{"id":"https://openalex.org/W2532525035","doi":"https://doi.org/10.1109/embc.2016.7591683","title":"Patient emulator: A tool for testing mechanical ventilation therapies","display_name":"Patient emulator: A tool for testing mechanical ventilation therapies","publication_year":2016,"publication_date":"2016-08-01","ids":{"openalex":"https://openalex.org/W2532525035","doi":"https://doi.org/10.1109/embc.2016.7591683","mag":"2532525035","pmid":"https://pubmed.ncbi.nlm.nih.gov/28269235"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2016.7591683","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2016.7591683","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102851570","display_name":"Nikolaos Karamolegkos","orcid":null},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nikolaos Karamolegkos","raw_affiliation_strings":["Biomedical Engineering Department, Columbia University, New York, NY, USA"],"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Department, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058770147","display_name":"Antonio Albanese","orcid":"https://orcid.org/0000-0001-7608-7278"},"institutions":[{"id":"https://openalex.org/I4210131230","display_name":"Philips (United States)","ror":"https://ror.org/03kw6wr76","country_code":"US","type":"company","lineage":["https://openalex.org/I4210122849","https://openalex.org/I4210131230"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonio Albanese","raw_affiliation_strings":["Philips Research North America, Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Philips Research North America, Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210131230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075090603","display_name":"Fernando Isaza","orcid":null},"institutions":[{"id":"https://openalex.org/I4210131230","display_name":"Philips (United States)","ror":"https://ror.org/03kw6wr76","country_code":"US","type":"company","lineage":["https://openalex.org/I4210122849","https://openalex.org/I4210131230"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fernando Isaza","raw_affiliation_strings":["Philips Respironics, Carlsbad, CA, USA"],"affiliations":[{"raw_affiliation_string":"Philips Respironics, Carlsbad, CA, USA","institution_ids":["https://openalex.org/I4210131230"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064079956","display_name":"Nicolas W. Chbat","orcid":"https://orcid.org/0000-0002-8802-241X"},"institutions":[{"id":"https://openalex.org/I4210131230","display_name":"Philips (United States)","ror":"https://ror.org/03kw6wr76","country_code":"US","type":"company","lineage":["https://openalex.org/I4210122849","https://openalex.org/I4210131230"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicolas W. Chbat","raw_affiliation_strings":["Philips Research North America, Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Philips Research North America, Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210131230"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5102851570"],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":0.2502,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.65628116,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"1868","issue":null,"first_page":"4321","last_page":"4324"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.987500011920929,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"Mechanical ventilation","score":0.6401876211166382},{"id":"https://openalex.org/keywords/piston","display_name":"Piston (optics)","score":0.5922101736068726},{"id":"https://openalex.org/keywords/actuator","display_name":"Actuator","score":0.5536518692970276},{"id":"https://openalex.org/keywords/ventilation","display_name":"Ventilation (architecture)","score":0.5488064289093018},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.48840993642807007},{"id":"https://openalex.org/keywords/simulation","display_name":"Simulation","score":0.4200795590877533},{"id":"https://openalex.org/keywords/reliability-engineering","display_name":"Reliability engineering","score":0.34406474232673645},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2529064118862152},{"id":"https://openalex.org/keywords/mechanical-engineering","display_name":"Mechanical engineering","score":0.23062434792518616},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.19134819507598877},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1316089928150177},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.1038108766078949}],"concepts":[{"id":"https://openalex.org/C2777080012","wikidata":"https://www.wikidata.org/wiki/Q3766250","display_name":"Mechanical ventilation","level":2,"score":0.6401876211166382},{"id":"https://openalex.org/C199524791","wikidata":"https://www.wikidata.org/wiki/Q7198512","display_name":"Piston (optics)","level":3,"score":0.5922101736068726},{"id":"https://openalex.org/C172707124","wikidata":"https://www.wikidata.org/wiki/Q423488","display_name":"Actuator","level":2,"score":0.5536518692970276},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.5488064289093018},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48840993642807007},{"id":"https://openalex.org/C44154836","wikidata":"https://www.wikidata.org/wiki/Q45045","display_name":"Simulation","level":1,"score":0.4200795590877533},{"id":"https://openalex.org/C200601418","wikidata":"https://www.wikidata.org/wiki/Q2193887","display_name":"Reliability engineering","level":1,"score":0.34406474232673645},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2529064118862152},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.23062434792518616},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.19134819507598877},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1316089928150177},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.1038108766078949},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C165699331","wikidata":"https://www.wikidata.org/wiki/Q461533","display_name":"Wavefront","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003199","descriptor_name":"Computer Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003199","descriptor_name":"Computer Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003199","descriptor_name":"Computer Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012121","descriptor_name":"Respiration, Artificial","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D012121","descriptor_name":"Respiration, Artificial","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D012121","descriptor_name":"Respiration, Artificial","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D012122","descriptor_name":"Ventilators, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012122","descriptor_name":"Ventilators, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012122","descriptor_name":"Ventilators, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062186","descriptor_name":"Arterial Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062186","descriptor_name":"Arterial Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062186","descriptor_name":"Arterial Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2016.7591683","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2016.7591683","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:28269235","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28269235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1242065934","https://openalex.org/W1559086381","https://openalex.org/W2008758240","https://openalex.org/W2012105227","https://openalex.org/W2096397061","https://openalex.org/W2138512718","https://openalex.org/W2143142571","https://openalex.org/W2229361031","https://openalex.org/W2237044322","https://openalex.org/W2299888665","https://openalex.org/W6674458800"],"related_works":["https://openalex.org/W2490690736","https://openalex.org/W2099333796","https://openalex.org/W1999058329","https://openalex.org/W2357054102","https://openalex.org/W2080330449","https://openalex.org/W3200576072","https://openalex.org/W2381702941","https://openalex.org/W2007221537","https://openalex.org/W2169474978","https://openalex.org/W785766289"],"abstract_inverted_index":{"Several":[0],"modes":[1,29],"of":[2,14,26,64,78,95,137],"mechanical":[3,27,65],"ventilation":[4,28,66,107],"are":[5,19],"clinically":[6],"available.":[7],"The":[8,68,93,110,124],"differences":[9],"among":[10],"them":[11],"in":[12,149],"terms":[13],"efficacy":[15],"and":[16,24,39,130,154],"patient":[17,48],"outcomes":[18],"not":[20],"clear":[21],"yet.":[22],"Testing":[23],"comparison":[25],"via":[30,88],"human":[31,80,122,155],"or":[32,148],"animal":[33,153],"trials":[34],"is":[35,70,99,114],"a":[36,51,59,73,85,89,103,145],"very":[37],"challenging":[38],"costly":[40],"process.":[41],"In":[42],"this":[43],"paper,":[44],"we":[45],"present":[46],"the":[47,79,96,127,135,138],"emulator":[49],"(PE),":[50],"novel":[52],"system":[53,69,82],"that":[54],"can":[55],"be":[56,142],"used":[57,143],"as":[58,144],"platform":[60],"for":[61,147],"in-silico":[62],"testing":[63],"therapies.":[67],"based":[71],"on":[72],"large-scale":[74],"integrated":[75],"mathematical":[76],"model":[77],"cardiopulmonary":[81],"interfaced":[83],"with":[84],"physical":[86],"ventilator":[87],"controlled":[90],"piston-cylinder":[91],"actuator.":[92],"performance":[94],"proposed":[97,139],"PE":[98,140],"demonstrated":[100],"by":[101],"simulating":[102],"realistic":[104],"pressure":[105],"support":[106],"step":[108],"protocol.":[109],"PE-simulated":[111],"patient's":[112],"response":[113],"then":[115],"compared":[116],"against":[117],"averaged":[118],"data":[119,129],"from":[120],"33":[121],"subjects.":[123],"agreement":[125],"between":[126],"simulated":[128],"their":[131],"experimental":[132],"counterparts":[133],"shows":[134],"potential":[136],"to":[141,151],"substitute":[146],"addition":[150],"conventional":[152],"trials.":[156]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
