{"id":"https://openalex.org/W2754599025","doi":"https://doi.org/10.1109/embc.2017.8037873","title":"Three-wavelength method for the optical differentiation of methemoglobin and sulfhemoglobin in oxygenated blood","display_name":"Three-wavelength method for the optical differentiation of methemoglobin and sulfhemoglobin in oxygenated blood","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2754599025","doi":"https://doi.org/10.1109/embc.2017.8037873","mag":"2754599025","pmid":"https://pubmed.ncbi.nlm.nih.gov/29060914"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2017.8037873","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2017.8037873","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069157794","display_name":"Spencer R. Van Leeuwen","orcid":null},"institutions":[{"id":"https://openalex.org/I151746483","display_name":"University of Waterloo","ror":"https://ror.org/01aff2v68","country_code":"CA","type":"education","lineage":["https://openalex.org/I151746483"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Spencer R. Van Leeuwen","raw_affiliation_strings":["Natural Phenomena Simulation Group, University of Waterloo, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Phenomena Simulation Group, University of Waterloo, Ontario, Canada","institution_ids":["https://openalex.org/I151746483"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025445179","display_name":"Gladimir V. G. Baranoski","orcid":"https://orcid.org/0000-0002-9215-2137"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gladimir V. G. Baranoski","raw_affiliation_strings":["University of Waterloo, Waterloo, ON, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Waterloo, Waterloo, ON, CA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112696230","display_name":"Bradley W. Kimmel","orcid":null},"institutions":[{"id":"https://openalex.org/I151746483","display_name":"University of Waterloo","ror":"https://ror.org/01aff2v68","country_code":"CA","type":"education","lineage":["https://openalex.org/I151746483"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Bradley W. Kimmel","raw_affiliation_strings":["Natural Phenomena Simulation Group, University of Waterloo, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Phenomena Simulation Group, University of Waterloo, Ontario, Canada","institution_ids":["https://openalex.org/I151746483"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4103,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.67959737,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"17","issue":null,"first_page":"4570","last_page":"4573"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12845","display_name":"Methemoglobinemia and Tumor Lysis Syndrome","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12845","display_name":"Methemoglobinemia and Tumor Lysis Syndrome","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.9803000092506409,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.9786999821662903,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methemoglobin","display_name":"Methemoglobin","score":0.9820070862770081},{"id":"https://openalex.org/keywords/hemolysis","display_name":"Hemolysis","score":0.6231887340545654},{"id":"https://openalex.org/keywords/methemoglobinemia","display_name":"Methemoglobinemia","score":0.6158112287521362},{"id":"https://openalex.org/keywords/reflectivity","display_name":"Reflectivity","score":0.4843486547470093},{"id":"https://openalex.org/keywords/wavelength","display_name":"Wavelength","score":0.4319309592247009},{"id":"https://openalex.org/keywords/hemoglobin","display_name":"Hemoglobin","score":0.36374908685684204},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3500758707523346},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.31830155849456787},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.31553658843040466},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.27092719078063965},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.24506667256355286},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.16505905985832214},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.15834903717041016},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.14540699124336243},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.12449431419372559}],"concepts":[{"id":"https://openalex.org/C26865036","wikidata":"https://www.wikidata.org/wiki/Q416833","display_name":"Methemoglobin","level":3,"score":0.9820070862770081},{"id":"https://openalex.org/C2779902561","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Hemolysis","level":2,"score":0.6231887340545654},{"id":"https://openalex.org/C2777737778","wikidata":"https://www.wikidata.org/wiki/Q748442","display_name":"Methemoglobinemia","level":2,"score":0.6158112287521362},{"id":"https://openalex.org/C108597893","wikidata":"https://www.wikidata.org/wiki/Q663650","display_name":"Reflectivity","level":2,"score":0.4843486547470093},{"id":"https://openalex.org/C6260449","wikidata":"https://www.wikidata.org/wiki/Q41364","display_name":"Wavelength","level":2,"score":0.4319309592247009},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.36374908685684204},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3500758707523346},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31830155849456