{"id":"https://openalex.org/W2899208160","doi":"https://doi.org/10.1109/embc.2018.8512361","title":"A Framework for Automatic Recognition of Cell Damage on Microscopic Images using Artificial Neural Networks","display_name":"A Framework for Automatic Recognition of Cell Damage on Microscopic Images using Artificial Neural Networks","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2899208160","doi":"https://doi.org/10.1109/embc.2018.8512361","mag":"2899208160","pmid":"https://pubmed.ncbi.nlm.nih.gov/30440477"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2018.8512361","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8512361","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006958936","display_name":"Mirayr Raul Quadros de Souza","orcid":null},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mirayr R. Q. de Souza","raw_affiliation_strings":["Electrical Engineering Graduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electrical Engineering Graduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031330481","display_name":"Raphael Ruschel","orcid":null},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Raphael Ruschel","raw_affiliation_strings":["Electrical Engineering Graduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electrical Engineering Graduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043190662","display_name":"Altamiro Susin","orcid":"https://orcid.org/0000-0001-7034-5336"},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"A. Susin","raw_affiliation_strings":["Electrical Engineering Graduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electrical Engineering Graduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025115305","display_name":"Jane Marlei Boeira","orcid":"https://orcid.org/0000-0002-5825-3874"},"institutions":[{"id":"https://openalex.org/I4210112140","display_name":"Universidade Estadual do Rio Grande do Sul","ror":"https://ror.org/01vxwy461","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210112140"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"J. M. Boeira","raw_affiliation_strings":["Department of Biology, Universidade Estadual do Rio Grande do Sul, Guaiba, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Universidade Estadual do Rio Grande do Sul, Guaiba, Brazil","institution_ids":["https://openalex.org/I4210112140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071731425","display_name":"Leticia V. Guimares","orcid":null},"institutions":[{"id":"https://openalex.org/I4210112140","display_name":"Universidade Estadual do Rio Grande do Sul","ror":"https://ror.org/01vxwy461","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210112140"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Leticia V. Guimares","raw_affiliation_strings":["Department of Computer Engineering, Universidade Estadual do Rio Grande do Sul, Guaiba, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Engineering, Universidade Estadual do Rio Grande do Sul, Guaiba, Brazil","institution_ids":["https://openalex.org/I4210112140"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066168430","display_name":"Adriane Parraga","orcid":"https://orcid.org/0000-0002-0924-0815"},"institutions":[{"id":"https://openalex.org/I4210112140","display_name":"Universidade Estadual do Rio Grande do Sul","ror":"https://ror.org/01vxwy461","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210112140"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"A. Parraga","raw_affiliation_strings":["Department of Computer Engineering, Universidade Estadual do Rio Grande do Sul, Guaiba, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Engineering, Universidade Estadual do Rio Grande do Sul, Guaiba, Brazil","institution_ids":["https://openalex.org/I4210112140"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2374,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.73806296,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2018","issue":null,"first_page":"636","last_page":"639"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.9277999997138977,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9251999855041504,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.7425956726074219},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7081547975540161},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.6062676310539246},{"id":"https://openalex.org/keywords/feature-extraction","display_name":"Feature extraction","score":0.5951212644577026},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.5836880207061768},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.5695753693580627},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.5340942740440369},{"id":"https://openalex.org/keywords/image-processing","display_name":"Image processing","score":0.5324863791465759},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.4810533821582794},{"id":"https://openalex.org/keywords/digital-image","display_name":"Digital image","score":0.47506827116012573},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.4632689952850342},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.4583129584789276},{"id":"https://openalex.org/keywords/digital-image-analysis","display_name":"Digital image analysis","score":0.4449726641178131},{"id":"https://openalex.org/keywords/field","display_name":"Field (mathematics)","score":0.4186170697212219},{"id":"https://openalex.org/keywords/digital-image-processing","display_name":"Digital image