{"id":"https://openalex.org/W2898791578","doi":"https://doi.org/10.1109/embc.2018.8513139","title":"Modeling Cardiac Hemodynamic Response During Exercise in Health and Hypertrophic Cardiomyopathy","display_name":"Modeling Cardiac Hemodynamic Response During Exercise in Health and Hypertrophic Cardiomyopathy","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2898791578","doi":"https://doi.org/10.1109/embc.2018.8513139","mag":"2898791578","pmid":"https://pubmed.ncbi.nlm.nih.gov/30441359"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2018.8513139","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8513139","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024496603","display_name":"Ignacio Farro","orcid":null},"institutions":[{"id":"https://openalex.org/I4210154927","display_name":"Hospital de Cl\u00ednicas","ror":"https://ror.org/04jdthe46","country_code":"UY","type":"healthcare","lineage":["https://openalex.org/I4210154927"]},{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":true,"raw_author_name":"I. Farro","raw_affiliation_strings":["Departamento de Ingenier\u00eda Biol\u00f3gica, Centro Universitario Regional Litoral Noroeste Universidad de la Rep\u00f9blica, Montevideo, Uruguay","Hospital de Cl\u00ednicas, Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ingenier\u00eda Biol\u00f3gica, Centro Universitario Regional Litoral Noroeste Universidad de la Rep\u00f9blica, Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]},{"raw_affiliation_string":"Hospital de Cl\u00ednicas, Montevideo, Uruguay","institution_ids":["https://openalex.org/I4210154927"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041626485","display_name":"Claudia R. Arbeitman","orcid":"https://orcid.org/0000-0002-8302-6825"},"institutions":[{"id":"https://openalex.org/I128590013","display_name":"National Technological University","ror":"https://ror.org/04t730v47","country_code":"AR","type":"education","lineage":["https://openalex.org/I128590013"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"C. R. Arbeitman","raw_affiliation_strings":["Universidad Tecnologica Nacional, Buenos Aires, AR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Tecnologica Nacional, Buenos Aires, AR","institution_ids":["https://openalex.org/I128590013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070823938","display_name":"Leandro J. Cymberknop","orcid":"https://orcid.org/0000-0002-0217-1239"},"institutions":[{"id":"https://openalex.org/I128590013","display_name":"National Technological University","ror":"https://ror.org/04t730v47","country_code":"AR","type":"education","lineage":["https://openalex.org/I128590013"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"L. J. Cymberknop","raw_affiliation_strings":["Universidad Tecnologica Nacional, Buenos Aires, AR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Tecnologica Nacional, Buenos Aires, AR","institution_ids":["https://openalex.org/I128590013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091109767","display_name":"Juan Cardelino","orcid":null},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"J. Cardelino","raw_affiliation_strings":["Departamento de Ingenier\u00eda Biol\u00f3gica, Centro Universitario Regional Litoral Noroeste Universidad de la Rep\u00f9blica, Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ingenier\u00eda Biol\u00f3gica, Centro Universitario Regional Litoral Noroeste Universidad de la Rep\u00f9blica, Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079077713","display_name":"Ricardo L. Armentano","orcid":"https://orcid.org/0000-0003-3455-2033"},"institutions":[{"id":"https://openalex.org/I128590013","display_name":"National Technological University","ror":"https://ror.org/04t730v47","country_code":"AR","type":"education","lineage":["https://openalex.org/I128590013"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"R. L. Armentano","raw_affiliation_strings":["Universidad Tecnologica Nacional, Buenos Aires, AR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Tecnologica Nacional, Buenos Aires, AR","institution_ids":["https://openalex.org/I128590013"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5024496603"],"corresponding_institution_ids":["https://openalex.org/I180910786","https://openalex.org/I4210154927"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2322233,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":null,"first_page":"4532","last_page":"4535"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.6912000179290771,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.6912000179290771,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.06499999761581421,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.0551999993622303,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypertrophic-cardiomyopathy","display_name":"Hypertrophic