{"id":"https://openalex.org/W2899006625","doi":"https://doi.org/10.1109/embc.2018.8512567","title":"Non-invasive method to monitor molecular changes in human stratum corneum during acute barrier disruption using reflectance NIR spectroscopy","display_name":"Non-invasive method to monitor molecular changes in human stratum corneum during acute barrier disruption using reflectance NIR spectroscopy","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2899006625","doi":"https://doi.org/10.1109/embc.2018.8512567","mag":"2899006625","pmid":"https://pubmed.ncbi.nlm.nih.gov/30440687"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2018.8512567","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8512567","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048791527","display_name":"Eui Seok Shin","orcid":null},"institutions":[{"id":"https://openalex.org/I2250650973","display_name":"Samsung (South Korea)","ror":"https://ror.org/04w3jy968","country_code":"KR","type":"company","lineage":["https://openalex.org/I2250650973"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eui Seok Shin","raw_affiliation_strings":["Samsung Electronics, Suwon, Gyeonggi-do, KR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samsung Electronics, Suwon, Gyeonggi-do, KR","institution_ids":["https://openalex.org/I2250650973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087653122","display_name":"June\u2010Young Lee","orcid":"https://orcid.org/0000-0002-6793-6108"},"institutions":[{"id":"https://openalex.org/I2250650973","display_name":"Samsung (South Korea)","ror":"https://ror.org/04w3jy968","country_code":"KR","type":"company","lineage":["https://openalex.org/I2250650973"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"June-Young Lee","raw_affiliation_strings":["Samsung Electronics, Suwon, Gyeonggi-do, KR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samsung Electronics, Suwon, Gyeonggi-do, KR","institution_ids":["https://openalex.org/I2250650973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100757276","display_name":"Seung\u2010Jun Lee","orcid":"https://orcid.org/0000-0002-9201-4818"},"institutions":[{"id":"https://openalex.org/I2250650973","display_name":"Samsung (South Korea)","ror":"https://ror.org/04w3jy968","country_code":"KR","type":"company","lineage":["https://openalex.org/I2250650973"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seung Jun Lee","raw_affiliation_strings":["Samsung Electronics, Suwon, Gyeonggi-do, KR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samsung Electronics, Suwon, Gyeonggi-do, KR","institution_ids":["https://openalex.org/I2250650973"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102011337","display_name":"Sung Hyun Nam","orcid":"https://orcid.org/0000-0002-9773-5649"},"institutions":[{"id":"https://openalex.org/I2250650973","display_name":"Samsung (South Korea)","ror":"https://ror.org/04w3jy968","country_code":"KR","type":"company","lineage":["https://openalex.org/I2250650973"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung Hyun Nam","raw_affiliation_strings":["Samsung Electronics, Suwon, Gyeonggi-do, KR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samsung Electronics, Suwon, Gyeonggi-do, KR","institution_ids":["https://openalex.org/I2250650973"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2071,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.4698063,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"28","issue":null,"first_page":"1542","last_page":"1545"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11386","display_name":"Bee Products Chemical Analysis","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stratum-corneum","display_name":"Stratum corneum","score":0.9961763620376587},{"id":"https://openalex.org/keywords/barrier-function","display_name":"Barrier function","score":0.6712312698364258},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5769761204719543},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.5365718603134155},{"id":"https://openalex.org/keywords/corneocyte","display_name":"Corneocyte","score":0.5035876631736755},{"id":"https://openalex.org/keywords/ceramide","display_name":"Ceramide","score":0.48237529397010803},{"id":"https://openalex.org/keywords/keratin","display_name":"Keratin","score":0.44856733083724976},{"id":"https://openalex.org/keywords/human-skin","display_name":"Human skin","score":0.42150625586509705},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.20165765285491943},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.16870641708374023},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.13434836268424988},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.10391083359718323},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.0932551920413971}],"concepts":[{"id":"https://openalex.org/C2778370115","wikidata":"https://www.wikidata.org/wiki/Q2038676","display_name":"Stratum