyzed":[46],"tissue":[47],"serum":[49,125,132],"samples":[50],"40":[52],"cases":[54],"25":[56],"patients":[57],"liver":[59],"(CIRR)":[61],"better":[63],"understand":[64],"mechanistic":[66],"differences":[67],"between":[68],"CIRR.":[71],"Through":[72],"pathway":[73,111],"network":[75],"analysis,":[76],"are":[78,104,138,146],"able":[79,105],"take":[81],"systems":[83],"biology":[84],"approach":[85],"conduct":[87],"multi-omic":[88,160],"analysis":[89,144,161],"transcriptomic,":[91],"glycoproteomic,":[92],"metabolomic":[94],"data":[95],"acquired":[96],"through":[97],"various":[98],"platforms.":[99],"As":[100],"result,":[102],"identify":[107],"FXR/RXR":[109],"Activation":[110],"as":[112],"being":[113],"represented":[114],"by":[115],"molecules":[116],"spanning":[117],"multiple":[118],"molecular":[119,175],"compartments":[120],"in":[121,183],"these":[122],"samples.":[123],"Specifically,":[124],"metabolites":[126],"deoxycholate":[127],"chenodeoxycholic":[129],"acid":[130],"glycoproteins":[133],"C4A/C4B,":[134],"KNG1,":[135],"HPX":[137],"biomarker":[139,168],"candidates":[140,169],"identified":[141],"that":[145,170],"interest":[148],"for":[149],"future":[150],"targeted":[151],"studies.":[152],"These":[153],"results":[154],"demonstrate":[155],"integrative":[157],"power":[158],"prioritize":[163],"clinically":[164],"biologically":[166],"relevant":[167],"can":[171],"increase":[172],"understanding":[173],"mechanisms":[176],"driving":[177],"make":[180],"an":[181],"impact":[182],"patient":[184],"care.":[185]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}