{"id":"https://openalex.org/W2898884735","doi":"https://doi.org/10.1109/embc.2018.8512613","title":"Frequency-Dependent Inhibition Induced by Stimulations in Rat Hippocampus","display_name":"Frequency-Dependent Inhibition Induced by Stimulations in Rat Hippocampus","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2898884735","doi":"https://doi.org/10.1109/embc.2018.8512613","mag":"2898884735","pmid":"https://pubmed.ncbi.nlm.nih.gov/30440837"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2018.8512613","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8512613","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100729550","display_name":"Chen Qiu","orcid":"https://orcid.org/0009-0000-7231-7777"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chen Qiu","raw_affiliation_strings":["Zhejiang University, Hangzhou, Zhejiang, CN"],"affiliations":[{"raw_affiliation_string":"Zhejiang University, Hangzhou, Zhejiang, CN","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023388890","display_name":"Zhouyan Feng","orcid":"https://orcid.org/0000-0003-4110-4239"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhouyan Feng","raw_affiliation_strings":["Zhejiang University, Hangzhou, Zhejiang, CN"],"affiliations":[{"raw_affiliation_string":"Zhejiang University, Hangzhou, Zhejiang, CN","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028849142","display_name":"Lvpiao Zheng","orcid":"https://orcid.org/0000-0003-0478-7034"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lvpiao Zheng","raw_affiliation_strings":["Zhejiang University, Hangzhou, Zhejiang, CN"],"affiliations":[{"raw_affiliation_string":"Zhejiang University, Hangzhou, Zhejiang, CN","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028204339","display_name":"Lu Huang","orcid":"https://orcid.org/0000-0003-0016-0111"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Huang","raw_affiliation_strings":["Zhejiang University, Hangzhou, Zhejiang, CN"],"affiliations":[{"raw_affiliation_string":"Zhejiang University, Hangzhou, Zhejiang, CN","institution_ids":["https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100729550"],"corresponding_institution_ids":["https://openalex.org/I76130692"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17763615,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":null,"first_page":"2182","last_page":"2185"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inhibitory-postsynaptic-potential","display_name":"Inhibitory postsynaptic potential","score":0.7560963034629822},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.7331767082214355},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6965115666389465},{"id":"https://openalex.org/keywords/orthodromic","display_name":"Orthodromic","score":0.6315727829933167},{"id":"https://openalex.org/keywords/hippocampal-formation","display_name":"Hippocampal formation","score":0.5700746774673462},{"id":"https://openalex.org/keywords/excitatory-postsynaptic-potential","display_name":"Excitatory postsynaptic potential","score":0.5641941428184509},{"id":"https://openalex.org/keywords/hippocampus","display_name":"Hippocampus","score":0.540578305721283},{"id":"https://openalex.org/keywords/pyramidal-cell","display_name":"Pyramidal cell","score":0.45776182413101196},{"id":"https://openalex.org/keywords/interneuron","display_name":"Interneuron","score":0.44256591796875},{"id":"https://openalex.org/keywords/deep-brain-stimulation","display_name":"Deep brain stimulation","score":0.41381925344467163},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.36166346073150635},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.29766350984573364},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.20748791098594666},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.12400171160697937}],"concepts":[{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.7560963034629822},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.7331767082214355},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6965115666389465},{"id":"https://openalex.org/C96376961","wikidata":"https://www.wikidata.org/wiki/Q7104520","display_name":"Orthodromic","level":3,"score":0.6315727829933167},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5700746774673462},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.5641941428184509},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.540578305721283},{"id":"https://openalex.org/C2778437258","wikidata":"https://www.wikidata.org/wiki/Q2116409","display_name":"Pyramidal