{"id":"https://openalex.org/W2899487955","doi":"https://doi.org/10.1109/embc.2018.8512194","title":"Multiple Kernel Learning Based Classification of Parkinson\u2019s Disease With Multi-Modal Transcranial Sonography","display_name":"Multiple Kernel Learning Based Classification of Parkinson\u2019s Disease With Multi-Modal Transcranial Sonography","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2899487955","doi":"https://doi.org/10.1109/embc.2018.8512194","mag":"2899487955","pmid":"https://pubmed.ncbi.nlm.nih.gov/30440341"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2018.8512194","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8512194","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032832318","display_name":"Jun Shi","orcid":"https://orcid.org/0000-0002-3226-3978"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Shi","raw_affiliation_strings":["Shanghai University, Shanghai, Shanghai, CN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai University, Shanghai, Shanghai, CN","institution_ids":["https://openalex.org/I113940042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113811128","display_name":"Minjun Yan","orcid":null},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minjun Yan","raw_affiliation_strings":["Shanghai University, Shanghai, Shanghai, CN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai University, Shanghai, Shanghai, CN","institution_ids":["https://openalex.org/I113940042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083447643","display_name":"Yun Dong","orcid":"https://orcid.org/0000-0001-8312-900X"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Dong","raw_affiliation_strings":["Tongji University, Shanghai, Shanghai, CN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tongji University, Shanghai, Shanghai, CN","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115597370","display_name":"Zheng Xiao","orcid":null},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Zheng","raw_affiliation_strings":["Shanghai University, Shanghai, Shanghai, CN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai University, Shanghai, Shanghai, CN","institution_ids":["https://openalex.org/I113940042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100348829","display_name":"Qi Zhang","orcid":"https://orcid.org/0000-0001-7041-643X"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Zhang","raw_affiliation_strings":["Shanghai University, Shanghai, Shanghai, CN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai University, Shanghai, Shanghai, CN","institution_ids":["https://openalex.org/I113940042"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017714871","display_name":"Hedi An","orcid":"https://orcid.org/0009-0008-4097-9395"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hedi An","raw_affiliation_strings":["Tongji University, Shanghai, Shanghai, CN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tongji University, Shanghai, Shanghai, CN","institution_ids":["https://openalex.org/I116953780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3668,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.67037875,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"2018","issue":null,"first_page":"61","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9767000079154968,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9764999747276306,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/modal","display_name":"Modal","score":0.699600875377655},{"id":"https://openalex.org/keywords/transcranial-doppler","display_name":"Transcranial Doppler","score":0.6810064315795898},{"id":"https://openalex.org/keywords/parkinsons-disease","display_name":"Parkinson's disease","score":0.589533805847168},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5308794975280762},{"id":"https://openalex.org/keywords/cad","display_name":"CAD","score":0.5143696069717407},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4794967770576477},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.46490371227264404},{"id":"https://openalex.org/keywords/kernel","display_name":"Kernel (algebra)","score":0.44168901443481445},{"id":"https://openalex.org/keywords/computer-aided-diagnosis","display_name":"Computer-aided diagnosis","score":0.42335280776023865},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3972581923007965},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.3046528697013855},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2841123938560486},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.23259428143501282},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.20479470491409302},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.19879257678985596},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.12216970324516296},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.11213669180870056}],"concepts":[{"id":"https://openalex.org/C71139939","wikidata":"https://www.wikidata.org/wiki/Q910194","display_name":"Modal","level":2,"score":0.699600875377655},{"id":"https://openalex.org/C191616109","wikidata":"https://www.wikidata.org/wiki/Q3512319","display_name":"Transcranial