{"id":"https://openalex.org/W2898814639","doi":"https://doi.org/10.1109/embc.2018.8512433","title":"Confocal imaging of cytosolic Ca<sup>2+</sup> and fuzzy clustering reveal the circuit topology details underlying synchronization in hippocampal neurons","display_name":"Confocal imaging of cytosolic Ca<sup>2+</sup> and fuzzy clustering reveal the circuit topology details underlying synchronization in hippocampal neurons","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2898814639","doi":"https://doi.org/10.1109/embc.2018.8512433","mag":"2898814639","pmid":"https://pubmed.ncbi.nlm.nih.gov/30440518"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2018.8512433","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8512433","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110665292","display_name":"Sarpras Swain","orcid":"https://orcid.org/0000-0002-7431-1843"},"institutions":[{"id":"https://openalex.org/I68891433","display_name":"Indian Institute of Technology Delhi","ror":"https://ror.org/049tgcd06","country_code":"IN","type":"education","lineage":["https://openalex.org/I68891433"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sarpras Swain","raw_affiliation_strings":["Indian Institute of Technology Delhi, New Delhi, Delhi, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indian Institute of Technology Delhi, New Delhi, Delhi, IN","institution_ids":["https://openalex.org/I68891433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056870153","display_name":"Priyanka D. Pantula","orcid":null},"institutions":[{"id":"https://openalex.org/I68891433","display_name":"Indian Institute of Technology Delhi","ror":"https://ror.org/049tgcd06","country_code":"IN","type":"education","lineage":["https://openalex.org/I68891433"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Priyanka Devi Pantula","raw_affiliation_strings":["Indian Institute of Technology Delhi, New Delhi, Delhi, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indian Institute of Technology Delhi, New Delhi, Delhi, IN","institution_ids":["https://openalex.org/I68891433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084880581","display_name":"Kishalay Mitra","orcid":"https://orcid.org/0000-0001-5660-6878"},"institutions":[{"id":"https://openalex.org/I68891433","display_name":"Indian Institute of Technology Delhi","ror":"https://ror.org/049tgcd06","country_code":"IN","type":"education","lineage":["https://openalex.org/I68891433"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kishalay Mitra","raw_affiliation_strings":["Indian Institute of Technology Delhi, New Delhi, Delhi, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indian Institute of Technology Delhi, New Delhi, Delhi, IN","institution_ids":["https://openalex.org/I68891433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035016811","display_name":"Lopamudra Giri","orcid":"https://orcid.org/0000-0002-2352-7919"},"institutions":[{"id":"https://openalex.org/I68891433","display_name":"Indian Institute of Technology Delhi","ror":"https://ror.org/049tgcd06","country_code":"IN","type":"education","lineage":["https://openalex.org/I68891433"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Lopamudra Giri","raw_affiliation_strings":["Indian Institute of Technology Delhi, New Delhi, Delhi, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indian Institute of Technology Delhi, New Delhi, Delhi, IN","institution_ids":["https://openalex.org/I68891433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I68891433"],"apc_list":null,"apc_paid":null,"fwci":0.8876,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.71387231,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2018","issue":null,"first_page":"822","last_page":"825"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synchronicity","display_name":"Synchronicity","score":0.7291146516799927},{"id":"https://openalex.org/keywords/confocal","display_name":"Confocal","score":0.6540439128875732},{"id":"https://openalex.org/keywords/hippocampal-formation","display_name":"Hippocampal formation","score":0.5942649841308594},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.577503502368927},{"id":"https://openalex.org/keywords/synchronization","display_name":"Synchronization (alternating current)","score":0.5681326985359192},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.517173707485199},{"id":"https://openalex.org/keywords/network-topology","display_name":"Network topology","score":0.5053625702857971},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.48661932349205017},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.4716426730155945},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4574089050292969},{"id":"https://openalex.org/keywords/confocal-microscopy","display_name":"Confocal