{"id":"https://openalex.org/W28269577","doi":"https://doi.org/10.1109/embc.2016.7592050","title":"\u5bb6\u65cf\u306e\u60a9\u307f\u76f8\u8ac7 \"\u3072\u3068\u308a\u3063\u3053\"\u306f\u554f\u984c\u3067\u3059\u304b","display_name":"\u5bb6\u65cf\u306e\u60a9\u307f\u76f8\u8ac7 \"\u3072\u3068\u308a\u3063\u3053\"\u306f\u554f\u984c\u3067\u3059\u304b","publication_year":2001,"publication_date":"2001-12-01","ids":{"openalex":"https://openalex.org/W28269577","doi":"https://doi.org/10.1109/embc.2016.7592050","mag":"28269577"},"language":"en","primary_location":{"id":"mag:28269577","is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/40003334351","pdf_url":null,"source":{"id":"https://openalex.org/S4306547056","display_name":"\u5a66\u4eba\u4e4b\u53cb","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"\u5a66\u4eba\u4e4b\u53cb","raw_type":null},"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091359465","display_name":"\u6566\u5b50 \u6751\u702c","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"\u6566\u5b50 \u6751\u702c","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5039016322","display_name":"\u5e78\u6d69 \u6751\u702c","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5e78\u6d69 \u6751\u702c","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5091359465"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00377953,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"95","issue":"13","first_page":"220","last_page":"222"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9900000095367432,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9900000095367432,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10614","display_name":"Transcranial Magnetic Stimulation Studies","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3381492793560028}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3381492793560028}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:28269577","is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/40003334351","pdf_url":null,"source":{"id":"https://openalex.org/S4306547056","display_name":"\u5a66\u4eba\u4e4b\u53cb","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"\u5a66\u4eba\u4e4b\u53cb","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46000000834465027,"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Deep":[0],"brain":[1],"stimulation":[2,61,87,122,143,154],"(DBS)":[3],"shows":[4],"promises":[5],"in":[6,50,176,186],"the":[7,14,19,30,39,44,66,76,91,100,114,128,135,153,162,168,177,182,188,197],"treatment":[8,199],"of":[9,17,21,33,38,71,85,94,116,131,145,181,190,200],"refractory":[10],"epilepsy.":[11,201],"Due":[12],"to":[13,56,65,74,126,196],"complex":[15],"causes":[16],"epilepsy,":[18],"mechanisms":[20,189],"DBS":[22],"are":[23],"still":[24],"unclear.":[25],"Depolarization":[26],"block":[27],"caused":[28],"by":[29],"persistent":[31],"excitation":[32],"neurons":[34,164],"may":[35],"be":[36],"one":[37],"possible":[40],"mechanisms.":[41],"To":[42],"test":[43],"hypothesis,":[45],"4-aminopyridine":[46],"(4-AP)":[47],"was":[48],"injected":[49],"rat":[51],"hippocampal":[52],"CA1":[53,72],"region":[54,73],"in-vivo":[55],"induce":[57],"epileptiform":[58,77,150],"activity.":[59],"Sinusoidal":[60],"trains":[62,84,144],"were":[63],"applied":[64],"afferent":[67],"pathway":[68],"(Schaffer":[69],"collaterals)":[70],"suppress":[75,149],"spikes.":[78,151],"Results":[79],"show":[80],"that":[81,142],"2-min":[82],"long":[83],"sinusoidal":[86,121,146],"(50":[88],"Hz)":[89,124],"decreased":[90,99,134],"firing":[92,129],"rate":[93,130],"population":[95],"spikes":[96],"(PS)":[97],"and":[98,166,192],"PS":[101,111,136],"amplitudes":[102,137],"significantly.":[103,138],"In":[104],"addition,":[105],"small":[106],"positive":[107],"sharp":[108],"waves":[109,147],"replaced":[110],"activity":[112],"during":[113],"periods":[115],"stimulation.":[117],"A":[118],"lower":[119],"frequency":[120,159],"(10":[123],"failed":[125],"decrease":[127],"PS,":[132],"but":[133],"These":[139],"results":[140],"suggest":[141],"could":[148],"Presumably,":[152],"with":[155],"a":[156],"high":[157],"enough":[158],"might":[160],"excite":[161],"downstream":[163],"persistently":[165],"elevate":[167],"membrane":[169],"potentials":[170],"continuously,":[171],"thereby":[172],"cause":[173],"depolarization":[174],"blocks":[175],"neurons.":[178],"The":[179],"findings":[180],"study":[183],"provide":[184],"insights":[185],"revealing":[187],"DBS,":[191],"have":[193],"important":[194],"implications":[195],"clinical":[198]},"counts_by_year":[],"updated_date":"2026-04-28T14:05:53.105641","created_date":"2016-06-24T00:00:00"}