{"id":"https://openalex.org/W2980268115","doi":"https://doi.org/10.1109/embc.2019.8856453","title":"Classification of Major Depressive Disorder from Resting-State fMRI","display_name":"Classification of Major Depressive Disorder from Resting-State fMRI","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2980268115","doi":"https://doi.org/10.1109/embc.2019.8856453","mag":"2980268115","pmid":"https://pubmed.ncbi.nlm.nih.gov/31946635"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2019.8856453","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2019.8856453","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006679502","display_name":"Bhaskar Sen","orcid":"https://orcid.org/0000-0002-4548-5625"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210101327","display_name":"Twin Cities Orthopedics","ror":"https://ror.org/01en4s460","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210101327"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bhaskar Sen","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Minnesota, Twin Cities"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Minnesota, Twin Cities","institution_ids":["https://openalex.org/I4210101327","https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069686854","display_name":"Bryon A. Mueller","orcid":"https://orcid.org/0000-0003-2429-0391"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210101327","display_name":"Twin Cities Orthopedics","ror":"https://ror.org/01en4s460","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210101327"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryon Mueller","raw_affiliation_strings":["Department of Psychiatry, University of Minnesota, Twin Cities"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Minnesota, Twin Cities","institution_ids":["https://openalex.org/I4210101327","https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081652342","display_name":"Bonnie Klimes\u2010Dougan","orcid":"https://orcid.org/0000-0002-2107-0038"},"institutions":[{"id":"https://openalex.org/I4210101327","display_name":"Twin Cities Orthopedics","ror":"https://ror.org/01en4s460","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210101327"]},{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bonnie Klimes-Dougan","raw_affiliation_strings":["Department of Psychiatry, University of Minnesota, Twin Cities"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Minnesota, Twin Cities","institution_ids":["https://openalex.org/I4210101327","https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003393701","display_name":"Kathryn R. Cullen","orcid":"https://orcid.org/0000-0001-9631-3770"},"institutions":[{"id":"https://openalex.org/I4210101327","display_name":"Twin Cities Orthopedics","ror":"https://ror.org/01en4s460","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210101327"]},{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn Cullen","raw_affiliation_strings":["Department of Psychiatry, University of Minnesota, Twin Cities"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Minnesota, Twin Cities","institution_ids":["https://openalex.org/I4210101327","https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007884053","display_name":"Keshab K. Parhi","orcid":"https://orcid.org/0000-0001-6543-2793"},"institutions":[{"id":"https://openalex.org/I4210101327","display_name":"Twin Cities Orthopedics","ror":"https://ror.org/01en4s460","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210101327"]},{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keshab K. Parhi","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Minnesota, Twin Cities"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Minnesota, Twin Cities","institution_ids":["https://openalex.org/I4210101327","https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5006679502"],"corresponding_institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210101327"],"apc_list":null,"apc_paid":null,"fwci":1.869,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.85359315,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"2019","issue":null,"first_page":"3511","last_page":"3514"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13283","display_name":"Mental Health Research Topics","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"Major depressive disorder","score":0.8070758581161499},{"id":"https://openalex.org/keywords/correlation","display_name":"Correlation","score":0.6680809259414673},{"id":"https://openalex.org/keywords/resting-state-fmri","display_name":"Resting state fMRI","score":0.556715190410614},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.5112099647521973},{"id":"https://openalex.org/keywords/pearson-product-moment-correlation-coefficient","display_name":"Pearson product-moment correlation coefficient","score":0.4845849275588989},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4721153974533081},{"id":"https://openalex.org/keywords/functional-magnetic-resonance-imaging","display_name":"Functional magnetic resonance imaging","score":0.46716225147247314},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.4671323597431183},{"id":"https://openalex.org/keywords/mood","display_name":"Mood","score":0.3907850384712219},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3878576457500458},{"id":"https://openalex.org/keywords/audiology","display_name":"Audiology","score":0.3637724816799164},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.34639036655426025},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.33648329973220825},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.29876601696014404},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.15698647499084473},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.14541694521903992},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.13937139511108398}],"concepts":[{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.8070758581161499},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.6680809259414673},{"id":"https://openalex.org/C66324658","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Resting