{"id":"https://openalex.org/W2899034855","doi":"https://doi.org/10.1109/embc.2018.8513420","title":"An Enhanced Mechanistic Model For Capnography, With Application To CHF-COPD Discrimination","display_name":"An Enhanced Mechanistic Model For Capnography, With Application To CHF-COPD Discrimination","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2899034855","doi":"https://doi.org/10.1109/embc.2018.8513420","mag":"2899034855","pmid":"https://pubmed.ncbi.nlm.nih.gov/30441526"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2018.8513420","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8513420","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011826443","display_name":"Ekin Karasan","orcid":null},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ekin Karasan","raw_affiliation_strings":["Massachusetts Institute of Technology, Cambridge, MA, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA, US","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080552239","display_name":"Abubakar Abid","orcid":null},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abubakar Abid","raw_affiliation_strings":["Stanford University, Stanford, CA, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Stanford, CA, US","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002436609","display_name":"Rebecca J. Mieloszyk","orcid":"https://orcid.org/0000-0003-1976-2980"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca J. Mieloszyk","raw_affiliation_strings":["University of Washington, Seattle, WA, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, Seattle, WA, US","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083632971","display_name":"Baruch Krauss","orcid":"https://orcid.org/0000-0002-3693-9082"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baruch S. Krauss","raw_affiliation_strings":["Harvard Medical School, Boston, MA, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Boston, MA, US","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089127853","display_name":"Thomas Heldt","orcid":null},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Heldt","raw_affiliation_strings":["Massachusetts Institute of Technology, Cambridge, MA, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA, US","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080571958","display_name":"George C. Verghese","orcid":null},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George C. Verghese","raw_affiliation_strings":["Massachusetts Institute of Technology, Cambridge, MA, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA, US","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.12544146,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"64","issue":null,"first_page":"5267","last_page":"5272"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11667","display_name":"Advanced Chemical Sensor Technologies","score":0.9909999966621399,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11667","display_name":"Advanced Chemical Sensor Technologies","score":0.9909999966621399,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/copd","display_name":"COPD","score":0.7024303674697876},{"id":"https://openalex.org/keywords/capnography","display_name":"Capnography","score":0.5465892553329468},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.46625837683677673},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.33932119607925415},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3242577612400055},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.29448002576828003},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.0986502468585968}],"concepts":[{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.7024303674697876},{"id":"https://openalex.org/C2778207410","wikidata":"https://www.wikidata.org/wiki/Q1728669","display_name":"Capnography","level":2,"score":0.5465892553329468},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.46625837683677673},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.33932119607925415},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3242577612400055},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29448002576828003},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.0986502468585968}],"mesh":[{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019296","descriptor_name":"Capnography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019296","descriptor_name":"Capnography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019296","descriptor_name":"Capnography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045853","descriptor_name":"Exhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045853","descriptor_name":"Exhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045853","descriptor_name":"Exhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2018.8513420","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8513420","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:30441526","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30441526","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.6600000262260437}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1875582044","https://openalex.org/W2152186962","https://openalex.org/W2168494657","https://openalex.org/W2228790483","https://openalex.org/W2274746292","https://openalex.org/W2610570861","https://openalex.org/W2754442126"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W4387497383","https://openalex.org/W3183948672","https://openalex.org/W3173606202","https://openalex.org/W3110381201","https://openalex.org/W2948807893","https://openalex.org/W2778153218","https://openalex.org/W2758277628","https://openalex.org/W2748952813","https://openalex.org/W1531601525"],"abstract_inverted_index":{"Capnography":[0],"records":[1],"CO":[2,89],"<sub":[3,90],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[4,91],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">2</sub>":[5,92],"partial":[6],"pressure":[7],"in":[8,52,83,106,121,142,169,225,245,264],"exhaled":[9,17],"breath":[10],"as":[11,59,160],"a":[12,26,84,113,131,161,166,226,233,270],"function":[13],"of":[14,45,55,80,88,115,151,198,204,207,251,259,273],"time":[15],"or":[16,39,242],"volume.":[18],"Time-based":[19],"capnography,":[20],"which":[21],"is":[22,25],"our":[23],"focus,":[24],"point-of-care,":[27],"noninvasive,":[28],"effort-independent":[29],"and":[30,48,70,154,178,193,222,230,256],"widely":[31],"available":[32],"clinical":[33],"monitoring":[34],"modality.":[35],"The":[36,124,181],"generated":[37],"waveform,":[38],"capnogram,":[40],"reflects":[41],"the":[42,46,53,116,122,136,140,143,170,184,188,194,205,238,252,260,265],"ventilation-perfusion":[43],"dynamics":[44],"lung,":[47],"thus":[49],"has":[50,240],"value":[51,197],"diagnosis":[54],"respiratory":[56,81],"conditions":[57],"such":[58],"chronic":[60],"obstructive":[61,71],"pulmonary":[62],"disease":[63,73],"(COPD).":[64],"Effective":[65],"discrimination":[66],"between":[67,176],"normal":[68],"respiration":[69],"lung":[72],"can":[74,101],"be":[75],"performed":[76],"using":[77],"capnogram-derived":[78],"estimates":[79],"parameters":[82,127,147],"simple":[85,234],"mechanistic":[86,98],"model":[87,99,137],"exhalation.":[93],"We":[94],"propose":[95],"an":[96],"enhanced":[97],"that":[100],"capture":[102],"specific":[103],"capnogram":[104],"characteristics":[105],"congestive":[107],"heart":[108],"failure":[109],"(CHF)":[110],"by":[111,134],"incorporating":[112],"representation":[114],"inertance":[117],"associated":[118,126],"with":[119],"fluid":[120],"lungs.":[123],"4":[125],"are":[128,209],"estimated":[129],"on":[130,232],"breath-by-breath":[132],"basis":[133,236],"fitting":[135],"output":[138],"to":[139,164,216,269],"exhalations":[141,150,218],"measured":[144],"capnogram.":[145],"Estimated":[146],"from":[148,219],"40":[149,217],"7":[152,155],"CHF":[153,177,221,241,254],"COPD":[156,179,223,262],"patients":[157,255,263],"were":[158],"used":[159],"training":[162,189],"set":[163,190],"design":[165],"quadratic":[167],"discriminator":[168,213],"parameter":[171],"space,":[172],"aimed":[173],"at":[174],"distinguishing":[175],"patients.":[180],"area":[182],"under":[183],"ROC":[185],"curve":[186],"for":[187],"was":[191],"0.94,":[192],"corresponding":[195,268],"equal-error-rate":[196],"approximately":[199],"0.1":[200],"suggests":[201],"classification":[202,271],"accuracies":[203],"order":[206],"90%":[208],"attainable.":[210],"Applying":[211],"this":[212],"without":[214],"modification":[215],"each":[220],"patient":[224,239],"fresh":[227],"test":[228,266],"set,":[229,267],"deciding":[231],"majority":[235],"whether":[237],"COPD,":[243],"results":[244],"correctly":[246],"labeling":[247],"all":[248],"8":[249,253,261],"out":[250,258],"6":[257],"accuracy":[272],"87.5%.":[274]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}