{"id":"https://openalex.org/W2754698287","doi":"https://doi.org/10.1109/embc.2017.8036769","title":"Development of a three dimensional, multiscale agent-based model of ductal carcinoma in situ","display_name":"Development of a three dimensional, multiscale agent-based model of ductal carcinoma in situ","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2754698287","doi":"https://doi.org/10.1109/embc.2017.8036769","mag":"2754698287","pmid":"https://pubmed.ncbi.nlm.nih.gov/29059817"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2017.8036769","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2017.8036769","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054229369","display_name":"Joseph D. Butner","orcid":"https://orcid.org/0000-0003-0608-2580"},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph D. Butner","raw_affiliation_strings":["Department of Chemical Engineering, University of New Mexico, Albuquerque, NM, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of New Mexico, Albuquerque, NM, USA","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033025983","display_name":"Vittorio Cristini","orcid":"https://orcid.org/0000-0002-7909-4278"},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vittorio Cristini","raw_affiliation_strings":["Center for Precision Biomedicine, University of Texas McGovern Medical School at Houston, Houston, TX, USA","Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX, USA","Houston Methodist Research Institute, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Precision Biomedicine, University of Texas McGovern Medical School at Houston, Houston, TX, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Houston Methodist Research Institute, Houston, TX, USA","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100438110","display_name":"Zhihui Wang","orcid":"https://orcid.org/0000-0002-1212-8525"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhihui Wang","raw_affiliation_strings":["Center for Precision Biomedicine, University of Texas McGovern Medical School at Houston, Houston, TX, USA","Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Precision Biomedicine, University of Texas McGovern Medical School at Houston, Houston, TX, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8051,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.71802935,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"2017","issue":null,"first_page":"86","last_page":"89"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ductal-carcinoma","display_name":"Ductal carcinoma","score":0.8904464244842529},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.6827734708786011},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5179457068443298},{"id":"https://openalex.org/keywords/in-situ","display_name":"In situ","score":0.5142843127250671},{"id":"https://openalex.org/keywords/mammography","display_name":"Mammography","score":0.5128757953643799},{"id":"https://openalex.org/keywords/carcinoma-in-situ","display_name":"Carcinoma in situ","score":0.4914635419845581},{"id":"https://openalex.org/keywords/resection","display_name":"Resection","score":0.4866238534450531},{"id":"https://openalex.org/keywords/surgical-resection","display_name":"Surgical resection","score":0.46295055747032166},{"id":"https://openalex.org/keywords/invasive-ductal-carcinoma","display_name":"Invasive ductal carcinoma","score":0.4584173560142517},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.4245939552783966},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.39439114928245544},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.3940431475639343},{"id":"https://openalex.org/keywords/surgery","display_name":"Surgery","score":0.32732322812080383},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.26324671506881714}],"concepts":[{"id":"https://openalex.org/C2780862961","wikidata":"https://www.wikidata.org/wiki/Q5311598","display_name":"Ductal carcinoma","level":4,"score":0.8904464244842529},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6827734708786011},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5179457068443298},{"id":"https://openalex.org/C2777822432","wikidata":"https://www.wikidata.org/wiki/Q216681","display_name":"In situ","level":2,"score":0.5142843127250671},{"id":"https://openalex.org/C2780472235","wikidata":"https://www.wikidata.org/wiki/Q324634","display_name":"Mammography","level":4,"score":0.5128757953643799},{"id":"https://openalex.org/C2777661416","wikidata":"https://www.wikidata.org/wiki/Q1035645","display_name":"Carcinoma in