{"id":"https://openalex.org/W2980077835","doi":"https://doi.org/10.1109/embc.2019.8856447","title":"Estimating Local Therapeutic Hypothermia in Case of Ischemic Stroke Using a 1D Hemodynamics Model and an Energetic Temperature Model","display_name":"Estimating Local Therapeutic Hypothermia in Case of Ischemic Stroke Using a 1D Hemodynamics Model and an Energetic Temperature Model","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2980077835","doi":"https://doi.org/10.1109/embc.2019.8856447","mag":"2980077835","pmid":"https://pubmed.ncbi.nlm.nih.gov/31946744"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2019.8856447","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2019.8856447","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066758185","display_name":"Yannick Lutz","orcid":"https://orcid.org/0000-0002-0505-4652"},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Yannick Lutz","raw_affiliation_strings":["Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028726222","display_name":"Rosa Daschner","orcid":null},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rosa Daschner","raw_affiliation_strings":["Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067256057","display_name":"Lorena Krames","orcid":null},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lorena Krames","raw_affiliation_strings":["Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039680827","display_name":"Axel Loewe","orcid":"https://orcid.org/0000-0002-2487-4744"},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Axel Loewe","raw_affiliation_strings":["Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109145660","display_name":"Olaf D\u00f6ssel","orcid":null},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Olaf Dossel","raw_affiliation_strings":["Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013473895","display_name":"Giorgio Cattaneo","orcid":"https://orcid.org/0000-0003-0550-7049"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giorgio Cattaneo","raw_affiliation_strings":["Adceris GmbH & Co KG, Pforzheim, Germany"],"affiliations":[{"raw_affiliation_string":"Adceris GmbH & Co KG, Pforzheim, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5066758185"],"corresponding_institution_ids":["https://openalex.org/I102335020"],"apc_list":null,"apc_paid":null,"fwci":0.3325,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.62025003,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"1","issue":null,"first_page":"3983","last_page":"3986"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.988099992275238,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses","score":0.9865000247955322,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypothermia","display_name":"Hypothermia","score":0.7666536569595337},{"id":"https://openalex.org/keywords/hemodynamics","display_name":"Hemodynamics","score":0.6175795197486877},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6154736280441284},{"id":"https://openalex.org/keywords/stenosis","display_name":"Stenosis","score":0.5852844715118408},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.5563976764678955},{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"Cerebral blood flow","score":0.5548195838928223},{"id":"https://openalex.org/keywords/hyperthermia","display_name":"Hyperthermia","score":0.53218013048172},{"id":"https://openalex.org/keywords/blood-flow","display_name":"Blood flow","score":0.4990425109863281},{"id":"https://openalex.org/keywords/stroke","display_name":"Stroke (engine)","score":0.49606165289878845},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.44589167833328247},{"id":"https://openalex.org/keywords/carotid-arteries","display_name":"Carotid arteries","score":0.42360007762908936},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"Ischemic stroke","score":0.42079228162765503},{"id":"https://openalex.org/keywords/middle-cerebral-artery","display_name":"Middle cerebral artery","score":0.4184935986995697},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.37952369451522827},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3779435157775879},{"id":"https://openalex.org/keywords/ischemia","display_name":"Ischemia","score":0.3777359127998352},{"id":"https://openalex.org/keywords/thermodynamics","display_name":"Thermodynamics","score":0.08175638318061829}],"concepts":[{"id":"https://openalex.org/C2777390192","wikidata":"https://www.wikidata.org/wiki/Q1036696","display_name":"Hypothermia","level":2,"score":0.7666536569595337},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.6175795197486877},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6154736280441284},{"id":"https://openalex.org/C2780007028","wikidata":"https://www.wikidata.org/wiki/Q2343082","display_name":"Stenosis","level":2,"score":0.5852844715118408},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5563976764678955},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.5548195838928223},{"id":"https://openalex.org/C2779949491","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Hyperthermia","level":2,"score":0.53218013048172},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.4990425109863281},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.49606165289878845},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44589167833328247},{"id":"https://openalex.org/C2987047532","wikidata":"https://www.wikidata.org/wiki/Q214275","display_name":"Carotid