state fMRI","level":2,"score":0.556715190410614},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.5112099647521973},{"id":"https://openalex.org/C55078378","wikidata":"https://www.wikidata.org/wiki/Q1136628","display_name":"Pearson product-moment correlation coefficient","level":2,"score":0.4845849275588989},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4721153974533081},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.46716225147247314},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4671323597431183},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.3907850384712219},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3878576457500458},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.3637724816799164},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34639036655426025},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.33648329973220825},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29876601696014404},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.15698647499084473},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.14541694521903992},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.13937139511108398},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Depressive Disorder, Major","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Depressive Disorder, Major","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2019.8856453","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2019.8856453","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:31946635","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31946635","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Peace, Justice and strong institutions","id":"https://metadata.un.org/sdg/16","score":0.5699999928474426}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1566415063","https://openalex.org/W1582811168","https://openalex.org/W2017303933","https://openalex.org/W2068992432","https://openalex.org/W2101135654","https://openalex.org/W2133903921","https://openalex.org/W2154053567","https://openalex.org/W2167822639","https://openalex.org/W2281380552","https://openalex.org/W2346576232","https://openalex.org/W2533647335","https://openalex.org/W2898709111","https://openalex.org/W2899143158","https://openalex.org/W2914765137","https://openalex.org/W2977883299","https://openalex.org/W6758980857"],"related_works":["https://openalex.org/W2601707947","https://openalex.org/W2168298321","https://openalex.org/W2387620927","https://openalex.org/W2294986132","https://openalex.org/W2365936003","https://openalex.org/W4401572343","https://openalex.org/W2790620361","https://openalex.org/W1964455563","https://openalex.org/W4293242195","https://openalex.org/W2319066238"],"abstract_inverted_index":{"Major":[0],"Depressive":[1],"Disorder":[2],"(MDD)":[3],"is":[4,23],"a":[5],"very":[6,57],"serious":[7],"mental":[8],"illness":[9],"that":[10],"can":[11,55],"affect":[12],"the":[13,33,38,42,78,82,90,128,135,158,205,217],"daily":[14],"lives":[15],"of":[16,20,50,75,92,127,169,179,190],"patients.":[17],"Accurate":[18],"diagnosis":[19],"this":[21],"disorder":[22],"necessary":[24],"for":[25,125,224],"planning":[26],"individualized":[27],"treatment.":[28],"However,":[29],"diagnosing":[30],"MDD":[31,67,101,181,226],"requires":[32],"clinicians":[34,83],"to":[35,80,99,120,133,156],"personally":[36],"interview":[37],"subjects":[39,171,182],"and":[40,47,63,96,116,138,147,185,212],"rate":[41],"symptoms":[43],"based":[44,214],"on":[45],"Diagnostic":[46],"Statistical":[48],"Manual":[49],"Mental":[51],"Disorders":[52],"(DSM),":[53],"which":[54],"be":[56],"time":[58],"consuming.":[59],"Discovering":[60],"quantifiable":[61],"signals":[62],"biomarkers":[64],"associated":[65],"with":[66,174,198],"using":[68,150,195],"functional":[69,94],"magnetic":[70],"resonance":[71],"imaging":[72],"(fMRI)":[73],"scans":[74],"patients":[76],"have":[77],"potential":[79],"assist":[81],"in":[84,208,220],"their":[85],"assessment.":[86],"This":[87],"paper":[88],"explores":[89],"use":[91],"resting-state":[93],"connectivity":[95],"network":[97,139,148,213],"features":[98,215],"classify":[100],"vs.":[102,227],"healthy":[103,228],"subjects.":[104,229],"For":[105],"each":[106,126],"subject,":[107],"mean":[108],"time-series":[109,124],"are":[110,118,131,142],"extracted":[111],"from":[112,145],"85":[113],"brain":[114],"regions":[115],"they":[117],"decomposed":[119],"4-frequency":[121],"bands.":[122],"Mean":[123],"frequency":[129],"bands":[130],"utilized":[132],"compute":[134],"Pearson":[136,202],"correlation":[137,146,203],"characteristics.":[140],"Features":[141],"selected":[143],"separately":[144],"characteristics":[149],"Minimum":[151],"Redundancy":[152],"Maximum":[153],"Relevance":[154],"(mRMR)":[155],"create":[157],"final":[159],"classifier.":[160],"The":[161],"proposed":[162],"scheme":[163],"achieves":[164],"79%":[165],"accuracy":[166],"(65":[167],"out":[168,178,189],"82":[170],"classified":[172],"correctly)":[173,184,194],"86%":[175],"sensitivity":[176],"(42":[177],"49":[180],"identified":[183,193],"70%":[186],"specificity":[187],"(23":[188],"33":[191],"controls":[192],"leave-one-out":[196],"classification":[197],"in-fold":[199],"feature":[200],"selection.":[201],"had":[204,216],"highest":[206,218],"discrimination":[207,219],"band":[209,221],"0.015-0.03":[210],"Hz":[211,223],"0.03-0.06":[222],"distinguishing":[225]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1}],"updated_date":"2026-05-05T08:41:31.759640","created_date":"2025-10-10T00:00:00"}