{"id":"https://openalex.org/W2898724051","doi":"https://doi.org/10.1109/embc.2018.8513016","title":"An Intelligent Theranostics Method Using Optical Coherence Tomography Guided Automatic Laser Ablation for Neurosurgery","display_name":"An Intelligent Theranostics Method Using Optical Coherence Tomography Guided Automatic Laser Ablation for Neurosurgery","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2898724051","doi":"https://doi.org/10.1109/embc.2018.8513016","mag":"2898724051","pmid":"https://pubmed.ncbi.nlm.nih.gov/30441078"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2018.8513016","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8513016","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000991362","display_name":"Wei Chang","orcid":"https://orcid.org/0000-0002-7037-3852"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Chang","raw_affiliation_strings":["Tsinghua University, Beijing, Beijing, CN"],"affiliations":[{"raw_affiliation_string":"Tsinghua University, Beijing, Beijing, CN","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007207506","display_name":"Yingwei Fan","orcid":"https://orcid.org/0000-0003-4535-3451"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingwei Fan","raw_affiliation_strings":["Tsinghua University, Beijing, Beijing, CN"],"affiliations":[{"raw_affiliation_string":"Tsinghua University, Beijing, Beijing, CN","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100775077","display_name":"Xinran Zhang","orcid":"https://orcid.org/0000-0002-2017-3182"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinran Zhang","raw_affiliation_strings":["Tsinghua University, Beijing, Beijing, CN"],"affiliations":[{"raw_affiliation_string":"Tsinghua University, Beijing, Beijing, CN","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018740222","display_name":"Hongen Liao","orcid":"https://orcid.org/0000-0003-3847-9347"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongen Liao","raw_affiliation_strings":["Tsinghua University, Beijing, Beijing, CN"],"affiliations":[{"raw_affiliation_string":"Tsinghua University, Beijing, Beijing, CN","institution_ids":["https://openalex.org/I99065089"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5000991362"],"corresponding_institution_ids":["https://openalex.org/I99065089"],"apc_list":null,"apc_paid":null,"fwci":0.6537,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.67621028,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"7","issue":null,"first_page":"3224","last_page":"3227"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/optical-coherence-tomography","display_name":"Optical coherence tomography","score":0.7652027606964111},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5949587821960449},{"id":"https://openalex.org/keywords/laser-ablation","display_name":"Laser ablation","score":0.5812422633171082},{"id":"https://openalex.org/keywords/ablation","display_name":"Ablation","score":0.4887263774871826},{"id":"https://openalex.org/keywords/laser","display_name":"Laser","score":0.4778296947479248},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.41879650950431824},{"id":"https://openalex.org/keywords/coherence","display_name":"Coherence (philosophical gambling strategy)","score":0.41679850220680237},{"id":"https://openalex.org/keywords/optical-fiber","display_name":"Optical fiber","score":0.4123607575893402},{"id":"https://openalex.org/keywords/medical-physics","display_name":"Medical physics","score":0.3659305274486542},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.3631948232650757},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.35192179679870605},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.29582735896110535},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.20567891001701355},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.11917775869369507},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.08279553055763245}],"concepts":[{"id":"https://openalex.org/C2778818243","wikidata":"https://www.wikidata.org/wiki/Q899552","display_name":"Optical coherence tomography","level":2,"score":0.7652027606964111},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5949587821960449},{"id":"https://openalex.org/C2779188808","wikidata":"https://www.wikidata.org/wiki/Q1806547","display_name":"Laser ablation","level":3,"score":0.5812422633171082},{"id":"https://openalex.org/C2778902805","wikidata":"https://www.wikidata.org/wiki/Q322177","display_name":"Ablation","level":2,"score":0.4887263774871826},{"id":"https://openalex.org/C520434653","wikidata":"https://www.wikidata.org/wiki/Q38867","display_name":"Laser","level":2,"score":0.4778296947479248},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.41879650950431824},{"id":"https://openalex.org/C2781181686","wikidata":"https://www.wikidata.org/wiki/Q4226068","display_name":"Coherence (philosophical gambling strategy)","level":2,"score":0.41679850220680237},{"id":"https://openalex.org/C194232370","wikidata":"https://www.wikidata.org/wiki/Q162","display_name":"Optical