{"id":"https://openalex.org/W2899490116","doi":"https://doi.org/10.1109/embc.2018.8512849","title":"Spatiotemporal Analysis of Mycobacterium-Dependent Macrophage Response","display_name":"Spatiotemporal Analysis of Mycobacterium-Dependent Macrophage Response","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2899490116","doi":"https://doi.org/10.1109/embc.2018.8512849","mag":"2899490116","pmid":"https://pubmed.ncbi.nlm.nih.gov/30440888"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2018.8512849","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8512849","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066645015","display_name":"Danielle L. Stolley","orcid":"https://orcid.org/0000-0003-0479-7902"},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Danielle L. Stolley","raw_affiliation_strings":["University of Houston, Houston, TX, US"],"affiliations":[{"raw_affiliation_string":"University of Houston, Houston, TX, US","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112306313","display_name":"Elebeoba E. May","orcid":null},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elebeoba E. May","raw_affiliation_strings":["University of Houston, Houston, TX, US"],"affiliations":[{"raw_affiliation_string":"University of Houston, Houston, TX, US","institution_ids":["https://openalex.org/I44461941"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5066645015"],"corresponding_institution_ids":["https://openalex.org/I44461941"],"apc_list":null,"apc_paid":null,"fwci":0.1608,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.56322104,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"2018","issue":null,"first_page":"2390","last_page":"2393"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9837999939918518,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pathogen","display_name":"Pathogen","score":0.6570370197296143},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.6226314306259155},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.6073984503746033},{"id":"https://openalex.org/keywords/macrophage","display_name":"Macrophage","score":0.5576382875442505},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.55161052942276},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.5122086405754089},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.5098389983177185},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.46133553981781006},{"id":"https://openalex.org/keywords/mycobacterium","display_name":"Mycobacterium","score":0.43575215339660645},{"id":"https://openalex.org/keywords/host","display_name":"Host (biology)","score":0.430833101272583},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.35529613494873047},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"Tuberculosis","score":0.3255902826786041},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.2058059573173523},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.19860795140266418},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.1932927668094635},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.07459789514541626}],"concepts":[{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.6570370197296143},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6226314306259155},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.6073984503746033},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5576382875442505},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.55161052942276},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5122086405754089},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5098389983177185},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.46133553981781006},{"id":"https://openalex.org/C2780374374","wikidata":"https://www.wikidata.org/wiki/Q194309","display_name":"Mycobacterium","level":3,"score":0.43575215339660645},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.430833101272583},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35529613494873047},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.3255902826786041},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2058059573173523},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19860795140266418},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1932927668094635},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07459789514541626}],"mesh":[{"descriptor_ui":"D000067996","descriptor_name":"RAW 264.7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000067996","descriptor_name":"RAW 264.7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000067996","descriptor_name":"RAW 264.7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006099","descriptor_name":"Granuloma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006099","descriptor_name":"Granuloma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006099","descriptor_name":"Granuloma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058491","descriptor_name":"Bacterial Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058491","descriptor_name":"Bacterial Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058491","descriptor_name":"Bacterial Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062211","descriptor_name":"Spatio-Temporal Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062211","descriptor_name":"Spatio-Temporal Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062211","descriptor_name":"Spatio-Temporal Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2018.8512849","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8512849","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:30440888","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30440888","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6800000071525574,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1582731448","https://openalex.org/W1638738262","https://openalex.org/W1788413159","https://openalex.org/W1883324033","https://openalex.org/W1965899093","https://openalex.org/W1966459214","https://openalex.org/W2012200136","https://openalex.org/W2055363992","https://openalex.org/W2066435331","https://openalex.org/W2073459066","https://openalex.org/W2096451472","https://openalex.org/W2099242680","https://openalex.org/W2127362646","https://openalex.org/W2146514801","https://openalex.org/W2166298869","https://openalex.org/W2291701222","https://openalex.org/W2331628193","https://openalex.org/W2483311974","https://openalex.org/W2521213603","https://openalex.org/W2569612340","https://openalex.org/W2586305489","https://openalex.org/W2744318356","https://openalex.org/W6668990524"],"related_works":["https://openalex.org/W2091398531","https://openalex.org/W2343234619","https://openalex.org/W3173815060","https://openalex.org/W2788776646","https://openalex.org/W4286497165","https://openalex.org/W2094282382","https://openalex.org/W4310951879","https://openalex.org/W3031409310","https://openalex.org/W1733763401","https://openalex.org/W2392278392"],"abstract_inverted_index":{"There":[0],"are":[1,30,54,66],"three":[2],"main":[3],"outcomes":[4],"of":[5,33,44,62,71,94,107,113],"Mycobacterium":[6,121],"tuberculosis":[7],"infection:":[8],"clearance,":[9],"dissemination,":[10],"and":[11,36,50,59,81],"containment":[12],"-":[13],"in":[14,24,41,48,51,79],"which":[15,65],"the":[16,21,34,42,69,109],"immune":[17],"system":[18],"physically":[19],"isolates":[20],"invading":[22],"microbes":[23],"lesions":[25],"called":[26],"granulomas.":[27,72],"These":[28],"structures":[29],"a":[31,91,104],"hallmark":[32],"disease":[35],"play":[37],"an":[38,76],"important":[39],"role":[40],"progression":[43],"infection.":[45,122],"However,":[46],"current":[47],"vitro":[49,80],"vivo":[52],"methods":[53],"ill":[55],"adapted":[56],"for":[57,68],"spatial":[58],"temporal":[60],"quantification":[61],"host-pathogen":[63,95],"dynamics,":[64],"necessary":[67],"development":[70],"We":[73],"have":[74],"developed":[75],"integrated":[77],"3D":[78],"computational":[82],"platform":[83],"with":[84],"longterm":[85],"time-lapse":[86],"confocal":[87],"imaging":[88],"to":[89],"provide":[90],"semi-automatic":[92],"analysis":[93],"interaction":[96],"data.":[97],"Through":[98],"exploratory":[99],"data":[100],"analysis,":[101],"we":[102],"conduct":[103],"preliminary":[105],"investigation":[106],"how":[108],"intracellular":[110],"bacterial":[111],"load":[112],"macrophages":[114],"can":[115],"impact":[116],"cellular":[117],"spatiotemporal":[118],"dynamics":[119],"during":[120]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}