{"id":"https://openalex.org/W2899146308","doi":"https://doi.org/10.1109/embc.2018.8512330","title":"Closed-loop administration of analgesic drugs based on heart rate variability analysis","display_name":"Closed-loop administration of analgesic drugs based on heart rate variability analysis","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2899146308","doi":"https://doi.org/10.1109/embc.2018.8512330","mag":"2899146308","pmid":"https://pubmed.ncbi.nlm.nih.gov/30440445"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2018.8512330","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8512330","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045763091","display_name":"Julien De Jonckheere","orcid":"https://orcid.org/0000-0002-3727-9434"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210090627","display_name":"Lille\u2019s Cardiology Hospital","ror":"https://ror.org/000z46s85","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406","https://openalex.org/I4210090627"]},{"id":"https://openalex.org/I4210150021","display_name":"Centre d'Investigation Clinique - Innovation Technologique","ror":"https://ror.org/04fmayc82","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210150021"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J. De jonckheere","raw_affiliation_strings":["INSERM CIC 1403, University Hospital of Lille, Maison R\u00e9gionale de la Recherche Clinique, 2 avenue Oscar Lambret 59037 Lille Cedex, france","CIC Lille - Centre d'Investigation Clinique - Innovation Technologique de Lille - CIC 1403 - CIC 9301 (CIC-IT Evalab -- H\u00f4pital Cardiologique - Boulevard du Professeur Jules Leclercq - 59037 Lille Cedex - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM CIC 1403, University Hospital of Lille, Maison R\u00e9gionale de la Recherche Clinique, 2 avenue Oscar Lambret 59037 Lille Cedex, france","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"CIC Lille - Centre d'Investigation Clinique - Innovation Technologique de Lille - CIC 1403 - CIC 9301 (CIC-IT Evalab -- H\u00f4pital Cardiologique - Boulevard du Professeur Jules Leclercq - 59037 Lille Cedex - France)","institution_ids":["https://openalex.org/I4210150021","https://openalex.org/I4210090627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054172823","display_name":"Mathieu Jeanne","orcid":"https://orcid.org/0000-0002-3400-5788"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210090627","display_name":"Lille\u2019s Cardiology Hospital","ror":"https://ror.org/000z46s85","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406","https://openalex.org/I4210090627"]},{"id":"https://openalex.org/I4210150021","display_name":"Centre d'Investigation Clinique - Innovation Technologique","ror":"https://ror.org/04fmayc82","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210150021"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M. Jeanne","raw_affiliation_strings":["INSERM CIC 1403, University Hospital of Lille, Maison R\u00e9gionale de la Recherche Clinique, 2 avenue Oscar Lambret 59037 Lille Cedex, france","CIC Lille - Centre d'Investigation Clinique - Innovation Technologique de Lille - CIC 1403 - CIC 9301 (CIC-IT Evalab -- H\u00f4pital Cardiologique - Boulevard du Professeur Jules Leclercq - 59037 Lille Cedex - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM CIC 1403, University Hospital of Lille, Maison R\u00e9gionale de la Recherche Clinique, 2 avenue Oscar Lambret 59037 Lille Cedex, france","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"CIC Lille - Centre d'Investigation Clinique - Innovation Technologique de Lille - CIC 1403 - CIC 9301 (CIC-IT Evalab -- H\u00f4pital Cardiologique - Boulevard du Professeur Jules Leclercq - 59037 Lille Cedex - France)","institution_ids":["https://openalex.org/I4210150021","https://openalex.org/I4210090627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041336755","display_name":"A. Keribedj","orcid":null},"institutions":[{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A. Keribedj","raw_affiliation_strings":["Institut Lillois d\u2019Ing\u00e8nieurie de la Sant\u00e8 Lille 2 University","Universit\u00e9 de Lille (EPE Universit\u00e9 de Lille. -- 42 rue Paul Duez, 59000 Lille - France)","Institut Lillois d'Ing\u00e8nieurie de la Sant\u00e8 Lille 2 University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Lillois d\u2019Ing\u00e8nieurie de la Sant\u00e8 Lille 2 University","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 de Lille (EPE Universit\u00e9 de Lille. -- 42 rue Paul Duez, 59000 Lille - France)","institution_ids":["https://openalex.org/I2279609970"]},{"raw_affiliation_string":"Institut Lillois d'Ing\u00e8nieurie de la Sant\u00e8 Lille 2 University","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110326750","display_name":"Michel Delecroix","orcid":null},"institutions":[{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"funder","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210101212","display_name":"H\u00f4pital Roger Salengro","ror":"https://ror.org/0165ax130","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406","https://openalex.org/I4210101212"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M. Delecroix","raw_affiliation_strings":["Pole d\u2019anesth\u2019\u00e8sie