{"id":"https://openalex.org/W2899409577","doi":"https://doi.org/10.1109/embc.2018.8513650","title":"Histotripsy for Non-Invasive Ablation of Hepatocellular Carcinoma (HCC) Tumor in a Subcutaneous Xenograft Murine Model","display_name":"Histotripsy for Non-Invasive Ablation of Hepatocellular Carcinoma (HCC) Tumor in a Subcutaneous Xenograft Murine Model","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2899409577","doi":"https://doi.org/10.1109/embc.2018.8513650","mag":"2899409577","pmid":"https://pubmed.ncbi.nlm.nih.gov/30441719"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2018.8513650","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8513650","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023127234","display_name":"Tejaswi Worlikar","orcid":"https://orcid.org/0000-0001-6828-022X"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tejaswi Worlikar","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI, US","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071475167","display_name":"Eli Vlaisavljevich","orcid":"https://orcid.org/0000-0002-4097-6257"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eli Vlaisavljevich","raw_affiliation_strings":["Virginia Polytechnic Institute and State University, Blacksburg, VA, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virginia Polytechnic Institute and State University, Blacksburg, VA, US","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025429987","display_name":"Tyler Gerhardson","orcid":"https://orcid.org/0000-0002-4548-5588"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tyler Gerhardson","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI, US","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102758836","display_name":"Joan M. Greve","orcid":"https://orcid.org/0000-0003-2493-752X"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan Greve","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI, US","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070580525","display_name":"Shanshan Wan","orcid":"https://orcid.org/0000-0002-2243-0584"},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shanshan Wan","raw_affiliation_strings":["NYU Langone Health, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NYU Langone Health, New York, NY","institution_ids":["https://openalex.org/I4210086933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058660221","display_name":"Sibu Kuruvilla","orcid":"https://orcid.org/0000-0001-5455-3485"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sibu Kuruvilla","raw_affiliation_strings":["Stanford University, Stanford, CA, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Stanford, CA, US","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005955998","display_name":"Jonathan Lundt","orcid":"https://orcid.org/0000-0002-1614-6464"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Lundt","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI, US","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039886990","display_name":"Kimberly Ives","orcid":"https://orcid.org/0000-0001-8444-1927"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly Ives","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI, US","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046270398","display_name":"Timothy L. Hall","orcid":"https://orcid.org/0000-0002-4867-2856"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Hall","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI, US","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042326252","display_name":"Theodore H. Welling","orcid":null},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodore H. Welling","raw_affiliation_strings":["NYU Langone Health, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NYU Langone Health, New York, NY","institution_ids":["https://openalex.org/I4210086933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101398908","display_name":"Fred Lee","orcid":"https://orcid.org/0000-0003-1275-5497"},"institutions":[{"id":"https://openalex.org/I1304256225","display_name":"University of Wisconsin System","ror":"https://ror.org/03ydkyb10","country_code":"US","type":"education","lineage":["https://openalex.org/I1304256225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred Lee","raw_affiliation_strings":["University of Wisconsin System, Madison, WI, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin System, Madison, WI, US","institution_ids":["https://openalex.org/I1304256225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017355711","display_name":"Zhen Xu","orcid":"https://orcid.org/0000-0003-0262-3044"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhen Xu","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI, US","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"2018","issue":null,"first_page":"6064","last_page":"6067"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"Hepatocellular carcinoma","score":0.7372374534606934},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6814128160476685},{"id":"https://openalex.org/keywords/ablation","display_name":"Ablation","score":0.6231457591056824},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"Liver cancer","score":0.4810526669025421},{"id":"https://openalex.org/keywords/histology","display_name":"Histology","score":0.4700525999069214},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.4356238842010498},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.41494932770729065},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.3686163127422333},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.23745623230934143},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.14628508687019348},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.09577208757400513}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7372374534606934},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6814128160476685},{"id":"https://openalex.org/C2778902805","wikidata":"https://www.wikidata.org/wiki/Q322177","display_name":"Ablation","level":2,"score":0.6231457591056824},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.4810526669025421},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.4700525999069214},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4356238842010498},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.41494932770729065},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3686163127422333},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.23745623230934143},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14628508687019348},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09577208757400513},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057086","descriptor_name":"High-Intensity