{"id":"https://openalex.org/W2899143158","doi":"https://doi.org/10.1109/embc.2018.8512505","title":"Biomarkers for Adolescent MDD from Anatomical Connectivity and Network Topology Using Diffusion MRI","display_name":"Biomarkers for Adolescent MDD from Anatomical Connectivity and Network Topology Using Diffusion MRI","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2899143158","doi":"https://doi.org/10.1109/embc.2018.8512505","mag":"2899143158","pmid":"https://pubmed.ncbi.nlm.nih.gov/30440595"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2018.8512505","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8512505","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014228259","display_name":"Shu-Hsien Chu","orcid":"https://orcid.org/0000-0002-1585-4135"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shu-Hsien Chu","raw_affiliation_strings":["Dept. of Electrical & Computer Engineering, University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Electrical & Computer Engineering, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069089076","display_name":"Christophe Lenglet","orcid":"https://orcid.org/0000-0003-4646-3185"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christophe Lenglet","raw_affiliation_strings":["Dept. of Radiology, University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Radiology, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048745279","display_name":"Mindy Westlund Schreiner","orcid":"https://orcid.org/0000-0002-2780-3327"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mindy Westlund Schreiner","raw_affiliation_strings":["Dept. of Psychology, University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Psychology, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081652342","display_name":"Bonnie Klimes\u2010Dougan","orcid":"https://orcid.org/0000-0002-2107-0038"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bonnie Klimes-Dougan","raw_affiliation_strings":["Dept. of Psychology, University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Psychology, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003393701","display_name":"Kathryn R. Cullen","orcid":"https://orcid.org/0000-0001-9631-3770"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn Cullen","raw_affiliation_strings":["Dept. of Psychiatry, University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Psychiatry, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007884053","display_name":"Keshab K. Parhi","orcid":"https://orcid.org/0000-0001-6543-2793"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keshab K. Parhi","raw_affiliation_strings":["Dept. of Electrical & Computer Engineering, University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Electrical & Computer Engineering, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5014228259"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":null,"apc_paid":null,"fwci":0.5134,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.6493992,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"49","issue":null,"first_page":"1152","last_page":"1155"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insula","display_name":"Insula","score":0.6285347938537598},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"Major depressive disorder","score":0.5864226818084717},{"id":"https://openalex.org/keywords/bonferroni-correction","display_name":"Bonferroni correction","score":0.5114902257919312},{"id":"https://openalex.org/keywords/caudate-nucleus","display_name":"Caudate nucleus","score":0.4995565414428711},{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"Diffusion MRI","score":0.4522767663002014},{"id":"https://openalex.org/keywords/hippocampus","display_name":"Hippocampus","score":0.4405978322029114},{"id":"https://openalex.org/keywords/clustering-coefficient","display_name":"Clustering coefficient","score":0.4189167618751526},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.39349448680877686},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3805882930755615},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.34996217489242554},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.22929531335830688},{"id":"https://openalex.org/keywords/amygdala","display_name":"Amygdala","score":0.1943407654762268},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.18777018785476685},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.17146751284599304},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.15396103262901306},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1357572078704834},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.12115824222564697},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.09531497955322266}],"concepts":[{"id":"https://openalex.org/C104996578","wikidata":"https://www.wikidata.org/wiki/Q827617","display_name":"Insula","level":2,"score":0.6285347938537598},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.5864226818084717},{"id":"https://openalex.org/C127808970","wikidata":"https://www.wikidata.org/wiki/Q385989","display_name":"Bonferroni correction","level":2,"score":0.5114902257919312},{"id":"https://openalex.org/C2781423529","wikidata":"https://www.wikidata.org/wiki/Q1132309","display_name":"Caudate