microscopy","score":0.4258020222187042},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.39679017663002014},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.31213057041168213},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.31201308965682983},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2585292160511017},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.1920415461063385},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.1259092390537262},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.09516316652297974},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.07845678925514221}],"concepts":[{"id":"https://openalex.org/C161394823","wikidata":"https://www.wikidata.org/wiki/Q1121101","display_name":"Synchronicity","level":2,"score":0.7291146516799927},{"id":"https://openalex.org/C136009344","wikidata":"https://www.wikidata.org/wiki/Q336201","display_name":"Confocal","level":2,"score":0.6540439128875732},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5942649841308594},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.577503502368927},{"id":"https://openalex.org/C2778562939","wikidata":"https://www.wikidata.org/wiki/Q1298791","display_name":"Synchronization (alternating current)","level":3,"score":0.5681326985359192},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.517173707485199},{"id":"https://openalex.org/C199845137","wikidata":"https://www.wikidata.org/wiki/Q145490","display_name":"Network topology","level":2,"score":0.5053625702857971},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.48661932349205017},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4716426730155945},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4574089050292969},{"id":"https://openalex.org/C2779178360","wikidata":"https://www.wikidata.org/wiki/Q902045","display_name":"Confocal microscopy","level":2,"score":0.4258020222187042},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.39679017663002014},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31213057041168213},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.31201308965682983},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2585292160511017},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1920415461063385},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.1259092390537262},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.09516316652297974},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.07845678925514221},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C11171543","wikidata":"https://www.wikidata.org/wiki/Q41630","display_name":"Psychoanalysis","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013702","descriptor_name":"Temporal Lobe","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013702","descriptor_name":"Temporal Lobe","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013702","descriptor_name":"Temporal Lobe","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2018.8512433","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8512433","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:30440518","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30440518","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1505739666","https://openalex.org/W1986246844","https://openalex.org/W2005989378","https://openalex.org/W2048639740","https://openalex.org/W2112601177","https://openalex.org/W2135266824","https://openalex.org/W2139604281","https://openalex.org/W2167638481","https://openalex.org/W2185212694","https://openalex.org/W2295306763"],"related_works":["https://openalex.org/W2726111829","https://openalex.org/W2008049857","https://openalex.org/W2056668469","https://openalex.org/W4250585504","https://openalex.org/W2105513520","https://openalex.org/W1978803831","https://openalex.org/W2999303294","https://openalex.org/W2580002495","https://openalex.org/W82035557","https://openalex.org/W1539232953"],"abstract_inverted_index":{"Neuronal":[0],"synchronization":[1],"contributes":[2],"to":[3,13,72],"various":[4,14],"cognitive":[5],"functions":[6],"and":[7,42,106,112],"disruption":[8],"in":[9,37,118],"synchronicity":[10,20,43,93,121],"may":[11],"lead":[12],"diseased":[15],"conditions.":[16],"However,":[17],"measurement":[18],"of":[19,34,52,57,80,87,98,122],"at":[21],"a":[22,78],"higher":[23],"spatial":[24],"resolution":[25],"remains":[26,44],"challenging.":[27],"Specifically,":[28],"investigation":[29],"on":[30],"understanding":[31],"the":[32,39,63,67,74,88,92,99,120,123],"role":[33,117],"network":[35,40],"topology":[36,113],"tuning":[38,119],"activity":[41],"sparse.":[45],"In":[46,70],"this":[47],"context,":[48],"we":[49,83],"propose":[50],"imaging":[51,105],"intracellular":[53],"Ca2+in":[54],"primary":[55],"cultures":[56],"hippocampal":[58],"neurons":[59],"using":[60,66],"Fluo-4":[61],"as":[62],"fluorescent":[64],"indicator":[65],"confocal":[68],"microscope.":[69],"order":[71],"identify":[73],"synchronous":[75],"response":[76],"from":[77],"set":[79],"heterogeneous":[81],"Ca2+spiking,":[82],"present":[84],"fuzzy":[85],"clustering":[86],"oscillatory":[89],"responses.":[90],"Further,":[91],"was":[94],"measured":[95],"through":[96],"evaluation":[97],"correlation":[100],"between":[101],"Ca2+spiking":[102],"trends.":[103],"Confocal":[104],"analysis":[107],"show":[108],"that":[109],"neuronal":[110,124],"connectivity":[111],"play":[114],"an":[115],"essential":[116],"network.":[125]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}