{"id":"https://openalex.org/W2898749632","doi":"https://doi.org/10.1109/embc.2018.8512734","title":"Modified Sequence Method to Assess Baroreflex Sensitivity in Rats","display_name":"Modified Sequence Method to Assess Baroreflex Sensitivity in Rats","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2898749632","doi":"https://doi.org/10.1109/embc.2018.8512734","mag":"2898749632","pmid":"https://pubmed.ncbi.nlm.nih.gov/30440974"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2018.8512734","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8512734","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110995186","display_name":"James Schultz","orcid":null},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Schultz","raw_affiliation_strings":["University of Minnesota, Minneapolis, MN, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota, Minneapolis, MN, US","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112395060","display_name":"Elizabeth M. Annoni","orcid":null},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth M. Annoni","raw_affiliation_strings":["University of Minnesota, Minneapolis, MN, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota, Minneapolis, MN, US","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065149954","display_name":"Elena G. Tolkacheva","orcid":"https://orcid.org/0000-0003-1624-5793"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena G. Tolkacheva","raw_affiliation_strings":["University of Minnesota, Minneapolis, MN, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota, Minneapolis, MN, US","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.17239798,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"3","issue":null,"first_page":"2764","last_page":"2767"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9847000241279602,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.9745000004768372,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/baroreflex","display_name":"Baroreflex","score":0.8806178569793701},{"id":"https://openalex.org/keywords/baroreceptor","display_name":"Baroreceptor","score":0.7604665756225586},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"Blood pressure","score":0.555879533290863},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.45234572887420654},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4359622597694397},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.4288880527019501},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.4200114905834198},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.3605222702026367},{"id":"https://openalex.org/keywords/heart-rate","display_name":"Heart rate","score":0.25358831882476807},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.18692663311958313}],"concepts":[{"id":"https://openalex.org/C191237925","wikidata":"https://www.wikidata.org/wiki/Q808725","display_name":"Baroreflex","level":4,"score":0.8806178569793701},{"id":"https://openalex.org/C79752029","wikidata":"https://www.wikidata.org/wiki/Q808732","display_name":"Baroreceptor","level":4,"score":0.7604665756225586},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.555879533290863},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45234572887420654},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4359622597694397},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4288880527019501},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4200114905834198},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3605222702026367},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.25358831882476807},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18692663311958313},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001795","descriptor_name":"Blood Pressure Determination","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D001795","descriptor_name":"Blood Pressure Determination","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D001795","descriptor_name":"Blood Pressure Determination","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D001795","descriptor_name":"Blood Pressure Determination","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D001795","descriptor_name":"Blood Pressure Determination","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D001795","descriptor_name":"Blood Pressure Determination","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017704","descriptor_name":"Baroreflex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017704","descriptor_name":"Baroreflex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017704","descriptor_name":"Baroreflex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2018.8512734","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8512734","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:30440974","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30440974","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G7381505036","display_name":null,"funder_award_id":"R21 HL128790","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W78644326","https://openalex.org/W1970836282","https://openalex.org/W1999369240","https://openalex.org/W2012317247","https://openalex.org/W2056503811","https://openalex.org/W2057576302","https://openalex.org/W2097431774","https://openalex.org/W2099476116","https://openalex.org/W2126548892","https://openalex.org/W2131558710","https://openalex.org/W2140104458","https://openalex.org/W2158316475","https://openalex.org/W2321201805","https://openalex.org/W6603202742"],"related_works":["https://openalex.org/W2784470254","https://openalex.org/W2326594690","https://openalex.org/W2329025098","https://openalex.org/W1986472926","https://openalex.org/W2115073568","https://openalex.org/W2417049126","https://openalex.org/W2158021652","https://openalex.org/W2417226223","https://openalex.org/W2898266525","https://openalex.org/W4205998347"],"abstract_inverted_index":{"Baroreceptors":[0],"respond":[1],"to":[2,13,24,59,152],"fluctuations":[3],"in":[4,11,62,70,78,141,163],"blood":[5],"pressure":[6],"(BP)":[7],"by":[8],"modifying":[9],"physiology":[10],"order":[12],"maintain":[14],"a":[15,30,80,94],"homeostatic":[16],"set":[17],"point.":[18],"Baroreflex":[19],"sensitivity":[20],"(BRS)":[21],"is":[22,29,57],"used":[23,58],"quantify":[25],"baroreceptor":[26],"function":[27,49],"and":[28,38,50,72,104,118,129],"useful":[31],"metric":[32],"for":[33],"tracking":[34],"cardiovascular":[35],"disease":[36],"state":[37],"treatment":[39],"effects.":[40],"Pathological":[41],"conditions":[42],"such":[43],"as":[44],"hypertension":[45],"(HTN)":[46],"alter":[47],"baroreflex":[48],"reduce":[51],"BRS.":[52],"Traditionally,":[53],"the":[54,64,85,88,106,109,146,153,158],"sequence":[55,89,96,138,148,160],"method":[56,97,113,139,161],"measure":[60],"BRS,":[61],"which":[63],"linear":[65],"slope":[66],"of":[67,87,108,124],"concomitant":[68],"changes":[69],"BP":[71,119],"RR":[73],"intervals":[74],"are":[75],"assessed.":[76],"However,":[77],"rats,":[79],"high":[81],"respiratory":[82],"rate":[83],"reduces":[84],"reliability":[86],"method.":[90],"Here,":[91],"we":[92],"present":[93],"modified":[95,137,159],"that":[98],"captures":[99],"BRS":[100,110,143,165],"at":[101],"lower":[102,142,164],"frequencies":[103],"decreases":[105],"variability":[107],"estimate.":[111],"This":[112],"was":[114],"demonstrated":[115],"using":[116],"ECG":[117],"data":[120,155],"from":[121],"two":[122],"groups":[123],"HTN":[125],"rats:":[126],"Sham":[127],"rats":[128,130],"treated":[131],"with":[132],"vagus":[133],"nerve":[134],"stimulation.":[135],"The":[136],"resulted":[140,162],"estimates":[144],"than":[145],"traditional":[147],"technique":[149],"when":[150],"applied":[151],"same":[154],"sets.":[156],"Additionally,":[157],"estimate":[166],"variability.":[167]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}