{"id":"https://openalex.org/W2964279023","doi":"https://doi.org/10.1109/embc.2018.8513070","title":"Predicting Lymph Node Metastasis in Head and Neck Cancer by Combining Many-objective Radiomics and 3-dimensioal Convolutional Neural Network through Evidential Reasoning","display_name":"Predicting Lymph Node Metastasis in Head and Neck Cancer by Combining Many-objective Radiomics and 3-dimensioal Convolutional Neural Network through Evidential Reasoning","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2964279023","doi":"https://doi.org/10.1109/embc.2018.8513070","mag":"2964279023","pmid":"https://pubmed.ncbi.nlm.nih.gov/30440295"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2018.8513070","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8513070","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100785328","display_name":"Zhiguo Zhou","orcid":"https://orcid.org/0000-0003-4031-3178"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"education","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhiguo Zhou","raw_affiliation_strings":["University of Texas Southwestern Medical Center, Dallas, TX, USA"],"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern Medical Center, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100715502","display_name":"Liyuan Chen","orcid":"https://orcid.org/0000-0002-5345-0086"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"education","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liyuan Chen","raw_affiliation_strings":["University of Texas Southwestern Medical Center, Dallas, TX, USA"],"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern Medical Center, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011724315","display_name":"David J. Sher","orcid":"https://orcid.org/0000-0003-3943-7480"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"education","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Sher","raw_affiliation_strings":["University of Texas Southwestern Medical Center, Dallas, TX, USA"],"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern Medical Center, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043408615","display_name":"Qiongwen Zhang","orcid":"https://orcid.org/0000-0003-2033-6663"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiongwen Zhang","raw_affiliation_strings":["Sichuan University, Chengdu, Sichuan, CN"],"affiliations":[{"raw_affiliation_string":"Sichuan University, Chengdu, Sichuan, CN","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083322184","display_name":"Jennifer Shah","orcid":"https://orcid.org/0000-0002-3847-8865"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"education","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Shah","raw_affiliation_strings":["University of Texas Southwestern Medical Center, Dallas, TX, USA"],"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern Medical Center, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026289601","display_name":"Nhat-Long Pham","orcid":null},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"education","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nhat-Long Pham","raw_affiliation_strings":["University of Texas Southwestern Medical Center, Dallas, TX, USA"],"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern Medical Center, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018120191","display_name":"Steve Jiang","orcid":"https://orcid.org/0000-0002-3083-6752"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"education","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve Jiang","raw_affiliation_strings":["University of Texas Southwestern Medical Center, Dallas, TX, USA"],"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern Medical Center, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100378601","display_name":"Jing Wang","orcid":"https://orcid.org/0000-0002-8491-4146"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"education","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Wang","raw_affiliation_strings":["University of Texas Southwestern Medical Center, Dallas, TX, USA"],"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern Medical Center, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5100785328"],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":null,"apc_paid":null,"fwci":3.0059,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.92043241,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"2018","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9549999833106995,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12386","display_name":"Advanced X-ray and CT Imaging","score":0.9445000290870667,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiomics","display_name":"Radiomics","score":0.9229946732521057},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.7543983459472656},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6991221904754639},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.6269823908805847},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6185113191604614},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"Lymph node