{"id":"https://openalex.org/W2980123675","doi":"https://doi.org/10.1109/embc.2019.8856548","title":"Analysis of Volume Conduction Effects on Different Functional Connectivity Metrics: Application to Alzheimer\u2019s Disease EEG Signals","display_name":"Analysis of Volume Conduction Effects on Different Functional Connectivity Metrics: Application to Alzheimer\u2019s Disease EEG Signals","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2980123675","doi":"https://doi.org/10.1109/embc.2019.8856548","mag":"2980123675","pmid":"https://pubmed.ncbi.nlm.nih.gov/31947315"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2019.8856548","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2019.8856548","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103212506","display_name":"Sa\u00fal J. Ruiz-G\u00f3mez","orcid":"https://orcid.org/0000-0003-1483-2265"},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Saul J. Ruiz-Gomez","raw_affiliation_strings":["Biomedical Engineering Group, University of Valladolid, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Group, University of Valladolid, Valladolid, Spain","institution_ids":["https://openalex.org/I108103353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066583841","display_name":"Carlos G\u00f3mez","orcid":"https://orcid.org/0000-0002-9488-0605"},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carlos Gomez","raw_affiliation_strings":["Biomedical Engineering Group, University of Valladolid, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Group, University of Valladolid, Valladolid, Spain","institution_ids":["https://openalex.org/I108103353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019033958","display_name":"Jes\u00fas Poza","orcid":"https://orcid.org/0000-0001-8577-9559"},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jesus Poza","raw_affiliation_strings":["Biomedical Engineering Group, University of Valladolid, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Group, University of Valladolid, Valladolid, Spain","institution_ids":["https://openalex.org/I108103353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049867577","display_name":"Aar\u00f3n Maturana-Candelas","orcid":"https://orcid.org/0000-0001-7445-6498"},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Aaron Maturana-Candelas","raw_affiliation_strings":["Biomedical Engineering Group, University of Valladolid, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Group, University of Valladolid, Valladolid, Spain","institution_ids":["https://openalex.org/I108103353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053146049","display_name":"V\u00edctor Rodr\u00edguez-Gonz\u00e1lez","orcid":"https://orcid.org/0000-0003-0878-0075"},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Victor Rodriguez-Gonzalez","raw_affiliation_strings":["Biomedical Engineering Group, University of Valladolid, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Group, University of Valladolid, Valladolid, Spain","institution_ids":["https://openalex.org/I108103353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077667648","display_name":"Mar\u00eda Garc\u00eda","orcid":"https://orcid.org/0000-0002-4037-0351"},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria Garcia","raw_affiliation_strings":["Biomedical Engineering Group, University of Valladolid, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Group, University of Valladolid, Valladolid, Spain","institution_ids":["https://openalex.org/I108103353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057970618","display_name":"Miguel \u00c1ngel Tola-Arribas","orcid":"https://orcid.org/0000-0003-4105-0998"},"institutions":[{"id":"https://openalex.org/I4210158107","display_name":"Hospital Universitario R\u00edo Hortega","ror":"https://ror.org/05jk45963","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158107"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Miguel A. Tola-Arribas","raw_affiliation_strings":["Department of Neurology, \u2018R\u00edo Hortega\u2019, University Hospital, Valladolid, Spain","Department of Neurology, 'R\u00edo Hortega', University Hospital, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, \u2018R\u00edo Hortega\u2019, University Hospital, Valladolid, Spain","institution_ids":["https://openalex.org/I4210158107"]},{"raw_affiliation_string":"Department of Neurology, 'R\u00edo Hortega', University Hospital, Valladolid, Spain","institution_ids":["https://openalex.org/I4210158107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034506800","display_name":"M\u00f3nica Cano","orcid":"https://orcid.org/0000-0003-3146-5057"},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Monica Cano","raw_affiliation_strings":["Department of Clinical Neurophysiology, University Hospital, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neurophysiology, University Hospital, Valladolid, Spain","institution_ids":["https://openalex.org/I108103353"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043513390","display_name":"Roberto Hornero","orcid":"https://orcid.org/0000-0001-9915-2570"},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Roberto Hornero","raw_affiliation_strings":["Biomedical Engineering Group, University of Valladolid, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Group, University of