fiber","level":2,"score":0.4123607575893402},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3659305274486542},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3631948232650757},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.35192179679870605},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.29582735896110535},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20567891001701355},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11917775869369507},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.08279553055763245},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068936","descriptor_name":"Theranostic Nanomedicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068936","descriptor_name":"Theranostic Nanomedicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068936","descriptor_name":"Theranostic Nanomedicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009493","descriptor_name":"Neurosurgery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009493","descriptor_name":"Neurosurgery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009493","descriptor_name":"Neurosurgery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019635","descriptor_name":"Neurosurgical Procedures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019635","descriptor_name":"Neurosurgical Procedures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019635","descriptor_name":"Neurosurgical Procedures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041623","descriptor_name":"Tomography, Optical Coherence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041623","descriptor_name":"Tomography, Optical Coherence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041623","descriptor_name":"Tomography, Optical Coherence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053685","descriptor_name":"Laser Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053685","descriptor_name":"Laser Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053685","descriptor_name":"Laser Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2018.8513016","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8513016","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:30441078","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30441078","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7599999904632568,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1528584926","https://openalex.org/W1931295675","https://openalex.org/W1995208714","https://openalex.org/W1996371270","https://openalex.org/W2019430163","https://openalex.org/W2092668319","https://openalex.org/W2095274218","https://openalex.org/W2108345603","https://openalex.org/W2133059825","https://openalex.org/W2143405185","https://openalex.org/W2167691746","https://openalex.org/W2599059164","https://openalex.org/W2744566836","https://openalex.org/W2752954302","https://openalex.org/W6649710680","https://openalex.org/W6742742709","https://openalex.org/W6743972634"],"related_works":["https://openalex.org/W2057758186","https://openalex.org/W2298870865","https://openalex.org/W2147794715","https://openalex.org/W2081305085","https://openalex.org/W1940885666","https://openalex.org/W2560330190","https://openalex.org/W2052524705","https://openalex.org/W3143833596","https://openalex.org/W1965319168","https://openalex.org/W2896812212"],"abstract_inverted_index":{"Methods":[0],"to":[1,41],"reduce":[2],"the":[3,44,78,83,89,95,122,129,134,136,160,170],"high":[4,48],"disability":[5],"and":[6,15,38,65,94,118,126,166,169],"fatality":[7],"rate":[8],"of":[9,17,56,82,152,162,172],"neurosurgery":[10],"caused":[11],"by":[12,72,159],"surgeon":[13],"tremor":[14],"uncertainty":[16],"intraoperative":[18],"tumor":[19,46],"boundary":[20],"have":[21,27],"long":[22],"been":[23,70,157],"greatly":[24],"concerned.":[25],"We":[26],"proposed":[28],"an":[29,100],"intelligent":[30],"theranostics":[31,103,154],"method":[32,155],"for":[33],"a":[34,57,66,73],"compact":[35],"integrated":[36],"diagnosis":[37],"therapeutic":[39],"platform":[40],"automatically":[42],"excise":[43],"brain":[45,145],"with":[47],"precision.":[49],"To":[50],"perform":[51],"this":[52,153],"operation,":[53],"hardware":[54],"combination":[55],"benchtop":[58],"spectral":[59],"domain":[60],"optical":[61],"coherence":[62],"tomography":[63],"(SD-OCT)":[64],"high-power":[67,139],"laser":[68,97,140],"has":[69,156],"implemented":[71],"customized":[74],"fiber":[75,80,93],"combiner.":[76],"By":[77],"double-clad":[79],"out":[81],"combiner":[84],"which":[85],"works":[86],"as":[87],"both":[88,115],"OCT":[90],"sample":[91],"arm":[92],"ablation":[96],"output":[98],"fiber,":[99],"in":[101,147],"situ":[102],"process":[104],"without":[105],"registration":[106],"can":[107],"be":[108],"conducted.":[109],"The":[110,150],"SD-OCT":[111],"image":[112],"analysis":[113],"from":[114],"en":[116],"face":[117],"depth":[119],"perspectives":[120],"shows":[121],"structural":[123],"information":[124],"intuitively":[125],"accordingly":[127],"generate":[128],"ablation-guiding":[130],"grid.":[131],"Based":[132],"on":[133],"grid,":[135],"continuous":[137],"wave":[138],"ablates":[141],"ex":[142],"vivo":[143],"porcine":[144],"models":[146],"submillimeter":[148],"automatically.":[149],"feasibility":[151],"verified":[158],"comparison":[161],"attenuation":[163],"maps":[164],"before":[165],"after":[167],"ablation,":[168],"contrast":[171],"its":[173],"pathology.":[174]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}