Doppler","level":2,"score":0.6810064315795898},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.589533805847168},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5308794975280762},{"id":"https://openalex.org/C194789388","wikidata":"https://www.wikidata.org/wiki/Q17855283","display_name":"CAD","level":2,"score":0.5143696069717407},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4794967770576477},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.46490371227264404},{"id":"https://openalex.org/C74193536","wikidata":"https://www.wikidata.org/wiki/Q574844","display_name":"Kernel (algebra)","level":2,"score":0.44168901443481445},{"id":"https://openalex.org/C2779549770","wikidata":"https://www.wikidata.org/wiki/Q1122413","display_name":"Computer-aided diagnosis","level":2,"score":0.42335280776023865},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3972581923007965},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3046528697013855},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2841123938560486},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.23259428143501282},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.20479470491409302},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19879257678985596},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.12216970324516296},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.11213669180870056},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C199639397","wikidata":"https://www.wikidata.org/wiki/Q1788588","display_name":"Engineering drawing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017585","descriptor_name":"Ultrasonography, Doppler, Transcranial","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017585","descriptor_name":"Ultrasonography, Doppler, Transcranial","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017585","descriptor_name":"Ultrasonography, Doppler, Transcranial","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2018.8512194","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2018.8512194","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:30440341","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30440341","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5400000214576721}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W45249900","https://openalex.org/W155831648","https://openalex.org/W1670132599","https://openalex.org/W1754781751","https://openalex.org/W1970314950","https://openalex.org/W1983962889","https://openalex.org/W2046862341","https://openalex.org/W2074071617","https://openalex.org/W2077078942","https://openalex.org/W2106223359","https://openalex.org/W2288062769","https://openalex.org/W2515917241","https://openalex.org/W2574038793","https://openalex.org/W2590160933","https://openalex.org/W2619795719","https://openalex.org/W6601868999","https://openalex.org/W6636883489"],"related_works":["https://openalex.org/W1589419489","https://openalex.org/W4229543669","https://openalex.org/W1783185948","https://openalex.org/W615772105","https://openalex.org/W2999505641","https://openalex.org/W2401866201","https://openalex.org/W2945629533","https://openalex.org/W1554029525","https://openalex.org/W1978794434","https://openalex.org/W2074183617"],"abstract_inverted_index":{"Parkinson's":[0],"Disease":[1],"(PD)":[2],"is":[3,48,71,113],"the":[4,35,42,56,63,90,104,149,157,164,172,196,202,210],"most":[5],"common":[6],"motor":[7],"neurodegenerative":[8],"disease":[9],"in":[10,26,130,175],"elderly":[11],"population.":[12],"Transcranial":[13],"sonography":[14,45,75],"(TCS)":[15],"has":[16,55,79,95],"become":[17],"a":[18,117,135,184],"popular":[19],"imaging":[20],"tool":[21],"for":[22,39,93,121,142,187,219],"diagnosis":[23,37,220],"of":[24,66,189,214,221],"PD":[25,40,84,94,122,143],"clinical":[27],"practice.":[28],"Moreover,":[29],"several":[30],"pioneering":[31],"work":[32],"have":[33],"developed":[34],"computer-aided":[36],"(CAD)":[38],"with":[41,86,144],"transcranial":[43,73],"B-mode":[44],"(TBS).":[46],"It":[47],"worth":[49],"noting":[50],"that":[51,195],"TCS":[52,146],"not":[53,96],"only":[54],"TBS":[57,100,126,161,216],"modality,":[58],"but":[59],"also":[60,78],"can":[61],"image":[62],"blood":[64,167],"flow":[65,168],"major":[67],"cerebral":[68],"arteries,":[69],"which":[70,208],"named":[72],"Doppler":[74],"(TDS).":[76],"TDS":[77,102,218],"been":[80,97],"applied":[81],"to":[82,115,183],"evaluate":[83],"patients":[85],"orthostatic":[87],"hypotension.":[88],"However,":[89],"TDS-based":[91,206],"CAD":[92,120,141],"investigated.":[98],"Since":[99],"and":[101,107,127,151,163,205,212,217],"provide":[103],"complementary":[105],"structural":[106],"functional":[108],"information":[109],"about":[110,166],"brain,":[111],"it":[112],"feasible":[114],"develop":[116],"multi-modal":[118,145,178,197],"TCS-based":[119,198],"by":[123],"combining":[124,215],"both":[125,201],"TDS.":[128,176],"Therefore,":[129],"this":[131],"work,":[132],"we":[133],"propose":[134],"multiple":[136],"kernel":[137],"learning":[138],"(MKL)":[139],"based":[140],"imaging.":[147],"Particularly,":[148],"statistical":[150],"texture":[152],"features":[153,165,179],"are":[154,169,180],"extracted":[155],"from":[156,160,171],"midbrain":[158],"region":[159],"images,":[162],"calculated":[170],"spectrum":[173],"curves":[174],"The":[177,191],"then":[181],"fed":[182],"MKL":[185],"classifier":[186],"classification":[188],"PD.":[190,222],"experimental":[192],"results":[193],"show":[194],"method":[199],"outperforms":[200],"single-modal":[203],"TBS-":[204],"algorithm,":[207],"suggests":[209],"feasibility":[211],"effectiveness":[213]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}