{"id":"https://openalex.org/W2899005318","doi":"https://doi.org/10.1109/embc.2018.8513004","title":"Chronically Implantable Package Based on Alumina Ceramics and Titanium with High-density Feedthroughs for Medical Implants","display_name":"Chronically Implantable Package Based on Alumina Ceramics and Titanium with High-density Feedthroughs for Medical Implants","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2899005318","doi":"https://doi.org/10.1109/embc.2018.8513004","mag":"2899005318","pmid":"https://pubmed.ncbi.nlm.nih.gov/30441113"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2018.8513004","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8513004","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052039332","display_name":"Hangao Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hangao Yang","raw_affiliation_strings":["Chinese Academy of Sciences, Beijing, Beijing, CN"],"affiliations":[{"raw_affiliation_string":"Chinese Academy of Sciences, Beijing, Beijing, CN","institution_ids":["https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063883163","display_name":"Tianzhun Wu","orcid":"https://orcid.org/0000-0001-6237-169X"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tianzhun Wu","raw_affiliation_strings":["University of Southern California, Los Angeles, CA, US"],"affiliations":[{"raw_affiliation_string":"University of Southern California, Los Angeles, CA, US","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109378526","display_name":"Saisai Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Saisai Zhao","raw_affiliation_strings":["Chinese Academy of Sciences, Beijing, Beijing, CN"],"affiliations":[{"raw_affiliation_string":"Chinese Academy of Sciences, Beijing, Beijing, CN","institution_ids":["https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007108734","display_name":"Shanshan Xiong","orcid":"https://orcid.org/0000-0003-1229-4600"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shanshan Xiong","raw_affiliation_strings":["Chinese Academy of Sciences, Beijing, Beijing, CN"],"affiliations":[{"raw_affiliation_string":"Chinese Academy of Sciences, Beijing, Beijing, CN","institution_ids":["https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046723172","display_name":"Bo Peng","orcid":"https://orcid.org/0000-0003-0416-9076"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Peng","raw_affiliation_strings":["Chinese Academy of Sciences, Beijing, Beijing, CN"],"affiliations":[{"raw_affiliation_string":"Chinese Academy of Sciences, Beijing, Beijing, CN","institution_ids":["https://openalex.org/I19820366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052140640","display_name":"Mark S. Humayun","orcid":"https://orcid.org/0000-0002-5830-5208"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark S. Humayun","raw_affiliation_strings":["University of Southern California, Los Angeles, CA, US"],"affiliations":[{"raw_affiliation_string":"University of Southern California, Los Angeles, CA, US","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5052039332"],"corresponding_institution_ids":["https://openalex.org/I19820366"],"apc_list":null,"apc_paid":null,"fwci":0.6513,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.63804286,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"2018","issue":null,"first_page":"3382","last_page":"3385"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10783","display_name":"Additive Manufacturing and 3D Printing Technologies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2203","display_name":"Automotive Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10338","display_name":"Advanced Sensor and Energy Harvesting Materials","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/feedthrough","display_name":"Feedthrough","score":0.8013672828674316},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.7978678345680237},{"id":"https://openalex.org/keywords/ceramic","display_name":"Ceramic","score":0.6902392506599426},{"id":"https://openalex.org/keywords/titanium","display_name":"Titanium","score":0.6256375908851624},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"Biocompatibility","score":0.567057192325592},{"id":"https://openalex.org/keywords/leakage","display_name":"Leakage (economics)","score":0.49699166417121887},{"id":"https://openalex.org/keywords/implant","display_name":"Implant","score":0.45833614468574524},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.42887917160987854},{"id":"https://openalex.org/keywords/composite-number","display_name":"Composite number","score":0.42596104741096497},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.34190303087234497},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.32129883766174316},{"id":"https://openalex.org/keywords/metallurgy","display_name":"Metallurgy","score":0.21437212824821472},{"id":"https://openalex.org/keywords/surgery","display_name":"Surgery","score":0.06943404674530029},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.06742841005325317}],"concepts":[{"id":"https://openalex.org/C2777303812","wikidata":"https://www.wikidata.org/wiki/Q5441253","display_name":"Feedthrough","level":2,"score":0.8013672828674316},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.7978678345680237},{"id":"https://openalex.org/C134132462","wikidata":"https://www.wikidata.org/wiki/Q45621","display_name":"Ceramic","level":2,"score":0.6902392506599426},{"id":"https://openalex.org/C506065880","wikidata":"https://www.wikidata.org/wiki/Q716","display_name":"Titanium","level":2,"score":0.6256375908851624},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.567057192325592},{"id":"https://openalex.org/C2777042071","wikidata":"https://www.wikidata.org/wiki/Q6509304","display_name":"Leakage (economics)","level":2,"score":0.49699166417121887},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.45833614468574524},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.42887917160987854},{"id":"https://openalex.org/C104779481","wikidata":"https://www.wikidata.org/wiki/Q50707","display_name":"Composite number","level":2,"score":0.42596104741096497},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.34190303087234497},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.32129883766174316},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.21437212824821472},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.06943404674530029},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.06742841005325317},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000537","descriptor_name":"Aluminum Oxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000537","descriptor_name":"Aluminum Oxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000537","descriptor_name":"Aluminum Oxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002516","descriptor_name":"Ceramics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002516","descriptor_name":"Ceramics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002516","descriptor_name":"Ceramics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010984","descriptor_name":"Platinum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010984","descriptor_name":"Platinum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010984","descriptor_name":"Platinum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014025","descriptor_name":"Titanium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014025","descriptor_name":"Titanium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014025","descriptor_name":"Titanium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019736","descriptor_name":"Prostheses and Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019736","descriptor_name":"Prostheses and Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019736","descriptor_name":"Prostheses and Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2018.8513004","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8513004","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:30441113","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30441113","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1507311512","https://openalex.org/W1989394823","https://openalex.org/W2016292555","https://openalex.org/W2037608973","https://openalex.org/W2038607835","https://openalex.org/W2062618621","https://openalex.org/W2076376195","https://openalex.org/W2108065075","https://openalex.org/W2109006034","https://openalex.org/W2119541398","https://openalex.org/W2149517164","https://openalex.org/W2150645972","https://openalex.org/W2150813291","https://openalex.org/W2339153240","https://openalex.org/W2395365870","https://openalex.org/W2460348664","https://openalex.org/W6703893235","https://openalex.org/W6712160538"],"related_works":["https://openalex.org/W1986839414","https://openalex.org/W2048871732","https://openalex.org/W2357288154","https://openalex.org/W2033569341","https://openalex.org/W3103904424","https://openalex.org/W2070512270","https://openalex.org/W4390444039","https://openalex.org/W2364929389","https://openalex.org/W4226100221","https://openalex.org/W2393655250"],"abstract_inverted_index":{"Implantable":[0],"package":[1,22,43],"to":[2],"hermetically":[3],"encapsulate":[4],"electronics":[5],"inside":[6],"human":[7],"body":[8],"is":[9,132],"critical":[10],"for":[11,24,37,127,134],"active":[12,136],"implant":[13,69,137],"devices":[14],"such":[15],"as":[16],"neuroprothesestextbf.":[17],"To":[18],"meet":[19],"the":[20,49,54,58,67,104],"demanding":[21],"requirement":[23],"smaller":[25],"size":[26],"and":[27,90,115,122],"higher":[28],"feedthrough":[29],"density,":[30],"we":[31],"propose":[32],"a":[33,97,108],"high-density":[34],"(100+":[35],"feedthroughs":[36],"10":[38],"mm":[39],"diameter)":[40],"ceramic/metal":[41],"composite":[42],"with":[44,76,96,107],"helium":[45,112],"leakage":[46,113],"rate":[47,114],"on":[48],"10<sup>-10</sup>":[50],"Pa":[51],"m<sup>3</sup>/s,":[52],"at":[53],"same":[55],"time":[56],"possessing":[57],"best":[59],"cytotoxicity":[60,116],"level":[61],"of":[62],"Grade":[63],"0,":[64],"which":[65,131],"enable":[66],"chronic":[68,129],"in":[70,81],"human.":[71],"Pure":[72],"alumina":[73],"substrate":[74],"co-sintered":[75],"platinum":[77],"(Pt)":[78],"paste":[79],"filled":[80],"micrometer":[82],"holes":[83],"have":[84,118],"demonstrated":[85],"extremely":[86],"good":[87],"hermetical":[88],"seal":[89],"biocompatibility,":[91],"then":[92],"its":[93],"braze":[94],"joint":[95,123],"titanium(Ti)":[98],"ring":[99],"was":[100],"achieved,":[101],"followed":[102],"by":[103],"laser":[105],"welding":[106],"Ti":[109],"cap.":[110],"Standard":[111],"experiments":[117],"shown":[119],"each":[120],"component":[121],"interface":[124],"are":[125],"qualified":[126],"100-year":[128],"implant,":[130],"significant":[133],"various":[135],"instruments.":[138]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2016,"cited_by_count":1}],"updated_date":"2026-04-04T08:04:53.788161","created_date":"2025-10-10T00:00:00"}
