{"id":"https://openalex.org/W2754102377","doi":"https://doi.org/10.1109/embc.2017.8037701","title":"Modeling electrical stimulation of mammalian nerve fibers: A mechanistic versus probabilistic approach","display_name":"Modeling electrical stimulation of mammalian nerve fibers: A mechanistic versus probabilistic approach","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2754102377","doi":"https://doi.org/10.1109/embc.2017.8037701","mag":"2754102377","pmid":"https://pubmed.ncbi.nlm.nih.gov/29060742"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2017.8037701","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2017.8037701","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://orbi.uliege.be/bitstream/2268/229682/1/sadashivaiah2017.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017331139","display_name":"Vijay Sadashivaiah","orcid":"https://orcid.org/0000-0003-3375-3810"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vijay Sadashivaiah","raw_affiliation_strings":["Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009797399","display_name":"Pierre Sacr\u00e9","orcid":"https://orcid.org/0000-0002-7228-1628"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pierre Sacre","raw_affiliation_strings":["Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031948083","display_name":"Yun Guan","orcid":"https://orcid.org/0000-0003-1321-6655"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yun Guan","raw_affiliation_strings":["Department of Anesthesiology/Critical Care Medicine, School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology/Critical Care Medicine, School of Medicine, Baltimore, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043335263","display_name":"William S. Anderson","orcid":"https://orcid.org/0000-0003-0958-050X"},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William S. Anderson","raw_affiliation_strings":["Department of Neurosurgery, School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088809750","display_name":"Sridevi V. Sarma","orcid":"https://orcid.org/0000-0002-4817-6625"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sridevi V. Sarma","raw_affiliation_strings":["Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2425,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.84484848,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"68","issue":null,"first_page":"3868","last_page":"3871"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10784","display_name":"Muscle activation and electromyography studies","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/probabilistic-logic","display_name":"Probabilistic logic","score":0.7127145528793335},{"id":"https://openalex.org/keywords/stimulus","display_name":"Stimulus (psychology)","score":0.6083688735961914},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6047782897949219},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5554448962211609},{"id":"https://openalex.org/keywords/neurostimulation","display_name":"Neurostimulation","score":0.5317612290382385},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.502730131149292},{"id":"https://openalex.org/keywords/neurophysiology","display_name":"Neurophysiology","score":0.5024302005767822},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.46257832646369934},{"id":"https://openalex.org/keywords/nerve-fiber","display_name":"Nerve fiber","score":0.42568355798721313},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.383327454328537},{"id":"https://openalex.org/keywords/simulation","display_name":"Simulation","score":0.17690297961235046},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.16395124793052673},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.16102010011672974},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.11546650528907776}],"concepts":[{"id":"https://openalex.org/C49937458","wikidata":"https://www.wikidata.org/wiki/Q2599292","display_name":"Probabilistic logic","level":2,"score":0.7127145528793335},{"id":"https://openalex.org/C2779918689","wikidata":"https://www.wikidata.org/wiki/Q3771842","display_name":"Stimulus (psychology)","level":2,"score":0.6083688735961914},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6047782897949219},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5554448962211609},{"id":"https://openalex.org/C2776443511","wikidata":"https://www.wikidata.org/wiki/Q1724687","display_name":"Neurostimulation","level":3,"score":0.5317612290382385},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.502730131149292},{"id":"https://openalex.org/C152478114","wikidata":"https://www.wikidata.org/wiki/Q660910","display_name":"Neurophysiology","level":2,"score":0.5024302005767822},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.46257832646369934},{"id":"https://openalex.org/C2776823239","wikidata":"https://www.wikidata.org/wiki/Q48834737","display_name":"Nerve fiber","level":2,"score":0.42568355798721313},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.383327454328537},{"id":"https://openalex.org/C44154836","wikidata":"https://www.wikidata.org/wiki/Q45045","display_name":"Simulation","level":1,"score":0.17690297961235046},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.16395124793052673},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16102010011672974},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.11546650528907776},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004599","descriptor_name":"Electric Stimulation Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004599","descriptor_name":"Electric Stimulation Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004599","descriptor_name":"Electric