cell","level":3,"score":0.45776182413101196},{"id":"https://openalex.org/C2779296341","wikidata":"https://www.wikidata.org/wiki/Q1500732","display_name":"Interneuron","level":3,"score":0.44256591796875},{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.41381925344467163},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36166346073150635},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29766350984573364},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20748791098594666},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12400171160697937},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056547","descriptor_name":"CA1 Region, Hippocampal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056547","descriptor_name":"CA1 Region, Hippocampal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056547","descriptor_name":"CA1 Region, Hippocampal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2018.8512613","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8512613","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:30440837","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30440837","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.75,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W644076287","https://openalex.org/W1970985512","https://openalex.org/W1973929174","https://openalex.org/W2015378456","https://openalex.org/W2015892563","https://openalex.org/W2017797517","https://openalex.org/W2024400089","https://openalex.org/W2024875626","https://openalex.org/W2025985508","https://openalex.org/W2027045997","https://openalex.org/W2051004303","https://openalex.org/W2091279154","https://openalex.org/W2092420754","https://openalex.org/W2150600497","https://openalex.org/W2166047785","https://openalex.org/W2588099107","https://openalex.org/W6663023011"],"related_works":["https://openalex.org/W2259195267","https://openalex.org/W2128108793","https://openalex.org/W1679118305","https://openalex.org/W1976262441","https://openalex.org/W2052191318","https://openalex.org/W4234955196","https://openalex.org/W1995971166","https://openalex.org/W1944255113","https://openalex.org/W4313020275","https://openalex.org/W2083868846"],"abstract_inverted_index":{"Deep":[0],"brain":[1,10],"stimulation":[2,79,192],"(DBS)":[3],"has":[4],"a":[5],"good":[6],"prospect":[7],"in":[8,34,60],"treating":[9],"diseases":[11],"such":[12],"as":[13,93],"epilepsy.":[14],"However,":[15,148],"its":[16],"therapeutic":[17],"mechanism":[18],"is":[19],"undetermined":[20],"yet.":[21],"To":[22],"investigate":[23],"the":[24,31,53,78,110,121,130,137,142,158,166,195,201,211],"inhibitory":[25,170],"effects":[26,171],"of":[27,40,56,65,96,107,114,141,160,172,187,197,213],"DBS":[28],"acting":[29],"on":[30,86,200],"downstream":[32,66],"neurons":[33],"target":[35],"region,":[36],"1-min":[37],"pulse":[38,105,131],"trains":[39],"orthodromic":[41],"stimulations":[42,103,151,177],"with":[43,104,152,178],"various":[44],"frequencies":[45,154,180],"(10":[46],"-":[47],"100":[48,135,183],"Hz)":[49],"were":[50,71,83,174],"applied":[51],"to":[52,134],"Schaffer":[54],"collaterals":[55],"hippocampal":[57],"CA1":[58],"region":[59],"anaesthetized":[61],"rats.":[62],"Unit":[63],"spikes":[64],"interneurons":[67,116,143,173,188],"and":[68,73,182],"pyramidal":[69,161],"cells":[70,162],"detected":[72],"analyzed.":[74],"Interneurons":[75],"activated":[76],"by":[77,165,190],"through":[80],"mono-synaptic":[81],"connections":[82],"recognized":[84],"based":[85],"short":[87],"latencies.":[88],"Their":[89],"firing":[90,112,139,159,186],"was":[91,117,163],"used":[92],"an":[94],"index":[95],"stimulation-induced":[97],"inhibition.":[98],"Results":[99],"showed":[100],"that":[101],"during":[102,123,150,176],"frequency":[106,132],"20":[108,156],"Hz,":[109,136],"mean":[111,138],"rate":[113,140],"mono-synaptically-activated":[115],"significantly":[118],"higher":[119,179],"than":[120],"value":[122],"10":[124],"Hz":[125],"stimulations.":[126],"Afterward,":[127],"even":[128],"if":[129],"increased":[133],"did":[144],"not":[145],"change":[146],"significantly.":[147],"only":[149],"lower":[153],"(10,":[155],"Hz),":[157],"suppressed":[164],"stimulation-activated":[167],"interneurons.":[168],"The":[169],"weakened":[175],"(50":[181],"Hz).":[184],"De-synchronous":[185],"induced":[189],"high-frequency":[191],"might":[193],"cause":[194],"loss":[196],"effective":[198],"inhibition":[199],"principal":[202],"neurons.":[203],"These":[204],"findings":[205],"provide":[206],"new":[207],"information":[208],"for":[209],"advancing":[210],"application":[212],"DBS.":[214]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
