{"id":"https://openalex.org/W2898822243","doi":"https://doi.org/10.1109/embc.2018.8513542","title":"Understanding Ductal Carcinoma In Situ Invasion using a Multiscale Agent-Based Model<sup>*</sup>","display_name":"Understanding Ductal Carcinoma In Situ Invasion using a Multiscale Agent-Based Model<sup>*</sup>","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2898822243","doi":"https://doi.org/10.1109/embc.2018.8513542","mag":"2898822243","pmid":"https://pubmed.ncbi.nlm.nih.gov/30441665"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2018.8513542","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8513542","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054229369","display_name":"Joseph D. Butner","orcid":"https://orcid.org/0000-0003-0608-2580"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Joseph D. Butner","raw_affiliation_strings":["University of Texas School of Biomedical Informatics, Houston, TX, US"],"affiliations":[{"raw_affiliation_string":"University of Texas School of Biomedical Informatics, Houston, TX, US","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033025983","display_name":"Vittorio Cristini","orcid":"https://orcid.org/0000-0002-7909-4278"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vittorio Cristini","raw_affiliation_strings":["University of Texas School of Biomedical Informatics, Houston, TX, US"],"affiliations":[{"raw_affiliation_string":"University of Texas School of Biomedical Informatics, Houston, TX, US","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100438103","display_name":"Zhihui Wang","orcid":"https://orcid.org/0000-0001-6262-700X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhihui Wang","raw_affiliation_strings":["University of Texas School of Biomedical Informatics, Houston, TX, US"],"affiliations":[{"raw_affiliation_string":"University of Texas School of Biomedical Informatics, Houston, TX, US","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5054229369"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.18454357,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"2018","issue":null,"first_page":"5846","last_page":"5849"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ductal-carcinoma","display_name":"Ductal carcinoma","score":0.6215022802352905},{"id":"https://openalex.org/keywords/calcification","display_name":"Calcification","score":0.5975438952445984},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5577011108398438},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4807141125202179},{"id":"https://openalex.org/keywords/surgical-resection","display_name":"Surgical resection","score":0.455564022064209},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.4480639696121216},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.4239596128463745},{"id":"https://openalex.org/keywords/hypoxia","display_name":"Hypoxia (environmental)","score":0.4113752841949463},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.3731726408004761},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.36660969257354736},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3597767949104309},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.33300185203552246},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.31199896335601807},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.17708691954612732},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.12592896819114685},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.11459207534790039}],"concepts":[{"id":"https://openalex.org/C2780862961","wikidata":"https://www.wikidata.org/wiki/Q5311598","display_name":"Ductal carcinoma","level":4,"score":0.6215022802352905},{"id":"https://openalex.org/C2780309369","wikidata":"https://www.wikidata.org/wiki/Q933382","display_name":"Calcification","level":2,"score":0.5975438952445984},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5577011108398438},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4807141125202179},{"id":"https://openalex.org/C3020562746","wikidata":"https://www.wikidata.org/wiki/Q7446275","display_name":"Surgical resection","level":2,"score":0.455564022064209},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4480639696121216},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4239596128463745},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.4113752841949463},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3731726408004761},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.36660969257354736},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3597767949104309},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33300185203552246},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31199896335601807},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17708691954612732},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.12592896819114685},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.11459207534790039},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072662","descriptor_name":"Margins