{"id":"https://openalex.org/W2753997670","doi":"https://doi.org/10.1109/embc.2017.8037082","title":"Computational estimation of the hemodynamic significance of coronary stenoses in arterial branches deriving from CCTA: A proof-of-concept study","display_name":"Computational estimation of the hemodynamic significance of coronary stenoses in arterial branches deriving from CCTA: A proof-of-concept study","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2753997670","doi":"https://doi.org/10.1109/embc.2017.8037082","mag":"2753997670","pmid":"https://pubmed.ncbi.nlm.nih.gov/29060126"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2017.8037082","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2017.8037082","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060566170","display_name":"Panagiotis K. Siogkas","orcid":"https://orcid.org/0000-0002-0343-0984"},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Panagiotis K. Siogkas","raw_affiliation_strings":["Dept. of Materials Science and Engineering, University of Ioannina"],"affiliations":[{"raw_affiliation_string":"Dept. of Materials Science and Engineering, University of Ioannina","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091264689","display_name":"George Rigas","orcid":"https://orcid.org/0000-0002-5102-6185"},"institutions":[{"id":"https://openalex.org/I4210105723","display_name":"FORTH Institute of Molecular Biology and Biotechnology","ror":"https://ror.org/01gzszr18","country_code":"GR","type":"facility","lineage":["https://openalex.org/I4210105723","https://openalex.org/I8901234"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"George Rigas","raw_affiliation_strings":["Dept. of Biomedical Research, FORTH-IMBB, Ioannina, Greece"],"affiliations":[{"raw_affiliation_string":"Dept. of Biomedical Research, FORTH-IMBB, Ioannina, Greece","institution_ids":["https://openalex.org/I4210105723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051663494","display_name":"Themis P. Exarchos","orcid":"https://orcid.org/0000-0001-9420-9419"},"institutions":[{"id":"https://openalex.org/I4210105723","display_name":"FORTH Institute of Molecular Biology and Biotechnology","ror":"https://ror.org/01gzszr18","country_code":"GR","type":"facility","lineage":["https://openalex.org/I4210105723","https://openalex.org/I8901234"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Themis P. Exarchos","raw_affiliation_strings":["Dept. of Biomedical Research, FORTH-IMBB, Ioannina, Greece"],"affiliations":[{"raw_affiliation_string":"Dept. of Biomedical Research, FORTH-IMBB, Ioannina, Greece","institution_ids":["https://openalex.org/I4210105723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079931924","display_name":"Antonis I. Sakellarios","orcid":"https://orcid.org/0000-0002-2272-9543"},"institutions":[{"id":"https://openalex.org/I4210105723","display_name":"FORTH Institute of Molecular Biology and Biotechnology","ror":"https://ror.org/01gzszr18","country_code":"GR","type":"facility","lineage":["https://openalex.org/I4210105723","https://openalex.org/I8901234"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Antonis I. Sakellarios","raw_affiliation_strings":["Dept. of Biomedical Research, FORTH-IMBB, Ioannina, Greece"],"affiliations":[{"raw_affiliation_string":"Dept. of Biomedical Research, FORTH-IMBB, Ioannina, Greece","institution_ids":["https://openalex.org/I4210105723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006939356","display_name":"Michail I. Papafaklis","orcid":"https://orcid.org/0000-0002-5646-0378"},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Michail I. Papafaklis","raw_affiliation_strings":["Dept. of Cardiology in Medical School, University of Ioannina, Ioannina, Greece"],"affiliations":[{"raw_affiliation_string":"Dept. of Cardiology in Medical School, University of Ioannina, Ioannina, Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067763637","display_name":"Gualtiero Pelosi","orcid":"https://orcid.org/0000-0001-7472-2186"},"institutions":[{"id":"https://openalex.org/I4210106076","display_name":"Istituto di Fisiologia Clinica","ror":"https://ror.org/01kdj2848","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210106076","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gualtiero Pelosi","raw_affiliation_strings":["CNR, Institute of Clinical Physiology, Pisa, Italy"],"affiliations":[{"raw_affiliation_string":"CNR, Institute