metastasis","score":0.48291298747062683},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.42732226848602295},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4185866713523865},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3511461615562439},{"id":"https://openalex.org/keywords/metastasis","display_name":"Metastasis","score":0.21908774971961975},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2106074094772339},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.2051159143447876}],"concepts":[{"id":"https://openalex.org/C2778559731","wikidata":"https://www.wikidata.org/wiki/Q23808793","display_name":"Radiomics","level":2,"score":0.9229946732521057},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.7543983459472656},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6991221904754639},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.6269823908805847},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6185113191604614},{"id":"https://openalex.org/C2992571226","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node metastasis","level":4,"score":0.48291298747062683},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.42732226848602295},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4185866713523865},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3511461615562439},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.21908774971961975},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2106074094772339},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2051159143447876},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc.2018.8513070","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8513070","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:30440295","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30440295","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:europepmc.org:6054332","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7103090","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6000000238418579}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1912982817","https://openalex.org/W1964620951","https://openalex.org/W1975434153","https://openalex.org/W1994136786","https://openalex.org/W2070291618","https://openalex.org/W2072466513","https://openalex.org/W2099698084","https://openalex.org/W2120160105","https://openalex.org/W2133301617","https://openalex.org/W2148143831","https://openalex.org/W2194775991","https://openalex.org/W2311857205","https://openalex.org/W2338137334","https://openalex.org/W2346343836","https://openalex.org/W2406213538","https://openalex.org/W2461805626","https://openalex.org/W2612594530","https://openalex.org/W2725008604","https://openalex.org/W2742317286","https://openalex.org/W2745940724","https://openalex.org/W2746549795","https://openalex.org/W2756184660","https://openalex.org/W2763355946","https://openalex.org/W2811120089","https://openalex.org/W2919115771","https://openalex.org/W2962915373","https://openalex.org/W2979917337","https://openalex.org/W6679616702","https://openalex.org/W6694310448","https://openalex.org/W6698491756"],"related_works":["https://openalex.org/W3000891326","https://openalex.org/W4205100762","https://openalex.org/W2559998622","https://openalex.org/W4226493464","https://openalex.org/W3133861977","https://openalex.org/W2951211570","https://openalex.org/W3103566983","https://openalex.org/W4405142306","https://openalex.org/W4405142285","https://openalex.org/W4402414556"],"abstract_inverted_index":{"Lymph":[0],"node":[1,62],"metastasis":[2],"(LNM)":[3],"is":[4,23],"a":[5,83,105,111,119],"significant":[6],"prognostic":[7],"factor":[8],"in":[9],"patients":[10],"with":[11],"head":[12],"and":[13,16,29,52,73,92,151,187],"neck":[14],"cancer,":[15],"the":[17,56,78,128,133,138,141,158,163,172,177],"ability":[18],"to":[19],"predict":[20],"it":[21],"accurately":[22],"essential":[24],"for":[25,35,45,61,148],"treatment":[26],"optimization.":[27],"PET":[28],"CT":[30],"imaging":[31],"are":[32,55,67],"routinely":[33],"used":[34],"LNM":[36,41],"identification.":[37],"However,":[38],"uncertainties":[39],"of":[40,140],"always":[42],"exist":[43],"especially":[44],"small":[46],"size":[47],"or":[48],"reactive":[49],"nodes.":[50],"Radiomics":[51,65],"deep":[53,74],"learning":[54,75],"two":[57,142,164],"preferred":[58],"imaging-based":[59],"strategies":[60],"malignancy":[63],"prediction.":[64],"models":[66,145],"built":[68,147],"based":[69],"on":[70],"handcrafted":[71],"features,":[72],"can":[76],"learn":[77],"features":[79],"automatically.":[80],"We":[81],"proposed":[82,110],"hybrid":[84,178],"predictive":[85],"model":[86,159,179],"that":[87,121,157,171],"combines":[88],"many-objective":[89,113],"radiomics":[90,114],"(MO-radiomics)":[91],"3-dimensional":[93],"convolutional":[94],"neural":[95],"network":[96],"(3D-CNN)":[97],"through":[98,132],"evidential":[99],"reasoning":[100],"(ER)":[101],"approach.":[102,135],"To":[103,136],"build":[104],"more":[106],"reliable":[107],"model,":[108],"we":[109,117,169],"new":[112],"model.":[115],"Meanwhile,":[116],"designed":[118],"3D-CNN":[120],"fully":[122],"utilizes":[123],"spatial":[124],"contextual":[125],"information.":[126],"Finally,":[127],"outputs":[129],"were":[130,146,166,180],"fused":[131],"ER":[134],"study":[137],"predictability":[139],"modalities,":[143],"three":[144],"PET,":[149],"CT,":[150],"PET&":[152],"CT.":[153],"The":[154],"results":[155,174],"showed":[156,170],"performed":[160],"best":[161],"when":[162],"modalities":[165],"combined.":[167],"Moreover,":[168],"quantitative":[173],"obtained":[175,184],"from":[176,185],"better":[181],"than":[182],"those":[183],"MO-radiomics":[186],"3D-CNN.":[188]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":4}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}