Focused Ultrasound Ablation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057086","descriptor_name":"High-Intensity Focused Ultrasound Ablation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057086","descriptor_name":"High-Intensity Focused Ultrasound Ablation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064593","descriptor_name":"Heterografts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064593","descriptor_name":"Heterografts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064593","descriptor_name":"Heterografts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2018.8513650","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8513650","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:30441719","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30441719","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G98345373","display_name":null,"funder_award_id":"R01 CA211217","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1969147320","https://openalex.org/W1970195707","https://openalex.org/W1971385195","https://openalex.org/W1978432461","https://openalex.org/W1979246588","https://openalex.org/W1981243220","https://openalex.org/W1983395182","https://openalex.org/W1986134680","https://openalex.org/W2017419213","https://openalex.org/W2019958865","https://openalex.org/W2020305814","https://openalex.org/W2022843396","https://openalex.org/W2040883398","https://openalex.org/W2055573775","https://openalex.org/W2067750459","https://openalex.org/W2069060013","https://openalex.org/W2070332894","https://openalex.org/W2076731393","https://openalex.org/W2088961912","https://openalex.org/W2103637700","https://openalex.org/W2113849698","https://openalex.org/W2114677264","https://openalex.org/W2116858453","https://openalex.org/W2125652783","https://openalex.org/W2127957555","https://openalex.org/W2153908407","https://openalex.org/W2165510365","https://openalex.org/W2321119966","https://openalex.org/W2344956073","https://openalex.org/W4206459106","https://openalex.org/W4244734949"],"related_works":["https://openalex.org/W2417822880","https://openalex.org/W628600844","https://openalex.org/W1570838273","https://openalex.org/W2157355069","https://openalex.org/W2410885201","https://openalex.org/W2385390897","https://openalex.org/W3172842848","https://openalex.org/W2418745692","https://openalex.org/W3110374601","https://openalex.org/W3091350106"],"abstract_inverted_index":{"Histotripsy":[0],"fractionates":[1],"tissue":[2,171],"through":[3],"a":[4,40,122,131,188,281],"mechanical,":[5],"non-invasive":[6,277],"ultrasonic":[7],"ablation":[8,38,151,279],"process":[9],"that":[10],"precisely":[11],"controls":[12],"acoustic":[13],"cavitation":[14],"while":[15],"utilizing":[16],"real-time":[17,147],"ultrasound":[18],"(US)":[19],"imaging":[20],"guidance.":[21],"This":[22],"study":[23,269,290],"investigates":[24],"the":[25,54,102,136,141,210,221,236,264,272,291],"potential,":[26],"feasibility":[27],"and":[28,60,76,85,88,95,159,169,198,212,234,256,266],"tumor":[29,103,143,202,222,242,247,299],"volume":[30,203],"reduction":[31,204],"effects":[32],"of":[33,57,178,184,261,274,293],"histotripsy":[34,110,275,294],"for":[35,175,276],"liver":[36,298],"cancer":[37],"in":[39,42,53,263,280,295],"subcutaneous":[41,282],"vivo":[43],"murine":[44,283],"Hepatocellular":[45],"Carcinoma":[46],"(HCC)":[47],"model.":[48,284],"Hep3B":[49],"tumors":[50],"were":[51,66,119,173,214,238],"generated":[52],"right":[55],"flanks":[56],"14":[58],"NSG":[59,72,81],"7":[61],"NOD-SCID":[62],"mice.":[63],"The":[64],"mice":[65,237],"grouped":[67],"as":[68,209,220],"follows:":[69],"A":[70,181],"(acute,":[71],"with":[73,82,92,187],"n=9":[74],"treatment":[75,84,94,206,232],"n=1":[77,96],"control),":[78],"B":[79,197,255],"(chronic,":[80],"n=2":[83,86],"control)":[87],"C":[89,199,257],"(chronic":[90],"NODSCID,":[91],"n=6":[93],"control).":[97],"Treatment":[98],"was":[99,153,223,226],"performed":[100],"when":[101],"diameters":[104],"reached":[105],">5":[106],"mm.":[107],"1-2":[108],"cycle":[109],"pulses":[111],"at":[112,249],"100":[113],"Hz":[114],"PRF":[115],"(p-":[116],">30":[117],"MPa)":[118],"delivered":[120],"using":[121],"custom":[123],"built":[124],"1":[125],"MHz":[126],"therapy":[127],"transducer":[128,137],"attached":[129],"to":[130,139,229,289],"motorized":[132],"positioner,":[133],"which":[134],"scanned":[135],"focus":[138],"traverse":[140],"targeted":[142,185],"volume,":[144],"guided":[145],"by":[146,155],"US":[148],"imaging.":[149],"Tumor":[150],"effectiveness":[152],"assessed":[154],"obtaining":[156],"T1,":[157],"T2":[158],"T2*":[160],"weighted":[161],"MR":[162],"images.":[163],"Post":[164],"euthanasia,":[165],"treated":[166],"tumor,":[167],"brain,":[168],"lung":[170,265],"samples":[172],"harvested":[174],"histology.":[176],"Histology":[177],"acute":[179],"group":[180],"showed":[182,258],"fractionation":[183],"region":[186],"sharp":[189],"boundary":[190],"separating":[191],"it":[192,225],"from":[193],"untreated":[194],"tissue.":[195],"Groups":[196,254],"demonstrated":[200,271],"effective":[201],"post":[205],"on":[207],"MRI":[208],"homogenate":[211],"edema":[213],"resorbed":[215],"within":[216],"23":[217],"weeks.":[218],"However,":[219],"subcutaneous,":[224],"not":[227],"possible":[228],"set":[230],"adequate":[231],"margin":[233],"since":[235],"immune-compromised,":[239],"residual":[240],"viable":[241],"cells":[243],"eventually":[244],"developed":[245],"into":[246],"regrowth":[248],"3-9":[250],"weeks":[251],"after":[252],"histotripsy.":[253],"no":[259],"signs":[260],"metastasis":[262],"brain.":[267],"Our":[268],"successfully":[270],"potential":[273],"HCC":[278],"Additional":[285],"work":[286],"is":[287],"ongoing":[288],"response":[292],"immune-competent":[296],"orthotopic":[297],"models.":[300]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":2}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
