{"id":"https://openalex.org/W2755928297","doi":"https://doi.org/10.1109/embc.2017.8037812","title":"The challenge of magnetic vagal nerve stimulation for myocardial infarction -preliminary clinical trial","display_name":"The challenge of magnetic vagal nerve stimulation for myocardial infarction -preliminary clinical trial","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2755928297","doi":"https://doi.org/10.1109/embc.2017.8037812","mag":"2755928297","pmid":"https://pubmed.ncbi.nlm.nih.gov/29060853"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2017.8037812","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2017.8037812","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069176748","display_name":"Takuya Nishikawa","orcid":"https://orcid.org/0000-0002-4951-7831"},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuya Nishikawa","raw_affiliation_strings":["Kyushu University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030101013","display_name":"Keita Saku","orcid":"https://orcid.org/0000-0002-6856-9362"},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keita Saku","raw_affiliation_strings":["Kyushu University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003699677","display_name":"Koji Todaka","orcid":"https://orcid.org/0000-0003-0805-9974"},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Todaka","raw_affiliation_strings":["Kyushu University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110100083","display_name":"Yukimitsu Kuwabara","orcid":null},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukimitsu Kuwabara","raw_affiliation_strings":["Kyushu University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045004729","display_name":"Shinobu Arai","orcid":"https://orcid.org/0000-0002-5888-5943"},"institutions":[{"id":"https://openalex.org/I63121688","display_name":"Nakamura Gakuen University","ror":"https://ror.org/00qm2vr07","country_code":"JP","type":"education","lineage":["https://openalex.org/I63121688"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinobu Arai","raw_affiliation_strings":["Nakamura Gakuen University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nakamura Gakuen University, Fukuoka, Japan","institution_ids":["https://openalex.org/I63121688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102768029","display_name":"Takuya Kishi","orcid":"https://orcid.org/0000-0001-5122-5793"},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuya Kishi","raw_affiliation_strings":["Kyushu University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021699667","display_name":"Tomomi Ide","orcid":"https://orcid.org/0000-0003-3387-1550"},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomomi Ide","raw_affiliation_strings":["Kyushu University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091849037","display_name":"Hiroyuki Tsutsui","orcid":"https://orcid.org/0000-0002-5291-2875"},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Tsutsui","raw_affiliation_strings":["Kyushu University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007483946","display_name":"Kenji Sunagawa","orcid":"https://orcid.org/0000-0003-0365-4619"},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Sunagawa","raw_affiliation_strings":["Kyushu University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2747,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.64921953,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2017","issue":null,"first_page":"4321","last_page":"4324"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.7623534202575684},{"id":"https://openalex.org/keywords/vagus-nerve-stimulation","display_name":"Vagus nerve stimulation","score":0.7084593772888184},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"Myocardial infarction","score":0.6716735363006592},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6424265503883362},{"id":"https://openalex.org/keywords/heart-rate","display_name":"Heart rate","score":0.6387397646903992},{"id":"https://openalex.org/keywords/transcranial-magnetic-stimulation","display_name":"Transcranial magnetic stimulation","score":0.6261956095695496},{"id":"https://openalex.org/keywords/bradycardia","display_name":"Bradycardia","score":0.6251270771026611},{"id":"https://openalex.org/keywords/vagus-nerve","display_name":"Vagus nerve","score":0.5328548550605774},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.5311475992202759},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.5044411420822144},{"id":"https://openalex.org/keywords/adverse-effect","display_name":"Adverse effect","score":0.4919717013835907},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.4611828923225403},{"id":"https://openalex.org/keywords/heart-failure","display_name":"Heart failure","score":0.4357249438762665},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"Blood pressure","score":0.3335767984390259}],"concepts":[{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.7623534202575684},{"id":"https://openalex.org/C2780087125","wikidata":"https://www.wikidata.org/wiki/Q2062293","display_name":"Vagus nerve stimulation","level":4,"score":0.7084593772888184},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.6716735363006592},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6424265503883362},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.6387397646903992},{"id":"https://openalex.org/C2778581513","wikidata":"https://www.wikidata.org/wiki/Q263962","display_name":"Transcranial magnetic