of Clinical Physiology, Pisa, Italy","institution_ids":["https://openalex.org/I4210106076"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057116470","display_name":"Oberdan Parodi","orcid":"https://orcid.org/0000-0003-2459-1047"},"institutions":[{"id":"https://openalex.org/I4210106076","display_name":"Istituto di Fisiologia Clinica","ror":"https://ror.org/01kdj2848","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210106076","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Oberdan Parodi","raw_affiliation_strings":["CNR, Institute of Clinical Physiology, Pisa, Italy"],"affiliations":[{"raw_affiliation_string":"CNR, Institute of Clinical Physiology, Pisa, Italy","institution_ids":["https://openalex.org/I4210106076"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108123560","display_name":"Lampros K. Michalis","orcid":"https://orcid.org/0000-0001-8834-4462"},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Lampros K. Michalis","raw_affiliation_strings":["Dept. of Cardiology in Medical School, University of Ioannina, Ioannina, Greece"],"affiliations":[{"raw_affiliation_string":"Dept. of Cardiology in Medical School, University of Ioannina, Ioannina, Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037813012","display_name":"Dimitrios I. Fotiadis","orcid":"https://orcid.org/0000-0002-7362-5082"},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]},{"id":"https://openalex.org/I4210105723","display_name":"FORTH Institute of Molecular Biology and Biotechnology","ror":"https://ror.org/01gzszr18","country_code":"GR","type":"facility","lineage":["https://openalex.org/I4210105723","https://openalex.org/I8901234"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitrios I. Fotiadis","raw_affiliation_strings":["Dept. of Biomedical Research, FORTH-IMBB, Ioannina, Greece","Dept. of Materials Science and Engineering, University of Ioannina"],"affiliations":[{"raw_affiliation_string":"Dept. of Biomedical Research, FORTH-IMBB, Ioannina, Greece","institution_ids":["https://openalex.org/I4210105723"]},{"raw_affiliation_string":"Dept. of Materials Science and Engineering, University of Ioannina","institution_ids":["https://openalex.org/I194019607"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5060566170"],"corresponding_institution_ids":["https://openalex.org/I194019607"],"apc_list":null,"apc_paid":null,"fwci":0.2417,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.60494439,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"18","issue":null,"first_page":"1348","last_page":"1351"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemodynamics","display_name":"Hemodynamics","score":0.7173335552215576},{"id":"https://openalex.org/keywords/fractional-flow-reserve","display_name":"Fractional flow reserve","score":0.6607292890548706},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.6432263851165771},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5706222653388977},{"id":"https://openalex.org/keywords/blood-flow","display_name":"Blood flow","score":0.549571692943573},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.5344241261482239},{"id":"https://openalex.org/keywords/pathological","display_name":"Pathological","score":0.4149984121322632},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.3806723952293396},{"id":"https://openalex.org/keywords/coronary-angiography","display_name":"Coronary angiography","score":0.12951847910881042},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"Myocardial infarction","score":0.10531800985336304}],"concepts":[{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.7173335552215576},{"id":"https://openalex.org/C2777987666","wikidata":"https://www.wikidata.org/wiki/Q1440572","display_name":"Fractional flow reserve","level":4,"score":0.6607292890548706},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6432263851165771},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5706222653388977},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.549571692943573},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5344241261482239},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4149984121322632},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3806723952293396},{"id":"https://openalex.org/C3019004856","wikidata":"https://www.wikidata.org/wiki/Q42297149","display_name":"Coronary