r\u00e8animation, Hopital Roger Salengro, University Hospital of Lille, 2 avenue Oscar Lambret","CHRU Lille - Centre Hospitalier R\u00e9gional Universitaire [CHU Lille] (CHU/CHRU Lille - 2, avenue Oscar Lambret - 59037 Lille Cedex - France)","Pole d'anesth'\u00e8sie r\u00e8animation, Hopital Roger Salengro, University Hospital of Lille, 2 avenue Oscar Lambret"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pole d\u2019anesth\u2019\u00e8sie r\u00e8animation, Hopital Roger Salengro, University Hospital of Lille, 2 avenue Oscar Lambret","institution_ids":["https://openalex.org/I4210101212"]},{"raw_affiliation_string":"CHRU Lille - Centre Hospitalier R\u00e9gional Universitaire [CHU Lille] (CHU/CHRU Lille - 2, avenue Oscar Lambret - 59037 Lille Cedex - France)","institution_ids":["https://openalex.org/I3018718406"]},{"raw_affiliation_string":"Pole d'anesth'\u00e8sie r\u00e8animation, Hopital Roger Salengro, University Hospital of Lille, 2 avenue Oscar Lambret","institution_ids":["https://openalex.org/I4210101212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060210841","display_name":"R. Logier","orcid":null},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210090627","display_name":"Lille\u2019s Cardiology Hospital","ror":"https://ror.org/000z46s85","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406","https://openalex.org/I4210090627"]},{"id":"https://openalex.org/I4210150021","display_name":"Centre d'Investigation Clinique - Innovation Technologique","ror":"https://ror.org/04fmayc82","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210150021"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"R. Logier.","raw_affiliation_strings":["INSERM CIC 1403, University Hospital of Lille, Maison R\u00e9gionale de la Recherche Clinique, 2 avenue Oscar Lambret 59037 Lille Cedex, france","CIC Lille - Centre d'Investigation Clinique - Innovation Technologique de Lille - CIC 1403 - CIC 9301 (CIC-IT Evalab -- H\u00f4pital Cardiologique - Boulevard du Professeur Jules Leclercq - 59037 Lille Cedex - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM CIC 1403, University Hospital of Lille, Maison R\u00e9gionale de la Recherche Clinique, 2 avenue Oscar Lambret 59037 Lille Cedex, france","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"CIC Lille - Centre d'Investigation Clinique - Innovation Technologique de Lille - CIC 1403 - CIC 9301 (CIC-IT Evalab -- H\u00f4pital Cardiologique - Boulevard du Professeur Jules Leclercq - 59037 Lille Cedex - France)","institution_ids":["https://openalex.org/I4210150021","https://openalex.org/I4210090627"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4858,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.82229465,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"17","issue":null,"first_page":"506","last_page":"509"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9779000282287598,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/analgesic","display_name":"Analgesic","score":0.7725672125816345},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.6018463373184204},{"id":"https://openalex.org/keywords/heart-rate","display_name":"Heart rate","score":0.6015021204948425},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5790884494781494},{"id":"https://openalex.org/keywords/bispectral-index","display_name":"Bispectral index","score":0.5093885064125061},{"id":"https://openalex.org/keywords/anesthetic","display_name":"Anesthetic","score":0.48364269733428955},{"id":"https://openalex.org/keywords/closed-loop","display_name":"Closed loop","score":0.48341357707977295},{"id":"https://openalex.org/keywords/hypnotic","display_name":"Hypnotic","score":0.4573165774345398},{"id":"https://openalex.org/keywords/hypnosis","display_name":"Hypnosis","score":0.418569952249527},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.32174837589263916},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"Blood pressure","score":0.2562474012374878},{"id":"https://openalex.org/keywords/propofol","display_name":"Propofol","score":0.25351017713546753},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.08775901794433594},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.06761470437049866},{"id":"https://openalex.org/keywords/control-engineering","display_name":"Control engineering","score":0.06295850872993469}],"concepts":[{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.7725672125816345},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6018463373184204},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.6015021204948425},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5790884494781494},{"id":"https://openalex.org/C2781097354","wikidata":"https://www.wikidata.org/wiki/Q4918396","display_name":"Bispectral index","level":3,"score":0.5093885064125061},{"id":"https://openalex.org/C2778162923","wikidata":"https://www.wikidata.org/wiki/Q4990531","display_name":"Anesthetic","level":2,"score":0.48364269733428955},{"id":"https://openalex.org/C3019251811","wikidata":"https://www.wikidata.org/wiki/Q5135346","display_name":"Closed