nucleus","level":2,"score":0.4995565414428711},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.4522767663002014},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4405978322029114},{"id":"https://openalex.org/C22047676","wikidata":"https://www.wikidata.org/wiki/Q898680","display_name":"Clustering coefficient","level":3,"score":0.4189167618751526},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39349448680877686},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3805882930755615},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.34996217489242554},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.22929531335830688},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.1943407654762268},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.18777018785476685},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.17146751284599304},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.15396103262901306},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1357572078704834},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.12115824222564697},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.09531497955322266}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Depressive Disorder, Major","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Depressive Disorder, Major","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2018.8512505","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8512505","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:30440595","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30440595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1964997677","https://openalex.org/W2003892612","https://openalex.org/W2018031501","https://openalex.org/W2035941098","https://openalex.org/W2036677044","https://openalex.org/W2037124948","https://openalex.org/W2069691026","https://openalex.org/W2074920686","https://openalex.org/W2098346662","https://openalex.org/W2107031757","https://openalex.org/W2112423489","https://openalex.org/W2121873218","https://openalex.org/W2122506124","https://openalex.org/W2144155852","https://openalex.org/W2167822639","https://openalex.org/W2281380552","https://openalex.org/W2300422661","https://openalex.org/W2479717569","https://openalex.org/W3046929799","https://openalex.org/W4210615620","https://openalex.org/W6659409887"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W3183948672","https://openalex.org/W3173606202","https://openalex.org/W3110381201","https://openalex.org/W2948807893","https://openalex.org/W2935909890","https://openalex.org/W2778153218","https://openalex.org/W2758277628","https://openalex.org/W1531601525","https://openalex.org/W3104290608"],"abstract_inverted_index":{"Due":[0],"to":[1,6,28,40,126,145,170,194,221],"the":[2,7,21,35,52,90,106,146,166,171,191,195,202,208],"high":[3],"resistance":[4],"(35%)":[5],"current":[8],"treatment":[9],"methods":[10],"in":[11,45,97,165,201,207,215],"adolescent":[12],"Major":[13],"Depressive":[14],"Disorder":[15],"(MDD)":[16],"and":[17,60,82,100,118,134,150,175,178,205,218],"its":[18],"tragic":[19],"outcomes,":[20],"discovery":[22],"of":[23,79,86,148,173],"treatmentrelated":[24],"responders":[25],"is":[26,38],"critical":[27],"developing":[29],"effective":[30],"treatments.":[31],"In":[32],"this":[33],"paper,":[34],"permutation":[36],"test":[37],"performed":[39],"identify":[41],"statistically":[42],"significant":[43,95],"changes":[44],"anatomical":[46,66,70,87],"characteristics":[47,67],"during":[48],"pairwise":[49],"comparisons":[50],"among":[51],"control":[53,149,174,196],"group":[54,58,63],"(n=27),":[55],"treated":[56,124,151,176],"MDD":[57,62],"(n=37),":[59],"untreated":[61,127,143,159],"(n=15).":[64],"The":[65],"include:":[68,111],"1)":[69,112],"connectivity":[71],"defined":[72],"using":[73],"DTI":[74],"metrics":[75],"between":[76],"a":[77,113,180],"pair":[78],"brain":[80],"regions,":[81],"2)":[83,129],"topological":[84],"measurements":[85],"networks.":[88],"With":[89],"Bonferroni":[91],"correction":[92],"for":[93,123,142,158,189],"multiple-comparison,":[94],"alterations":[96],"community":[98],"structure":[99],"local":[101,135],"topology":[102],"were":[103,211],"identified":[104],"as":[105],"p-value":[107],"<":[108],"5%,":[109],"which":[110],"reduced":[114],"nodal":[115],"centrality":[116],"(degree":[117],"strength)":[119],"on":[120,137,161,185],"right":[121,138,186,203],"hippocampus":[122],"compared":[125,144,169,193],"group,":[128],"an":[130,154],"elevated":[131],"clustering":[132],"coefficient":[133,157],"efficiency":[136],"lateral":[139],"orbitofrontal":[140],"cortex":[141,164],"combination":[147,172],"groups,":[152,177],"3)":[153],"increased":[155],"participation":[156],"patients":[160,192],"left":[162,209],"insula":[163],"meandiffusivity":[167],"network":[168],"4)":[179],"degraded":[181],"module":[182],"degree":[183],"z-score":[184],"caudate":[187],"nucleus":[188],"all":[190],"group.":[197],"Two":[198],"connections,":[199],"hippocampus-insula":[200],"hemisphere":[204],"parahippocampal-insula":[206],"hemisphere,":[210],"found":[212],"significantly":[213],"altered":[214],"TR,":[216],"AD,":[217],"FA":[219],"due":[220],"MDD.":[222]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2}],"updated_date":"2026-05-05T08:41:31.759640","created_date":"2025-10-10T00:00:00"}
