{"id":"https://openalex.org/W2899450342","doi":"https://doi.org/10.1109/embc.2018.8512372","title":"A Novel Multimodal MRI Analysis for Alzheimer's Disease Based on Convolutional Neural Network","display_name":"A Novel Multimodal MRI Analysis for Alzheimer's Disease Based on Convolutional Neural Network","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2899450342","doi":"https://doi.org/10.1109/embc.2018.8512372","mag":"2899450342","pmid":"https://pubmed.ncbi.nlm.nih.gov/30440505"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2018.8512372","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8512372","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100322712","display_name":"Yan Wang","orcid":"https://orcid.org/0000-0002-5344-1884"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan Wang","raw_affiliation_strings":["Harbin Institute of Technology, Harbin, Heilongjiang, CN"],"affiliations":[{"raw_affiliation_string":"Harbin Institute of Technology, Harbin, Heilongjiang, CN","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029228576","display_name":"Yanwu Yang","orcid":"https://orcid.org/0000-0002-7547-4580"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanwu Yang","raw_affiliation_strings":["Harbin Institute of Technology, Harbin, Heilongjiang, CN"],"affiliations":[{"raw_affiliation_string":"Harbin Institute of Technology, Harbin, Heilongjiang, CN","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100638371","display_name":"Xin Guo","orcid":"https://orcid.org/0000-0002-7273-9387"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Guo","raw_affiliation_strings":["Harbin Institute of Technology, Harbin, Heilongjiang, CN"],"affiliations":[{"raw_affiliation_string":"Harbin Institute of Technology, Harbin, Heilongjiang, CN","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021063919","display_name":"Chenfei Ye","orcid":"https://orcid.org/0000-0001-5265-3546"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenfei Ye","raw_affiliation_strings":["Harbin Institute of Technology, Harbin, Heilongjiang, CN"],"affiliations":[{"raw_affiliation_string":"Harbin Institute of Technology, Harbin, Heilongjiang, CN","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043886610","display_name":"Na Gao","orcid":"https://orcid.org/0000-0002-1831-8354"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Na Gao","raw_affiliation_strings":["Harbin Institute of Technology, Harbin, Heilongjiang, CN"],"affiliations":[{"raw_affiliation_string":"Harbin Institute of Technology, Harbin, Heilongjiang, CN","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049269998","display_name":"Yuan Fang","orcid":"https://orcid.org/0000-0002-0363-6050"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Fang","raw_affiliation_strings":["Harbin Institute of Technology, Harbin, Heilongjiang, CN"],"affiliations":[{"raw_affiliation_string":"Harbin Institute of Technology, Harbin, Heilongjiang, CN","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009763761","display_name":"T. Heather","orcid":null},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Heather T. Ma","raw_affiliation_strings":["Harbin Institute of Technology, Harbin, Heilongjiang, CN"],"affiliations":[{"raw_affiliation_string":"Harbin Institute of Technology, Harbin, Heilongjiang, CN","institution_ids":["https://openalex.org/I204983213"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5100322712"],"corresponding_institution_ids":["https://openalex.org/I204983213"],"apc_list":null,"apc_paid":null,"fwci":1.6049,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.82839221,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"2018","issue":null,"first_page":"754","last_page":"757"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9921000003814697,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.8487458229064941},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7486897706985474},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.7314199209213257},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.5525436997413635},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.5427373647689819},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.5297542214393616},{"id":"https://openalex.org/keywords/functional-magnetic-resonance-imaging","display_name":"Functional magnetic resonance imaging","score":0.4980347156524658},{"id":"https://openalex.org/keywords/kernel","display_name":"Kernel (algebra)","score":0.464288592338562},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.38044488430023193},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.09263524413108826},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.07742992043495178}],"concepts":[{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.8487458229064941},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7486897706985474},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.7314199209213257},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5525436997413635},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.5427373647689819},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5297542214393616},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.4980347156524658},{"id":"https://openalex.org/C74193536","wikidata":"https://www.wikidata.org/wiki/Q574844","display_name":"Kernel (algebra)","level":2,"score":0.464288592338562},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.38044488430023193},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09263524413108826},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.07742992043495178},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064847","descriptor_name":"Multimodal Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064847","descriptor_name":"Multimodal Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064847","descriptor_name":"Multimodal Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2018.8512372","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8512372","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:30440505","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30440505","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1483555958","https://openalex.org/W1535448720","https://openalex.org/W1586771686","https://openalex.org/W1714729838","https://openalex.org/W1910109443","https://openalex.org/W2007572953","https://openalex.org/W2057550180","https://openalex.org/W2098120923","https://openalex.org/W2106396500","https://openalex.org/W2118323338","https://openalex.org/W2138991775","https://openalex.org/W2162615325","https://openalex.org/W2513024842","https://openalex.org/W2580003478","https://openalex.org/W2601947521","https://openalex.org/W2753190710","https://openalex.org/W2755518529","https://openalex.org/W3014251530"],"related_works":["https://openalex.org/W4375867731","https://openalex.org/W2611989081","https://openalex.org/W4321487865","https://openalex.org/W4313906399","https://openalex.org/W3021493803","https://openalex.org/W2257755506","https://openalex.org/W4226493464","https://openalex.org/W3133861977","https://openalex.org/W2951211570","https://openalex.org/W3103566983"],"abstract_inverted_index":{"Recent":[0],"years,":[1],"Alzheimer's":[2],"disease":[3],"(AD)":[4],"has":[5],"become":[6],"a":[7,22,42,76,115,158,193],"significant":[8],"threat":[9],"to":[10,32,56,121,191],"human":[11,96],"health":[12],"while":[13],"the":[14,34,48,95,109,123,165],"accurate":[15],"screening":[16,70],"and":[17,39,71,126,135,156,173],"diagnosis":[18],"of":[19,36,141,169],"AD":[20,69],"remain":[21],"tough":[23],"problem.":[24],"Multimodal":[25],"Magnetic":[26],"resonance":[27],"imaging":[28],"(MRI)":[29],"can":[30,53],"help":[31],"identify":[33],"variation":[35],"brain":[37,97],"function":[38],"structure":[40],"in":[41,145],"non-invasive":[43],"way.":[44],"Deep":[45],"learning,":[46],"especially":[47],"convolutional":[49],"neural":[50],"networks":[51],"(CNN),":[52],"be":[54],"utilized":[55],"automatically":[57],"detect":[58],"appropriate":[59],"features":[60],"for":[61,67,88,112,195],"classification,":[62],"which":[63,84,187],"is":[64,85,188],"well":[65],"adapted":[66],"computer-aided":[68],"identification.":[72],"This":[73],"paper":[74],"proposed":[75,120],"multimodal":[77,104,149,182,196],"MRI":[78,91,105,150,183,197],"analytical":[79],"method":[80,143],"based":[81],"on":[82],"CNN,":[83],"also":[86],"suitable":[87],"single":[89],"type":[90],"data":[92,111,184,198],"analysis.":[93,199],"First,":[94],"network":[98,124],"connectivity":[99],"matrix":[100,125],"were":[101],"extracted":[102],"from":[103],"data,":[106],"used":[107],"as":[108,176,178,185],"input":[110],"CNN.":[113],"Then":[114],"novel":[116],"CNN":[117,153],"framework":[118],"was":[119,175],"process":[122],"classify":[127],"AD,":[128,170],"amnestic":[129],"mild":[130],"cognitive":[131],"impairment":[132],"(aMCI)":[133],"patients":[134,172],"normal":[136],"controls":[137],"(NC).":[138],"The":[139],"advantage":[140],"this":[142],"lies":[144],"that":[146],"we":[147],"combined":[148],"information":[151],"through":[152],"convolution":[154],"kernel,":[155],"achieved":[157],"higher":[159],"classification":[160,167],"accuracy.":[161],"In":[162],"our":[163],"experiments,":[164],"comprehensive":[166],"accuracy":[168],"aMCI":[171],"NC":[174],"high":[177],"92.06%":[179],"when":[180],"using":[181],"input,":[186],"effective":[189],"enough":[190],"provide":[192],"reference":[194]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}