angiography","level":3,"score":0.12951847910881042},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.10531800985336304}],"mesh":[{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017023","descriptor_name":"Coronary Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017023","descriptor_name":"Coronary Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017023","descriptor_name":"Coronary Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023921","descriptor_name":"Coronary Stenosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023921","descriptor_name":"Coronary Stenosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023921","descriptor_name":"Coronary Stenosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053805","descriptor_name":"Fractional Flow Reserve, Myocardial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053805","descriptor_name":"Fractional Flow Reserve, Myocardial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053805","descriptor_name":"Fractional Flow Reserve, Myocardial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2017.8037082","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2017.8037082","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:29060126","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29060126","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.699999988079071,"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W42615294","https://openalex.org/W1965440677","https://openalex.org/W1966388328","https://openalex.org/W1997199500","https://openalex.org/W2053836922","https://openalex.org/W2056188388","https://openalex.org/W2074882203","https://openalex.org/W2084216591","https://openalex.org/W2084768640","https://openalex.org/W2088439050","https://openalex.org/W2095061540","https://openalex.org/W2095680098","https://openalex.org/W2111441732","https://openalex.org/W2118810625","https://openalex.org/W2127649313","https://openalex.org/W2129534965","https://openalex.org/W2171820116","https://openalex.org/W2259710953","https://openalex.org/W2276422413","https://openalex.org/W2429092935","https://openalex.org/W6641554982","https://openalex.org/W6679367408","https://openalex.org/W6717803786"],"related_works":["https://openalex.org/W2022486491","https://openalex.org/W2049556828","https://openalex.org/W2196390651","https://openalex.org/W2074491218","https://openalex.org/W2368568469","https://openalex.org/W2126856789","https://openalex.org/W3034393383","https://openalex.org/W139562449","https://openalex.org/W1977024184","https://openalex.org/W4205527386"],"abstract_inverted_index":{"The":[0],"development":[1],"of":[2,10,58,61,98,119,125],"non-invasive":[3],"methods":[4],"for":[5,19,55,94],"the":[6,11,20,37,56,59,95,99,102,112],"accurate":[7],"hemodynamic":[8],"assessment":[9],"coronary":[12,44,62],"vasculature":[13],"has":[14,28],"become":[15],"a":[16,33,52,122],"non-trivial":[17],"matter":[18],"everyday":[21],"clinical":[22],"practice.":[23],"Virtual":[24],"Functional":[25],"Assessment":[26],"Index":[27],"already":[29],"been":[30],"suggested":[31],"as":[32,143],"valid":[34],"alternative":[35],"to":[36,89],"invasively":[38],"measured":[39],"FFR":[40],"but":[41],"only":[42],"on":[43],"arterial":[45,65,73,104],"segments.":[46],"In":[47],"this":[48],"work,":[49],"we":[50],"propose":[51],"novel":[53],"method":[54,142],"estimation":[57],"severity":[60],"lesions":[63],"in":[64,77],"branches":[66,74],"from":[67],"CCTA":[68],"derived":[69],"images.":[70],"Four":[71],"left":[72],"were":[75,87,129,137],"reconstructed":[76],"3D":[78,83],"using":[79],"our":[80,141],"in-house":[81],"developed":[82],"reconstruction":[84],"algorithm,":[85],"and":[86,121],"subjected":[88],"computational":[90],"blood":[91],"flow":[92],"simulations":[93],"final":[96],"calculation":[97],"vFAI":[100],"through":[101],"whole":[103],"branch.":[105],"Strong":[106],"correlation":[107],"was":[108],"found":[109],"(r=0.82)":[110],"between":[111],"two":[113],"methods.":[114],"A":[115],"small":[116,123],"relative":[117],"error":[118],"3.2%":[120],"trend":[124],"overestimation":[126],"(0.023,":[127],"SD=0.088)":[128],"also":[130],"observed.":[131],"All":[132],"pathological":[133],"cases":[134],"presenting":[135],"ischemia,":[136],"correctly":[138],"discriminated":[139],"by":[140],"hemodynamically":[144],"significant":[145],"lesions.":[146]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}