corneum","level":2,"score":0.9961763620376587},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.6712312698364258},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5769761204719543},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5365718603134155},{"id":"https://openalex.org/C179927520","wikidata":"https://www.wikidata.org/wiki/Q5171590","display_name":"Corneocyte","level":3,"score":0.5035876631736755},{"id":"https://openalex.org/C2777851122","wikidata":"https://www.wikidata.org/wiki/Q424213","display_name":"Ceramide","level":3,"score":0.48237529397010803},{"id":"https://openalex.org/C81241287","wikidata":"https://www.wikidata.org/wiki/Q189474","display_name":"Keratin","level":2,"score":0.44856733083724976},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.42150625586509705},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20165765285491943},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16870641708374023},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13434836268424988},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.10391083359718323},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0932551920413971},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012871","descriptor_name":"Skin Diseases","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D012871","descriptor_name":"Skin Diseases","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D012871","descriptor_name":"Skin Diseases","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D019265","descriptor_name":"Spectroscopy, Near-Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019265","descriptor_name":"Spectroscopy, Near-Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019265","descriptor_name":"Spectroscopy, Near-Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2018.8512567","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8512567","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:30440687","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30440687","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5,"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1497705411","https://openalex.org/W1531982843","https://openalex.org/W1965982370","https://openalex.org/W1970375881","https://openalex.org/W1993882354","https://openalex.org/W2017738904","https://openalex.org/W2079085720","https://openalex.org/W2082729064","https://openalex.org/W2092883117","https://openalex.org/W2111040242","https://openalex.org/W2160736029","https://openalex.org/W2175960133","https://openalex.org/W2474553364","https://openalex.org/W2574306648","https://openalex.org/W2793147758","https://openalex.org/W3134986606","https://openalex.org/W4211145137","https://openalex.org/W6629532753","https://openalex.org/W6731870356"],"related_works":["https://openalex.org/W2419211612","https://openalex.org/W2071263468","https://openalex.org/W2030382923","https://openalex.org/W2027795748","https://openalex.org/W2969347887","https://openalex.org/W1531982843","https://openalex.org/W4322701231","https://openalex.org/W2017152972","https://openalex.org/W2072798835","https://openalex.org/W1986433217"],"abstract_inverted_index":{"Stratum":[0],"corneum":[1,15],"is":[2,16,48],"the":[3,34,39,106,128],"outer":[4],"most":[5],"part":[6],"of":[7,33,42,70,90,116,134],"skin":[8,20,53,72,78,202],"for":[9,97],"barrier":[10,40,54,81,111,121,149,162,206],"function.":[11],"Disorder":[12],"in":[13,38,56,59,77,127,142,153,169,185,191,211,216],"stratum":[14,43,60,143,171,192,217],"related":[17,130,204],"with":[18,131,140,205],"many":[19],"diseases":[21],"including":[22],"acne,":[23],"atopic":[24],"dermatitis":[25],"and":[26,100,137,167,188,213],"psoriasis.":[27],"In":[28,62],"developed":[29],"countries,":[30],"about":[31],"20%":[32],"population":[35],"has":[36],"disorder":[37,58],"function":[41,55],"corneum.":[44,61,144,172,193,218],"Adhesive":[45],"tape":[46,74],"stripping":[47],"a":[49],"method":[50,199],"to":[51,105,124,182,200],"disrupt":[52],"studying":[57],"this":[63],"study,":[64],"we":[65],"obtained":[66],"NIR":[67,154,177,194],"(Near-Infrared)":[68],"spectrum":[69,117],"human":[71,170],"after":[73,80],"stripping.":[75],"Changes":[76],"spectra":[79],"disruption":[82,122,150,163,207],"were":[83],"investigated":[84],"through":[85],"principal":[86],"component":[87],"analysis":[88,93],"(PCA)":[89],"spectrum.":[91,155],"PCA":[92],"revealed":[94,118,159],"that":[95,119,147,160,176],"peaks":[96],"-NH":[98],"stretching":[99],"-CH":[101],"vibration":[102],"mainly":[103],"contributed":[104],"spectral":[107,125,157],"variation":[108],"caused":[109],"by":[110,208],"disruption.":[112],"Furthermore,":[113],"second":[114],"derivative":[115],"acute":[120,148,161],"contributes":[123],"changes":[126,158,184],"region":[129],"secondary":[132],"structure":[133,190,215],"protein,":[135],"lipid":[136,141,214],"water":[138],"associated":[139],"We":[145],"demonstrated":[146],"affected":[151,164],"features":[152],"These":[156,173],"keratin":[165],"protein":[166,212],"ceramide":[168],"results":[174],"suggest":[175],"spectroscopy":[178,195],"can":[179,196],"be":[180],"used":[181],"monitor":[183],"filamentous":[186],"network":[187],"lamellar":[189],"provide":[197],"non-invasive":[198],"investigate":[201],"disease":[203],"monitoring":[209],"disturbance":[210]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}