Valladolid, Valladolid, Spain","institution_ids":["https://openalex.org/I108103353"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3739,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.6100668,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"2019","issue":null,"first_page":"6434","last_page":"6437"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11187","display_name":"Nonlinear Dynamics and Pattern Formation","score":0.9882000088691711,"subfield":{"id":"https://openalex.org/subfields/1705","display_name":"Computer Networks and Communications"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/electroencephalography","display_name":"Electroencephalography","score":0.7241016030311584},{"id":"https://openalex.org/keywords/functional-connectivity","display_name":"Functional connectivity","score":0.6266921758651733},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5563656687736511},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4725101888179779},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.43527036905288696},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.37880170345306396},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.37418287992477417},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2289845049381256},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.16814664006233215},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.07959100604057312}],"concepts":[{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.7241016030311584},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.6266921758651733},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5563656687736511},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4725101888179779},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.43527036905288696},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.37880170345306396},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.37418287992477417},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2289845049381256},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.16814664006233215},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07959100604057312}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019985","descriptor_name":"Benchmarking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019985","descriptor_name":"Benchmarking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019985","descriptor_name":"Benchmarking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2019.8856548","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2019.8856548","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:31947315","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31947315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1990207779","https://openalex.org/W1991362940","https://openalex.org/W1997207893","https://openalex.org/W2020272041","https://openalex.org/W2057930292","https://openalex.org/W2060228994","https://openalex.org/W2075032588","https://openalex.org/W2092782423","https://openalex.org/W2096450505","https://openalex.org/W2109582949","https://openalex.org/W2130518506","https://openalex.org/W2151393950","https://openalex.org/W2764285534"],"related_works":["https://openalex.org/W2922348724","https://openalex.org/W200322357","https://openalex.org/W2130428257","https://openalex.org/W4308951944","https://openalex.org/W2057366091","https://openalex.org/W4312960290","https://openalex.org/W2049513647","https://openalex.org/W2988848585","https://openalex.org/W4233722919","https://openalex.org/W4323929055"],"abstract_inverted_index":{"The":[0],"aim":[1],"of":[2,10,39,49,134],"this":[3,90,149],"study":[4],"was":[5],"to":[6,55,80,89],"evaluate":[7],"the":[8,75,83,128,143],"effect":[9],"volume":[11,77],"conduction":[12,78],"on":[13],"different":[14],"connectivity":[15,114],"metrics:":[16],"Amplitude":[17],"Envelope":[18],"Correlation":[19],"(AEC),":[20],"Phase":[21],"Lag":[22],"Index":[23],"(PLI),":[24],"and":[25,43,59,69,112,118,137],"Magnitude":[26],"Squared":[27],"Coherence":[28],"(MSCOH).":[29],"These":[30,124],"measures":[31],"were":[32],"applied":[33],"to:":[34],"(i)":[35],"a":[36,45],"synthetic":[37],"model":[38],"64":[40],"coupled":[41],"oscillators;":[42],"(ii)":[44],"resting-state":[46],"EEG":[47,96,132],"database":[48],"72":[50],"patients":[51,101,136],"with":[52,94,148],"dementia":[53],"due":[54],"Alzheimer's":[56],"disease":[57],"(AD)":[58],"37":[60],"cognitively":[61],"healthy":[62],"controls.":[63],"Our":[64],"results":[65,93],"revealed":[66],"that":[67,99],"AEC":[68,106],"PLI":[70],"are":[71,86,102],"weakly":[72],"influenced":[73],"by":[74,104],"simulated":[76],"compared":[79],"MSCOH,":[81],"although":[82],"three":[84],"metrics":[85],"not":[87],"immune":[88],"effect.":[91],"Furthermore,":[92],"real":[95],"recordings":[97],"showed":[98],"AD":[100,135],"characterized":[103],"an":[105],"increase":[107],"in":[108,116,130],"\u03b4":[109],"frequency":[110],"band":[111],"widespread":[113],"decreases":[115],"\u03b1":[117],"\u03b2":[119],"<sub":[120],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[121],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">1</sub>":[122],"bands.":[123],"coupling":[125],"changes":[126],"reflect":[127],"abnormalities":[129],"spontaneous":[131],"activity":[133],"might":[138],"provide":[139],"further":[140],"insights":[141],"into":[142],"underlying":[144],"brain":[145],"dynamics":[146],"associated":[147],"disorder.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}