{"id":"https://openalex.org/W2753993079","doi":"https://doi.org/10.1109/embc.2017.8037302","title":"Low-latency VLSI architecture for neural cross-frequency coupling analysis","display_name":"Low-latency VLSI architecture for neural cross-frequency coupling analysis","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2753993079","doi":"https://doi.org/10.1109/embc.2017.8037302","mag":"2753993079","pmid":"https://pubmed.ncbi.nlm.nih.gov/29060344"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2017.8037302","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2017.8037302","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026369499","display_name":"Gerard O\u2019Leary","orcid":"https://orcid.org/0000-0002-9768-2065"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Gerard O'Leary","raw_affiliation_strings":["Department of Electrical & Computer Engineering, University of Toronto, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Electrical & Computer Engineering, University of Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068870868","display_name":"Taufik A. Valiante","orcid":"https://orcid.org/0000-0002-3443-3790"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Taufik A. Valiante","raw_affiliation_strings":["Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021668898","display_name":"Roman Genov","orcid":"https://orcid.org/0000-0001-7506-1746"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Roman Genov","raw_affiliation_strings":["Department of Electrical & Computer Engineering, University of Toronto, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Electrical & Computer Engineering, University of Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5026369499"],"corresponding_institution_ids":["https://openalex.org/I185261750"],"apc_list":null,"apc_paid":null,"fwci":0.3954,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.60831915,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"2017","issue":null,"first_page":"2247","last_page":"2250"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/very-large-scale-integration","display_name":"Very-large-scale integration","score":0.7257609963417053},{"id":"https://openalex.org/keywords/latency","display_name":"Latency (audio)","score":0.6977294087409973},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6273342967033386},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.560799777507782},{"id":"https://openalex.org/keywords/epilepsy","display_name":"Epilepsy","score":0.47940823435783386},{"id":"https://openalex.org/keywords/neuromodulation","display_name":"Neuromodulation","score":0.4600211977958679},{"id":"https://openalex.org/keywords/computer-architecture","display_name":"Computer architecture","score":0.39163973927497864},{"id":"https://openalex.org/keywords/embedded-system","display_name":"Embedded system","score":0.33958953619003296},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.3239947259426117},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.21033453941345215},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.09952950477600098}],"concepts":[{"id":"https://openalex.org/C14580979","wikidata":"https://www.wikidata.org/wiki/Q876049","display_name":"Very-large-scale integration","level":2,"score":0.7257609963417053},{"id":"https://openalex.org/C82876162","wikidata":"https://www.wikidata.org/wiki/Q17096504","display_name":"Latency (audio)","level":2,"score":0.6977294087409973},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6273342967033386},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.560799777507782},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.47940823435783386},{"id":"https://openalex.org/C2780375056","wikidata":"https://www.wikidata.org/wiki/Q905905","display_name":"Neuromodulation","level":3,"score":0.4600211977958679},{"id":"https://openalex.org/C118524514","wikidata":"https://www.wikidata.org/wiki/Q173212","display_name":"Computer architecture","level":1,"score":0.39163973927497864},{"id":"https://openalex.org/C149635348","wikidata":"https://www.wikidata.org/wiki/Q193040","display_name":"Embedded system","level":1,"score":0.33958953619003296},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.3239947259426117},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.21033453941345215},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.09952950477600098}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2017.8037302","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2017.8037302","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:29060344","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29060344","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W812715811","https://openalex.org/W1967428268","https://openalex.org/W1978389345","https://openalex.org/W1987095365","https://openalex.org/W2018167794","https://openalex.org/W2098280111","https://openalex.org/W2099046443","https://openalex.org/W2112575160","https://openalex.org/W2155331948","https://openalex.org/W2165730296"],"related_works":["https://openalex.org/W4400956346","https://openalex.org/W3110657840","https://openalex.org/W4200466513","https://openalex.org/W2897335300","https://openalex.org/W2947088850","https://openalex.org/W4301179390","https://openalex.org/W4241353914","https://openalex.org/W2134640991","https://openalex.org/W3027318491","https://openalex.org/W101478184"],"abstract_inverted_index":{"Growing":[0],"evidence":[1],"suggests":[2],"that":[3,48],"cross-frequency":[4],"coupling":[5,39],"(CFC)":[6],"is":[7,73,95],"a":[8,52,104],"key":[9],"mechanism":[10],"in":[11,17,25,37,43,56],"neuronal":[12],"computation,":[13],"communication,":[14],"and":[15,32,90],"learning":[16],"the":[18,65,84],"brain.":[19],"Abnormal":[20],"CFC":[21,49,81],"has":[22,40],"been":[23,41],"implicated":[24],"pathological":[26],"brain":[27],"states":[28],"such":[29,68],"as":[30],"epilepsy":[31],"Parkinson's":[33],"disease.":[34],"A":[35,70],"reduction":[36],"excessive":[38],"shown":[42],"effective":[44],"neuromodulation":[45],"treatments,":[46],"suggesting":[47],"may":[50],"be":[51],"useful":[53],"feedback":[54],"measure":[55],"closed-loop":[57],"neural":[58],"stimulation":[59],"devices.":[60],"However,":[61],"processing":[62],"latency":[63,105],"limits":[64],"responsiveness":[66],"of":[67,80,106],"systems.":[69],"VLSI":[71],"architecture":[72,94],"presented":[74],"which":[75],"implements":[76],"three":[77],"selectable":[78],"measures":[79],"to":[82],"enable":[83],"application":[85],"specific":[86],"trade-off":[87],"between":[88],"low-latency":[89],"high-accuracy":[91],"processing.":[92],"The":[93],"demonstrated":[96],"using":[97],"in-vitro":[98],"human":[99],"neocortical":[100],"slice":[101],"recordings,":[102],"with":[103],"48ms.":[107]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2018,"cited_by_count":3}],"updated_date":"2026-03-25T13:04:00.132906","created_date":"2025-10-10T00:00:00"}