{"id":"https://openalex.org/W2516329019","doi":"https://doi.org/10.1109/embc.2016.7592008","title":"Nonlinear 3-D simulation of high-intensity focused ultrasound therapy in the Kidney","display_name":"Nonlinear 3-D simulation of high-intensity focused ultrasound therapy in the Kidney","publication_year":2016,"publication_date":"2016-08-01","ids":{"openalex":"https://openalex.org/W2516329019","doi":"https://doi.org/10.1109/embc.2016.7592008","mag":"2516329019","pmid":"https://pubmed.ncbi.nlm.nih.gov/28269536"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2016.7592008","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2016.7592008","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["arxiv","crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/1608.08919","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036886201","display_name":"Visa Suomi","orcid":"https://orcid.org/0000-0002-1300-3425"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Visa Suomi","raw_affiliation_strings":["Department of Engineering Science, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering Science, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059879181","display_name":"Ji\u0159\u00ed Jaro\u0161","orcid":"https://orcid.org/0000-0002-0087-8804"},"institutions":[{"id":"https://openalex.org/I60587646","display_name":"Brno University of Technology","ror":"https://ror.org/03613d656","country_code":"CZ","type":"education","lineage":["https://openalex.org/I60587646"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jiri Jaros","raw_affiliation_strings":["Faculty of Information Technology, Brno University of Technology, Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Information Technology, Brno University of Technology, Brno, Czech Republic","institution_ids":["https://openalex.org/I60587646"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045664151","display_name":"Bradley E. Treeby","orcid":"https://orcid.org/0000-0001-7782-011X"},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bradley Treeby","raw_affiliation_strings":["Department of Medical Physics and Biomedical Engineering, University College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physics and Biomedical Engineering, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054317942","display_name":"Robin O. Cleveland","orcid":"https://orcid.org/0000-0002-1797-4704"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robin Cleveland","raw_affiliation_strings":["Department of Engineering Science, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering Science, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"2016","issue":null,"first_page":"5648","last_page":"5651"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-intensity-focused-ultrasound","display_name":"High-intensity focused ultrasound","score":0.7815840244293213},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.6378846168518066},{"id":"https://openalex.org/keywords/intensity","display_name":"Intensity (physics)","score":0.46348029375076294},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4325825273990631},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.4228634834289551},{"id":"https://openalex.org/keywords/ultrasound","display_name":"Ultrasound","score":0.3701631426811218},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.19431734085083008},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.1773417890071869},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.17306232452392578},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1139494776725769}],"concepts":[{"id":"https://openalex.org/C2777365067","wikidata":"https://www.wikidata.org/wiki/Q564897","display_name":"High-intensity focused ultrasound","level":3,"score":0.7815840244293213},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.6378846168518066},{"id":"https://openalex.org/C93038891","wikidata":"https://www.wikidata.org/wiki/Q1061524","display_name":"Intensity (physics)","level":2,"score":0.46348029375076294},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4325825273990631},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4228634834289551},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.3701631426811218},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19431734085083008},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.1773417890071869},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.17306232452392578},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1139494776725769},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057086","descriptor_name":"High-Intensity Focused Ultrasound Ablation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057086","descriptor_name":"High-Intensity Focused Ultrasound Ablation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057086","descriptor_name":"High-Intensity Focused Ultrasound Ablation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1109/embc.2016.7592008","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2016.7592008","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:28269536","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28269536","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:arXiv.org:1608.08919","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1608.08919","pdf_url":"https://arxiv.org/pdf/1608.08919","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1515774","is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1515774/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"In: The Proceedings of the 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). (pp. pp. 5648-5651). Institute of Electrical and Electronics