situ","level":3,"score":0.4914635419845581},{"id":"https://openalex.org/C159110652","wikidata":"https://www.wikidata.org/wiki/Q17078201","display_name":"Resection","level":2,"score":0.4866238534450531},{"id":"https://openalex.org/C3020562746","wikidata":"https://www.wikidata.org/wiki/Q7446275","display_name":"Surgical resection","level":2,"score":0.46295055747032166},{"id":"https://openalex.org/C3020375857","wikidata":"https://www.wikidata.org/wiki/Q1671685","display_name":"Invasive ductal carcinoma","level":4,"score":0.4584173560142517},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4245939552783966},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.39439114928245544},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3940431475639343},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32732322812080383},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26324671506881714},{"id":"https://openalex.org/C153294291","wikidata":"https://www.wikidata.org/wiki/Q25261","display_name":"Meteorology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008327","descriptor_name":"Mammography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008327","descriptor_name":"Mammography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008327","descriptor_name":"Mammography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2017.8036769","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2017.8036769","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:29059817","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29059817","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","score":0.6800000071525574,"display_name":"Life in Land"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W70460403","https://openalex.org/W1971614181","https://openalex.org/W2011003763","https://openalex.org/W2013507620","https://openalex.org/W2036861430","https://openalex.org/W2046664158","https://openalex.org/W2090722238","https://openalex.org/W2091955415","https://openalex.org/W2115168672","https://openalex.org/W2121010053","https://openalex.org/W2125857415","https://openalex.org/W2142171814","https://openalex.org/W2218205604","https://openalex.org/W2410611073","https://openalex.org/W6602789270","https://openalex.org/W6688584433"],"related_works":["https://openalex.org/W2119418116","https://openalex.org/W2060374165","https://openalex.org/W2054704224","https://openalex.org/W196621553","https://openalex.org/W4242046722","https://openalex.org/W4308631024","https://openalex.org/W2029567565","https://openalex.org/W4240443517","https://openalex.org/W2089969489","https://openalex.org/W2255866468"],"abstract_inverted_index":{"Ductal":[0],"carcinoma":[1],"in":[2,23,115],"situ":[3],"(DCIS)":[4],"is":[5,30],"the":[6,24,51,146],"most":[7],"commonly":[8],"diagnosed":[9],"form":[10],"of":[11,17,73,106,127],"non-invasive":[12,139],"breast":[13,20,58],"cancer,":[14],"constituting":[15],"20%":[16],"all":[18],"new":[19],"cancer":[21],"cases":[22],"United":[25],"States.":[26],"Although":[27],"non-invasive,":[28],"DCIS":[29,107],"usually":[31],"treated":[32],"surgically":[33],"through":[34,60],"resection.":[35],"Interestingly,":[36],"long-term":[37],"survival":[38,44,91],"studies":[39],"have":[40,97],"shown":[41],"that":[42,56,77],"patient":[43,87],"rates":[45],"are":[46],"not":[47],"significantly":[48],"impacted":[49],"by":[50],"type":[52],"or":[53],"resection,":[54],"indicating":[55],"increased":[57],"conservation":[59],"minimized":[61],"surgical":[62,83,132],"resection":[63],"may":[64,79],"indeed":[65],"be":[66],"possible.":[67],"This":[68],"requires":[69],"a":[70,99],"greater":[71],"understanding":[72],"disease":[74,123],"development,":[75],"so":[76],"clinicians":[78,119],"more":[80],"accurately":[81],"determine":[82],"margins":[84,133],"which":[85],"minimize":[86],"impact":[88],"while":[89],"maintaining":[90],"rates.":[92],"To":[93],"this":[94],"end,":[95],"we":[96,144],"developed":[98],"three-dimensional,":[100],"lattice-free":[101],"multiscale":[102],"agent":[103],"based":[104,134],"model":[105,147],"designed":[108],"to":[109,117,120,130,149],"help":[110],"quantify":[111],"ductal":[112],"invasion":[113],"rates,":[114],"order":[116],"allow":[118],"better":[121],"estimate":[122],"age":[124],"and":[125,129,151],"extent":[126],"invasion,":[128],"predict":[131],"on":[135],"parameters":[136],"obtainable":[137],"from":[138],"testing":[140],"(i.e.,":[141],"mammography).":[142],"Here,":[143],"present":[145],"development":[148],"date,":[150],"discuss":[152],"some":[153],"preliminary":[154],"results.":[155]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}