loop","level":2,"score":0.48341357707977295},{"id":"https://openalex.org/C2780930544","wikidata":"https://www.wikidata.org/wiki/Q62962","display_name":"Hypnotic","level":2,"score":0.4573165774345398},{"id":"https://openalex.org/C514803892","wikidata":"https://www.wikidata.org/wiki/Q8609","display_name":"Hypnosis","level":3,"score":0.418569952249527},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32174837589263916},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2562474012374878},{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.25351017713546753},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08775901794433594},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06761470437049866},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.06295850872993469},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000698","descriptor_name":"Analgesia","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000698","descriptor_name":"Analgesia","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000698","descriptor_name":"Analgesia","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000768","descriptor_name":"Anesthesia, General","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000768","descriptor_name":"Anesthesia, General","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000768","descriptor_name":"Anesthesia, General","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008991","descriptor_name":"Monitoring, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008991","descriptor_name":"Monitoring, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008991","descriptor_name":"Monitoring, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059225","descriptor_name":"Nociception","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059225","descriptor_name":"Nociception","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059225","descriptor_name":"Nociception","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059408","descriptor_name":"Pain Management","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059408","descriptor_name":"Pain Management","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059408","descriptor_name":"Pain Management","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc.2018.8512330","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8512330","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:30440445","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30440445","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:HAL:hal-05086441v1","is_oa":false,"landing_page_url":"https://hal.univ-lille.fr/hal-05086441","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Conference proceedings : .. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2018, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2018, ⟨10.1109/EMBC.2018.8512330⟩","raw_type":"Journal articles"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6100000143051147}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1970513373","https://openalex.org/W2024687868","https://openalex.org/W2059448132","https://openalex.org/W2097776660","https://openalex.org/W2122992285","https://openalex.org/W2125381150","https://openalex.org/W2128513826","https://openalex.org/W2137139861","https://openalex.org/W2259583242","https://openalex.org/W2483698312","https://openalex.org/W2613033866","https://openalex.org/W2623298289","https://openalex.org/W2682814308","https://openalex.org/W4242722344","https://openalex.org/W6739873057"],"related_works":["https://openalex.org/W2079177716","https://openalex.org/W2126490144","https://openalex.org/W4221042944","https://openalex.org/W2039035640","https://openalex.org/W2012848514","https://openalex.org/W1993345589","https://openalex.org/W2559963711","https://openalex.org/W3158810316","https://openalex.org/W2121023217","https://openalex.org/W2031151413"],"abstract_inverted_index":{"General":[0],"anesthesia":[1],"is":[2,29,97],"based":[3,98,107],"on":[4,75,99],"the":[5,18,22,33,76,89,100,109],"use":[6],"of":[7,41,58,79,92,102],"hypnotic,":[8],"muscle":[9],"relaxant":[10],"and":[11,61,121,126],"analgesic":[12,93],"drugs":[13],"in":[14,53,128],"order":[15,54],"to":[16,21,31,37,55],"render":[17],"patient":[19],"unresponsive":[20],"surgical":[23],"procedure.":[24],"The":[25],"difficulty":[26],"for":[27],"anesthesiologists":[28],"then":[30],"determinate":[32],"minimum":[34],"efficient":[35],"dose":[36],"avoid":[38],"any":[39],"risk":[40],"under":[42],"or":[43],"over":[44],"dosing.":[45],"For":[46],"several":[47,72],"years,":[48],"monitoring":[49,68],"systems":[50,69],"were":[51],"developed":[52,84],"measure":[56],"depth":[57],"hypnosis,":[59],"myorelaxation":[60],"analgesia.":[62],"As":[63],"soon":[64],"as":[65],"all":[66],"these":[67],"became":[70],"available,":[71],"teams":[73],"worked":[74],"closed-loop":[77,86],"administration":[78,91],"anesthetic":[80],"agents.":[81],"We":[82],"have":[83],"a":[85,103,129],"system":[87,96],"allowing":[88],"automatic":[90],"drugs.":[94],"This":[95],"analysis":[101],"heart":[104],"rate":[105],"variability":[106],"index:":[108],"ANI":[110],"(Analgesia":[111],"Nociception":[112],"Index).":[113],"In":[114],"this":[115,119],"paper,":[116],"we":[117],"describe":[118],"device":[120],"demonstrate":[122],"its":[123],"efficiency,":[124],"repeatability":[125],"safety":[127],"simulation":[130],"environment.":[131]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}