of Excision","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072662","descriptor_name":"Margins of Excision","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072662","descriptor_name":"Margins of Excision","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008327","descriptor_name":"Mammography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008327","descriptor_name":"Mammography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008327","descriptor_name":"Mammography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018270","descriptor_name":"Carcinoma, Ductal, Breast","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018270","descriptor_name":"Carcinoma, Ductal, Breast","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018270","descriptor_name":"Carcinoma, Ductal, Breast","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2018.8513542","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8513542","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:30441665","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30441665","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W2013507620","https://openalex.org/W2021197729","https://openalex.org/W2036861430","https://openalex.org/W2083610791","https://openalex.org/W2090722238","https://openalex.org/W2115168672","https://openalex.org/W2125401785","https://openalex.org/W2125857415","https://openalex.org/W2141704910","https://openalex.org/W2142171814","https://openalex.org/W2160221345","https://openalex.org/W2410611073","https://openalex.org/W2494434795","https://openalex.org/W2590118603","https://openalex.org/W2754698287","https://openalex.org/W2890426268","https://openalex.org/W4243727397"],"related_works":["https://openalex.org/W2419349733","https://openalex.org/W2393187347","https://openalex.org/W1981293817","https://openalex.org/W2437424849","https://openalex.org/W2369015664","https://openalex.org/W3013888696","https://openalex.org/W2803580226","https://openalex.org/W2354005113","https://openalex.org/W3093870694","https://openalex.org/W4380794270"],"abstract_inverted_index":{"Ductal":[0],"carcinoma":[1],"in":[2,38,151,167],"situ":[3],"(DCIS)":[4],"is":[5,19,22,33],"commonly":[6],"treated":[7],"clinically":[8],"through":[9],"surgical":[10,13,41,50,208],"resection.":[11],"Although":[12],"options":[14],"exist":[15],"for":[16,206],"resection,":[17],"it":[18],"unclear":[20],"which":[21],"optimal":[23],"to":[24,71,79,131,188],"reduce":[25],"the":[26,91,129,135,141,171,194,199],"likelihood":[27],"of":[28,69,99,144,153,201],"future":[29],"invasive":[30],"disease.":[31],"This":[32],"further":[34],"complicated":[35],"by":[36,52,164],"challenges":[37,89],"determining":[39],"correct":[40],"margins":[42,51],"from":[43],"disease":[44,73,145,172],"diagnostics,":[45],"with":[46,102],"mammographic":[47],"imaging":[48,139],"misidentifying":[49],"as":[53,55,180],"much":[54],"2":[56],"cm":[57],"vs.":[58],"histological":[59],"examination.":[60],"We":[61,147],"have":[62],"implemented":[63],"a":[64,118,181,190],"threedimensional,":[65],"hybrid":[66],"multiscale":[67],"model":[68,130],"DCIS":[70,195],"study":[72],"initiation":[74],"and":[75,87,112,122,140,176,185,198],"progression.":[76],"In":[77,116],"order":[78],"shed":[80],"new":[81],"light":[82],"on":[83],"current":[84],"biological":[85],"questions":[86],"clinical":[88],"surrounding":[90],"disease,":[92],"we":[93],"present":[94],"here":[95],"an":[96],"improved":[97],"version":[98],"this":[100],"model,":[101],"more":[103],"biologically":[104],"relevant":[105],"molecular":[106,154],"signaling":[107,155],"pathways,":[108],"cell":[109,119,159],"phenotype":[110],"hierarchies,":[111],"duct":[113],"architecture":[114],"variation.":[115],"particular,":[117],"necrosis,":[120,175],"lysis":[121],"calcification":[123,177],"pathway":[124],"has":[125],"been":[126],"incorporated":[127],"into":[128],"help":[132],"better":[133],"understand":[134],"relationship":[136],"between":[137,193],"diagnostic":[138],"true":[142],"extent":[143],"invasion.":[146],"observe":[148],"that":[149,157],"deficiencies":[150],"availability":[152],"molecules":[156],"upregulate":[158],"proliferation":[160],"may":[161],"be":[162],"overcome":[163],"dynamic":[165],"shifts":[166],"phenotypic":[168],"distributions":[169],"within":[170],"mass.":[173],"Hypoxia,":[174],"together":[178],"functioned":[179],"hypoxia":[182],"relief":[183],"mechanism,":[184],"were":[186],"observed":[187],"maintain":[189],"consistent":[191],"distance":[192],"leading":[196],"edge":[197],"site":[200],"necrosis":[202],"onset,":[203],"providing":[204],"insights":[205],"improving":[207],"margins.":[209]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2025-11-25T21:42:39.735039","created_date":"2018-11-09T00:00:00"}