{"id":"https://openalex.org/W2898961406","doi":"https://doi.org/10.1109/embc.2018.8512889","title":"In Silico Model of Vitamin D&lt;inf&gt;3&lt;/inf&gt; Dependent NADPH Oxidase Complex Activation During Mycobacterium Infection","display_name":"In Silico Model of Vitamin D&lt;inf&gt;3&lt;/inf&gt; Dependent NADPH Oxidase Complex Activation During Mycobacterium Infection","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2898961406","doi":"https://doi.org/10.1109/embc.2018.8512889","mag":"2898961406","pmid":"https://pubmed.ncbi.nlm.nih.gov/30440886"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2018.8512889","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8512889","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104038201","display_name":"Maya Gough","orcid":null},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maya Gough","raw_affiliation_strings":["University of Houston, Houston, TX, US"],"affiliations":[{"raw_affiliation_string":"University of Houston, Houston, TX, US","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111888155","display_name":"Elebeoba May","orcid":null},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elebeoba May","raw_affiliation_strings":["University of Houston, Houston, TX, US"],"affiliations":[{"raw_affiliation_string":"University of Houston, Houston, TX, US","institution_ids":["https://openalex.org/I44461941"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5104038201"],"corresponding_institution_ids":["https://openalex.org/I44461941"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.16857135,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"2018","issue":null,"first_page":"2382","last_page":"2385"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9908999800682068,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.98089998960495,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/effector","display_name":"Effector","score":0.6198540329933167},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5213202834129333},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.44998571276664734},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.44862842559814453},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.44493404030799866},{"id":"https://openalex.org/keywords/molecular-biology","display_name":"Molecular biology","score":0.3228246867656708},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.32150954008102417},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.25232720375061035},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.18714749813079834},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"Tuberculosis","score":0.15450379252433777},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.08393186330795288}],"concepts":[{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.6198540329933167},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5213202834129333},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.44998571276664734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44862842559814453},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.44493404030799866},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3228246867656708},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.32150954008102417},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25232720375061035},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18714749813079834},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.15450379252433777},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08393186330795288},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002762","descriptor_name":"Cholecalciferol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002762","descriptor_name":"Cholecalciferol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002762","descriptor_name":"Cholecalciferol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2018.8512889","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8512889","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:30440886","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30440886","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","score":0.7699999809265137,"display_name":"Zero hunger"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W631551263","https://openalex.org/W1579451442","https://openalex.org/W1652069479","https://openalex.org/W1973875208","https://openalex.org/W1983129403","https://openalex.org/W2000564108","https://openalex.org/W2025694904","https://openalex.org/W2028613340","https://openalex.org/W2035986671","https://openalex.org/W2037280957","https://openalex.org/W2038118096","https://openalex.org/W2038519931","https://openalex.org/W2040636351","https://openalex.org/W2050661504","https://openalex.org/W2052505493","https://openalex.org/W2061528612","https://openalex.org/W2067566672","https://openalex.org/W2124070987","https://openalex.org/W2132696478","https://openalex.org/W2140937954","https://openalex.org/W2159628188","https://openalex.org/W2167872299","https://openalex.org/W2539201457","https://openalex.org/W2744318356","https://openalex.org/W4211180275"],"related_works":["https://openalex.org/W3129816939","https://openalex.org/W2912862995","https://openalex.org/W4320492283","https://openalex.org/W1530034981","https://openalex.org/W2985427592","https://openalex.org/W4214695225","https://openalex.org/W3197607994","https://openalex.org/W2783284266","https://openalex.org/W2101501829","https://openalex.org/W2153919606"],"abstract_inverted_index":{"Mycobacterium":[0],"tuberculosis":[1],"(Mtb)":[2],"is":[3,38,67],"a":[4,39,56,72,148],"highly":[5],"infectious":[6],"aerosolizable":[7],"bacterium,":[8],"which":[9],"causes":[10],"upward":[11],"of":[12,24,32,46,81,101,104,121,156],"1.5":[13],"million":[14],"deaths":[15],"per":[16],"year.":[17],"Alveolar":[18],"macrophages,":[19],"the":[20,25,28,44,61,79,132,154],"primary":[21],"defense":[22],"cell":[23,31],"lung,":[26],"are":[27],"preferred":[29],"host":[30],"this":[33],"intracellular":[34],"bacterium.":[35],"Vitamin":[36],"D<sub>3</sub>":[37,58,84,108],"known":[40,135],"transcription":[41,45],"factor,":[42],"modulating":[43],"pro-":[47],"and":[48,51],"anti-inflammatory":[49],"cytokines":[50],"immunologically":[52],"relevant":[53],"proteins.":[54],"In":[55],"vitamin":[57,83,107,141],"deficient":[59],"host,":[60],"immune":[62,160],"systems":[63,74],"response":[64],"to":[65,77,96,136],"infection":[66,103],"greatly":[68],"impaired.":[69],"We":[70,90],"used":[71],"quantitative":[73],"biology":[75],"approach":[76],"model":[78,100,114,145],"impact":[80],"long-term":[82],"deficiency":[85,158],"on":[86,159],"macrophage":[87],"effector":[88,128],"response.":[89,161],"then":[91],"compared":[92],"our":[93,97],"simulation":[94],"output":[95],"in":[98,112,118],"vitro":[99,119],"mycobacterium":[102],"macrophages":[105],"from":[106],"supplemented":[109],"hosts.":[110],"Our":[111],"silico":[113],"results":[115],"agreed":[116],"with":[117],"levels":[120],"hydrogen":[122],"peroxide":[123],"(H<sub>2</sub>O<sub>2</sub>)":[124],"production,":[125],"an":[126],"antimicrobial":[127],"molecule":[129],"produced":[130],"by":[131,140],"host's":[133],"macrophage,":[134],"be":[137],"modulated":[138],"indirectly":[139],"D<sub>3</sub>.":[142],"The":[143],"current":[144],"will":[146],"provide":[147],"foundation":[149],"for":[150],"further":[151],"studies":[152],"into":[153],"effects":[155],"micronutrient":[157]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2018-11-09T00:00:00"}