Stimulation Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009412","descriptor_name":"Nerve Fibers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009412","descriptor_name":"Nerve Fibers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009412","descriptor_name":"Nerve Fibers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1109/embc.2017.8037701","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2017.8037701","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:29060742","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29060742","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:orbi.ulg.ac.be:2268/229682","is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/229682","pdf_url":"https://orbi.uliege.be/bitstream/2268/229682/1/sadashivaiah2017.pdf","source":{"id":"https://openalex.org/S4306400651","display_name":"Open Repository and Bibliography (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (2017); 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Seogwipo, South Korea [KR], from 11-07-2017 to 15-07-2017","raw_type":"http://purl.org/coar/resource_type/c_5794"},{"id":"pmh:oai:europepmc.org:4922211","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5972077","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:orbi.ulg.ac.be:2268/229682","is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/229682","pdf_url":"https://orbi.uliege.be/bitstream/2268/229682/1/sadashivaiah2017.pdf","source":{"id":"https://openalex.org/S4306400651","display_name":"Open Repository and Bibliography (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (2017); 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Seogwipo, South Korea [KR], from 11-07-2017 to 15-07-2017","raw_type":"http://purl.org/coar/resource_type/c_5794"},"sustainable_development_goals":[{"score":0.4699999988079071,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G4988659329","display_name":null,"funder_award_id":"R01 AT009401","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"},{"id":"https://openalex.org/G5520316217","display_name":null,"funder_award_id":"NIH-R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2754102377.pdf","grobid_xml":"https://content.openalex.org/works/W2754102377.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W146198468","https://openalex.org/W1761785605","https://openalex.org/W1764887409","https://openalex.org/W2008927843","https://openalex.org/W2013608789","https://openalex.org/W2057059514","https://openalex.org/W2059300393","https://openalex.org/W2116762695","https://openalex.org/W2117120818","https://openalex.org/W2118098191","https://openalex.org/W2142416079","https://openalex.org/W2470660511","https://openalex.org/W2498682607","https://openalex.org/W2963624240","https://openalex.org/W3135709413","https://openalex.org/W4296220478"],"related_works":["https://openalex.org/W4214563745","https://openalex.org/W4256510171","https://openalex.org/W2791717398","https://openalex.org/W2944375777","https://openalex.org/W2137484429","https://openalex.org/W2117151692","https://openalex.org/W4376988959","https://openalex.org/W4386860882","https://openalex.org/W2072473777","https://openalex.org/W1530324831"],"abstract_inverted_index":{"Electrical":[0],"neurostimulation":[1],"is":[2,26,179],"increasingly":[3],"used":[4],"over":[5],"neuropharmacology":[6],"to":[7,13,64,106,126,139],"treat":[8],"various":[9,143],"diseases.":[10],"Despite":[11],"efforts":[12],"model":[14,153,170,183],"the":[15,33,36,41,91,99,102,107,110,118,127,131,136,140,151,168,181,213],"effects":[16,34],"of":[17,75,79,82,98,109,120,130,192,225],"electrical":[18,37,226],"stimulation,":[19],"its":[20],"underlying":[21,54,92,203],"mechanisms":[22,224],"remain":[23],"unclear.":[24],"This":[25,178,208],"because":[27,180],"current":[28],"mechanistic":[29,169],"models":[30,74],"just":[31],"quantify":[32,65],"that":[35,123,150],"field":[38],"produces":[39],"near":[40],"fiber":[42,78,141,218],"and":[43,53,66,101,145,194,202],"do":[44],"not":[45],"capture":[46],"interactions":[47,214],"between":[48,197],"stimulus-initiated":[49,198],"action":[50,199],"potentials":[51,200],"(APs)":[52,201],"physiological":[55,93,121,204],"activity":[56,94,205],"initiated":[57,206],"APs.":[58,207],"In":[59],"this":[60],"study,":[61],"we":[62],"aim":[63],"compare":[67],"these":[68],"interactions.":[69],"We":[70,112,134,148],"construct":[71],"two":[72,89,137],"computational":[73],"a":[76,175,216],"nerve":[77,132,217],"varying":[80],"degrees":[81],"complexity":[83],"(probabilistic":[84],"versus":[85],"mechanistic)":[86],"each":[87],"receiving":[88],"inputs:":[90],"at":[95,142],"one":[96],"end":[97,129],"fiber,":[100],"external":[103],"stimulus":[104],"applied":[105],"middle":[108],"fiber.":[111,133],"then":[113,165],"define":[114],"reliability,":[115],"R,":[116],"as":[117],"percentage":[119],"APs":[122],"make":[124],"it":[125],"other":[128],"apply":[135],"inputs":[138],"frequencies":[144,160],"analyze":[146],"reliability.":[147],"find":[149],"probabilistic":[152,182],"captures":[154],"relay":[155],"properties":[156],"for":[157,186],"low":[158],"input":[159,173],"(<;":[161],"10":[162],"Hz)":[163],"but":[164],"differs":[166],"from":[167],"if":[171],"either":[172],"has":[174],"larger":[176],"frequency.":[177],"only":[184,187],"accounts":[185],"(i)":[188],"inter":[189],"signal":[190],"loss":[191],"excitability":[193],"(ii)":[195],"collisions":[196],"first":[209],"step":[210],"towards":[211,222],"modeling":[212],"in":[215],"opens":[219],"up":[220],"opportunities":[221],"understanding":[223],"stimulation":[227],"therapies.":[228]},"counts_by_year":[{"year":2018,"cited_by_count":3}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}