processing","score":0.4112110733985901},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.32978472113609314}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.7425956726074219},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7081547975540161},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.6062676310539246},{"id":"https://openalex.org/C52622490","wikidata":"https://www.wikidata.org/wiki/Q1026626","display_name":"Feature extraction","level":2,"score":0.5951212644577026},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.5836880207061768},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.5695753693580627},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5340942740440369},{"id":"https://openalex.org/C9417928","wikidata":"https://www.wikidata.org/wiki/Q1070689","display_name":"Image processing","level":3,"score":0.5324863791465759},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.4810533821582794},{"id":"https://openalex.org/C42781572","wikidata":"https://www.wikidata.org/wiki/Q1250322","display_name":"Digital image","level":4,"score":0.47506827116012573},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.4632689952850342},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.4583129584789276},{"id":"https://openalex.org/C2909954168","wikidata":"https://www.wikidata.org/wiki/Q860755","display_name":"Digital image analysis","level":2,"score":0.4449726641178131},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.4186170697212219},{"id":"https://openalex.org/C104317675","wikidata":"https://www.wikidata.org/wiki/Q1070689","display_name":"Digital image processing","level":4,"score":0.4112110733985901},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.32978472113609314},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008974","descriptor_name":"Mollusca","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008974","descriptor_name":"Mollusca","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008974","descriptor_name":"Mollusca","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020552","descriptor_name":"Comet Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020552","descriptor_name":"Comet Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020552","descriptor_name":"Comet Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2018.8512361","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8512361","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:30440477","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30440477","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W230130932","https://openalex.org/W1522301498","https://openalex.org/W1976921333","https://openalex.org/W1993771267","https://openalex.org/W2034485370","https://openalex.org/W2122959256","https://openalex.org/W2140311754","https://openalex.org/W2414911872","https://openalex.org/W2495920728","https://openalex.org/W2563686712","https://openalex.org/W2963623381"],"related_works":["https://openalex.org/W2356087891","https://openalex.org/W3036827782","https://openalex.org/W1504972346","https://openalex.org/W2348439329","https://openalex.org/W2553152692","https://openalex.org/W2951194758","https://openalex.org/W2183514925","https://openalex.org/W2120108081","https://openalex.org/W2080625741","https://openalex.org/W1997609524"],"abstract_inverted_index":{"Despite":[0],"several":[1,30],"technological":[2],"advances":[3],"in":[4,18,42,104,133],"the":[5,8,113,126,137,148],"past":[6],"years,":[7],"vast":[9],"majority":[10],"of":[11,73,99,128,150,164,181],"microscopy":[12],"examinations":[13],"continue":[14],"to":[15,28,32,39,64,87,94,125,135,174],"be":[16,175],"performed":[17],"a":[19,70,82,105,155,160],"very":[20],"laborious,":[21],"time-consuming":[22],"manner,":[23],"requiring":[24],"highly":[25],"experienced":[26],"personnel":[27],"spend":[29],"hours":[31],"visually":[33],"examine":[34],"each":[35],"microscope":[36],"slide.":[37],"Due":[38],"recent":[40],"improvements":[41],"modern":[43],"Digital":[44],"Image":[45],"Processing,":[46],"professionals":[47],"that":[48,58],"work":[49],"on":[50],"microscopic":[51],"exams":[52],"could":[53],"benefit":[54],"from":[55],"new":[56],"tools":[57],"can":[59],"apply":[60],"image":[61,75],"processing":[62],"possibilities":[63],"their":[65],"specific":[66],"field.":[67],"We":[68],"propose":[69],"framework":[71,91,172],"consisting":[72],"an":[74,178],"segmentation":[76],"stage,":[77],"feature":[78],"extraction,":[79],"and":[80,146,162],"then":[81],"Shallow":[83],"Neural":[84],"Network":[85],"related":[86],"human":[88],"perception.":[89],"The":[90,108],"is":[92],"used":[93,111,154],"classify":[95],"among":[96],"5":[97],"types":[98],"animal":[100],"cell":[101],"damage":[102,139],"analyzed":[103],"case":[106,109],"study.":[107],"study":[110],"applies":[112],"Single":[114],"Cell":[115],"Gel":[116],"Electrophoresis":[117],"assay":[118],"(SCGE,":[119],"also":[120],"known":[121],"as":[122],"comet":[123],"assay)":[124],"cells":[127],"land":[129],"mollusk":[130],"Helix":[131],"aspersa":[132],"order":[134],"measure":[136],"DNA":[138],"caused":[140],"by":[141,159],"mutagenic":[142],"agents.":[143],"To":[144],"train":[145],"analyze":[147],"performance":[149],"our":[151],"approach,":[152],"we":[153],"dataset":[156],"manually":[157],"segmented":[158],"biologist":[161],"comprised":[163],"130":[165],"slide":[166],"samples":[167],"with":[168],"labeled":[169],"cells.":[170],"Our":[171],"proved":[173],"robust,":[176],"achieving":[177],"average":[179],"accuracy":[180],"88.3%.":[182]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}