{"id":"https://openalex.org/W2755320450","doi":"https://doi.org/10.1109/embc.2017.8037535","title":"Complexity analysis of resting state fMRI signals in depressive patients","display_name":"Complexity analysis of resting state fMRI signals in depressive patients","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2755320450","doi":"https://doi.org/10.1109/embc.2017.8037535","mag":"2755320450","pmid":"https://pubmed.ncbi.nlm.nih.gov/29060576"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2017.8037535","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2017.8037535","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103146706","display_name":"Pei\u2010Shan Ho","orcid":"https://orcid.org/0000-0002-0860-1690"},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Pei-Shan Ho","raw_affiliation_strings":["Department of Engineering and System Science, National Tsing Hua University, Hsinchu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering and System Science, National Tsing Hua University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100622236","display_name":"Chemin Lin","orcid":"https://orcid.org/0000-0001-6889-4686"},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chemin Lin","raw_affiliation_strings":["Department of Engineering and System Science, National Tsing Hua University, Hsinchu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering and System Science, National Tsing Hua University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030475403","display_name":"Guan-Yen Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Guan-Yen Chen","raw_affiliation_strings":["Department of Engineering and System Science, National Tsing Hua University, Hsinchu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering and System Science, National Tsing Hua University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013558458","display_name":"Ho\u2010Ling Liu","orcid":"https://orcid.org/0000-0002-0284-5889"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I4210111603","display_name":"Keelung Chang Gung Memorial Hospital","ror":"https://ror.org/020dg9f27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210111603"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Ho-Ling Liu","raw_affiliation_strings":["Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, Texas","Department of Psychiatry, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Psychiatry, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan","institution_ids":["https://openalex.org/I4210111603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010039976","display_name":"Chih\u2010Mao Huang","orcid":"https://orcid.org/0000-0002-6209-2575"},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chih-Mao Huang","raw_affiliation_strings":["Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019992763","display_name":"Tatia M.C. Lee","orcid":"https://orcid.org/0000-0002-9992-6609"},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tatia Mei-Chun Lee","raw_affiliation_strings":["Department of Engineering and System Science, National Tsing Hua University, Hsinchu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering and System Science, National Tsing Hua University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046587891","display_name":"Shwu\u2010Hua Lee","orcid":"https://orcid.org/0000-0001-5606-1118"},"institutions":[{"id":"https://openalex.org/I4210116208","display_name":"Linkou Chang Gung Memorial Hospital","ror":"https://ror.org/02dnn6q67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK","TW"],"is_corresponding":false,"raw_author_name":"Shwu-Hua Lee","raw_affiliation_strings":["Department of Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan","Department of Psychology, The University of Hong Kong, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I4210116208"]},{"raw_affiliation_string":"Department of Psychology, The University of Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063607510","display_name":"Shun\u2010Chi Wu","orcid":"https://orcid.org/0000-0001-9337-2927"},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shun-Chi Wu","raw_affiliation_strings":["Department of Engineering and System Science, National Tsing Hua University, Hsinchu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering and System Science, National Tsing Hua University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I25846049"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.399,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.61355066,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"2017","issue":null,"first_page":"3190","last_page":"3193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9847000241279602,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/resting-state-fmri","display_name":"Resting state fMRI","score":0.7808654308319092},{"id":"https://openalex.org/keywords/functional-magnetic-resonance-imaging","display_name":"Functional magnetic resonance imaging","score":0.7174596190452576},{"id":"https://openalex.org/keywords/depression","display_name":"Depression (economics)","score":0.5753992795944214},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.5317792892456055},{"id":"https://openalex.org/keywords/audiology","display_name":"Audiology","score":0.460843563079834},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"Major depressive disorder","score":0.45147672295570374},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.40714117884635925},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.3295486867427826},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.31973692774772644},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.269804447889328}],"concepts":[{"id":"https://openalex.org/C66324658","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Resting state fMRI","level":2,"score":0.7808654308319092},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.7174596190452576},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.5753992795944214},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5317792892456055},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.460843563079834},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.45147672295570374},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40714117884635925},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3295486867427826},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31973692774772644},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.269804447889328},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013597","descriptor_name":"Systems Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013597","descriptor_name":"Systems Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013597","descriptor_name":"Systems Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2017.8037535","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2017.8037535","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:29060576","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29060576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.44999998807907104}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1413510374","https://openalex.org/W1799123644","https://openalex.org/W1862394037","https://openalex.org/W1976504892","https://openalex.org/W1999718518","https://openalex.org/W2020493679","https://openalex.org/W2031377725","https://openalex.org/W2047931034","https://openalex.org/W2057099110","https://openalex.org/W2058046532","https://openalex.org/W2059851411","https://openalex.org/W2080298947","https://openalex.org/W2104811988","https://openalex.org/W2109201669","https://openalex.org/W2112519660","https://openalex.org/W2112735526","https://openalex.org/W2114613490","https://openalex.org/W2142257054","https://openalex.org/W2144421443","https://openalex.org/W2232442412","https://openalex.org/W2500753599","https://openalex.org/W6628494139"],"related_works":["https://openalex.org/W2601707947","https://openalex.org/W2168298321","https://openalex.org/W2387620927","https://openalex.org/W2294986132","https://openalex.org/W1964455563","https://openalex.org/W2365936003","https://openalex.org/W2790620361","https://openalex.org/W4293242195","https://openalex.org/W2371524820","https://openalex.org/W2319066238"],"abstract_inverted_index":{"Analysis":[0],"of":[1,17,27,66,110],"brain":[2,64],"signal":[3],"complexity":[4,26,83],"reveals":[5],"the":[6,15,25,67,85,108,116],"intrinsic":[7],"network":[8,88],"dynamics":[9],"and":[10,50,53,73,114],"is":[11,96],"widely":[12],"utilized":[13],"in":[14,19,37,62,84,92,112],"investigation":[16],"mechanisms":[18],"mental":[20,117],"disorders.":[21],"In":[22],"this":[23,106],"study,":[24,107],"resting-state":[28],"functional":[29],"magnetic":[30],"resonance":[31],"imaging":[32],"(fMRI)":[33],"signals":[34],"was":[35,119],"explored":[36],"patients":[38,46,80],"with":[39,48],"depression":[40,49],"using":[41],"multiscale":[42],"entropy":[43],"(MSE).":[44],"Thirty-five":[45],"diagnosed":[47],"22":[51],"age-":[52],"gender-matched":[54],"healthy":[55,93],"controls":[56],"were":[57,71],"considered.":[58],"The":[59,75],"MSE":[60,111],"profiles":[61],"five":[63],"networks":[65],"two":[68],"participant":[69],"groups":[70],"evaluated":[72],"analyzed.":[74],"results":[76],"showed":[77],"that":[78,90],"depressive":[79],"exhibited":[81],"higher":[82],"left":[86],"frontoparietal":[87],"than":[89],"seen":[91],"controls,":[94],"which":[95],"known":[97],"to":[98],"be":[99],"critical":[100],"for":[101],"executive":[102],"control":[103],"functions.":[104],"Through":[105],"efficacy":[109],"identifying":[113],"understanding":[115],"disorders":[118],"also":[120],"demonstrated.":[121]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}