{"id":"https://openalex.org/W2899095026","doi":"https://doi.org/10.1109/embc.2018.8512303","title":"Assessment of disease severity in a Canine Model of Duchenne Muscular Dystrophy: Classification of Quantitative MRI","display_name":"Assessment of disease severity in a Canine Model of Duchenne Muscular Dystrophy: Classification of Quantitative MRI","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2899095026","doi":"https://doi.org/10.1109/embc.2018.8512303","mag":"2899095026","pmid":"https://pubmed.ncbi.nlm.nih.gov/30440480"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2018.8512303","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8512303","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028951034","display_name":"Ayd\u0131n Eresen","orcid":"https://orcid.org/0000-0002-9414-9986"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A. Eresen","raw_affiliation_strings":["Texas A&M University College Station, College Station, TX, US"],"affiliations":[{"raw_affiliation_string":"Texas A&M University College Station, College Station, TX, US","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006980883","display_name":"Lejla Ali\u0107","orcid":"https://orcid.org/0000-0001-6487-6958"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Alic","raw_affiliation_strings":["Texas A&M University College Station, College Station, TX, US"],"affiliations":[{"raw_affiliation_string":"Texas A&M University College Station, College Station, TX, US","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060212143","display_name":"Joe N. Kornegay","orcid":"https://orcid.org/0000-0002-5594-1882"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Kornegay","raw_affiliation_strings":["Texas A&M University College Station, College Station, TX, US"],"affiliations":[{"raw_affiliation_string":"Texas A&M University College Station, College Station, TX, US","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024277918","display_name":"Jim Ji","orcid":"https://orcid.org/0000-0001-7147-7920"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. X. Ji","raw_affiliation_strings":["Texas A&M University College Station, College Station, TX, US"],"affiliations":[{"raw_affiliation_string":"Texas A&M University College Station, College Station, TX, US","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5028951034"],"corresponding_institution_ids":["https://openalex.org/I91045830"],"apc_list":null,"apc_paid":null,"fwci":0.0919,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.48283594,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2018","issue":null,"first_page":"648","last_page":"651"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10783","display_name":"Additive Manufacturing and 3D Printing Technologies","score":0.9366999864578247,"subfield":{"id":"https://openalex.org/subfields/2203","display_name":"Automotive Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10338","display_name":"Advanced Sensor and Energy Harvesting Materials","score":0.9290000200271606,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/duchenne-muscular-dystrophy","display_name":"Duchenne muscular dystrophy","score":0.8978221416473389},{"id":"https://openalex.org/keywords/dystrophin","display_name":"Dystrophin","score":0.6124844551086426},{"id":"https://openalex.org/keywords/muscular-dystrophy","display_name":"Muscular dystrophy","score":0.5931819677352905},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5759600400924683},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.5216015577316284},{"id":"https://openalex.org/keywords/mdx-mouse","display_name":"mdx mouse","score":0.4555247724056244},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.21712183952331543}],"concepts":[{"id":"https://openalex.org/C2778943923","wikidata":"https://www.wikidata.org/wiki/Q1648484","display_name":"Duchenne muscular dystrophy","level":2,"score":0.8978221416473389},{"id":"https://openalex.org/C2780394045","wikidata":"https://www.wikidata.org/wiki/Q412285","display_name":"Dystrophin","level":3,"score":0.6124844551086426},{"id":"https://openalex.org/C2779030066","wikidata":"https://www.wikidata.org/wiki/Q1137767","display_name":"Muscular dystrophy","level":2,"score":0.5931819677352905},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5759600400924683},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5216015577316284},{"id":"https://openalex.org/C2778750056","wikidata":"https://www.wikidata.org/wiki/Q24976962","display_name":"mdx mouse","level":4,"score":0.4555247724056244},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21712183952331543}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009137","descriptor_name":"Muscular Dystrophy, Animal","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009137","descriptor_name":"Muscular Dystrophy, Animal","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009137","descriptor_name":"Muscular Dystrophy, Animal","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D020388","descriptor_name":"Muscular Dystrophy, Duchenne","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D020388","descriptor_name":"Muscular Dystrophy, Duchenne","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D020388","descriptor_name":"Muscular Dystrophy, Duchenne","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2018.8512303","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8512303","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:30440480","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30440480","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6000000238418579}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W5594912","https://openalex.org/W1588504034","https://openalex.org/W1995068750","https://openalex.org/W2019190989","https://openalex.org/W2059156500","https://openalex.org/W2097155618","https://openalex.org/W2101455790","https://openalex.org/W2116484895","https://openalex.org/W2117340355","https://openalex.org/W2124156889","https://openalex.org/W2133287637","https://openalex.org/W2156909104","https://openalex.org/W2277280343","https://openalex.org/W2478207761","https://openalex.org/W2536705355","https://openalex.org/W2741280726"],"related_works":["https://openalex.org/W4380290265","https://openalex.org/W2025620776","https://openalex.org/W2794581573","https://openalex.org/W1978523507","https://openalex.org/W2328102844","https://openalex.org/W2027588464","https://openalex.org/W2560773829","https://openalex.org/W2004824383","https://openalex.org/W4296122678","https://openalex.org/W2993136013"],"abstract_inverted_index":{"Duchenne":[0],"muscular":[1,30,79],"dystrophy":[2,31,80],"(DMD)":[3],"is":[4,33,51],"a":[5,18,34,54,108,141],"fatal":[6],"Xlinked":[7],"muscle":[8],"disorder":[9],"caused":[10],"by":[11,101],"mutations":[12],"in":[13,103],"the":[14,74],"dystrophin":[15],"gene":[16],"with":[17,41],"consequence":[19],"of":[20,23,39,76,88,144],"progressive":[21],"degeneration":[22],"skeletal":[24],"and":[25,66,84,98,119,131,138],"cardiac":[26],"muscle.":[27],"Golden":[28],"retriever":[29,78],"(GRMD)":[32,81],"spontaneous":[35],"X-linked":[36],"canine":[37],"model":[38],"DMD":[40],"similar":[42],"effects.":[43],"Due":[44],"to":[45,57,61,72,115],"high":[46],"soft-tissue":[47],"contrast":[48],"images,":[49],"MRI":[50,86,105],"preferred":[52],"as":[53],"non-invasive":[55,68],"method":[56],"extract":[58],"information":[59],"corresponding":[60],"biological":[62],"characteristics.":[63],"We":[64],"propose":[65],"evaluate":[67],"MRI-based":[69],"imaging":[70,92],"biomarkers":[71,93],"assess":[73],"severity":[75],"golden":[77],"using":[82],"3T":[83],"4.7T":[85],"data":[87],"nine":[89],"animals.":[90,122],"These":[91],"use":[94,113],"first":[95],"order":[96],"statistics":[97],"texture":[99],"(assessed":[100],"wavelets)":[102],"quantitative":[104],"(qMRI).":[106],"In":[107],"leave-one-sampleout":[109],"cross-validation":[110],"framework,":[111],"we":[112],"SVM":[114],"differentiate":[116],"between":[117,129],"young":[118,130],"old":[120,132],"GRMD":[121],"The":[123],"preliminary":[124],"results":[125],"show":[126],"good":[127],"differentiation":[128],"animals":[133],"for":[134],"different":[135,142],"qMRI":[136],"sequences":[137],"based":[139],"on":[140],"selection":[143],"features.":[145]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}