stimulation","level":3,"score":0.6261956095695496},{"id":"https://openalex.org/C2777495988","wikidata":"https://www.wikidata.org/wiki/Q217111","display_name":"Bradycardia","level":4,"score":0.6251270771026611},{"id":"https://openalex.org/C2781404750","wikidata":"https://www.wikidata.org/wiki/Q190140","display_name":"Vagus nerve","level":3,"score":0.5328548550605774},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5311475992202759},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5044411420822144},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4919717013835907},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4611828923225403},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.4357249438762665},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3335767984390259}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014630","descriptor_name":"Vagus Nerve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014630","descriptor_name":"Vagus Nerve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014630","descriptor_name":"Vagus Nerve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055536","descriptor_name":"Vagus Nerve Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055536","descriptor_name":"Vagus Nerve Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055536","descriptor_name":"Vagus Nerve Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2017.8037812","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2017.8037812","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:29060853","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29060853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8100000023841858,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W122590305","https://openalex.org/W1965036361","https://openalex.org/W1990224341","https://openalex.org/W2002797282","https://openalex.org/W2011124666","https://openalex.org/W2028280452","https://openalex.org/W2030434698","https://openalex.org/W2033050446","https://openalex.org/W2046070496","https://openalex.org/W2068884498","https://openalex.org/W2101234419","https://openalex.org/W2109454934","https://openalex.org/W2116095873","https://openalex.org/W2118618693","https://openalex.org/W2123181530","https://openalex.org/W2139540538","https://openalex.org/W2159516049","https://openalex.org/W2337818477","https://openalex.org/W2545477489","https://openalex.org/W3142594879"],"related_works":["https://openalex.org/W4301396970","https://openalex.org/W2006689666","https://openalex.org/W2550683708","https://openalex.org/W3146991102","https://openalex.org/W3010486731","https://openalex.org/W2899224757","https://openalex.org/W2015202629","https://openalex.org/W2094219890","https://openalex.org/W2013954586","https://openalex.org/W4280569028"],"abstract_inverted_index":{"Numerous":[0],"studies":[1],"have":[2],"shown":[3],"in":[4,52,70,81,93,192,201,204,238],"animal":[5],"models":[6],"that":[7],"vagal":[8,34,68],"nerve":[9,35,69],"stimulation":[10,43,62,115,148,215,227],"(VNS)":[11],"strikingly":[12],"reduces":[13],"infarct":[14],"size":[15],"of":[16,28,48,114,125,134,140,145,166,226,241],"acute":[17],"myocardial":[18],"infarction":[19],"(AMI)":[20],"and":[21,46,76,142,158,224],"prevents":[22],"heart":[23,155],"failure.":[24],"However,":[25],"the":[26,33,60,66,94,100,111,119,123,160,221,239],"lack":[27],"techniques":[29],"to":[30,102,197,234],"noninvasively":[31,64],"stimulate":[32],"hinders":[36],"VNS":[37,187,237],"from":[38],"clinical":[39],"applications.":[40],"Transcranial":[41],"magnetic":[42,61,183,186,214,222,236],"is":[44,118],"noninvasive":[45],"capable":[47],"stimulating":[49],"central":[50],"neurons":[51],"patients.":[53],"In":[54],"this":[55,82],"study,":[56],"we":[57],"examined":[58],"whether":[59],"could":[63],"activate":[65],"cervical":[67],"healthy":[71,74],"human.":[72],"Sixteen":[73],"males":[75],"4":[77],"females":[78],"were":[79],"enrolled":[80],"study.":[83],"We":[84,97,109,128,153],"used":[85],"Magstim":[86],"Rapid2":[87],"with":[88],"a":[89,132],"70-mm":[90],"double":[91],"coil":[92],"right":[95],"neck.":[96],"randomly":[98],"assigned":[99],"subjects":[101,170],"5":[103],"Hz":[104,107],"or":[105],"20":[106],"stimulation.":[108],"defined":[110,129],"maximum":[112],"intensity":[113,120],"(MAX)":[116],"which":[117],"just":[121],"below":[122],"threshold":[124],"adverse":[126,178],"effects.":[127],"HALF":[130],"as":[131,163],"half":[133],"MAX.":[135],"Protocols":[136],"comprised":[137],"2":[138,143],"sets":[139,144],"MAX":[141],"HALF.":[146],"Each":[147],"continued":[149],"for":[150],"3":[151],"minutes.":[152],"monitored":[154],"rate":[156],"(HR)":[157],"assessed":[159],"bradycardic":[161,190],"response":[162],"an":[164],"index":[165],"successful":[167],"VNS.":[168,184],"Nineteen":[169],"completed":[171],"all":[172],"protocols.":[173],"They":[174],"had":[175],"no":[176],"problematic":[177],"events":[179],"during":[180],"and/or":[181],"after":[182],"The":[185],"induced":[188],"transient":[189],"responses":[191],"some":[193],"subjects,":[194],"whereas":[195],"failed":[196],"induce":[198],"sustained":[199],"bradycardia":[200],"pooled":[202],"data":[203],"any":[205],"settings.":[206],"Arterial":[207],"pressure":[208],"did":[209],"not":[210],"change":[211],"either.":[212],"Successful":[213],"requires":[216],"technical":[217],"improvements":[218,230],"including":[219],"narrowing":[220],"focus":[223],"optimization":[225],"site.":[228],"These":[229],"may":[231],"enable":[232],"us":[233],"apply":[235],"management":[240],"AMI.":[242]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}