{"id":"https://openalex.org/W2755959760","doi":"https://doi.org/10.1109/embc.2017.8037260","title":"Improve blood compatibility of bioresorbable magnesium stents coated with functionalized anti-CD34 antibody and heparin-collagen multiplayers","display_name":"Improve blood compatibility of bioresorbable magnesium stents coated with functionalized anti-CD34 antibody and heparin-collagen multiplayers","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2755959760","doi":"https://doi.org/10.1109/embc.2017.8037260","mag":"2755959760","pmid":"https://pubmed.ncbi.nlm.nih.gov/29060303"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2017.8037260","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2017.8037260","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039707731","display_name":"Yi\u2010Ping Lai","orcid":null},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Yi-Ping Lai","raw_affiliation_strings":["Department of Biomedical Engineering, Chung Kung University, Tainan, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Chung Kung University, Tainan, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113623972","display_name":"Chung\u2010Dann Kan","orcid":null},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chung-Dann Kan","raw_affiliation_strings":["Division of Cardiovascular Surgery, National Cheng Kung University, Tainan City, Taiwan"],"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Surgery, National Cheng Kung University, Tainan City, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039707731"],"corresponding_institution_ids":["https://openalex.org/I91807558"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14553124,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"54","issue":null,"first_page":"2068","last_page":"2071"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.991599977016449,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biocompatibility","display_name":"Biocompatibility","score":0.7782943844795227},{"id":"https://openalex.org/keywords/heparin","display_name":"Heparin","score":0.7087703943252563},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.5444208383560181},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5014894008636475},{"id":"https://openalex.org/keywords/cd34","display_name":"CD34","score":0.49686935544013977},{"id":"https://openalex.org/keywords/surface-modification","display_name":"Surface modification","score":0.4628220498561859},{"id":"https://openalex.org/keywords/nuclear-chemistry","display_name":"Nuclear chemistry","score":0.3475654125213623},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3308570384979248},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.1757970154285431},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.15254032611846924},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.06155574321746826}],"concepts":[{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.7782943844795227},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.7087703943252563},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5444208383560181},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5014894008636475},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.49686935544013977},{"id":"https://openalex.org/C115537861","wikidata":"https://www.wikidata.org/wiki/Q7645993","display_name":"Surface modification","level":2,"score":0.4628220498561859},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.3475654125213623},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3308570384979248},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.1757970154285431},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15254032611846924},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06155574321746826},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015607","descriptor_name":"Stents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015607","descriptor_name":"Stents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015607","descriptor_name":"Stents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018952","descriptor_name":"Antigens, CD34","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018952","descriptor_name":"Antigens, CD34","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018952","descriptor_name":"Antigens, CD34","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020099","descriptor_name":"Coated Materials, Biocompatible","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020099","descriptor_name":"Coated Materials, Biocompatible","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020099","descriptor_name":"Coated Materials, Biocompatible","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020341","descriptor_name":"Absorbable Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020341","descriptor_name":"Absorbable Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020341","descriptor_name":"Absorbable Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2017.8037260","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2017.8037260","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:29060303","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29060303","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.699999988079071}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322933","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1971428935","https://openalex.org/W2079818105","https://openalex.org/W2097559067","https://openalex.org/W2130684433","https://openalex.org/W2163606238","https://openalex.org/W2341713608","https://openalex.org/W2359757439"],"related_works":["https://openalex.org/W2393655250","https://openalex.org/W2393417063","https://openalex.org/W2561756220","https://openalex.org/W2365560514","https://openalex.org/W2414282704","https://openalex.org/W2917354508","https://openalex.org/W2067214849","https://openalex.org/W2497443468","https://openalex.org/W2039688101","https://openalex.org/W2027564318"],"abstract_inverted_index":{"Instentrestenosis":[0],"and":[1,34,54,59,68],"late":[2],"stent":[3],"thrombosis":[4],"continue":[5],"to":[6,31,51],"be":[7],"the":[8,64,71],"greatest":[9],"limitations":[10],"of":[11,22,66],"drug-eluting":[12],"stents.":[13],"In":[14],"this":[15],"study,":[16],"an":[17],"anti-CD34":[18,80],"antibody":[19,81],"functionalized":[20],"multilayer":[21],"heparin/collagen":[23],"type":[24],"I":[25],"is":[26],"developed":[27],"by":[28],"layer-by-layer":[29],"assemble":[30],"enhance":[32],"biocompatibility":[33],"recruit":[35],"endothelial":[36],"progenitor":[37],"cells.":[38],"The":[39,57,74],"SEM":[40],"results":[41,61],"demonstrate":[42],"that":[43,79],"(Hep/Col)5-coated":[44],"samples":[45,53],"have":[46],"a":[47],"rougher":[48],"surface":[49],"compared":[50],"(Hep/Col)2-coated":[52],"untreated":[55],"samples.":[56,73],"EDX":[58],"FTIR":[60],"both":[62],"confirmed":[63],"presence":[65],"heparin":[67],"collagen":[69],"onto":[70,85],"modified":[72,86],"immunofluorescence":[75],"staining":[76],"outcomes":[77],"demonstrated":[78],"has":[82],"successfully":[83],"immobilized":[84],"Mg":[87],"discs.":[88]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}