Engineers (IEEE): Orlando, Florida, USA. (2016)","raw_type":"Proceedings paper"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:3916e0df-4ffa-41cb-911f-845a10631e7c","is_oa":false,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:3916e0df-4ffa-41cb-911f-845a10631e7c","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference item"},{"id":"pmh:oai:pubmedcentral.nih.gov:5525134","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5525134","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Conf Proc IEEE Eng Med Biol Soc","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:1608.08919","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1608.08919","pdf_url":"https://arxiv.org/pdf/1608.08919","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[{"score":0.6700000166893005,"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6"}],"awards":[{"id":"https://openalex.org/G1858952963","display_name":null,"funder_award_id":"1245198","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G2003452119","display_name":null,"funder_award_id":"EP/M011119/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G2276662389","display_name":null,"funder_award_id":"EP/K02020X/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G4790210175","display_name":null,"funder_award_id":"EP/L020262/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G5009901196","display_name":"Development &amp; Clinical Translation of Scalable HPC Ultrasound Models","funder_award_id":"EP/M011119/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G5533512618","display_name":"Radio and sound waves to image cancer treatment","funder_award_id":"EP/K02020X/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G6829994400","display_name":null,"funder_award_id":"P01 DK043881","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7142309450","display_name":"Model-Based Treatment Planning for Focused Ultrasound Surgery","funder_award_id":"EP/L020262/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W144809703","https://openalex.org/W1526092665","https://openalex.org/W1863908278","https://openalex.org/W1981989535","https://openalex.org/W1998953558","https://openalex.org/W2006592230","https://openalex.org/W2021528401","https://openalex.org/W2046161862","https://openalex.org/W2048989117","https://openalex.org/W2064060158","https://openalex.org/W2072926290","https://openalex.org/W2085131028","https://openalex.org/W2107438504","https://openalex.org/W2110603325","https://openalex.org/W2159777863","https://openalex.org/W2167545922","https://openalex.org/W2907277541","https://openalex.org/W3151241602","https://openalex.org/W4245722877","https://openalex.org/W6639176076"],"related_works":["https://openalex.org/W2333115645","https://openalex.org/W4402299999","https://openalex.org/W4246450666","https://openalex.org/W4388998267","https://openalex.org/W2898370298","https://openalex.org/W2137437058","https://openalex.org/W2093309763","https://openalex.org/W2357177413","https://openalex.org/W2115523377","https://openalex.org/W2035158409"],"abstract_inverted_index":{"Kidney":[0],"cancer":[1],"is":[2],"a":[3,61,74,80,130],"severe":[4],"disease":[5],"which":[6,82],"can":[7,30],"be":[8],"treated":[9],"non-invasively":[10],"using":[11,60],"high-intensity":[12],"focused":[13],"ultrasound":[14,63],"(HIFU)":[15],"therapy.":[16],"However,":[17],"tissue":[18,50,70,154],"in":[19,106,111,117,144,169,176],"front":[20],"of":[21,28,37,42,55,68,79,97,195,203],"the":[22,25,35,38,56,69,118,142,196,204,217],"transducer":[23],"and":[24,45,92,100,138,172,179,220],"deep":[26],"location":[27,219],"kidney":[29,57,119],"cause":[31],"significant":[32],"losses":[33,148],"to":[34,48,104,121,141,150,165,213],"efficiency":[36],"treatment.":[39],"The":[40,66,94,124,147,192],"effect":[41,96],"attenuation,":[43],"refraction":[44,127,139,166],"reflection":[46],"due":[47,149,164],"different":[49],"types":[51],"on":[52],"HIFU":[53],"therapy":[54,222],"was":[58,71,102,190,200],"studied":[59],"nonlinear":[62],"simulation":[64,125],"model.":[65],"geometry":[67],"derived":[72],"from":[73],"computed":[75],"tomography":[76],"(CT)":[77],"dataset":[78],"patient":[81],"had":[83],"been":[84],"segmented":[85],"for":[86],"water,":[87],"bone,":[88],"soft":[89,153],"tissue,":[90],"fat":[91],"kidney.":[93],"combined":[95],"inhomogeneous":[98],"attenuation":[99,137],"soundspeed":[101],"found":[103],"result":[105],"an":[107],"11.0":[108],"dB":[109,132],"drop":[110],"spatial":[112],"peak-temporal":[113],"average":[114],"(SPTA)":[115],"intensity":[116],"compared":[120],"pure":[122],"water.":[123],"without":[126],"effects":[128,167],"showed":[129],"6.3":[131],"decrease":[133],"indicating":[134],"that":[135],"both":[136],"contribute":[140],"loss":[143],"focal":[145,183,198,207],"intensity.":[146],"reflections":[151],"at":[152],"interfaces":[155],"were":[156],"less":[157],"than":[158],"0.1":[159],"dB.":[160],"Focal":[161],"point":[162,184],"shifting":[163],"resulted":[168],"-1.3,":[170],"2.6":[171],"1.3":[173],"mm":[174],"displacements":[175],"x-,":[177],"y-":[178],"z-directions":[180],"respectively.":[181],"Furthermore,":[182],"splitting":[185],"into":[186],"several":[187],"smaller":[188],"subvolumes":[189],"observed.":[191],"total":[193],"volume":[194],"secondary":[197],"points":[199],"approximately":[201],"46%":[202],"largest":[205],"primary":[206],"point.":[208],"This":[209],"could":[210],"potentially":[211],"lead":[212],"undesired":[214],"heating":[215],"outside":[216],"target":[218],"longer":[221],"times.":[223]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2}],"updated_date":"2026-07-28T07:46:37.118299","created_date":"2025-10-10T00:00:00"}