arteries","level":2,"score":0.42360007762908936},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.42079228162765503},{"id":"https://openalex.org/C2775841333","wikidata":"https://www.wikidata.org/wiki/Q498179","display_name":"Middle cerebral artery","level":3,"score":0.4184935986995697},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.37952369451522827},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3779435157775879},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.3777359127998352},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.08175638318061829},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001831","descriptor_name":"Body Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001831","descriptor_name":"Body Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001831","descriptor_name":"Body Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007036","descriptor_name":"Hypothermia, Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007036","descriptor_name":"Hypothermia, Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007036","descriptor_name":"Hypothermia, Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2019.8856447","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2019.8856447","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:31946744","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31946744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8700000047683716,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1500601525","https://openalex.org/W1883075202","https://openalex.org/W1948181060","https://openalex.org/W2029070417","https://openalex.org/W2082138205","https://openalex.org/W2103113979","https://openalex.org/W2114822564","https://openalex.org/W2144025192","https://openalex.org/W2166979150","https://openalex.org/W2178423890","https://openalex.org/W2305819842","https://openalex.org/W2909517085","https://openalex.org/W4285719527","https://openalex.org/W6639296830","https://openalex.org/W6677291738","https://openalex.org/W6757784494"],"related_works":["https://openalex.org/W2412647768","https://openalex.org/W2071759860","https://openalex.org/W2107241099","https://openalex.org/W645160927","https://openalex.org/W2417036867","https://openalex.org/W2086358699","https://openalex.org/W2043809791","https://openalex.org/W3015734201","https://openalex.org/W2063706756","https://openalex.org/W2363305592"],"abstract_inverted_index":{"In":[0,104],"Western":[1],"countries,":[2],"stroke":[3],"is":[4,53],"the":[5,42,47,56,78,81,99,113,131,134,138,145,197,205,208,214,221],"third-most":[6],"widespread":[7],"cause":[8,61],"of":[9,12,22,27,55,80,112,137,144,158,183,187,192,204,217,226],"death.":[10],"80%":[11],"all":[13],"strokes":[14],"are":[15],"ischemic":[16],"and":[17,41,83,128,143,163,223],"show":[18],"a":[19,31,107,169,178],"mortality":[20],"rate":[21],"about":[23],"25%.":[24],"Furthermore,":[25],"35-55%":[26],"affected":[28],"patients":[29],"retain":[30],"permanent":[32],"disability.":[33],"Therapeutic":[34],"hypothermia":[35],"(TH)":[36],"could":[37,94],"decrease":[38,153,182,210],"inflammatory":[39],"processes":[40],"stroke-induced":[43],"cerebral":[44,85,114,140,180],"damage.":[45],"Currently,":[46],"standard":[48],"technique":[49],"to":[50,73,97],"induce":[51,74],"TH":[52],"cooling":[54,67,72,159,172,198],"whole":[57],"body,":[58],"which":[59,219],"can":[60],"several":[62],"side":[63],"effects.":[64],"A":[65,150,189],"novel":[66],"sheath":[68],"uses":[69],"intra-carotid":[70,227],"blood":[71,228],"local":[75],"TH.":[76],"Unfortunately,":[77],"control":[79],"temporal":[82],"spatial":[84],"temperature":[86,90,101,122,152,181,209],"course":[87],"requires":[88],"invasive":[89],"measurements.":[91],"Computational":[92],"modeling":[93],"be":[95],"used":[96],"predict":[98],"resulting":[100,176],"courses":[102],"instead.":[103],"this":[105],"work,":[106],"detailed":[108],"1D":[109],"hemodynamics":[110],"model":[111],"arterial":[115],"system":[116],"was":[117,148,154,174,200,211],"coupled":[118],"with":[119],"an":[120],"energetic":[121],"model.":[123],"For":[124,166],"physiological":[125,161],"conditions,":[126],"50%":[127,164],"100%":[129,167],"M1-stenoses,":[130],"temperatures":[132],"in":[133,177],"supply":[135],"area":[136],"middle":[139],"artery":[141],"(MCA)":[142],"systemic":[146],"body":[147],"analyzed.":[149],"2K":[151],"reached":[155],"within":[156,213],"10min":[157],"for":[160],"conditions":[162],"stenosis.":[165],"stenosis,":[168],"significant":[170,190],"lower":[171],"effect":[173,199],"observed,":[175],"maximum":[179],"0.7K":[184],"after":[185],"30min":[186],"cooling.":[188,229],"influence":[191],"collateral":[193],"flow":[194],"rates":[195],"on":[196],"observed.":[201],"However,":[202],"regardless":[203],"stenosis":[206],"degree,":[207],"strongest":[212],"first":[215],"20min":[216],"cooling,":[218],"demonstrates":[220],"fast":[222],"effective":[224],"impact":[225]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