cardiomyopathy","score":0.7622711658477783},{"id":"https://openalex.org/keywords/hemodynamics","display_name":"Hemodynamics","score":0.6625741124153137},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.6603597402572632},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.572262704372406},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5136634707450867},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"Cardiomyopathy","score":0.4579336941242218},{"id":"https://openalex.org/keywords/heart-failure","display_name":"Heart failure","score":0.27664434909820557}],"concepts":[{"id":"https://openalex.org/C2780185194","wikidata":"https://www.wikidata.org/wiki/Q1364270","display_name":"Hypertrophic cardiomyopathy","level":2,"score":0.7622711658477783},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.6625741124153137},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6603597402572632},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.572262704372406},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5136634707450867},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.4579336941242218},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.27664434909820557}],"mesh":[{"descriptor_ui":"D002312","descriptor_name":"Cardiomyopathy, Hypertrophic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002312","descriptor_name":"Cardiomyopathy, Hypertrophic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002312","descriptor_name":"Cardiomyopathy, Hypertrophic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005080","descriptor_name":"Exercise Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005080","descriptor_name":"Exercise Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005080","descriptor_name":"Exercise Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2018.8513139","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8513139","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:30441359","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30441359","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W22674372","https://openalex.org/W26417677","https://openalex.org/W1568936177","https://openalex.org/W1965836193","https://openalex.org/W1979333298","https://openalex.org/W2001069628","https://openalex.org/W2006660609","https://openalex.org/W2011319276","https://openalex.org/W2017322749","https://openalex.org/W2020823489","https://openalex.org/W2064352787","https://openalex.org/W2076034570","https://openalex.org/W2079254928","https://openalex.org/W2084651047","https://openalex.org/W2103089817","https://openalex.org/W2109560166","https://openalex.org/W2118933677","https://openalex.org/W2120888944","https://openalex.org/W2132213773","https://openalex.org/W2145651104","https://openalex.org/W2155244168","https://openalex.org/W2160789215","https://openalex.org/W2303651371","https://openalex.org/W2330082844","https://openalex.org/W3134574291","https://openalex.org/W4211100568"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W3183948672","https://openalex.org/W3173606202","https://openalex.org/W3110381201","https://openalex.org/W2948807893","https://openalex.org/W2935909890","https://openalex.org/W2778153218","https://openalex.org/W2758277628","https://openalex.org/W1531601525","https://openalex.org/W2006176619"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Hypertrophic":[1],"cardiomyopathy":[2],"(HCM)":[3],"is":[4],"associated":[5],"with":[6,102],"altered":[7],"hemodynamics":[8],"in":[9,34,51,130,134,148],"the":[10,28,46,141,149,155],"left":[11],"ventricular":[12],"outflow":[13],"tract":[14],"and":[15,24,53,71,110],"tissue":[16],"abnormalities.":[17],"Exercise":[18],"testing":[19],"has":[20],"become":[21],"an":[22],"integral":[23],"powerful":[25],"tool":[26],"for":[27,154],"noninvasive":[29,58],"evaluation":[30,81],"of":[31,93,118,128,140,151],"HCM":[32,54,103,135],"and,":[33],"some":[35],"patients,":[36,55],"it":[37,120],"could":[38],"define":[39],"a":[40,83,90,124],"treatment":[41],"strategy.":[42],"Obiective:":[43],"To":[44],"model":[45,143],"hemodynamic":[47],"alterations":[48],"during":[49,78,115],"exercise":[50,107],"healthy":[52,131],"obtained":[56],"by":[57],"methods.":[59],"METHODS:":[60],"Cardiac":[61],"output":[62,109],"(CO),":[63],"heart":[64],"rate":[65,127],"(HR),":[66],"arterial":[67],"blood":[68],"pressure":[69],"(ABP)":[70],"Total":[72],"Peripheral":[73],"Resistance":[74],"(TPR)":[75],"were":[76],"assessed":[77],"exercise.":[79,116],"The":[80,138],"included":[82],"curve-fitting":[84],"approach":[85],"(sigmoidal":[86],"model)":[87],"that":[88],"allowed":[89],"quantitative":[91],"comparison":[92],"CO":[94,121,152],"profiles.":[95],"RESULTS:":[96],"When":[97],"compared":[98],"to":[99,145],"controls,":[100],"patients":[101],"showed":[104,144],"reduced":[105],"peak":[106],"cardiac":[108],"demonstrated":[111],"high":[112],"peripheral":[113],"resistance":[114],"Analysis":[117],"modeled":[119],"curves":[122],"revealed":[123],"higher":[125],"maximum":[126],"recovery":[129],"individuals":[132],"than":[133],"patients.":[136],"CONCLUSION:":[137],"application":[139],"sigmoidal":[142],"be":[146],"efficient":[147],"characterization":[150],"dynamics":[153],"different":[156],"studied":[157],"groups.":[158]},"counts_by_year":[],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}