787},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.31553658843040466},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.27092719078063965},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24506667256355286},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.16505905985832214},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15834903717041016},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.14540699124336243},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12449431419372559}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008706","descriptor_name":"Methemoglobin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008706","descriptor_name":"Methemoglobin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008706","descriptor_name":"Methemoglobin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008708","descriptor_name":"Methemoglobinemia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008708","descriptor_name":"Methemoglobinemia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008708","descriptor_name":"Methemoglobinemia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013435","descriptor_name":"Sulfhemoglobin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013435","descriptor_name":"Sulfhemoglobin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013435","descriptor_name":"Sulfhemoglobin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013436","descriptor_name":"Sulfhemoglobinemia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013436","descriptor_name":"Sulfhemoglobinemia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013436","descriptor_name":"Sulfhemoglobinemia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2017.8037873","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2017.8037873","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:29060914","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29060914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/12","score":0.46000000834465027,"display_name":"Responsible consumption and production"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W202478782","https://openalex.org/W1589378501","https://openalex.org/W1870494617","https://openalex.org/W1975299758","https://openalex.org/W1988627290","https://openalex.org/W2022154442","https://openalex.org/W2054019746","https://openalex.org/W2059835776","https://openalex.org/W2061420513","https://openalex.org/W2073006535","https://openalex.org/W2096625632","https://openalex.org/W2132898527","https://openalex.org/W2164197326","https://openalex.org/W2172159076","https://openalex.org/W3109856192","https://openalex.org/W4241109989","https://openalex.org/W4285719527","https://openalex.org/W4298869479","https://openalex.org/W6608179106"],"related_works":["https://openalex.org/W2062754382","https://openalex.org/W1978778150","https://openalex.org/W1977630491","https://openalex.org/W2317303800","https://openalex.org/W4224066215","https://openalex.org/W3162545594","https://openalex.org/W2437098814","https://openalex.org/W2311100371","https://openalex.org/W190355009","https://openalex.org/W2116416578"],"abstract_inverted_index":{"Methemoglobinemia":[0],"and":[1,88,118,136,152,173],"sulfhemoglobinemia":[2],"are":[3],"rare,":[4],"but":[5],"potentially":[6],"life":[7],"threatening,":[8],"diseases":[9,63],"that":[10],"refer":[11],"to":[12,42,49,72,104],"an":[13],"abnormal":[14,28],"amount":[15],"of":[16,30,61,86,116,138,156],"methemoglobin":[17,31,87,117],"or":[18,32],"sulfhemoglobin":[19,33,89],"in":[20,90,110],"the":[21,62,73,84,134,145,150,154,168],"blood,":[22,91],"respectively.":[23],"Unfortunately,":[24],"blood":[25,140],"samples":[26],"containing":[27],"quantities":[29],"have":[34],"similar":[35],"spectral":[36],"characteristics.":[37],"This":[38],"makes":[39],"it":[40],"difficult":[41,48],"optically":[43],"differentiate":[44],"them":[45],"and,":[46],"hence,":[47],"diagnose":[50],"a":[51,65,80,123],"patient":[52],"with":[53],"either":[54],"disease.":[55],"However,":[56],"performing":[57],"treatments":[58],"for":[59,82,133],"one":[60],"without":[64],"correct":[66],"diagnosis":[67],"can":[68],"introduce":[69],"increased":[70],"risk":[71],"patient.":[74],"In":[75,102,159],"this":[76],"paper,":[77],"we":[78,108,161],"propose":[79],"method":[81],"differentiating":[83],"presence":[85],"under":[92],"several":[93],"conditions,":[94],"using":[95],"reflectance":[96,146],"values":[97],"measured":[98],"at":[99],"three":[100],"wavelengths.":[101],"order":[103],"validate":[105],"our":[106,157],"method,":[107],"perform":[109],"silico":[111],"experiments":[112,121,151],"considering":[113],"various":[114,163],"levels":[115],"sulfhemoglobin.":[119],"These":[120],"employ":[122],"cell-based":[124],"light":[125,175],"interaction":[126],"model,":[127],"known":[128],"as":[129],"CLBlood,":[130],"which":[131],"accounts":[132],"orientation":[135],"distribution":[137],"red":[139],"cells.":[141],"We":[142],"then":[143],"discuss":[144],"curves":[147],"produced":[148],"by":[149,166],"evaluate":[153],"efficacy":[155],"method.":[158],"particular,":[160],"consider":[162],"experimental":[164],"conditions":[165],"modifying":[167],"flow":[169],"rate,":[170],"hemolysis":[171],"level":[172],"incident":[174],"direction.":[176]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
