{"id":"https://openalex.org/W2755578054","doi":"https://doi.org/10.1109/embc.2017.8037420","title":"In silico investigation of the effects of hemolysis on the hyperspectral absorptance of blood in motion","display_name":"In silico investigation of the effects of hemolysis on the hyperspectral absorptance of blood in motion","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2755578054","doi":"https://doi.org/10.1109/embc.2017.8037420","mag":"2755578054","pmid":"https://pubmed.ncbi.nlm.nih.gov/29060461"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2017.8037420","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2017.8037420","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069157794","display_name":"Spencer R. Van Leeuwen","orcid":null},"institutions":[{"id":"https://openalex.org/I151746483","display_name":"University of Waterloo","ror":"https://ror.org/01aff2v68","country_code":"CA","type":"education","lineage":["https://openalex.org/I151746483"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Spencer R. Van Leeuwen","raw_affiliation_strings":["Natural Phenomena Simulation Group, University of Waterloo, Waterloo, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Natural Phenomena Simulation Group, University of Waterloo, Waterloo, Ontario, Canada","institution_ids":["https://openalex.org/I151746483"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025445179","display_name":"Gladimir V. G. Baranoski","orcid":"https://orcid.org/0000-0002-9215-2137"},"institutions":[{"id":"https://openalex.org/I151746483","display_name":"University of Waterloo","ror":"https://ror.org/01aff2v68","country_code":"CA","type":"education","lineage":["https://openalex.org/I151746483"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gladimir V. G. Baranoski","raw_affiliation_strings":["Natural Phenomena Simulation Group, University of Waterloo, Waterloo, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Natural Phenomena Simulation Group, University of Waterloo, Waterloo, Ontario, Canada","institution_ids":["https://openalex.org/I151746483"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112696230","display_name":"Bradley W. Kimmel","orcid":null},"institutions":[{"id":"https://openalex.org/I151746483","display_name":"University of Waterloo","ror":"https://ror.org/01aff2v68","country_code":"CA","type":"education","lineage":["https://openalex.org/I151746483"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Bradley W. Kimmel","raw_affiliation_strings":["Natural Phenomena Simulation Group, University of Waterloo, Waterloo, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Natural Phenomena Simulation Group, University of Waterloo, Waterloo, Ontario, Canada","institution_ids":["https://openalex.org/I151746483"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5069157794"],"corresponding_institution_ids":["https://openalex.org/I151746483"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.15809034,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"17","issue":null,"first_page":"2724","last_page":"2727"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9915000200271606,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9377999901771545,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/absorptance","display_name":"Absorptance","score":0.8872412443161011},{"id":"https://openalex.org/keywords/hemolysis","display_name":"Hemolysis","score":0.7767241597175598},{"id":"https://openalex.org/keywords/hyperspectral-imaging","display_name":"Hyperspectral imaging","score":0.7128615379333496},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.481693834066391},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.47946274280548096},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.35091105103492737},{"id":"https://openalex.org/keywords/reflectivity","display_name":"Reflectivity","score":0.33472493290901184},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3302798569202423},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.30089741945266724},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2343044877052307},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.16940683126449585},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.11111113429069519},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.08436474204063416}],"concepts":[{"id":"https://openalex.org/C2780851986","wikidata":"https://www.wikidata.org/wiki/Q16635541","display_name":"Absorptance","level":3,"score":0.8872412443161011},{"id":"https://openalex.org/C2779902561","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Hemolysis","level":2,"score":0.7767241597175598},{"id":"https://openalex.org/C159078339","wikidata":"https://www.wikidata.org/wiki/Q959005","display_name":"Hyperspectral imaging","level":2,"score":0.7128615379333496},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.481693834066391},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.47946274280548096},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.35091105103492737},{"id":"https://openalex.org/C108597893","wikidata":"https://www.wikidata.org/wiki/Q663650","display_name":"Reflectivity","level":2,"score":0.33472493290901184},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3302798569202423},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.30089741945266724},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2343044877052307},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.16940683126449585},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11111113429069519},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08436474204063416},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009038","descriptor_name":"Motion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009038","descriptor_name":"Motion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009038","descriptor_name":"Motion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2017.8037420","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2017.8037420","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:29060461","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29060461","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1589378501","https://openalex.org/W1968936982","https://openalex.org/W1976021780","https://openalex.org/W1988627290","https://openalex.org/W1992001865","https://openalex.org/W1992395985","https://openalex.org/W2028424190","https://openalex.org/W2041988397","https://openalex.org/W2042693441","https://openalex.org/W2054019746","https://openalex.org/W2070327739","https://openalex.org/W2132898527","https://openalex.org/W2172159076","https://openalex.org/W2331267590","https://openalex.org/W3109856192","https://openalex.org/W3125742422","https://openalex.org/W6789352889"],"related_works":["https://openalex.org/W4319159815","https://openalex.org/W2072166414","https://openalex.org/W1539029371","https://openalex.org/W2390761163","https://openalex.org/W3209970181","https://openalex.org/W2060875994","https://openalex.org/W2373610016","https://openalex.org/W2381790324","https://openalex.org/W2138109042","https://openalex.org/W4400769668"],"abstract_inverted_index":{"Measurement":[0],"of":[1,5,31,39,51,66,95,106,132,136,142,157,160,166],"the":[2,29,46,64,91,104,117,130,133,158,163],"optical":[3,16,164],"absorptance":[4,30,65,134,165],"blood":[6,67,97,137],"can":[7],"provide":[8],"insight":[9],"into":[10],"its":[11,177],"composition":[12],"and":[13,18,68,93,120,172,179],"behaviour.":[14],"Accordingly,":[15],"devices":[17],"sensors":[19],"are":[20,77],"commonly":[21],"used":[22],"in":[23,116,140,151],"a":[24,52,80],"clinical":[25],"setting":[26],"to":[27,62,102,138,170],"measure":[28],"blood,":[32,167],"either":[33],"directly":[34],"or":[35,48],"indirectly":[36],"through":[37],"measurement":[38],"skin":[40],"spectral":[41],"responses.":[42],"These":[43,75],"measurements":[44],"enable":[45],"evaluation":[47],"constant":[49],"monitoring":[50],"patient's":[53],"blood.":[54],"In":[55],"this":[56,152],"paper,":[57],"we":[58,113],"perform":[59],"predictive":[60],"simulations":[61,76],"investigate":[63],"how":[69],"it":[70],"is":[71],"affected":[72],"by":[73],"hemolysis.":[74],"performed":[78],"using":[79,123],"cell-based":[81],"light":[82],"interaction":[83],"model,":[84],"known":[85],"as":[86],"CLBlood,":[87],"which":[88],"accounts":[89],"for":[90,176],"orientation":[92],"distribution":[94],"red":[96],"cells.":[98],"This":[99],"allows":[100],"us":[101],"evaluate":[103,129],"effect":[105],"hemolysis":[107,139,161],"under":[108,145],"different":[109],"flow":[110],"conditions.":[111,148],"Furthermore,":[112],"produce":[114],"results":[115],"ultraviolet,":[118],"visible":[119],"infrared":[121],"domains":[122,144],"CLBlood's":[124],"hyperspectral":[125],"capabilities.":[126],"We":[127],"then":[128],"sensitivity":[131],"signature":[135],"each":[141],"these":[143],"several":[146],"experimental":[147],"The":[149],"observations":[150],"paper":[153],"enhance":[154],"our":[155],"understanding":[156],"impact":[159],"on":[162],"potentially":[168],"leading":[169],"simplified":[171],"more":[173],"accurate":[174],"methods":[175],"detection":[178],"monitoring.":[180]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}